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    Chemistry

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    Also known as: Thallium(i) chloride, Thallous chloride, Thallium monochloride, 7791-12-0, Thallium(1+) chloride, Chlorothallium
    Molecular Formula
    ClTl
    Molecular Weight
    239.83  g/mol
    InChI Key
    GBECUEIQVRDUKB-UHFFFAOYSA-M
    Thallium Chloride
    Thallous Chloride Tl-201 is the chloride salt form of thallium-201, a cyclotron produced isotope use in diagnostic imaging. Thallous chloride TI-201 accumulates in myocardial cells and other tissues in an analogous way as potassium, and can be evaluated as a function of blood flow. By scintigraphic means, areas with decreased blood flow, consisting of ischemic cells, can be visualized due to decreased uptake of TI-201 in contrast to areas with normal blood flow.
    1 2D Structure

    Thallium Chloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    chlorothallium
    2.1.2 InChI
    InChI=1S/ClH.Tl/h1H;/q;+1/p-1
    2.1.3 InChI Key
    GBECUEIQVRDUKB-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    Cl[Tl]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Thallium Chloride, (201)tl-labeled

    2. Thallium Chloride, (203)tl,(35)cl-labeled

    3. Thallium Chloride, (203)tl,(37)cl-labeled

    4. Thallium Chloride, (205)tl,(35)cl-labeled

    5. Thallium Chloride, (205)tl,(37)cl-labeled

    6. Thallium Monochloride

    7. Thallous Chloride

    2.2.2 Depositor-Supplied Synonyms

    1. Thallium(i) Chloride

    2. Thallous Chloride

    3. Thallium Monochloride

    4. 7791-12-0

    5. Thallium(1+) Chloride

    6. Chlorothallium

    7. Tlcl

    8. Thallium Chloride (tlcl)

    9. Thallium Chloride (van)

    10. Mfcd00011274

    11. Thallous Chloride Tl-201

    12. Rcra Waste Number U216

    13. Hsdb 6066

    14. Einecs 232-241-4

    15. Nsc 15197

    16. Rcra Waste No. U216

    17. Chloridothallium

    18. Unii-37cb58v15b

    19. [tlcl]

    20. Wln: Tl G

    21. Thallium Chloride, (tlcl)

    22. Thallium(i) Chloride, 99%

    23. Chebi:37117

    24. Thallium(i) Chloride, Ultra Dry

    25. Nsc15197

    26. Akos015916191

    27. Db09316

    28. Q425234

    29. Thallium(i) Chloride, 99.999% Trace Metals Basis

    2.3 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 239.83 g/mol
    Molecular Formula ClTl
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count0
    Rotatable Bond Count0
    Exact Mass239.94328 g/mol
    Monoisotopic Mass239.94328 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count2
    Formal Charge0
    Complexity2
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For use as a diagnostic radiopharmaceutical. It is indicated to help diagnose heart disease (eg, coronary artery disease, heart attack). It is also used for the diagnosis of parathyroid problems.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Data not found.

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Radiopharmaceutical Activity [MoA]; Radioactive Diagnostic Agent [EPC]
    5.3 Absorption, Distribution and Excretion

    Absorption

    After IV administration, thallous chloride clears rapidly from the blood, with maximum concentration in the myocardium after about 10 min. Only 5-8% of injected activity remained in the blood, following 5 minutes of intravenous administration.

    Route of Elimination

    Thallous Chloride Tl 201 is excreted slowly and to an equal extent in both feces and urine.

    Volume of Distribution

    310 L/kg

    Clearance

    Approximately 4-8% of the injected dose was excreted in the urine in the first 24 hours. The whole body disappearance half-time was 9.8 2.5 days. Kidney concentration was found to be about 3 percent of the injected activity and the testicular content was 0.15 percent. Net thyroid activity was determined to be only 0.2 percent of the injected dose, and the activity disappeared in 24 hours. From anterior and posterior whole-body scans, it was determined that about 45 percent of the injected dose was in the large intestines and contiguous structures (liver, kidneys, abdominal musculature).

    In acute thallium poisoning, human brain areas densely populated with neurons were found to accumulate thallium more than other areas, and the gray matter contained higher thallium levels than nonneural tissues. /Soluble thallium cmpd/

    Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 680

    5.4 Metabolism/Metabolites

    Data not found

    5.5 Biological Half-Life

    91% of the blood radioactivity has a t1/2 of 5 min. 9% has t1/2 of 40 hours.

    BODY BURDEN AS % OF ADMIN DOSE WAS DETERMINED IN RATS FOLLOWING ADMIN OF (204)THALLIUM ... OVER A PERIOD OF 21 DAYS. BODY CLEARANCE /OCCURRED/ ... EXPONENTIALLY WITH HALFTIME 3.3 DAYS ... AT THE END OF 21 DAYS ... 1% OF ADMIN DOSE REMAINED. ... WITH BIOLOGICAL HALF-TIME OF 3.3 DAYS ... DAILY DOSING /GIVES/ AN EQUILIBRIUM ... @ 20 DAYS. /SOLUBLE THALLIUM SALTS/

    Friberg, L., Nordberg, G.F., Kessler, E. and Vouk, V.B. (eds). Handbook of the Toxicology of Metals. 2nd ed. Vols I, II.: Amsterdam: Elsevier Science Publishers B.V., 1986., p. V2 555

    5.6 Mechanism of Action

    Thallous Chloride TI201 without carrier, accumulates in the heart (myocardium) in a similar way to that of potassium. Thallous Chloride Tl 201 images have been found to visualize areas of infarction as cold or nonlabeled regions which are confirmed by electrocardiographic and enzyme changes. Regions of transient myocardial ischemia corresponding to areas perfused by coronary arteries with partial stenoses have been visualized when Thallous Chloride Tl 201 was administered in conjunction with an exercise stress test. Anatomic configurations may interfere with visualization of the right coronary artery.

