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CHSD Tetracaine Hydrochloride

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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xyz-pharma-m-2024-10-07

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Nuray Tetracaine HCl

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Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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xyz-pharma-m-2024-10-07

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

21 API Suppliers, 6 USDMF, 2 CEP/COS, 1 JDMF, 3 EU WC, 11 NDC API, 16 Listed Suppliers, $ API Reference Price

21 API Suppliers
6 USDMF
2 CEP/COS
1 JDMF
3 EU WC
11 NDC API
16 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

15 FDF Dossiers, 3 FDA Orange Book, 1 Europe, 6 Canada, 4 South Africa, 1 Listed Dossiers

15 FDF Dossiers
3 FDA Orange Book
1 Europe
6 Canada
4 South Africa
1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

2 Seqens, 6 DKSH, 2 Faran Shimi Pharmaceutical, 4 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 13 Actylis, 1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 11 BASF, 10 Corel Pharma Chem, 2 DFE Pharma, 5 Finar, 3 Gangwal Chemicals, 4 Ideal Cures Pvt Ltd, 26 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 6 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 3 Pluviaendo, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 4 Roquette, 6 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 Sigachi Industries, 2 The Dow Chemical Company, 1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

42 Coating Systems & Additives, 25 Fillers, Diluents & Binders, 22 Controlled & Modified Release, 21 Topical, 14 Parenteral, 12 Film Formers & Plasticizers, 10 Solubilizers, 10 Direct Compression, 10 Thickeners and Stabilizers, 8 Granulation, 5 Co-Processed Excipients, 5 Empty Capsules, 4 Rheology Modifiers, 4 Vegetarian Capsules, 3 Lubricants & Glidants, 3 API Stability Enhancers, 3 Taste Masking, 2 Emulsifying Agents, 2 Coloring Agents, 1 Chewable & Orodispersible Aids, 1 Disintegrants & Superdisintegrants

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 3 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

globalSalesInformation
1 US Medicaid Prescriptions

MARKET PLACE

4 APIs

marketPlace
4 APIs

PATENTS & EXCLUSIVITIES

2 US Patents

patents
2 US Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 1 USP , 1 Others

otherSolutions
3 EDQM
1 USP
1 Others

CHSD Tetracaine Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

21

API Suppliers

6

USDMF

2

CEP/COS

CEP/COS Certifications

1

JDMF

3

EU WC

0

KDMF

11

NDC API

0

VMF

16

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 172

MARKET PLACE

4

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

15

FDF Dossiers

3

FDA Orange Book

FDA (Orange Book)

1

Europe

6

Canada

0

Australia

4

South Africa

1

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

3

EDQM

1

USP

0

JP

1

Others

PATENTS & EXCLUSIVITIES

2

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

1

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

3

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

5,762

Annual Reports (USD Million)

NA

Finished Drug Prices

NA

132 RELATED EXCIPIENT COMPANIES

207EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 136-47-0, Tetracaine hcl, Butethanol, Amethocaine hydrochloride, Pantocaine, Curtacain

Molecular Formula

C₁₅H₂₅ClN₂O₂

Molecular Weight

300.82 g/mol

InChI Key

PPWHTZKZQNXVAE-UHFFFAOYSA-N

FDA UNII

5NF5D4OPCI

Tetracaine Hydrochloride

A potent local anesthetic of the ester type used for surface and spinal anesthesia.

