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    Chemistry

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    Also known as: 63074-08-8, Terazosin hcl, Hytrin, Fosfomic, Zayasel, Blavin
    Molecular Formula
    C19H26ClN5O4
    Molecular Weight
    423.9  g/mol
    InChI Key
    IWSWDOUXSCRCKW-UHFFFAOYSA-N
    FDA UNII
    8QOP8Z9955
    Terazosin HCl
    1 2D Structure

    Terazosin HCl

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
    2.1.3 InChI Key
    IWSWDOUXSCRCKW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    8QOP8Z9955
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. A 45975

    2. Adecur

    3. Apo-terazosin

    4. Deflox

    5. Dysalfa

    6. Flotrin

    7. Heitrin

    8. Hytrin

    9. Hytrin Bph

    10. Hytrine

    11. Magnurol

    12. Novo-terazosin

    13. Nu-terazosin

    14. Pms-terazosin

    15. Ratio-terazosin

    16. Sutif

    17. Tazusin

    18. Terazoflo

    19. Terazosin

    20. Terazosin Azu

    21. Terazosin Hexal

    22. Terazosin Hydrochloride Anhydrous

    23. Terazosin, Monohydrochloride, Dihydrate

    24. Terazosina Alter

    25. Terazosina Kern

    26. Terazosina Qualix

    27. Zayasel

    2.3.2 Depositor-Supplied Synonyms

    1. 63074-08-8

    2. Terazosin Hcl

    3. Hytrin

    4. Fosfomic

    5. Zayasel

    6. Blavin

    7. Terazosin Hydrochloride Anhydrous

    8. Vasocard

    9. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone Hydrochloride

    10. Flumarc

    11. Mls000040261

    12. Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-, Monohydrochloride

    13. Terazosin (hydrochloride)

    14. 8qop8z9955

    15. Terazocin Hydrochloride (anhydrous)

    16. Smr000044015

    17. Dsstox_cid_25493

    18. Dsstox_rid_80913

    19. Dsstox_gsid_45493

    20. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine Hydrochloride

    21. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine Hydrochloride

    22. Abbott-45975 Anhydrous

    23. Cas-63074-08-8

    24. Sr-01000000197

    25. Unii-8qop8z9955

    26. Prestwick_146

    27. Opera_id_398

    28. Ncgc00016903-01

    29. Schembl41545

    30. Terazosin Hydrochloride,pharma

    31. Mls001077301

    32. Mls001305722

    33. Chembl1256665

    34. Dtxsid7045493

    35. Hy-b0371f

    36. Hms1570g04

    37. Pharmakon1600-01505576

    38. Bcp12795

    39. Terazosin Hydrochloride [mi]

    40. Tox21_110674

    41. Mfcd00467965

    42. Nsc759168

    43. S4679

    44. Akos007930686

    45. Tox21_110674_1

    46. Ac-2074

    47. Ccg-220751

    48. Lp01138

    49. Ncgc00016026-10

    50. Ncgc00094404-01

    51. Ncgc00094404-02

    52. Terazosin Hydrochloride, Anhydrous

    53. Ds-11401

    54. Db-018541

    55. Cs-0013075

    56. Eu-0101138

    57. Ft-0605647

    58. T2751

    59. D11585

    60. D70611

    61. T 4680

    62. Terazosin Hydrochloride, >=98% (tlc), Powder

    63. 074t088

    64. Terazosin Hydrochloride Anhydrous [who-dd]

    65. Sr-01000000197-2

    66. Sr-01000000197-4

    67. Q27270906

    68. Sr-01000000197-12

    69. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine Hydrochloride

    70. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine Hydrochloride

    71. 2[4-(tetrahydro-2-furoy1)piperazinyl]-4-amino-6,7-dimethoxyquinazoline Hydrochloride

    72. 4-amino-6,7-dimethoxy-2-[4-(tetrahydro-2-furoyl)-1-piperazinyl]quinazoline Hydrochloride

    73. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanonehydrochloride

    74. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydrochloride

    75. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydron;chloride

    76. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine Hydrochloride

    77. Methanone, (4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl)(tetrahydro-2-furanyl)-, Hydrochloride (1:1)

    78. Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, Monohydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 423.9 g/mol
    Molecular Formula C19H26ClN5O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count4
    Exact Mass423.1673320 g/mol
    Monoisotopic Mass423.1673320 g/mol
    Topological Polar Surface Area103 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity544
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameTerazosin hydrochloride
    Drug LabelTerazosin hydrochloride, an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative represented by the following chemical name and structural formula: (RS)-Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furan...
    Active IngredientTerazosin hydrochloride
    Dosage FormCapsule
    RouteOral
    Strengtheq 5mg base; eq 2mg base; eq 1mg base; eq 10mg base
    Market StatusPrescription
    CompanyJubilant Cadista; Apotex; Sandoz; Ivax Sub Teva Pharms; Mylan

    2 of 2  
    Drug NameTerazosin hydrochloride
    Drug LabelTerazosin hydrochloride, an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative represented by the following chemical name and structural formula: (RS)-Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furan...
    Active IngredientTerazosin hydrochloride
    Dosage FormCapsule
    RouteOral
    Strengtheq 5mg base; eq 2mg base; eq 1mg base; eq 10mg base
    Market StatusPrescription
    CompanyJubilant Cadista; Apotex; Sandoz; Ivax Sub Teva Pharms; Mylan

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Urological Agents

    Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

    Adrenergic alpha-1 Receptor Antagonists

    Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    alpha-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]

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