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Chemistry

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Also known as: Bricanyl, Terbutaline hemisulfate, Tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium;sulfate, Bricanyl turbuhaler, 576pu70y8e, 1,3-benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, sulfate (2:1) (salt)
Molecular Formula
C24H40N2O10S
Molecular Weight
548.6  g/mol
InChI Key
KFVSLSTULZVNPG-UHFFFAOYSA-N

Terbutaline Sulphate
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
1 2D Structure

Terbutaline Sulphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium;sulfate
2.1.2 InChI
InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
2.1.3 InChI Key
KFVSLSTULZVNPG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.[O-]S(=O)(=O)[O-]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Arubendol

2. Asthmoprotect

3. Brethine

4. Bricanyl

5. Bricanyl Sa

6. Butaliret

7. Butalitab

8. Contimit

9. Kwd 2019

10. Kwd-2019

11. Kwd2019

12. Monovent

13. Taziken

14. Tedipulmo

15. Terbasmin

16. Terbul

17. Terbutalin Al

18. Terbutalin Ratiopharm

19. Terbutalin Stada

20. Terbutalin Von Ct

21. Terbutalin-ratiopharm

22. Terbutaline

23. Terbutaline Sulfate

24. Terbuturmant

2.2.2 Depositor-Supplied Synonyms

1. Bricanyl

2. Terbutaline Hemisulfate

3. Tert-butyl-[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]azanium;sulfate

4. Bricanyl Turbuhaler

5. 576pu70y8e

6. 1,3-benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, Sulfate (2:1) (salt)

7. Einecs 245-386-3

8. Unii-576pu70y8e

9. 1-(3,5-dihydroxyphenyl)-2-tert-butylaminoethanol Sulphate

10. Terbutaline Sulfate [usan:usp:jan]

11. Nsc 757336

12. (+-)-alpha-((tert-butylamino)methyl)-3,5-dihydroxybenzyl Alcohol Sulfate (2:1) (salt)

13. Benzyl Alcohol, Alpha-((tert-butylamino)methyl)-3,5-dihydroxy-, Sulfate (2:1)

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 548.6 g/mol
Molecular Formula C24H40N2O10S
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass548.24036665 g/mol
Monoisotopic Mass548.24036665 g/mol
Topological Polar Surface Area243 Ų
Heavy Atom Count37
Formal Charge0
Complexity267
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameTerbutaline sulfate
Drug LabelTerbutaline Sulfate, USP, the active ingredient of Terbutaline Sulfate Injection, USP, is a betaadrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. Each milliliter of...
Active IngredientTerbutaline sulfate
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg/ml; 5mg
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; United Biomedcl; Fresenius Kabi Usa; Lannett; Impax Labs; Akorn

2 of 2  
Drug NameTerbutaline sulfate
Drug LabelTerbutaline Sulfate, USP, the active ingredient of Terbutaline Sulfate Injection, USP, is a betaadrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. Each milliliter of...
Active IngredientTerbutaline sulfate
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg/ml; 5mg
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; United Biomedcl; Fresenius Kabi Usa; Lannett; Impax Labs; Akorn

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic beta-2 Receptor Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Tocolytic Agents

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


API SUPPLIERS

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Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Jai Radhe Sales

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Zeon Pharma Industries India Pvt L...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothZeon Pharma is a manufacturer and supplier of APIs & Intermediates.

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Zeon Pharma Industries India Pvt Ltd

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Melody Healthcare Pvt Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
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Melody Healthcare Pvt Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF arrow-down CEP/COS JDMF EU-WCarrow-down NDC KDMF VMF Others AUDIT
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AstraZeneca

United Kingdom

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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AstraZeneca

United Kingdom

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Lusochimica

Italy

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Lusochimica

Italy

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COSMA S.p.A

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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COSMA S.p.A

Italy

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DEAFARMA

Italy

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DEAFARMA

Italy

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Hermes Chemical

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Hermes Chemical

India

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Jayco Chemical Industries

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF

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Astra Pharmaceutical Products Inc

United Kingdom

USDMF

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Antibody Engineering
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 7942

Submission : 1989-03-01

Status : Inactive

Type : II

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Cosma Spa

Italy

USDMF

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02

Cosma Spa

Italy
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 4748

Submission : 1982-11-29

Status : Inactive

Type : II

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Lusochimica Spa

Italy

USDMF

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Antibody Engineering
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 26563

Submission : 2012-09-14

Status : Active

Type : II

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EU WC

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AstraZeneca

United Kingdom
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AstraZeneca

United Kingdom
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Terbutaline Sulphate

Date of Issue : 2013-06-20

Valid Till : 2016-07-02

Written Confirmation Number : WC-0129

Address of the Firm : Avishkar’,Post Box No. 2483 off Bellary Road, Hebbal, Bangalore-24

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Terbutaline Sulphate BP/EP/USP

Date of Issue : 2022-07-28

Valid Till : 2025-07-02

Written Confirmation Number : WC-0227n

Address of the Firm : Plot No. J-73, MIDC, Tarapur, Boisar, Dist- Palghar 401506, Maharashtra, India

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Listed Suppliers

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01

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Antibody Engineering
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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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Terbutaline Sulphate

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
Jai Radhe Sales

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Antibody Engineering
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Virtual BoothZeon Pharma is a manufacturer and supplier of APIs & Intermediates.

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Terbutaline Sulphate

About the Company : Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish form...

Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish formulations/Excipients, Phytochemicals/Enzymes & Intermediate and also has a GMP certified Manufacturing facility for Phytochemicals/Herbal extract and Enzymes through our associates.
Zeon Pharma Industries India Pvt Ltd

03

DEAFARMA

Italy
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DEAFARMA

Italy
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Bricanyl Turbuhaler

About the Company : In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territo...

In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territory. DEAFARMA works with success in the pharmaceutical raw materials field through Agencies and professional relations with the most important European and Asiatic factories. Our partners are well known, reliable producers and all of them are operating in accordance with the latest GMP Rules. The APIs mentioned in the DEAFARMA catalogue are always supported by DMF and/or CEP.
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Terbutaline Sulphate

About the Company : Hermes Chemical Company Pvt Ltd is a chemicals company established in 2001 and headquartered in Hyderabad. It is specialized in developing, manufacturing, and selling complex molec...

Hermes Chemical Company Pvt Ltd is a chemicals company established in 2001 and headquartered in Hyderabad. It is specialized in developing, manufacturing, and selling complex molecules. The core competence of Hermes lies in its ability to develop and deliver niche molecules from gram scales to multi-ton levels. They have been credited with being the first company in India to manufacture N-Butyl Lithium, Montelukast Intermediates, Donepezil Intermediates, and Biperiden Hydrochloride.
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Terbutaline Sulphate

About the Company : Jayco Chemical Industries is one of the fastest growing manufacturers and exporters of Active Pharmaceutical Ingredients and advanced intermediates dealing in Anti-Asthmatics, Vaso...

Jayco Chemical Industries is one of the fastest growing manufacturers and exporters of Active Pharmaceutical Ingredients and advanced intermediates dealing in Anti-Asthmatics, Vasodilators and Analgesics. The company is also one of the largest manufacturers of Isoxsuprine Hydrochloride and Salbutamol Sulphate. Driven by ethical standard, we follow the global standards of manufacturing practices. Our manufacturing facilities are capable of producing API’s & intermediates and we take utmost care to provide consistency in product specifications. We also undertake Custom Synthesis for Advanced Intermediates.
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API Reference Price

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20-Jan-2021
29-Sep-2024
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

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