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13 API Suppliers, 3 USDMF, 2 CEP/COS, 2 EU WC, 9 NDC API, 11 Listed Suppliers, $ API Reference Price

13 API Suppliers
3 USDMF
2 CEP/COS
2 EU WC
9 NDC API
11 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

11 FDF Dossiers, 2 FDA Orange Book, 3 Europe, 1 Canada, 2 South Africa, 3 Listed Dossiers

11 FDF Dossiers
2 FDA Orange Book
3 Europe
1 Canada
2 South Africa
3 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

PATCH;TOPICAL - 70MG;70MG, CREAM;TOPICAL - 7%;7%

drugProductComposition
PATCH;TOPICAL - 70MG;70MG
CREAM;TOPICAL - 7%;7%

RELATED EXCIPIENT COMPANIES

2 DKSH, 1 Faran Shimi Pharmaceutical, 7 Nanjing Well Pharmaceutical, 3 Actylis, 17 BASF, 7 Corel Pharma Chem, 2 Finar, 4 Gangwal Chemicals, 2 Ideal Cures Pvt Ltd, 9 Kerry, 3 Lubrizol Life Science Health, 3 Microlex e.U, 1 Novo Excipients, 2 Pluviaendo, 4 Roquette, 3 Seppic, 2 Shandong Focus Biotechnology Co., Ltd, 1 Valens Pharmachem

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2 DKSH
1 Faran Shimi Pharmaceutical
7 Nanjing Well Pharmaceutical
3 Actylis
17 BASF
7 Corel Pharma Chem
2 Finar
4 Gangwal Chemicals
2 Ideal Cures Pvt Ltd
9 Kerry
3 Lubrizol Life Science Health
3 Microlex e.U
1 Novo Excipients
2 Pluviaendo
4 Roquette
3 Seppic
2 Shandong Focus Biotechnology Co., Ltd
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

26 Topical, 21 Coating Systems & Additives, 12 Solubilizers, 9 Parenteral, 8 Thickeners and Stabilizers, 8 Film Formers & Plasticizers, 7 Emulsifying Agents, 7 Surfactant & Foaming Agents, 6 Controlled & Modified Release, 6 Lubricants & Glidants, 5 Co-Processed Excipients, 5 Fillers, Diluents & Binders, 5 Granulation, 4 Direct Compression, 3 Taste Masking, 2 Disintegrants & Superdisintegrants, 1 API Stability Enhancers

excipientsByApplications
26 Topical
21 Coating Systems & Additives
12 Solubilizers
9 Parenteral
8 Thickeners and Stabilizers
8 Film Formers & Plasticizers
7 Emulsifying Agents
7 Surfactant & Foaming Agents
6 Controlled & Modified Release
6 Lubricants & Glidants
5 Co-Processed Excipients
5 Fillers, Diluents & Binders
5 Granulation
4 Direct Compression
3 Taste Masking
2 Disintegrants & Superdisintegrants
1 API Stability Enhancers

DIGITAL CONTENT

7 NEWS #PharmaBuzz

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7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices

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2 Finished Drug Prices

MARKET PLACE

8 APIs

marketPlace
8 APIs

PATENTS & EXCLUSIVITIES

3 US Patents

patents
3 US Patents

REF. STANDARDS & IMPURITIES

2 USP , 4 Others

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2 USP
4 Others

CHSD Tetracaine

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

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JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 356

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

5DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

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US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

73 RELATED EXCIPIENT COMPANIES

135EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 94-24-6, Amethocaine, 2-(dimethylamino)ethyl 4-(butylamino)benzoate, Pontocaine, Dicaine, Laudocaine

Molecular Formula

C₁₅H₂₄N₂O₂

Molecular Weight

264.36 g/mol

InChI Key

GKCBAIGFKIBETG-UHFFFAOYSA-N

FDA UNII

0619F35CGV

A potent local anesthetic of the ester type used for surface and spinal anesthesia.

Tetracaine is an Ester Local Anesthetic. The physiologic effect of tetracaine is by means of Local Anesthesia.

