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    Also known as: Tenofovir alafenamide fumarate, 1392275-56-7, Gs-7340 hemifumarate, Tenofovir alafenamide hemifumarate, Gs-7340-03, Tenofovir alafenamide fumarate [usan]
    Molecular Formula
    C46H62N12O14P2
    Molecular Weight
    1069.0  g/mol
    InChI Key
    SVUJNSGGPUCLQZ-FQQAACOVSA-N
    FDA UNII
    FWF6Q91TZO
    Tenofovir Alafenamide Fumarate
    1 2D Structure

    Tenofovir Alafenamide Fumarate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (E)-but-2-enedioic acid;propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
    2.1.2 InChI
    InChI=1S/2C21H29N6O5P.C4H4O4/c2*1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27;5-3(6)1-2-4(7)8/h2*5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*15-,16+,33+;/m11./s1
    2.1.3 InChI Key
    SVUJNSGGPUCLQZ-FQQAACOVSA-N
    2.1.4 Canonical SMILES
    CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3.C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3.C(=C/C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    FWF6Q91TZO
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Gs-7340

    2. Gs-734003

    3. L-alanine, N-((s)-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl Ester

    4. Tenofovir Alafenamide

    2.3.2 Depositor-Supplied Synonyms

    1. Tenofovir Alafenamide Fumarate

    2. 1392275-56-7

    3. Gs-7340 Hemifumarate

    4. Tenofovir Alafenamide Hemifumarate

    5. Gs-7340-03

    6. Tenofovir Alafenamide Fumarate [usan]

    7. Fwf6q91tzo

    8. Gs-7340 (hemifumarate)

    9. Vemlidy (tn)

    10. Taf

    11. Chembl2364637

    12. Chebi:90923

    13. Dtxsid401027740

    14. (s)-isopropyl 2-(((s)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate Fumarate(2:1)

    15. Ex-a2641

    16. Mfcd30534429

    17. S4427

    18. Ac-30255

    19. Tenofovir Alafenamide Fumarate (usan/jan)

    20. Tenofovir Alafenamide Fumarate [mi]

    21. Tenofovir Alafenamide Fumarate [jan]

    22. Tenofovir Alafenamide Fumarate (2:1)

    23. D10605

    24. Tenofovir Alafenamide Fumarate [who-dd]

    25. Tenofovir Alafenamide Fumarate [orange Book]

    26. Descovy Component Tenofovir Alafenamide Fumarate

    27. Odefsey Component Tenofovir Alafenamide Fumarate

    28. Q27162911

    29. Symtuza Component Tenofovir Alafenamide Fumarate

    30. Biktarvy Component Tenofovir Alafenamide Fumarate

    31. Tenofovir Alafenamide Fumarate Component Of Biktarvy

    32. Tenofovir Alafenamide Fumarate Component Of Descovy

    33. Tenofovir Alafenamide Fumarate Component Of Genvoya

    34. Tenofovir Alafenamide Fumarate Component Of Odefsey

    35. Tenofovir Alafenamide Fumarate Component Of Symtuza

    36. (s)-isopropyl 2-(((s)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate Hemifumarate

    37. 1-methylethyl N-((s)-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl(phenoxyphosphinoyl)-l-alaninate, (2e)-2-butenedioate

    38. Bis{9-[(2r,5s,7e)-2,7,10-trimethyl-5,8-dioxo-5-phenoxy-3,9-dioxa-6-aza-5lambda5-phosphaundecan-1-yl]-9h-purin-6-aminium} (2e)-but-2-enedioate

    39. Bis{propan-2-yl N-[(s)-({[(2r)-1-(6-amino-9h-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]-l-alaninate} (2e)-but-2-enedioate

    2.4 Create Date
    2013-06-10
    3 Chemical and Physical Properties
    Molecular Weight 1069.0 g/mol
    Molecular Formula C46H62N12O14P2
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count24
    Rotatable Bond Count26
    Exact Mass1068.39836869 g/mol
    Monoisotopic Mass1068.39836869 g/mol
    Topological Polar Surface Area362 Ų
    Heavy Atom Count74
    Formal Charge0
    Complexity799
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Vemlidy is indicated for the treatment of chronic hepatitis B in adults and adolescents (aged 12 years and older with body weight at least 35 kg).

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    J05AF

    API Reference Price

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HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"TENOFOVIR ALAFENAMIDE FUMARATE BATCH NO;TAFA24009P1 & TAFA24011P1","address":"N0 116\/117, KIADB INDUSTRIAL AREA,","city":"BANGALORE","supplier":"CDYMAX (INDIA) PHARMA PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"ANKARA","customer":"M\/S.DROGSAN ILACLARI SANAYI VE","customerCountry":"TURKEY","quantity":"17.04","actualQuantity":"17.04","unit":"KGS","unitRateFc":"4500","totalValueFC":"75149.2","currency":"USD","unitRateINR":369577.08978873241,"date":"27-Sep-2024","totalValueINR":"6297593.61","totalValueInUsd":"75149.2","indian_port":"Bangalore Air","hs_no":"29335990","bill_no":"4397887","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"N0 116\/117, KIADB INDUSTRIAL AREA,, 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Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732905000,"product":"TENOFOVIR ALAFENAMIDE FUMARATE","address":"C-21\/A, ROAD NO.9, FILM NAGAR","city":"HYDERABAD\/AP","supplier":"TYCHE INDUSTRIES LTD","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"AIRPHARM","customerCountry":"SWITZERLAND","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"1955.3","totalValueFC":"7589.1","currency":"USD","unitRateINR":160107.64999999999,"date":"30-Nov-2024","totalValueINR":"640430.6","totalValueInUsd":"7589.1","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"6074129","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"C-21\/A, ROAD NO.9, FILM NAGAR, HYDERABAD\/AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733164200,"product":"TENOFOVIR ALAFENAMIDE FUMARATE 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    07-Jan-2021
    03-Dec-2024
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    DOSAGE - TABLET;ORAL - 150MG;150MG;200MG;EQ 1...DOSAGE - TABLET;ORAL - 150MG;150MG;200MG;EQ 10MG BASE

