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1. A 45975
2. Adecur
3. Apo-terazosin
4. Deflox
5. Dysalfa
6. Flotrin
7. Heitrin
8. Hytrin
9. Hytrin Bph
10. Hytrine
11. Magnurol
12. Novo-terazosin
13. Nu-terazosin
14. Pms-terazosin
15. Ratio-terazosin
16. Sutif
17. Tazusin
18. Terazoflo
19. Terazosin Azu
20. Terazosin Hexal
21. Terazosin Hydrochloride
22. Terazosin Hydrochloride Anhydrous
23. Terazosin, Monohydrochloride, Dihydrate
24. Terazosina Alter
25. Terazosina Kern
26. Terazosina Qualix
27. Zayasel
1. 63590-64-7
2. Terazosine
3. Hytrin
4. Terazosina
5. Terazosinum
6. Flumarc
7. Vasomet
8. Terazosine [inn-french]
9. Terazosinum [inn-latin]
10. Terazosina [inn-spanish]
11. Terazosabb
12. Terazosin Hcl
13. Terazosin (inn)
14. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine
15. Chembl611
16. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
17. Mls000069703
18. Chebi:9445
19. 141269-44-5
20. Terazosin (hydrochloride)
21. 8l5014xet7
22. 141269-45-6
23. Smr000058309
24. Terazosin [inn]
25. Terazosin [inn:ban]
26. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine
27. 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine
28. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
29. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone
30. 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
31. Abbott 45975
32. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine
33. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-{(tetnaphydro-2-furanyl)carbonyl}piperazine
34. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine
35. Terazosabb (tn)
36. 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine Hydrochloride
37. Terazosin A
38. Unii-8l5014xet7
39. Terazosinhydrochloride
40. Terazosin [mi]
41. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine Hydrochloride
42. Opera_id_1910
43. Prestwick0_000751
44. Prestwick1_000751
45. Prestwick2_000751
46. Prestwick3_000751
47. Terazosin [vandf]
48. Schembl6528
49. Terazosin [who-dd]
50. Lopac0_001138
51. Regid_for_cid_5401
52. Bspbio_000762
53. Mls001201836
54. Mls006011889
55. Spbio_002701
56. Bpbio1_000840
57. Gtpl7302
58. Dtxsid3023639
59. Hms2090p21
60. Hms2232n21
61. Hms3259f04
62. Hms3369p14
63. Hms3371e20
64. Hms3742i09
65. Hy-b0371
66. Bbl010743
67. Bdbm50033111
68. Stk567029
69. Akos005266642
70. Ccg-205212
71. Db01162
72. Nc00689
73. Sdccgsbi-0051105.p002
74. 6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
75. Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-
76. Ncgc00016026-04
77. Ncgc00016026-05
78. Ncgc00016026-08
79. Ncgc00016026-11
80. Ncgc00025191-03
81. Ac-11120
82. Ls-14728
83. Ft-0630739
84. C07127
85. D08569
86. 590t647
87. A834201
88. L000692
89. Q280786
90. Brd-a22256192-003-03-7
91. Brd-a22256192-003-14-4
92. Z1172269406
93. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine
94. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine
95. 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-imine
96. 6,7-dimethoxy-2-[4-(tetrahydro-2-furanylcarbonyl)-1-piperazinyl]-4-quinazolinamine #
97. 6,7-dimethoxy-2-{4-[(oxolan-2-yl)carbonyl]piperazin-1-yl}quinazolin-4-amine
98. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazinehydrochloride
99. 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2rs)-2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine
Molecular Weight | 387.4 g/mol |
---|---|
Molecular Formula | C19H25N5O4 |
XLogP3 | 1.4 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 8 |
Rotatable Bond Count | 4 |
Exact Mass | 387.19065430 g/mol |
Monoisotopic Mass | 387.19065430 g/mol |
Topological Polar Surface Area | 103 Ų |
Heavy Atom Count | 28 |
Formal Charge | 0 |
Complexity | 544 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Terazosin is indicated for use in treating symptomatic benign prostatic hyperplasia and hypertension.