1 2D Structure

Tetracaine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(dimethylamino)ethyl 4-(butylamino)benzoate

2.1.2 InChI

InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3

2.1.3 InChI Key

GKCBAIGFKIBETG-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C

2.2 Other Identifiers

2.2.1 UNII

0619F35CGV

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Amethocaine

2. Ametop

3. Dicaine

4. Hydrochloride, Tetrracaine

5. Pantocaine

6. Pontocaine

7. Tetracaine Monohydrochloride

8. Tetrakain

9. Tetrracaine Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 94-24-6

2. Amethocaine

3. 2-(dimethylamino)ethyl 4-(butylamino)benzoate

4. Pontocaine

5. Dicaine

6. Laudocaine

7. Metraspray

8. Tetrakain

9. Anetain

10. Contralgin

11. Meethobalm

12. Mucaesthin

13. Tetracaina

14. Tetracainum

15. Uromucaesthin

16. Fissucain

17. Intercain

18. Medicaine

19. Niphanoid

20. Rexocaine

21. Dicain

22. Dikain

23. Medihaler-tetracaine

24. 2-(dimethylamino)ethyl P-(butylamino)benzoate

25. P-butylaminobenzoyl-2-dimethylaminoethanol

26. Benzoic Acid, 4-(butylamino)-, 2-(dimethylamino)ethyl Ester

27. Diaethylaminoaethanol Ester Der P-butylaminobenzoesaeure

28. 4-(butylamino)benzoic Acid 2-(dimethylamino)ethyl Ester

29. Dimethylaminoethyl P-butyl-aminobenzoate

30. Chebi:9468

31. P-(butylamino)benzoic Acid, 2-(dimethylamino)ethyl Ester

32. Mfcd00053787

33. Chembl698

34. Benzoic Acid, P-(butylamino)-, 2-(dimethylamino)ethyl Ester

35. 2-dimethylaminoethylester Kyseliny P-butylaminobenzoove

36. Tetracaine Base

37. 0619f35cgv

38. Butylocaine

39. Tetrakain [czech]

40. Tetracainum [inn-latin]

41. Tetracaina [inn-spanish]

42. P-(butylamino)benzoic Acid Beta-(dimethylamino)ethyl Ester

43. Amethocaine (tn)

44. Tetracaine (usp/inn)

45. Ncgc00016049-02

46. Cas-136-47-0

47. Einecs 202-316-6

48. Brn 2216051

49. Landocaine

50. Tetracaine [usp:inn:ban]

51. Unii-0619f35cgv

52. Amethocaine Hcl

53. 2-dimethylaminoethylester Kyseliny P-butylaminobenzoove [czech]

54. Diaethylaminoaethanol Ester Der P-butylaminobenzoesaeure [german]

55. Te4

56. Spectrum_001032

57. Pantocaine (salt/mix)

58. Tetracaine [inn]

59. 100311-22-6

60. Prestwick0_000571

61. Prestwick1_000571

62. Prestwick2_000571

63. Prestwick3_000571

64. Spectrum2_001328

65. Spectrum3_000562

66. Spectrum4_000351

67. Spectrum5_001072

68. Lopac-t-7508

69. Tetracaine [vandf]

70. Epitope Id:174843

71. Tetracaine [mart.]

72. Tetracaine [usp-rs]

73. Tetracaine [who-dd]

74. Lopac0_001211

75. Schembl34714

76. Bspbio_000382

77. Bspbio_001944

78. Kbiogr_000781

79. Kbioss_001512

80. 4-14-00-01172 (beilstein Handbook Reference)

