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1. Cdb 4124
2. Cdb-4124
3. Cdb4124
4. Proellex
1. Proellex
2. 198414-31-2
3. Telapristone Acetate [usan]
4. 1k9eyk92pq
5. Zpv-200
6. Ru-44675
7. 17alpha-acetoxy-11beta-(4-(dimethylamino)phenyl)-21-methoxy-19-norpregna-4,9-dien-3,20-dione
8. Telapristone Acetate (usan)
9. (8s,11r,13s,14s,17r)-11-(4-(dimethylamino)phenyl)-17-(2-methoxyacetyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl Acetate
10. [(8s,11r,13s,14s,17r)-11-[4-(dimethylamino)phenyl]-17-(2-methoxyacetyl)-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] Acetate
11. Unii-1k9eyk92pq
12. Ccris 9331
13. Cdb 4124
14. Schembl374762
15. Chembl2105694
16. Cdb4124
17. Dtxsid60173587
18. Chebi:188804
19. Telapristone Acetate [who-dd]
20. Db05253
21. D09972
22. Q7695644
23. 11.beta.-(4-(dimethylamino)phenyl)-17-acetoxy-21-methoxy- 19-norpregna-4,9-diene-3,20-dione
24. 19-norpregna-4,9-diene-3,20-dione, 17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-21-methoxy-, (11.beta.)-
25. 19-norpregna-4,9-diene-3,20-dione, 17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-21-methoxy-, (11beta)-
Molecular Weight | 505.6 g/mol |
---|---|
Molecular Formula | C31H39NO5 |
XLogP3 | 3.4 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 7 |
Exact Mass | 505.28282334 g/mol |
Monoisotopic Mass | 505.28282334 g/mol |
Topological Polar Surface Area | 72.9 Ų |
Heavy Atom Count | 37 |
Formal Charge | 0 |
Complexity | 1020 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 5 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
For the treatment of uterine fibroids and endometriosis.
Patients receiving Proellex saw improvements in key symptoms associated with uterine fibroids, namely reduced pain and bleeding, as well as effects on bone retention.
Absorption
Orally-available
Proellex selectively blocks the progesterone receptor thus avoiding the adverse effects of GnRH agonists associated with the induction of a low estrogen, menopausal-like state in women.