1 2D Structure

Tetracaine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride

2.1.2 InChI

InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

2.1.3 InChI Key

PPWHTZKZQNXVAE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C.Cl

2.2 Other Identifiers

2.2.1 UNII

5NF5D4OPCI

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Amethocaine

2. Ametop

3. Dicaine

4. Hydrochloride, Tetrracaine

5. Pantocaine

6. Pontocaine

7. Tetracaine

8. Tetracaine Monohydrochloride

9. Tetrakain

10. Tetrracaine Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 136-47-0

2. Tetracaine Hcl

3. Butethanol

4. Amethocaine Hydrochloride

5. Pantocaine

6. Curtacain

7. Menonasal

8. Anethaine

9. Dicainum

10. Tetracaine, Hcl

11. Tetracaine (hydrochloride)

12. Butylocaine

13. 2-(dimethylamino)ethyl 4-(butylamino)benzoate Hydrochloride

14. Tetocaine

15. Tetraca

16. Tetracainehydrochloride

17. 5nf5d4opci

18. 2-(dimethylamino)ethyl P-(butylamino)benzoate Monohydrochloride

19. Nsc-757337

20. 4-(butylamino)benzoic Acid 2-(dimethylamino)ethyl Ester Hydrochloride

21. Benzoic Acid, 4-(butylamino)-, 2-(dimethylamino)ethyl Ester, Monohydrochloride

22. Mls000069780

23. Tetracaine Hydrochloride (pontocaine)

24. Anethain

25. Decicain

26. Decicaine

27. Dessicain

28. Intercaine

29. Leocaine

30. Pantocain

31. Smr000058522

32. Tonexol

33. Anacel

34. Gingicain M

35. Dsstox_cid_22448

36. Dsstox_rid_80027

37. Dsstox_gsid_42448

38. Tetracainium Chloridum

39. Tetracaine Chlorhydrate

40. 2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride

41. Viractin

42. Tetracaine Monohydrochloride

43. Amethocaine Monohydrochloride

44. Sr-01000075240

45. Ncgc00016049-02

46. Cas-136-47-0

47. Einecs 205-248-5

48. Unii-5nf5d4opci

49. Exactacain

50. Amethocalne Hcl

51. Tetracaine Hydrochloride [usp:jan]

52. Mfcd00038912

53. P-butylaminobenzoyl-2-dimethylaminoethanol Hydrochloride

54. 2-dimethylaminoethanol 4-n-butylaminobenzoate Hydrochloride

55. Pontocaine Hydrochloride

56. 2-(dimethylamino)ethyl P-(butylamino)benzoate Hydrochloride

57. Tetracaini Hydrochloridum

58. Opera_id_1220

59. P-(butylamino)benzoic Acid, 2-(dimethylamino)ethyl Ester, Hydrochloride

60. Dicainum [who-ip]

61. Schembl24370

62. Mls002222164

63. Protocaine Hydrochloride (tn)

64. Spectrum1500564

65. 4-butylaminobenzoic Acid Dimethylaminoethyl Ester Hcl

66. Chebi:9469

67. Chembl1255654

68. Dtxsid6042448

69. Tetracaine For System Suitability

70. Tetracaine Hydrochloride, >=99%

71. Hms1569d04

72. Hms1921c17

73. Pharmakon1600-01500564

74. Act04762

75. Bcp26339

76. Hy-b0473

77. Tox21_110290

78. Tox21_501211

79. Ac-774

80. Ccg-39266

81. Nsc757337

82. S2573

83. Tetracaine Hydrochloride [mi]

84. Tetracaine Hydrochloride (jp17/usp)

85. Tetracaine Hydrochloride [jan]

86. Akos015888160

87. Tox21_110290_1

88. Ks-5059

89. Lp01211

90. Nsc 757337

91. Benzoic Acid, P-(butylamino)-, 2-(dimethylamino)ethyl Ester, Monohydrochloride

92. Tetracaine Hydrochloride [mart.]

93. Tetracaine Hydrochloride [vandf]

94. Ncgc00016049-07

95. Ncgc00094458-01

96. Ncgc00094458-02

97. Ncgc00094458-03

98. Ncgc00094458-04

99. Ncgc00094458-05

100. Ncgc00261896-01

101. Tetracaine Hydrochloride [usp-rs]

102. Tetracaine Hydrochloride [who-dd]

103. Tetracaine Hydrochloride [who-ip]

104. 53762-93-9

105. Amethocaine Hydrochloride [who-ip]

106. Db-042341

107. Eu-0101211

108. Ft-0603346

109. Ft-0674941

110. Sw196411-3

111. T1688

112. Tetracaine Hydrochloride [green Book]

113. Tetracaine Hydrochloride [orange Book]

114. D00741

115. T 7508

116. Tetracaine Hydrochloride [ep Monograph]

117. Tetracaine Hydrochloride [usp Monograph]

118. Tetracaini Hydrochloridum [who-ip Latin]

119. 136t470

120. A807078

121. Kovanaze Component Tetracaine Hydrochloride

122. Tetracaine Hydrochloride, Sigma Reference Standard

123. Q-201806

124. Sr-01000075240-1

125. Sr-01000075240-6

126. Q27262597

127. Tetracaine Hydrochloride Component Of Kovanaze