81. Divk1c_000607

82. Spbio_001455

83. Spbio_002601

84. Bpbio1_000422

85. Tetracaine [green Book]

86. Tetracaine, >=98% (tlc)

87. Dtxsid1043883

88. Tetracaine [orange Book]

89. Kbio1_000607

90. Kbio2_001512

91. Kbio2_004080

92. Kbio2_006648

93. Kbio3_001444

94. Tetracaine [ep Monograph]

95. Ninds_000607

96. Synera Component Tetracaine

97. Bcpp000048

98. Tetracaine [usp Monograph]

99. Act04765

100. Albb-025902

101. Bcp04777

102. Hy-a0079

103. Zinc1530811

104. Bdbm50017659

105. Stl483844

106. Tetracaine Component Of Synera

107. Akos015889234

108. Ac-3480

109. Ccg-205285

110. Db09085

111. Sdccgsbi-0051178.p005

112. Idi1_000607

113. Ncgc00016049-01

114. Ncgc00016049-03

115. Ncgc00016049-04

116. Ncgc00016049-14

117. Ncgc00162367-01

118. As-81743

119. Sy066710

120. Bcp0726000001

121. Sbi-0051178.p004

122. Ab00053549

123. Ft-0656378

124. T2789

125. Tetracaine, Meets Usp Testing Specifications

126. .beta.-dimethylaminoethyl P-butylaminobenzoate

127. 2-(dimethylamino)ethyl4-(n-butylamino)benzoate

128. C07526

129. D00551

130. 2-(dimethylamino)ethyl 4-(butylamino)benzoate #

131. Ab00053549-11

132. Ab00053549_12

133. Ab00053549_13

134. Q419608

135. Q-201805

136. Brd-k45071273-003-05-8

137. Brd-k45071273-003-15-7

138. Tetracaine, United States Pharmacopeia (usp) Reference Standard

139. Benzoic Acid, 4-(butylamino)-, 2-(dimethylamino)ethyl Ester ,hydrochloride

140. Benzoic Acid,4-butylamino,2-dimethylaminoethyl Ester Pantocain Base

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₄N₂O₂
Molecular Weight	264.36 g/mol
XLogP3	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	264.183778013 g/mol
Monoisotopic Mass	264.183778013 g/mol
Topological Polar Surface Area	41.6 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	249
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic. The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.

FDA Label

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

5.2 FDA Pharmacological Classification

5.2.1 Active Moiety

TETRACAINE

5.2.2 FDA UNII

0619F35CGV

5.2.3 Pharmacological Classes

Esters [CS]; Local Anesthesia [PE]; Ester Local Anesthetic [EPC]

5.3 ATC Code

S01HA03

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

C - Cardiovascular system

C05 - Vasoprotectives

C05A - Agents for treatment of hemorrhoids and anal fissures for topical use

C05AD - Local anesthetics

C05AD02 - Tetracaine

D - Dermatologicals

D04 - Antipruritics, incl. antihistamines, anesthetics, etc.

D04A - Antipruritics, incl. antihistamines, anesthetics, etc.

D04AB - Anesthetics for topical use

D04AB06 - Tetracaine

N - Nervous system

N01 - Anesthetics

N01B - Anesthetics, local

N01BA - Esters of aminobenzoic acid

N01BA03 - Tetracaine

S - Sensory organs

S01 - Ophthalmologicals

S01H - Local anesthetics

S01HA - Local anesthetics

S01HA03 - Tetracaine

5.4 Absorption, Distribution and Excretion

Absorption

Systemic absorption of anaesthetic from the combination cream is directly related to the duration and surface area of application. Although peak plasma concentrations for lidocaine were measured, plasma levels for tetracaine could not be determined due to low levels (<0.9 ng/mL)

Volume of Distribution

Tetracaine is rapidly hydrolyzed in the plasma; therefore, volume of distribution could not be determined.

Clearance

Tetracaine is hydrolyzed rapidly in the plasma; therefore, clearance has not been determined.

5.5 Metabolism/Metabolites

Tetracaine is rapidly hydrolyzed by plasma esterases to the following primary metabolites: para-aminobenzoic acid and diethylaminoethanol. The activity of both metabolites is unspecified.

5.6 Biological Half-Life

Tetracaine is hydrolyzed rapidly in the plasma; therefore, half-life has not been determined.

5.7 Mechanism of Action

Tetracaine is an ester-type anesthetic and produces local anesthesia by blocking the sodium ion channels involved in initiation and conduction of neuronal impulses.

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API Reference Price

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