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1. Thallium Chloride, (201)tl-labeled
2. Thallium Chloride, (203)tl,(35)cl-labeled
3. Thallium Chloride, (203)tl,(37)cl-labeled
4. Thallium Chloride, (205)tl,(35)cl-labeled
5. Thallium Chloride, (205)tl,(37)cl-labeled
6. Thallium Monochloride
7. Thallous Chloride
1. Thallium(i) Chloride
2. Thallous Chloride
3. Thallium Monochloride
4. 7791-12-0
5. Thallium(1+) Chloride
6. Chlorothallium
7. Tlcl
8. Thallium Chloride (tlcl)
9. Thallium Chloride (van)
10. Mfcd00011274
11. Thallous Chloride Tl-201
12. Rcra Waste Number U216
13. Hsdb 6066
14. Einecs 232-241-4
15. Nsc 15197
16. Rcra Waste No. U216
17. Chloridothallium
18. Unii-37cb58v15b
19. [tlcl]
20. Wln: Tl G
21. Thallium Chloride, (tlcl)
22. Thallium(i) Chloride, 99%
23. Chebi:37117
24. Thallium(i) Chloride, Ultra Dry
25. Nsc15197
26. Akos015916191
27. Db09316
28. Q425234
29. Thallium(i) Chloride, 99.999% Trace Metals Basis
| Molecular Weight | 239.83 g/mol |
|---|---|
| Molecular Formula | ClTl |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 239.94328 g/mol |
| Monoisotopic Mass | 239.94328 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 2 |
| Formal Charge | 0 |
| Complexity | 2 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For use as a diagnostic radiopharmaceutical. It is indicated to help diagnose heart disease (eg, coronary artery disease, heart attack). It is also used for the diagnosis of parathyroid problems.
Data not found.
Absorption
After IV administration, thallous chloride clears rapidly from the blood, with maximum concentration in the myocardium after about 10 min. Only 5-8% of injected activity remained in the blood, following 5 minutes of intravenous administration.
Route of Elimination
Thallous Chloride Tl 201 is excreted slowly and to an equal extent in both feces and urine.
Volume of Distribution
310 L/kg
Clearance
Approximately 4-8% of the injected dose was excreted in the urine in the first 24 hours. The whole body disappearance half-time was 9.8 2.5 days. Kidney concentration was found to be about 3 percent of the injected activity and the testicular content was 0.15 percent. Net thyroid activity was determined to be only 0.2 percent of the injected dose, and the activity disappeared in 24 hours. From anterior and posterior whole-body scans, it was determined that about 45 percent of the injected dose was in the large intestines and contiguous structures (liver, kidneys, abdominal musculature).
In acute thallium poisoning, human brain areas densely populated with neurons were found to accumulate thallium more than other areas, and the gray matter contained higher thallium levels than nonneural tissues. /Soluble thallium cmpd/
Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 680
Data not found
91% of the blood radioactivity has a t1/2 of 5 min. 9% has t1/2 of 40 hours.
BODY BURDEN AS % OF ADMIN DOSE WAS DETERMINED IN RATS FOLLOWING ADMIN OF (204)THALLIUM ... OVER A PERIOD OF 21 DAYS. BODY CLEARANCE /OCCURRED/ ... EXPONENTIALLY WITH HALFTIME 3.3 DAYS ... AT THE END OF 21 DAYS ... 1% OF ADMIN DOSE REMAINED. ... WITH BIOLOGICAL HALF-TIME OF 3.3 DAYS ... DAILY DOSING /GIVES/ AN EQUILIBRIUM ... @ 20 DAYS. /SOLUBLE THALLIUM SALTS/
Friberg, L., Nordberg, G.F., Kessler, E. and Vouk, V.B. (eds). Handbook of the Toxicology of Metals. 2nd ed. Vols I, II.: Amsterdam: Elsevier Science Publishers B.V., 1986., p. V2 555
Thallous Chloride TI201 without carrier, accumulates in the heart (myocardium) in a similar way to that of potassium. Thallous Chloride Tl 201 images have been found to visualize areas of infarction as cold or nonlabeled regions which are confirmed by electrocardiographic and enzyme changes. Regions of transient myocardial ischemia corresponding to areas perfused by coronary arteries with partial stenoses have been visualized when Thallous Chloride Tl 201 was administered in conjunction with an exercise stress test. Anatomic configurations may interfere with visualization of the right coronary artery.
... STUDY INVOLVING /THALLIUM SOLUBLE SALTS EFFECTS ON MOUSE CELL CULTURES SHOWED/ ... CYTOPATHIC EFFECTS ... GREATLY ENLARGED MITOCHONDRIA IN AXONS OF PERIPHERAL NERVE FIBERS. ... MECHANISM /CONCERNS INACTIVATION OF/ ... SH GROUPS THAT /ALLOW/ ... INCR PERMEABILITY OF MITOCHONDRIA LEADING TO WATER INFLUX & SWELLING. /THALLIUM CMPD/
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 1927
TRIVALENT THALLIUM COMPOUNDS ARE SOMEWHAT LESS TOXIC THAN ARE THALLIUM ION COMPOUNDS ... THALLIUM ACTS AS A MITOTIC AGENT & GENERAL CELLULAR POISON. CELLULAR ACCUM OF THALLIUM IN MUSCLE & OTHER TISSUES CAUSES DERANGEMENT OF NORMAL CELLULAR METABOLISM ... HIGH THALLIUM CONCN IN BLOOD AGGLUTINATES ERYTHROCYTES & LYSES THEM FOLLOWING THALLIUM ION ACCUMMULATION WITHIN ERYTHROCYTES. /THALLIUM SALTS/
Venugopal, B. and T.D. Luckey. Metal Toxicity in Mammals, 2. New York: Plenum Press, 1978., p. 125
Thallium inhibits enzymes, but nothing is really known of a biochemical lesion. In fatal cases, there usually is extensive peripheral paralysis and cardiovascular involvement. The immediate cause of death may be peripheral respiratory failure of cardiac arrest. /Thallium/
Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide Toxicology. Volume 2. Classes of Pesticides. New York, NY: Academic Press, Inc., 1991., p. 526
FDF Dossiers
FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]DRUG PRODUCT COMPOSITIONS
DOSAGE - INJECTABLE;INJECTION - 1mCi/ML
USFDA APPLICATION NUMBER - 17806
DOSAGE - INJECTABLE;INTRAVENOUS - 2mCi/ML
USFDA APPLICATION NUMBER - 17806
DOSAGE - INJECTABLE;INJECTION - 1mCi/ML
USFDA APPLICATION NUMBER - 18110
DOSAGE - INJECTABLE;INJECTION - 1mCi/ML
USFDA APPLICATION NUMBER - 18150
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