    USFDA APPLICATION NUMBER - 207561

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    DOSAGE - TABLET;ORAL - 120MG;EQ 15MG BASE

    USFDA APPLICATION NUMBER - 208215

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    DOSAGE - TABLET;ORAL - 200MG;EQ 25MG BASE

    USFDA APPLICATION NUMBER - 208215

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    DOSAGE - TABLET;ORAL - 200MG;EQ 25MG BASE;EQ ...DOSAGE - TABLET;ORAL - 200MG;EQ 25MG BASE;EQ 25MG BASE

    USFDA APPLICATION NUMBER - 208351

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    DOSAGE - TABLET;ORAL - EQ 30MG BASE;120MG;EQ ...DOSAGE - TABLET;ORAL - EQ 30MG BASE;120MG;EQ 15MG BASE

    USFDA APPLICATION NUMBER - 210251

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    DOSAGE - TABLET;ORAL - EQ 50MG BASE;200MG;EQ ...DOSAGE - TABLET;ORAL - EQ 50MG BASE;200MG;EQ 25MG BASE

    USFDA APPLICATION NUMBER - 210251

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    ABOUT THIS PAGE

    Tenofovir Alafenamide Fumarate Manufacturers

    A Tenofovir Alafenamide Fumarate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tenofovir Alafenamide Fumarate, including repackagers and relabelers. The FDA regulates Tenofovir Alafenamide Fumarate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tenofovir Alafenamide Fumarate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Tenofovir Alafenamide Fumarate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Tenofovir Alafenamide Fumarate Suppliers

    A Tenofovir Alafenamide Fumarate supplier is an individual or a company that provides Tenofovir Alafenamide Fumarate active pharmaceutical ingredient (API) or Tenofovir Alafenamide Fumarate finished formulations upon request. The Tenofovir Alafenamide Fumarate suppliers may include Tenofovir Alafenamide Fumarate API manufacturers, exporters, distributors and traders.

    click here to find a list of Tenofovir Alafenamide Fumarate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Tenofovir Alafenamide Fumarate USDMF

    A Tenofovir Alafenamide Fumarate DMF (Drug Master File) is a document detailing the whole manufacturing process of Tenofovir Alafenamide Fumarate active pharmaceutical ingredient (API) in detail. Different forms of Tenofovir Alafenamide Fumarate DMFs exist exist since differing nations have different regulations, such as Tenofovir Alafenamide Fumarate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Tenofovir Alafenamide Fumarate DMF submitted to regulatory agencies in the US is known as a USDMF. Tenofovir Alafenamide Fumarate USDMF includes data on Tenofovir Alafenamide Fumarate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tenofovir Alafenamide Fumarate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Tenofovir Alafenamide Fumarate suppliers with USDMF on PharmaCompass.

    Tenofovir Alafenamide Fumarate KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Tenofovir Alafenamide Fumarate Drug Master File in Korea (Tenofovir Alafenamide Fumarate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Tenofovir Alafenamide Fumarate. The MFDS reviews the Tenofovir Alafenamide Fumarate KDMF as part of the drug registration process and uses the information provided in the Tenofovir Alafenamide Fumarate KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Tenofovir Alafenamide Fumarate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Tenofovir Alafenamide Fumarate API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Tenofovir Alafenamide Fumarate suppliers with KDMF on PharmaCompass.

    Tenofovir Alafenamide Fumarate WC

    A Tenofovir Alafenamide Fumarate written confirmation (Tenofovir Alafenamide Fumarate WC) is an official document issued by a regulatory agency to a Tenofovir Alafenamide Fumarate manufacturer, verifying that the manufacturing facility of a Tenofovir Alafenamide Fumarate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Tenofovir Alafenamide Fumarate APIs or Tenofovir Alafenamide Fumarate finished pharmaceutical products to another nation, regulatory agencies frequently require a Tenofovir Alafenamide Fumarate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Tenofovir Alafenamide Fumarate suppliers with Written Confirmation (WC) on PharmaCompass.

    Tenofovir Alafenamide Fumarate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Tenofovir Alafenamide Fumarate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Tenofovir Alafenamide Fumarate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Tenofovir Alafenamide Fumarate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Tenofovir Alafenamide Fumarate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Tenofovir Alafenamide Fumarate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Tenofovir Alafenamide Fumarate suppliers with NDC on PharmaCompass.

    Tenofovir Alafenamide Fumarate GMP

    Tenofovir Alafenamide Fumarate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Tenofovir Alafenamide Fumarate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tenofovir Alafenamide Fumarate GMP manufacturer or Tenofovir Alafenamide Fumarate GMP API supplier for your needs.

    Tenofovir Alafenamide Fumarate CoA

    A Tenofovir Alafenamide Fumarate CoA (Certificate of Analysis) is a formal document that attests to Tenofovir Alafenamide Fumarate's compliance with Tenofovir Alafenamide Fumarate specifications and serves as a tool for batch-level quality control.

    Tenofovir Alafenamide Fumarate CoA mostly includes findings from lab analyses of a specific batch. For each Tenofovir Alafenamide Fumarate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Tenofovir Alafenamide Fumarate may be tested according to a variety of international standards, such as European Pharmacopoeia (Tenofovir Alafenamide Fumarate EP), Tenofovir Alafenamide Fumarate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tenofovir Alafenamide Fumarate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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