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Chemistry

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Also known as: 25683-71-0, Terizidonum, Terizidone [inn], 1199lex5n8, Terizidone (inn), 4,4'-(((1e,1'e)-1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(isoxazolidin-3-one)
Molecular Formula
C14H14N4O4
Molecular Weight
302.29  g/mol
InChI Key
ODKYYBOHSVLGNU-UHFFFAOYSA-N
FDA UNII
1199LEX5N8

Terizidone
Terizidone is a broad spectrum antibiotic used as a second-line antitubercular drug, effective against pulmonary and extrapulmonary tuberculosis. Terizidone has activity against Mycobacterium strains that are resistant to first-line drugs.
1 2D Structure

Terizidone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[[4-[(3-oxo-1,2-oxazolidin-4-yl)iminomethyl]phenyl]methylideneamino]-1,2-oxazolidin-3-one
2.1.2 InChI
InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)
2.1.3 InChI Key
ODKYYBOHSVLGNU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1C(C(=O)NO1)N=CC2=CC=C(C=C2)C=NC3CONC3=O
2.2 Other Identifiers
2.2.1 UNII
1199LEX5N8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4,4'-(p-phenylenebis(methyleneimino))bis-3-isoxazolidone

2. Terazolidone

3. Terivalidin

4. Terivalidine

5. Terizidon

6. Terizidone, Calcium Salt, (r-(r*,r*))-isomer

2.3.2 Depositor-Supplied Synonyms

1. 25683-71-0

2. Terizidonum

3. Terizidone [inn]

4. 1199lex5n8

5. Terizidone (inn)

6. 4,4'-(((1e,1'e)-1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(isoxazolidin-3-one)

7. 4-[[4-[(3-oxo-1,2-oxazolidin-4-yl)iminomethyl]phenyl]methylideneamino]-1,2-oxazolidin-3-one

8. Terizidona

9. 4,4'-(p-phenylenebis(methyleneamino))di-(isoxazolidin-3-one)

10. Terizidonum [inn-latin]

11. Terizidona [inn-spanish]

12. Unii-1199lex5n8

13. Terivalidin (tn)

14. Einecs 247-186-1

15. D-terizidone

16. Terizidone [mart.]

17. Terizidone [who-dd]

18. Schembl193690

19. Fmoc-d-3-(2-furyl)-alanine

20. Chembl2107553

21. Dtxsid30865245

22. Dtxsid70905098

23. Chebi:135278

24. 4,4'-[1,4-phenylenebis(methylidynenitrilo)]bis-3-isoxazolidinone

25. Bcp15839

26. Mfcd00866818

27. Akos025311219

28. Db12954

29. As-16056

30. Hy-112324

31. Cs-0045228

32. Ft-0674867

33. C13574

34. D07247

35. A911347

36. Q1318344

37. 4,4'-[1,4-phenylenebis(methanylylideneazanylylidene)]di(1,2-oxazolidin-3-one)

38. 4,4'-((1e,1'e)-(1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(isoxazolidin-3-one)

39. 4,4'-(1e,1'e)-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(azan-1-yl-1-ylidene)diisoxazolidin-3-one

40. 6819-23-4

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 302.29 g/mol
Molecular Formula C14H14N4O4
XLogP3-0.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass302.10150494 g/mol
Monoisotopic Mass302.10150494 g/mol
Topological Polar Surface Area101 Ų
Heavy Atom Count22
Formal Charge0
Complexity441
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 ATC Code

