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Chemistry

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Also known as: Terbutaline solution, Terbutaline (sulfate), Mls000069693, Smr000058516, Kwd-2019, Sr-01000000174
Molecular Formula
C12H21NO7S
Molecular Weight
323.36  g/mol
InChI Key
MUPQZWGSBCWCAV-UHFFFAOYSA-N

Terbutaline Sulfate
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
1 2D Structure

Terbutaline Sulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol;sulfuric acid
2.1.2 InChI
InChI=1S/C12H19NO3.H2O4S/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
2.1.3 InChI Key
MUPQZWGSBCWCAV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Arubendol

2. Asthmoprotect

3. Brethaire

4. Brethine

5. Bricanyl

6. Bricanyl Sa

7. Butaliret

8. Butalitab

9. Contimit

10. Kwd 2019

11. Kwd-2019

12. Kwd2019

13. Monovent

14. Taziken

15. Tedipulmo

16. Terbasmin

17. Terbul

18. Terbutalin Al

19. Terbutalin Ratiopharm

20. Terbutalin Stada

21. Terbutalin Von Ct

22. Terbutalin-ratiopharm

23. Terbutaline

24. Terbutaline Sulfate

25. Terbuturmant

2.2.2 Depositor-Supplied Synonyms

1. Terbutaline Solution

2. Terbutaline (sulfate)

3. Mls000069693

4. Smr000058516

5. Kwd-2019

6. Sr-01000000174

7. Opera_id_498

8. Schembl41870

9. Mls001148384

10. Spectrum1500558

11. Chembl1160544

12. Regid_for_cid_657301

13. Hms500d20

14. Hms1921c15

15. Hms2092k19

16. Hms2231h10

17. Hms3259j05

18. Hms3372i16

19. Pharmakon1600-01500558

20. Ccg-39265

21. Nsc757336

22. Akos015960700

23. Nc00619

24. Ncgc00094789-01

25. Ncgc00094789-02

26. Ncgc00094789-03

27. Ncgc00094789-04

28. Ac-12158

29. Ac-33172

30. Vu0244552-7

31. Sr-01000000174-4

32. 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol,sulfuric Acid

2.3 Create Date
2005-06-29
3 Chemical and Physical Properties
Molecular Weight 323.36 g/mol
Molecular Formula C12H21NO7S
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass323.10387318 g/mol
Monoisotopic Mass323.10387318 g/mol
Topological Polar Surface Area156 Ų
Heavy Atom Count21
Formal Charge0
Complexity286
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameTerbutaline sulfate
Drug LabelTerbutaline Sulfate, USP, the active ingredient of Terbutaline Sulfate Injection, USP, is a betaadrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. Each milliliter of...
Active IngredientTerbutaline sulfate
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg/ml; 5mg
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; United Biomedcl; Fresenius Kabi Usa; Lannett; Impax Labs; Akorn

2 of 2  
Drug NameTerbutaline sulfate
Drug LabelTerbutaline Sulfate, USP, the active ingredient of Terbutaline Sulfate Injection, USP, is a betaadrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. Each milliliter of...
Active IngredientTerbutaline sulfate
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg/ml; 5mg
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; United Biomedcl; Fresenius Kabi Usa; Lannett; Impax Labs; Akorn

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic beta-2 Receptor Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Tocolytic Agents

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)


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19-May-2021
30-Jul-2024
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Terbutaline Sulfate Manufacturers

A Terbutaline Sulfate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Terbutaline Sulfate, including repackagers and relabelers. The FDA regulates Terbutaline Sulfate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Terbutaline Sulfate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Terbutaline Sulfate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Terbutaline Sulfate Suppliers

A Terbutaline Sulfate supplier is an individual or a company that provides Terbutaline Sulfate active pharmaceutical ingredient (API) or Terbutaline Sulfate finished formulations upon request. The Terbutaline Sulfate suppliers may include Terbutaline Sulfate API manufacturers, exporters, distributors and traders.

click here to find a list of Terbutaline Sulfate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Terbutaline Sulfate USDMF

A Terbutaline Sulfate DMF (Drug Master File) is a document detailing the whole manufacturing process of Terbutaline Sulfate active pharmaceutical ingredient (API) in detail. Different forms of Terbutaline Sulfate DMFs exist exist since differing nations have different regulations, such as Terbutaline Sulfate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Terbutaline Sulfate DMF submitted to regulatory agencies in the US is known as a USDMF. Terbutaline Sulfate USDMF includes data on Terbutaline Sulfate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Terbutaline Sulfate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Terbutaline Sulfate suppliers with USDMF on PharmaCompass.

Terbutaline Sulfate CEP

A Terbutaline Sulfate CEP of the European Pharmacopoeia monograph is often referred to as a Terbutaline Sulfate Certificate of Suitability (COS). The purpose of a Terbutaline Sulfate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Terbutaline Sulfate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Terbutaline Sulfate to their clients by showing that a Terbutaline Sulfate CEP has been issued for it. The manufacturer submits a Terbutaline Sulfate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Terbutaline Sulfate CEP holder for the record. Additionally, the data presented in the Terbutaline Sulfate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Terbutaline Sulfate DMF.

A Terbutaline Sulfate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Terbutaline Sulfate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Terbutaline Sulfate suppliers with CEP (COS) on PharmaCompass.

Terbutaline Sulfate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Terbutaline Sulfate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Terbutaline Sulfate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Terbutaline Sulfate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Terbutaline Sulfate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Terbutaline Sulfate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Terbutaline Sulfate suppliers with NDC on PharmaCompass.

Terbutaline Sulfate GMP

Terbutaline Sulfate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Terbutaline Sulfate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Terbutaline Sulfate GMP manufacturer or Terbutaline Sulfate GMP API supplier for your needs.

Terbutaline Sulfate CoA

A Terbutaline Sulfate CoA (Certificate of Analysis) is a formal document that attests to Terbutaline Sulfate's compliance with Terbutaline Sulfate specifications and serves as a tool for batch-level quality control.

Terbutaline Sulfate CoA mostly includes findings from lab analyses of a specific batch. For each Terbutaline Sulfate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Terbutaline Sulfate may be tested according to a variety of international standards, such as European Pharmacopoeia (Terbutaline Sulfate EP), Terbutaline Sulfate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Terbutaline Sulfate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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