    ... STUDY INVOLVING /THALLIUM SOLUBLE SALTS EFFECTS ON MOUSE CELL CULTURES SHOWED/ ... CYTOPATHIC EFFECTS ... GREATLY ENLARGED MITOCHONDRIA IN AXONS OF PERIPHERAL NERVE FIBERS. ... MECHANISM /CONCERNS INACTIVATION OF/ ... SH GROUPS THAT /ALLOW/ ... INCR PERMEABILITY OF MITOCHONDRIA LEADING TO WATER INFLUX & SWELLING. /THALLIUM CMPD/

    Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 1927

    TRIVALENT THALLIUM COMPOUNDS ARE SOMEWHAT LESS TOXIC THAN ARE THALLIUM ION COMPOUNDS ... THALLIUM ACTS AS A MITOTIC AGENT & GENERAL CELLULAR POISON. CELLULAR ACCUM OF THALLIUM IN MUSCLE & OTHER TISSUES CAUSES DERANGEMENT OF NORMAL CELLULAR METABOLISM ... HIGH THALLIUM CONCN IN BLOOD AGGLUTINATES ERYTHROCYTES & LYSES THEM FOLLOWING THALLIUM ION ACCUMMULATION WITHIN ERYTHROCYTES. /THALLIUM SALTS/

    Venugopal, B. and T.D. Luckey. Metal Toxicity in Mammals, 2. New York: Plenum Press, 1978., p. 125

    Thallium inhibits enzymes, but nothing is really known of a biochemical lesion. In fatal cases, there usually is extensive peripheral paralysis and cardiovascular involvement. The immediate cause of death may be peripheral respiratory failure of cardiac arrest. /Thallium/

    Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide Toxicology. Volume 2. Classes of Pesticides. New York, NY: Academic Press, Inc., 1991., p. 526

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    DOSAGE - INJECTABLE;INJECTION - 1mCi/ML

    USFDA APPLICATION NUMBER - 17806

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    DOSAGE - INJECTABLE;INTRAVENOUS - 2mCi/ML

    USFDA APPLICATION NUMBER - 17806

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    DOSAGE - INJECTABLE;INJECTION - 1mCi/ML

    USFDA APPLICATION NUMBER - 18110

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    DOSAGE - INJECTABLE;INJECTION - 1mCi/ML

    USFDA APPLICATION NUMBER - 18150

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    ABOUT THIS PAGE

    THALLOUS CHLORIDE TL-201 Manufacturers

    A THALLOUS CHLORIDE TL-201 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of THALLOUS CHLORIDE TL-201, including repackagers and relabelers. The FDA regulates THALLOUS CHLORIDE TL-201 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. THALLOUS CHLORIDE TL-201 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    THALLOUS CHLORIDE TL-201 Suppliers

    A THALLOUS CHLORIDE TL-201 supplier is an individual or a company that provides THALLOUS CHLORIDE TL-201 active pharmaceutical ingredient (API) or THALLOUS CHLORIDE TL-201 finished formulations upon request. The THALLOUS CHLORIDE TL-201 suppliers may include THALLOUS CHLORIDE TL-201 API manufacturers, exporters, distributors and traders.

    click here to find a list of THALLOUS CHLORIDE TL-201 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    THALLOUS CHLORIDE TL-201 USDMF

    A THALLOUS CHLORIDE TL-201 DMF (Drug Master File) is a document detailing the whole manufacturing process of THALLOUS CHLORIDE TL-201 active pharmaceutical ingredient (API) in detail. Different forms of THALLOUS CHLORIDE TL-201 DMFs exist exist since differing nations have different regulations, such as THALLOUS CHLORIDE TL-201 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A THALLOUS CHLORIDE TL-201 DMF submitted to regulatory agencies in the US is known as a USDMF. THALLOUS CHLORIDE TL-201 USDMF includes data on THALLOUS CHLORIDE TL-201's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The THALLOUS CHLORIDE TL-201 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of THALLOUS CHLORIDE TL-201 suppliers with USDMF on PharmaCompass.

    THALLOUS CHLORIDE TL-201 GMP

    THALLOUS CHLORIDE TL-201 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of THALLOUS CHLORIDE TL-201 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right THALLOUS CHLORIDE TL-201 GMP manufacturer or THALLOUS CHLORIDE TL-201 GMP API supplier for your needs.

    THALLOUS CHLORIDE TL-201 CoA

    A THALLOUS CHLORIDE TL-201 CoA (Certificate of Analysis) is a formal document that attests to THALLOUS CHLORIDE TL-201's compliance with THALLOUS CHLORIDE TL-201 specifications and serves as a tool for batch-level quality control.

    THALLOUS CHLORIDE TL-201 CoA mostly includes findings from lab analyses of a specific batch. For each THALLOUS CHLORIDE TL-201 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    THALLOUS CHLORIDE TL-201 may be tested according to a variety of international standards, such as European Pharmacopoeia (THALLOUS CHLORIDE TL-201 EP), THALLOUS CHLORIDE TL-201 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (THALLOUS CHLORIDE TL-201 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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