FDA Label
Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocker.
Adrenergic alpha-1 Receptor Antagonists
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)
Urological Agents
Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)
G04CA03
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
G - Genito urinary system and sex hormones
G04 - Urologicals
G04C - Drugs used in benign prostatic hypertrophy
G04CA - Alpha-adrenoreceptor antagonists
G04CA03 - Terazosin
Absorption
Approximately 90%.
Route of Elimination
Approximately 10% of the oral dose is excreted unchanged in the urine and approximately 20% is excreted in the feces. 40% of the total dose is eliminated in urine and 60% of the total dose is eliminated in the feces.
Volume of Distribution
25L to 30L.
Clearance
Plasma clearance is 80mL/min and renal clearance is 10mL/min.
The majority of terazosin is hepatically metabolized. The metabolites recovered include 6-O-demethyl terazosin, 7-O-methyl terazosin, a piperozine derivative, and a diamine derivative.
Terazosin has a mean half life 12 hours though this can be as high as 14 hours in patients over 70 years and as low as 11.4 hours in patients 20 to 39 years old.
Terazosin is selective for alpha-1-adrenoceptors but not their individual subtypes. Inhibition of these alpha-1-adrenoceptors results in relaxation of smooth muscle in blood vessels and the prostate, lowering blood pressure and improving urinary flow. Smooth muscle cells accounts for roughly 40% of the volume of the prostate and so their relaxation reduces pressure on the urethra. It has also been shown that catecholamines induce factors responsible for mitogenesis and alpha-1-adrenergic receptor blockers inhibit this effect. A final long term mechanism of terazosin and other alpha-1-adrenergic receptor blockers is the induction of apoptosis of prostate cells. Treatment with terazosin enhances the expression of transforming growth factor beta-1 (TGF-beta1), which upregulates p27kip1, and the caspase cascade.
1.1k
11 - 50
1.3k
1.4M
API Imports and Exports
Importing Country | Total Quantity (KGS) |
Average Price (USD/KGS) |
Number of Transactions |
---|---|---|---|
INDIA | 245.00 | 1,536.6 | <10 |
ARGENTINA | 325.00 | 735.3 | <10 |
INDIA | 163.59 | 1,383.0 | <10 |
NETHERLANDS | 155.00 | 1,232.6 | <10 |
PAKISTAN | 33.00 | 1,287.0 | <10 |
UNITED ARAB EMIRATES | 60.00 | 777.3 | <10 |
UNITED STATES | 31.00 | 1,441.8 | <10 |
TURKEY | 104.65 | 659.4 | <10 |
MALAYSIA | 50.00 | 854.4 | <10 |
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Regulatory Info :
Registration Country : Switzerland
Brand Name : Hytrin BPH
Dosage Form : Tabl
Dosage Strength : 5mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Italy
Brand Name : TERAZOSIN DOC GENERIC
Dosage Form : Divisible Tablet
Dosage Strength : 2mg
Packaging : 30 UNITS 2 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : PROSTATIL
Dosage Form : Tablets
Dosage Strength : 5 mg
Packaging : 14 UNIT 5 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : UNOPROST
Dosage Form : Divisible Tablet
Dosage Strength : 2mg
Packaging : 10 UNITS 2 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : TERAPROST
Dosage Form : Divisible Tablet
Dosage Strength : 2mg
Packaging : 10 UNITS 2 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : TERAFLUX
Dosage Form : Tablets
Dosage Strength : 2 mg
Packaging : 30 UNITS 2 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : TERAFLUX
Dosage Form : Divisible Tablet
Dosage Strength : 5mg
Packaging : 28 UNITS 5 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : UROFLUS
Dosage Form : Tablets
Dosage Strength : 2 mg
Packaging : 10 UNITS 2 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : UROFLUS
Dosage Form : Tablets
Dosage Strength : 5 mg
Packaging : 14 UNIT 5 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : TERAZOSIN TEVA
Dosage Form : Tablet
Dosage Strength : 5mg
Packaging : 14 UNIT 5 MG - ORAL USE
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
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