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Also known as: 80908-09-4, Phosphonomethylphosphonic acid;technetium-99, Technetium tc 99m medronate (usp), Technetium tc-99m medronate anhydrous, 8v3fgc4j77, Technetium (99mtc) medronic acid
Molecular Formula
CH6O6P2Tc
Molecular Weight
274.91  g/mol
InChI Key
IGLHHEWLHQOTJM-IEOVAKBOSA-N

Technetium (99Mtc) Methylenediphosphonate
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
1 2D Structure

Technetium (99Mtc) Methylenediphosphonate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
phosphonomethylphosphonic acid;technetium-99
2.1.2 InChI
InChI=1S/CH6O6P2.Tc/c2-8(3,4)1-9(5,6)7;/h1H2,(H2,2,3,4)(H2,5,6,7);/i;1+1
2.1.3 InChI Key
IGLHHEWLHQOTJM-IEOVAKBOSA-N
2.1.4 Canonical SMILES
C(P(=O)(O)O)P(=O)(O)O.[Tc]
2.1.5 Isomeric SMILES
C(P(=O)(O)O)P(=O)(O)O.[99Tc]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 99mtc Methylene Diphosphonate

2. 99mtc-mdp

3. 99mtc-methylene Diphosphonate

4. Diphosphonate, 99mtc-methylene

5. Diphosphonate, Tc-99m Methylene

6. Diphosphonate, Technetium Methylene

7. Medronate, Tc-99

8. Methylene Diphosphonate, Tc-99m

9. Methylene Diphosphonate, Technetium

10. Tc 99 Medronate

11. Tc 99m Methylene Diphosphonate

12. Tc-99 Medronate

13. Tc-99m Methylene Diphosphonate

14. Technetium Methylene Diphosphonate

15. Technetium Tc 99m Medronate

16. Technetium Tc 99m Methylenediphosphonate

2.2.2 Depositor-Supplied Synonyms

1. 80908-09-4

2. Phosphonomethylphosphonic Acid;technetium-99

3. Technetium Tc 99m Medronate (usp)

4. Technetium Tc-99m Medronate Anhydrous

5. 8v3fgc4j77

6. Technetium (99mtc) Medronic Acid

7. Technetium (99mtc) Methylenediphosphonate

8. Technetium-99 Medronate

9. Technetium-99mtc-hydroxymethylene Diphosphonate

10. An-mdp (tn)

11. Unii-8v3fgc4j77

12. 63347-66-0

13. Phosphonic Acid, Methylenebis-, Technetium-99tc Salt

14. Chebi:32186

15. Moli000842

16. Nsc749127

17. Nsc-749127

18. D02029

19. Q7692228

20. Radiolabeled Technetium Tc 99m Medronate (99mtc-mdp)

2.3 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 274.91 g/mol
Molecular Formula CH6O6P2Tc
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass274.870212 g/mol
Monoisotopic Mass274.870212 g/mol
Topological Polar Surface Area115 Ų
Heavy Atom Count10
Formal Charge0
Complexity152
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Radiopharmaceuticals

Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)


4.2 ATC Code

V - Various

V09 - Diagnostic radiopharmaceuticals

V09B - Skeleton

V09BA - Technetium (99mtc) compounds

V09BA02 - Technetium (99mTc) medronic acid


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