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    Chemistry

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    Also known as: 25683-71-0, Terizidonum, Terizidone [inn], 1199lex5n8, Terizidone (inn), 4,4'-(((1e,1'e)-1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(isoxazolidin-3-one)
    Molecular Formula
    C14H14N4O4
    Molecular Weight
    302.29  g/mol
    InChI Key
    ODKYYBOHSVLGNU-UHFFFAOYSA-N
    FDA UNII
    1199LEX5N8
    Terizidone
    Terizidone is a broad spectrum antibiotic used as a second-line antitubercular drug, effective against pulmonary and extrapulmonary tuberculosis. Terizidone has activity against Mycobacterium strains that are resistant to first-line drugs.
    1 2D Structure

    Terizidone

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[[4-[(3-oxo-1,2-oxazolidin-4-yl)iminomethyl]phenyl]methylideneamino]-1,2-oxazolidin-3-one
    2.1.2 InChI
    InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)
    2.1.3 InChI Key
    ODKYYBOHSVLGNU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1C(C(=O)NO1)N=CC2=CC=C(C=C2)C=NC3CONC3=O
    2.2 Other Identifiers
    2.2.1 UNII
    1199LEX5N8
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4,4'-(p-phenylenebis(methyleneimino))bis-3-isoxazolidone

    2. Terazolidone

    3. Terivalidin

    4. Terivalidine

    5. Terizidon

    6. Terizidone, Calcium Salt, (r-(r*,r*))-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. 25683-71-0

    2. Terizidonum

    3. Terizidone [inn]

    4. 1199lex5n8

    5. Terizidone (inn)

    6. 4,4'-(((1e,1'e)-1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(isoxazolidin-3-one)

    7. 4-[[4-[(3-oxo-1,2-oxazolidin-4-yl)iminomethyl]phenyl]methylideneamino]-1,2-oxazolidin-3-one

    8. Terizidona

    9. 4,4'-(p-phenylenebis(methyleneamino))di-(isoxazolidin-3-one)

    10. Terizidonum [inn-latin]

    11. Terizidona [inn-spanish]

    12. Unii-1199lex5n8

    13. Terivalidin (tn)

    14. Einecs 247-186-1

    15. D-terizidone

    16. Terizidone [mart.]

    17. Terizidone [who-dd]

    18. Schembl193690

    19. Fmoc-d-3-(2-furyl)-alanine

    20. Chembl2107553

    21. Dtxsid30865245

    22. Dtxsid70905098

    23. Chebi:135278

    24. 4,4'-[1,4-phenylenebis(methylidynenitrilo)]bis-3-isoxazolidinone

    25. Bcp15839

    26. Mfcd00866818

    27. Akos025311219

    28. Db12954

    29. As-16056

    30. Hy-112324

    31. Cs-0045228

    32. Ft-0674867

    33. C13574

    34. D07247

    35. A911347

    36. Q1318344

    37. 4,4'-[1,4-phenylenebis(methanylylideneazanylylidene)]di(1,2-oxazolidin-3-one)

    38. 4,4'-((1e,1'e)-(1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(isoxazolidin-3-one)

    39. 4,4'-(1e,1'e)-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(azan-1-yl-1-ylidene)diisoxazolidin-3-one

    40. 6819-23-4

    2.4 Create Date
    2005-08-01
    3 Chemical and Physical Properties
    Molecular Weight 302.29 g/mol
    Molecular Formula C14H14N4O4
    XLogP3-0.2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass302.10150494 g/mol
    Monoisotopic Mass302.10150494 g/mol
    Topological Polar Surface Area101 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity441
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 ATC Code

