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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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NDC API

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Chemistry

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Also known as: 66148-78-5, Temocillinum, Temocillina, Temocilline, Negaban, Brl 17421
Molecular Formula
C16H18N2O7S2
Molecular Weight
414.5  g/mol
InChI Key
BVCKFLJARNKCSS-DWPRYXJFSA-N
FDA UNII
03QB156W6I

Temocillin Disodium
Temocillin is a semisynthetic, narrow-spectrum, beta-lactamase-resistant penicillin with antibacterial activity. Temocillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
1 2D Structure

Temocillin Disodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,5R,6S)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C16H18N2O7S2/c1-15(2)9(12(22)23)18-13(24)16(25-3,14(18)27-15)17-10(19)8(11(20)21)7-4-5-26-6-7/h4-6,8-9,14H,1-3H3,(H,17,19)(H,20,21)(H,22,23)/t8?,9-,14+,16-/m0/s1
2.1.3 InChI Key
BVCKFLJARNKCSS-DWPRYXJFSA-N
2.1.4 Canonical SMILES
CC1(C(N2C(S1)C(C2=O)(NC(=O)C(C3=CSC=C3)C(=O)O)OC)C(=O)O)C
2.1.5 Isomeric SMILES
CC1([C@@H](N2[C@H](S1)[C@@](C2=O)(NC(=O)C(C3=CSC=C3)C(=O)O)OC)C(=O)O)C
2.2 Other Identifiers
2.2.1 UNII
03QB156W6I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Brl 17421

2. Disodium 6beta-(2-carboxy-2-thien-3-ylacetamido)-6alpha-methoxypenicillanate

3. Temocillin, (2s-(2alpha,5alpha,6alpha))-isomer

2.3.2 Depositor-Supplied Synonyms

1. 66148-78-5

2. Temocillinum

3. Temocillina

4. Temocilline

5. Negaban

6. Brl 17421

7. Brl-17421

8. N-((2s,5r,6s)-2-carboxy-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-3-thiophenemalonamic Acid

9. Brl 17421 [as Sodium]

10. (2s,5r,6s)-6-[(3-hydroxy-3-oxo-2-thiophen-3-ylpropanoyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

11. Brl 17421 Free Acid

12. Brl-17421 Free Acid

13. Chebi:51817

14. 03qb156w6i

15. Temocillin (usan)

16. (2s,5r,6s)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

17. Temocillin [usan]

18. Temocilline [inn-french]

19. Temocillinum [inn-latin]

20. Temocillina [inn-spanish]

21. 6beta-[carboxy(thiophen-3-yl)acetamido]-6-methoxy-2,2-dimethylpenam-3alpha-carboxylic Acid

22. (2s,5r,6s)-6-{[carboxy(3-thienyl)acetyl]amino}-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

23. (2s,5r,6s)-6-{[carboxy(thiophen-3-yl)acetyl]amino}-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

24. Einecs 266-184-1

25. Temocillin [usan:inn:ban]

26. Unii-03qb156w6i

27. Temocillin [mi]

28. Temocillin [inn]

29. Temocillin [mart.]

30. Temocillin [who-dd]

31. Schembl34084

32. Chembl1276310

33. Gtpl10926

34. Dtxsid201009398

35. Brl17421

36. Db12343

37. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-((carboxy-3-thienylacetyl)amino)-6-methoxy-3,3-dimethyl-7-oxo-, (2s-(2alpha,5alpha,6alpha))-

38. Hy-145158

39. Cs-0356857

40. D06064

41. 148t785

42. A900942

43. Q3983108

44. (2s,5r,6s)-6-(2-carboxy-2-(thiophen-3-yl)acetamido)-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

45. (2s,5r,6s)-6-[2-carboxy(thiophen-3-yl)acetamido]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

46. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-((carboxy-3-thienylacetyl)amino)-6-methoxy-3,3-dimethyl-7-oxo-, (2s-(2.alpha.,5.alpha.,6.alpha.))-

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 414.5 g/mol
Molecular Formula C16H18N2O7S2
XLogP31.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass414.05554326 g/mol
Monoisotopic Mass414.05554326 g/mol
Topological Polar Surface Area187 Ų
Heavy Atom Count27
Formal Charge0
Complexity700
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


4.2 ATC Code

J01CA17

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01C - Beta-lactam antibacterials, penicillins

J01CA - Penicillins with extended spectrum

J01CA17 - Temocillin


API SUPPLIERS

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Bioquim

Spain

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Ningbo Inno Pharmchem

China

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Conscientia Industrial

China

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Conscientia Industrial

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Angene International

United Kingdom

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Angene International

United Kingdom

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J&H CHEM

China

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J&H CHEM

China

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Bioquim

Spain
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Virtual BoothBioquim: An European GMP-certified company manufacturing bulk APIs, specializing in sterile lyophilization and chemical synthesis.