128. Tetracaine Hydrochloride, Meets Usp Testing Specifications

129. Tetracaine Hydrochloride 1.0 Mg/ml In Acetonitrile (as Free Base)

130. Tetracaine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

131. Benzoic Acid, 4-(butylamino)-, 2-(dimethylamino)ethyl Ester,monohydrochloride

132. Tetracaine For System Suitability, European Pharmacopoeia (ep) Reference Standard

133. Tetracaine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

134. Tetracaine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₅ClN₂O₂
Molecular Weight	300.82 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	300.1604557 g/mol
Monoisotopic Mass	300.1604557 g/mol
Topological Polar Surface Area	41.6 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	249
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Esters [CS]; Local Anesthesia [PE]; Ester Local Anesthetic [EPC]

API SUPPLIERS

01

Shandong Chenghui Shuangda Pharmac...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

Contact Supplier

Contact Supplier

China

Digital Content

USDMF CEP/COS JDMF EU-WC

NDC KDMF VMF Others AUDIT

Shandong Chenghui Shuangda Pharmaceutical

Product Web Link

Digital Content

02

Nuray Chemicals Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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Contact Supplier

India

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Nuray Chemicals

Product Web Link

Digital Content

03

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

Contact Supplier

U.S.A

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

04

Pharm-RX Chemical

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Pharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

Contact Supplier

Contact Supplier

U.S.A

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

Corporate PDF

05

Venkata Narayana Active Ingredient...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

06

Changzhou Tianhua Pharmaceutical C...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

07

Siegfried AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

08

Siegfried AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

09

Grace

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

10

BEIJING JIKANLITONG PHARM TECH CO ...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Only 10 entries up to this point, click to access all

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USDMF

01

Beijing Jikanlitong Pharm Tech Co Lt...

China

Antibody Engineering

Not Confirmed

02

Changzhou Tianhua Pharmaceutical Co ...

China

Antibody Engineering

Not Confirmed

03

W R Grace And Co -conn

U.S.A

Antibody Engineering

Not Confirmed

04

Siegfried Evionnaz Sa

Switzerland

Antibody Engineering

Not Confirmed

05

Siegfried Evionnaz Sa

Switzerland

Antibody Engineering

Not Confirmed

06

Venkata Narayana Active Ingredients ...

India

Antibody Engineering

Not Confirmed

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Listed Suppliers

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API Reference Price

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MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1687545000,"product":"AMETHOCAINE HYDROCHLORIDE (TETRACAINE HYDROCHLORIDE(POI-220601)","address":"NEELAM CENTRE, B WING 4TH FLOOR HIND CYCLE ROAD, WORLI","city":"MUMBAI","supplier":"ADCOCK INGRAM","supplierCountry":"SOUTH AFRICA","foreign_port":"NA","customer":"J.B.CHEMICALS & PHARMACEUTICALS","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25000","unit":"GMS","unitRateFc":"7.7","totalValueFC":"10710","currency":"ZAR","unitRateINR":"35","date":"24-Jun-2023","totalValueINR":"880325.229","totalValueInUsd":"10710","indian_port":"BOMBAY AIR","hs_no":"29222990","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"NEELAM CENTRE, B WING 4TH FLOOR HIND CYCLE ROAD, WORLI"}]

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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