J - Antiinfectives for systemic use

J04 - Antimycobacterials

J04A - Drugs for treatment of tuberculosis

J04AK - Other drugs for treatment of tuberculosis

J04AK03 - Terizidone


API Reference Price

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JWC-0 1\/354\/20-21\/BACC DT.03.03.2021 ( BE NO.: 2926057 DT. 26.02.2021)RE-EXPORT UNDER","address":"324, CORPORATE CENTRE, 3RD FLOOR, NIRMAL LIFESTYLE, L.B.S. MARG,","city":"MULUND-(WEST), MUMBAI, MAHARASHTRA.","supplier":"LOK BETA PHARMACEUTICALS ","supplierCountry":"INDIA","foreign_port":"MONGO","customer":"ADVANCED PHARMACEUTICALS LTD","customerCountry":"RUSSIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1340.6","totalValueFC":"132673.8","currency":"USD","unitRateINR":96588.397500000006,"date":"25-Mar-2021","totalValueINR":"9658839.75","totalValueInUsd":"132673.8","indian_port":"BOMBAY AIR","hs_no":"29332990","bill_no":"9648699","productDescription":"Re-export","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"324, CORPORATE CENTRE, 3RD FLOOR, NIRMAL LIFESTYLE, L.B.S. MARG,, MULUND-(WEST), MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"TERIZIDONE","year":"2021","qtr":"Q2","strtotime":1620325800,"product":"TERIZIDONE(IMPORTED UNDER BOND NO. JWC-0 1\/01\/21-22\/BACC DT.03.04.2021 ( BE NO.: 3311716 DT. 26.03.2021)RE-EXPORT UNDER S","address":"324, CORPORATE CENTRE, 3RD FLOOR, NIRMAL LIFESTYLE, L.B.S. 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MARG,, MULUND-(WEST), MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1623781800,"product":"BULK DRUG API TERIZIDONE API","address":"304,ATLANTA ARCADE,MAROL CHURCH RD,ANDHERI(E)","city":"MUMBAI","supplier":"MACLEODS PHARMACEUTICALS LTD","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"ADVANCED PHARMACEUTICALS LTD","customerCountry":"RUSSIA","quantity":"195.00","actualQuantity":"195","unit":"KGS","unitRateFc":"1044.1","totalValueFC":"199462","currency":"USD","unitRateINR":75228.515384615384,"date":"16-Jun-2021","totalValueINR":"14669560.5","totalValueInUsd":"199462","indian_port":"BOMBAY AIR","hs_no":"29225090","bill_no":"2449347","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"304,ATLANTA ARCADE,MAROL CHURCH RD,ANDHERI(E), MUMBAI","customerAddress":""},{"dataSource":"API Import","activeIngredients":"TERIZIDONE","year":"2021","qtr":"Q1","strtotime":1610303400,"product":"TERIZIDONE (FOR THIRD COUNTRY EXPORTS","address":"205,P.N.KOTHARI INDL.ESTATE,L.B.S.MARG,BHANDUP(W)","city":"MUMBAI,MAHARASHTRA","supplier":"DONG-A ST CO., LTD.","supplierCountry":"KOREA, REPUBLIC OF","foreign_port":"SEOUL - INCHEON INT\\'","customer":"SANJIVANI PARANTERAL LIMITED","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"1150","totalValueFC":"2327.1","currency":"USD","unitRateINR":"85100","date":"11-Jan-2021","totalValueINR":"170200","totalValueInUsd":"2327.1","indian_port":"BOMBAY AIR","hs_no":"29142990","bill_no":"2315116","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"SEOUL - INCHEON INT\\'","supplierAddress":"","customerAddress":"205,P.N.KOTHARI INDL.ESTATE,L.B.S.MARG,BHANDUP(W)"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1630002600,"product":"TERIZIDONE BATCH NO.TER(2)-C-21003 MFG DATE 14.03.2021 EXP DATE 13.03.2024","address":"205,P.N.KOTHARI INDL.ESTATE,L.B.S.MARG,BHANDUP(W)","city":"MUMBAI,MAHARASHTRA","supplier":"DONG-A ST CO., LTD.","supplierCountry":"KOREA, REPUBLIC OF","foreign_port":"","customer":"SANJIVANI PARANTERAL LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1150","totalValueFC":"1166","currency":"USD","unitRateINR":"86480","date":"27-Aug-2021","totalValueINR":"86480","totalValueInUsd":"1166","indian_port":"BOMBAY AIR","hs_no":"29411090","bill_no":"5212746","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"205,P.N.KOTHARI INDL.ESTATE,L.B.S.MARG,BHANDUP(W)"}]
11-Jan-2021
27-Aug-2021
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Terizidone

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Regulatory Info : Originator

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Terizidone

Brand Name : Terivalidin

Dosage Form : CAP

Dosage Strength : 250mg

Packaging : 100X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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Brand Name : Terizidone Macleods 250mg Capsules

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Registration Country : South Africa

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Terizidone manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Terizidone API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Terizidone manufacturer or Terizidone supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Terizidone manufacturer or Terizidone supplier.

PharmaCompass also assists you with knowing the Terizidone API Price utilized in the formulation of products. Terizidone API Price is not always fixed or binding as the Terizidone Price is obtained through a variety of data sources. The Terizidone Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Terizidone

Synonyms

25683-71-0, Terizidonum, Terizidone [inn], 1199lex5n8, Terizidone (inn), 4,4'-(((1e,1'e)-1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(isoxazolidin-3-one)

Cas Number

25683-71-0

Unique Ingredient Identifier (UNII)

1199LEX5N8

About Terizidone

Terizidone is a broad spectrum antibiotic used as a second-line antitubercular drug, effective against pulmonary and extrapulmonary tuberculosis. Terizidone has activity against Mycobacterium strains that are resistant to first-line drugs.

Terizidone Manufacturers

A Terizidone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Terizidone, including repackagers and relabelers. The FDA regulates Terizidone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Terizidone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Terizidone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Terizidone Suppliers

A Terizidone supplier is an individual or a company that provides Terizidone active pharmaceutical ingredient (API) or Terizidone finished formulations upon request. The Terizidone suppliers may include Terizidone API manufacturers, exporters, distributors and traders.

click here to find a list of Terizidone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Terizidone WC

A Terizidone written confirmation (Terizidone WC) is an official document issued by a regulatory agency to a Terizidone manufacturer, verifying that the manufacturing facility of a Terizidone active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Terizidone APIs or Terizidone finished pharmaceutical products to another nation, regulatory agencies frequently require a Terizidone WC (written confirmation) as part of the regulatory process.

click here to find a list of Terizidone suppliers with Written Confirmation (WC) on PharmaCompass.

Terizidone GMP

Terizidone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Terizidone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Terizidone GMP manufacturer or Terizidone GMP API supplier for your needs.

Terizidone CoA

A Terizidone CoA (Certificate of Analysis) is a formal document that attests to Terizidone's compliance with Terizidone specifications and serves as a tool for batch-level quality control.

Terizidone CoA mostly includes findings from lab analyses of a specific batch. For each Terizidone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Terizidone may be tested according to a variety of international standards, such as European Pharmacopoeia (Terizidone EP), Terizidone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Terizidone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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