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Chemistry

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Also known as: 911208-73-6, Hdp-tenofovir, Cmx157, Cmx-157, 3-(hexadecyloxy)propyl hydrogen ((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate, Cmx 157
Molecular Formula
C28H52N5O5P
Molecular Weight
569.7  g/mol
InChI Key
SCTJKHUUZLXJIP-RUZDIDTESA-N
FDA UNII
K7J545MEMA

Tenofovir Exalidex
Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers).
1 2D Structure

Tenofovir Exalidex

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid
2.1.2 InChI
InChI=1S/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/m1/s1
2.1.3 InChI Key
SCTJKHUUZLXJIP-RUZDIDTESA-N
2.1.4 Canonical SMILES
CCCCCCCCCCCCCCCCOCCCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)O
2.1.5 Isomeric SMILES
CCCCCCCCCCCCCCCCOCCCOP(=O)(CO[C@H](C)CN1C=NC2=C(N=CN=C21)N)O
2.2 Other Identifiers
2.2.1 UNII
K7J545MEMA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cmx 157

2. Cmx-157

3. Cmx157

4. Hdp-tenofovir

5. Hexadecyloxypropyl 9-(2-(phosphonomethoxy)propyl)adenine

2.3.2 Depositor-Supplied Synonyms

1. 911208-73-6

2. Hdp-tenofovir

3. Cmx157

4. Cmx-157

5. 3-(hexadecyloxy)propyl Hydrogen ((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

6. Cmx 157

7. K7j545mema

8. 9-r-(2-(phosphonomethoxy)propyl)adenine

9. Phosphonic Acid, (((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-, Mono(3-(hexadecyloxy)propyl) Ester

10. Hexadecyloxypropyl Tenofovir

11. Unii-k7j545mema

12. Phosphonic Acid, [[(1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methyl]-, Mono[3-(hexadecyloxy)propyl] Ester

13. Hdp-pmpa

14. Hdp-(r)-pmpa

15. Tenofovir Exalidex(cmx157)

16. Chembl515564

17. Schembl2299893

18. Tenofovir Exalidex [inn]

19. Bdbm77092

20. Tenofovir Exalidex [who-dd]

21. Hexadecyloxypropyl Ester Of Tenofovir

22. Zinc42875215

23. Db14925

24. Hy-109014

25. Cs-0030512

26. J3.616.616i

27. Q27282054

28. Hexadecyloxypropyl 9-(2-(phosphonomethoxy)propyl)adenine

29. [(1r)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(3-hexadecoxypropoxy)phosphinic Acid

30. [(2r)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic Acid

31. 3-(hexadecyloxy)propyl Hydrogen ((((2r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

32. 3-(hexadecyloxy)propylhydrogen((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

33. Phosphonic Acid, P-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-, Mono(3(hexadecyloxy)propyl) Ester

34. Phosphonic Acid, P-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-, Mono(3-(hexadecyloxy)propyl) Ester

2.4 Create Date
2007-12-26
3 Chemical and Physical Properties
Molecular Weight 569.7 g/mol
Molecular Formula C28H52N5O5P
XLogP36.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count25
Exact Mass569.37060677 g/mol
Monoisotopic Mass569.37060677 g/mol
Topological Polar Surface Area135 Ų
Heavy Atom Count39
Formal Charge0
Complexity650
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-HIV Agents

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)


Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)


ABOUT THIS PAGE

Tenofovir Exalidex Manufacturers

A Tenofovir Exalidex manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tenofovir Exalidex, including repackagers and relabelers. The FDA regulates Tenofovir Exalidex manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tenofovir Exalidex API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tenofovir Exalidex Suppliers

A Tenofovir Exalidex supplier is an individual or a company that provides Tenofovir Exalidex active pharmaceutical ingredient (API) or Tenofovir Exalidex finished formulations upon request. The Tenofovir Exalidex suppliers may include Tenofovir Exalidex API manufacturers, exporters, distributors and traders.

Tenofovir Exalidex GMP

Tenofovir Exalidex Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tenofovir Exalidex GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tenofovir Exalidex GMP manufacturer or Tenofovir Exalidex GMP API supplier for your needs.

Tenofovir Exalidex CoA

A Tenofovir Exalidex CoA (Certificate of Analysis) is a formal document that attests to Tenofovir Exalidex's compliance with Tenofovir Exalidex specifications and serves as a tool for batch-level quality control.

Tenofovir Exalidex CoA mostly includes findings from lab analyses of a specific batch. For each Tenofovir Exalidex CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tenofovir Exalidex may be tested according to a variety of international standards, such as European Pharmacopoeia (Tenofovir Exalidex EP), Tenofovir Exalidex JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tenofovir Exalidex USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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