DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 2 NDC API, 1 Listed Suppliers

1 API Suppliers
2 NDC API
1 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 1 FDA Orange Book, 1 Canada

2 FDF Dossiers
1 FDA Orange Book
1 Canada

PATENTS & EXCLUSIVITIES

5 US Patents, 1 US Exclusivities

patents
5 US Patents
1 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 1137608-69-5, Lx1606 hippurate, Telotristat ethyl hippurate, Lx1032 hippurate, Telotristat etiprate [usan], Lx 1606 hippurate

Molecular Formula

C₃₆H₃₅ClF₃N₇O₆

Molecular Weight

754.2 g/mol

InChI Key

XSFPZBUIBYMVEA-CELUQASASA-N

FDA UNII

3T25U84H4U

Telotristat Etiprate is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor prodrug, with potential antiserotonergic activity. Upon administration, telotristat etiprate is converted to its active moiety, telotristat (LP-778902), which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells.

1 2D Structure

Telotristat Etiprate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-benzamidoacetic acid;ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate

2.1.2 InChI

InChI=1S/C27H26ClF3N6O3.C9H9NO3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37;11-8(12)6-10-9(13)7-4-2-1-3-5-7/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35);1-5H,6H2,(H,10,13)(H,11,12)/t20-,24+;/m0./s1

2.1.3 InChI Key

XSFPZBUIBYMVEA-CELUQASASA-N

2.1.4 Canonical SMILES

CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N.C1=CC=C(C=C1)C(=O)NCC(=O)O

2.1.5 Isomeric SMILES

CCOC(=O)[C@H](CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)O[C@H](C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N.C1=CC=C(C=C1)C(=O)NCC(=O)O

2.2 Other Identifiers

2.2.1 UNII

3T25U84H4U

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Lx1606

2. Telotristat

2.3.2 Depositor-Supplied Synonyms

1. 1137608-69-5

2. Lx1606 Hippurate

3. Telotristat Ethyl Hippurate

4. Lx1032 Hippurate

5. Telotristat Etiprate [usan]

6. Lx 1606 Hippurate

7. Lx1606 (hippurate)

8. 1137608-69-5 (etiprate)

9. Lx-1606 Hippurate

10. 3t25u84h4u

11. Telotristat Etiprate (usan)

12. 2-benzamidoacetic Acid, ((s)-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-1-ethoxy-1-oxopr

13. (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate 2-benzamidoacetate .

14. 4-[2-amino-6-[(1r)-1-[4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-l-phenylalanine Ethyl Ester N-benzoylglycine Salt

15. Telotristat Etiprate (lx 1606 Hippurate)

16. Unii-3t25u84h4u

17. Lx 1032 Hippurate

18. Lx-1032 Hippurate

19. Chembl3348963

20. Telotristat Etiprate [mi]

21. Amy38702

22. Ex-a1619

23. S2173

24. Telotristat Etiprate [who-dd]

25. Akos027250730

26. Ccg-270440

27. Cs-0429

28. Ncgc00346476-01

29. (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate Hippurate

30. 4-[2-amino-6-[(1r)-1-[4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidi

31. Ac-30898

32. Hy-13055

33. Telotristat Etiprate [orange Book]

34. Sw219281-1

35. D09975

36. Q27257995

37. 2-benzamidoacetic Acid, ((s)-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-1-ethoxy-1-oxopropan-2-yl)amide Salt

38. 2-benzamidoacetic Acid;ethyl (2s)-2-amino-3-[4-[2-amino-6-[(1r)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate

39. Ethyl 4-(2-amino-6-((1r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pryrimidin-4-yl)-l-phenylalaninate N-benzoylglycinate (1:1)

40. L-phenylalanine, 4-(2-amino-6-((1r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)- 2,2,2-trifluoroethoxy)-4-pryrimidinyl)-, Ethyl Ester, Compd. With N-benzoylglycine (1:1)

2.4 Create Date

2009-05-18

3 Chemical and Physical Properties

Molecular Formula	C₃₆H₃₅ClF₃N₇O₆
Molecular Weight	754.2 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	13
Exact Mass	753.2289440 g/mol
Monoisotopic Mass	753.2289440 g/mol
Topological Polar Surface Area	198 Å²
Heavy Atom Count	53
Formal Charge	0
Complexity	1020
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 1
Drug Name	XERMELO
Active Ingredient	TELOTRISTAT ETIPRATE
Company	LEXICON PHARMS INC (Application Number: N208794. Patents: 7553840, 7709493, 7968559, 8193204, 8653094)

4.2 Drug Indication

Xermelo is indicated for the treatment of carcinoid syndrome diarrhoea in combination with somatostatin analogue (SSA) therapy in adults inadequately controlled by SSA therapy.

Treatment of carcinoid syndrome

5 Pharmacology and Biochemistry

5.1 ATC Code

A16A

API SUPPLIERS