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Temocillin Disodium

About the Company : Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, pep...

Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, peptides, amino acids, penicillin derivatives, non-penicillin antibiotics, and HPAPIs for human & veterinary markets. We adhere to stringent GMP and operate state-of-the-art facilities with advanced technology. Bioquim also provides Custom Synthesis & Contract Manufacturing services, delivering tailored solutions backed by our expertise in chemical synthesis & lyophilization of sterile APIs. Trust Bioquim for your API needs & experience our commitment to quality.
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Angene International

United Kingdom
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Angene International

United Kingdom
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Temocillin Disodium

About the Company : Angene is pledged to providing quality chemicals for use in research and development and commercial manufacturing. Angenes offers over 100,000 products including lab reagents, inte...

Angene is pledged to providing quality chemicals for use in research and development and commercial manufacturing. Angenes offers over 100,000 products including lab reagents, intermediates, bulk commodities, agro-chemicals, natural ingredients and active pharmaceutical ingredients (APIs). In addition to the 100,000+ products, Angene offers custom synthesis of chemicals that are not commercially available.
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Temocillin Disodium

About the Company : Conscientia Industrial is a pharmaceutical company, mainly developing, manufacturing, marketing APIs (Active Pharmaceutical Ingredients), intermediates, fine chemicals in China. We...

Conscientia Industrial is a pharmaceutical company, mainly developing, manufacturing, marketing APIs (Active Pharmaceutical Ingredients), intermediates, fine chemicals in China. We started business in early 2010, producing and providing products for both human and veterinary health at home and abroad. Conscientia Industrial makes regular productions and also provides custom synthesis, contract manufacturing services. We have series of products, such as Hormones, Prostaglandins, Peptides, Anti-cancer, Anti-tumor, Anti-virus, Anti-diabetic APIs and their related intermediates, impurities, chemicals.
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J&H CHEM

China
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J&H CHEM

China
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Temocillin Disodium

About the Company : J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Valu...

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals, pharmaceuticals, and specialities. As a highly customer-oriented enterprise, we always believe "Customer first, service foremost", put forward innovation, continuously improve pipeline, integrate our broad range of products and services with our technical expertise, customise a competitive package to meet our customers' specific needs.
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About the Company : NINGBO INNO PHARMCHEM CO.,LTD. develop, pilot and commercial produce organic chemicals, pharmaceutical intermediates and nutraceuticals. We also offer custom synthesis and manufact...

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https://www.sciencedaily.com/releases/2021/10/211029074859.htm

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29 Oct 2021

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ABOUT THIS PAGE

Temocillin Disodium Manufacturers

A Temocillin Disodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Temocillin Disodium, including repackagers and relabelers. The FDA regulates Temocillin Disodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Temocillin Disodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Temocillin Disodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Temocillin Disodium Suppliers

A Temocillin Disodium supplier is an individual or a company that provides Temocillin Disodium active pharmaceutical ingredient (API) or Temocillin Disodium finished formulations upon request. The Temocillin Disodium suppliers may include Temocillin Disodium API manufacturers, exporters, distributors and traders.

click here to find a list of Temocillin Disodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Temocillin Disodium GMP

Temocillin Disodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Temocillin Disodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Temocillin Disodium GMP manufacturer or Temocillin Disodium GMP API supplier for your needs.

Temocillin Disodium CoA

A Temocillin Disodium CoA (Certificate of Analysis) is a formal document that attests to Temocillin Disodium's compliance with Temocillin Disodium specifications and serves as a tool for batch-level quality control.

Temocillin Disodium CoA mostly includes findings from lab analyses of a specific batch. For each Temocillin Disodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Temocillin Disodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Temocillin Disodium EP), Temocillin Disodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Temocillin Disodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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