    J - Antiinfectives for systemic use

    J04 - Antimycobacterials

    J04A - Drugs for treatment of tuberculosis

    J04AK - Other drugs for treatment of tuberculosis

    J04AK03 - Terizidone

    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"TERIZIDONE","year":"2021","qtr":"Q1","strtotime":1611081000,"product":"TERIZIDONE (FOR THIRD COUNTRY EXPORTS IMPORTED VIDE BOE NO: 2315116 DTD: 11.01 2021) (VALUE ADDITIONAL: 2% APPROX","address":"205,P.N.KOTHARI INDL.ESTATE,L.B.S.MARG,BHANDUP(W)","city":"MUMBAI,MAHARASHTRA","supplier":"SANJIVANI PARANTERAL LIMITED","supplierCountry":"INDIA","foreign_port":"MOSCOW DOMODEDOVO","customer":"INTER PHARMA LLC","customerCountry":"RUSSIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"1171.6","totalValueFC":"2372.5","currency":"USD","unitRateINR":86760,"date":"20-Jan-2021","totalValueINR":"173520","totalValueInUsd":"2372.5","indian_port":"BOMBAY AIR","hs_no":"29142990","bill_no":"8037863","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"205,P.N.KOTHARI INDL.ESTATE,L.B.S.MARG,BHANDUP(W), MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1623695400,"product":"BULK DRUG API TERIZIDONE API","address":"304,ATLANTA ARCADE,MAROL CHURCH RD,ANDHERI(E)","city":"MUMBAI","supplier":"MACLEODS PHARMACEUTICALS LTD","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"ADVANCED PHARMACEUTICALS LTD","customerCountry":"RUSSIA","quantity":"195.00","actualQuantity":"195","unit":"KGS","unitRateFc":"1050","totalValueFC":"201004.5","currency":"USD","unitRateINR":75810.256410256407,"date":"15-Jun-2021","totalValueINR":"14783000","totalValueInUsd":"201004.5","indian_port":"BOMBAY AIR","hs_no":"29225090","bill_no":"2437069","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"304,ATLANTA ARCADE,MAROL CHURCH RD,ANDHERI(E), MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1623781800,"product":"BULK DRUG API TERIZIDONE API","address":"304,ATLANTA ARCADE,MAROL CHURCH RD,ANDHERI(E)","city":"MUMBAI","supplier":"MACLEODS PHARMACEUTICALS LTD","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"ADVANCED PHARMACEUTICALS LTD","customerCountry":"RUSSIA","quantity":"195.00","actualQuantity":"195","unit":"KGS","unitRateFc":"1044.1","totalValueFC":"199462","currency":"USD","unitRateINR":75228.515384615384,"date":"16-Jun-2021","totalValueINR":"14669560.5","totalValueInUsd":"199462","indian_port":"BOMBAY AIR","hs_no":"29225090","bill_no":"2449347","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"304,ATLANTA ARCADE,MAROL CHURCH RD,ANDHERI(E), MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710959400,"product":"DRUGS AND PHARMACEUTICALS HARMLESS MEDICINES TERIZIDONE (IN-HOUSE)","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"MACLEODS PHARMACEUTICALS LTD","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"ADVANCED PHARMACEUTICALS LTD","customerCountry":"RUSSIA","quantity":"199.69","actualQuantity":"199.69","unit":"KGS","unitRateFc":"78755","totalValueFC":"187210","currency":"INR","unitRateINR":77846.296509589854,"date":"21-Mar-2024","totalValueINR":"15545126.95","totalValueInUsd":"187210","indian_port":"Bombay Air","hs_no":"29225090","bill_no":"8531388","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"304,ATLANTA ARCADE,, MUMBAI MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"TERIZIDONE","year":"2021","qtr":"Q1","strtotime":1614277800,"product":"TERIZIDONE (BATCH NO.TER(2)-C-20003 & TER(2)-C-20015 )FOR THIRD COUNTRY EXPORT","address":"324, CORPORATE CENTRE, 3RD FLOOR, NIRMAL LIFESTYLE, L.B.S. 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MARG,","city":"MULUND WEST,MAHARASHTRA","supplier":"DONG-A ST CO., LTD.","supplierCountry":"KOREA, REPUBLIC OF","foreign_port":"NA","customer":"LOK-BETA PHARMACEUTICALS (INDIA )PRIVATE LIMITED","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1050","totalValueFC":"107367.3","currency":"USD","unitRateINR":"81007.5","date":"29-Apr-2022","totalValueINR":"8100750","totalValueInUsd":"107367.3","indian_port":"BOMBAY AIR","hs_no":"29332990","bill_no":"8483144","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"324, CORPORATE CENTRE, 3RD FLOOR,, NIRMAL LIFESTYLE, L.B.S. MARG,"}]
    20-Jan-2021
    21-Mar-2024
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