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Chemistry

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Also known as: 15318-45-3, Thiophenicol, Raceophenidol, (+)-thiamphenicol, Dextrosulphenidol, Thiocymetin
Molecular Formula
C12H15Cl2NO5S
Molecular Weight
356.2  g/mol
InChI Key
OTVAEFIXJLOWRX-NXEZZACHSA-N
FDA UNII
283383NO13

Thiamphenicol
A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.
1 2D Structure

Thiamphenicol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
2.1.2 InChI
InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
2.1.3 InChI Key
OTVAEFIXJLOWRX-NXEZZACHSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)C1=CC=C(C=C1)C(C(CO)NC(=O)C(Cl)Cl)O
2.1.5 Isomeric SMILES
CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O
2.2 Other Identifiers
2.2.1 UNII
283383NO13
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dextrosulfenidol

2. Raceophenidol

3. Thiamcol

4. Thiomycetin

5. Thiophenicol

6. Urfamycin

7. Vicemycetin

2.3.2 Depositor-Supplied Synonyms

1. 15318-45-3

2. Thiophenicol

3. Raceophenidol

4. (+)-thiamphenicol

5. Dextrosulphenidol

6. Thiocymetin

7. Thiocymetin (tn)

8. Armai (tn)

9. Racefenicol

10. Urfamycine

11. Dexawin

12. Igralin

13. Racephenicol [usan]

14. Racephenicol

15. Armai

16. Win-5063-2

17. 847-25-6

18. Thiamphenicol (thiophenicol)

19. Racefenicol [inn]

20. 2,2-dichloro-n-[(1r,2r)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide

21. Flq7571npm

22. 2,2-dichloro-n-{(1r,2r)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide

23. Mls001332640

24. D-(+)-threo-2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)acetamide

25. Chebi:32215

26. 2,2-dichloro-n-((1r,2r)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide

27. Nsc-522822

28. Thiamphenicolum

29. Smr000857096

30. D-thiocymetin

31. D-thiophenicol

32. 283383no13

33. Dsstox_cid_1338

34. Dsstox_rid_76092

35. Dsstox_gsid_21338

36. Acetamide, 2,2-dichloro-n-((1r,2r)-2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-

37. Tiamfenicolo [dcit]

38. Racefenicolo

39. Racefenicolum

40. Tiamfenicol

41. Tiamfenicolo

42. Thiamphenicol Dl-form

43. Win 5063-2

44. Acetamide, 2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, (r-(r*,r*))-

45. Tiamfenicol [inn-spanish]

46. 2,2-dichloro-n-[(1r,2r)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide

47. Thiamphenicolum [inn-latin]

48. 8065 C.b.

49. Racefenicolo [dcit]

50. (+/-)-thiamphenicol

51. Sr-05000001829

52. Einecs 239-355-3

53. Thiamphenicol [usan:inn:ban:jan]

54. Unii-flq7571npm

55. Nsc 522822

56. Racefenicolum [inn-latin]

57. Win-5063

58. Ccris 8588

59. Thiamphenicol Dl-

60. Unii-283383no13

61. Ncgc00016714-01

62. 2,2-dichloro-n-((1r,2r)-2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide

63. Prestwick_885

64. Cas-15318-45-3

65. Mfcd00467983

66. Spectrum_001428

67. Prestwick0_000025

68. Prestwick1_000025

69. Prestwick2_000025

70. Prestwick3_000025

71. Spectrum2_000856

72. Spectrum3_001562

73. Spectrum4_000733

74. Spectrum5_001617

75. Thiamphenicol [mi]

76. D-d-threo-2-dichloroacetamido-1-(4-methylsulfonylphenyl)-1,3-propanediol

77. D-threo-(1r,2r)-1-(p-methylsulfonylphenyl)-2-dichloroacetamido-1,3-propanediol

78. Thiamphenicol [inn]

79. Thiamphenicol [jan]

80. Thiamphenicol [usan]

81. Schembl34635

82. Bspbio_000089

83. Bspbio_003064

84. Kbiogr_001026

85. Kbioss_001908

86. Cid_27200

87. Mls001332639

88. Mls002154177

89. Divk1c_000842

90. Spectrum1503136

91. Thiamphenicol [mart.]

92. Spbio_000871

93. Spbio_002010

94. Thiamphenicol [who-dd]

95. Bpbio1_000099

96. Chembl1236282

97. Dtxsid5021338

98. Thiamphenicol (jan/usan/inn)

99. Bdbm58925

100. Hms502k04

101. Kbio1_000842

102. Kbio2_001908

103. Kbio2_004476

104. Kbio2_007044

105. Kbio3_002564

106. Ninds_000842

107. Thiamphenicol, Analytical Standard

108. Hms1568e11

109. Hms1922g19

110. Hms2092l18

111. Hms2095e11

112. Hms2232e21

113. Hms3712e11

114. Pharmakon1600-01503136

115. Zinc538440

116. Thiamphenicol Dl-form [mi]

117. Bcp32746

118. Hy-b0479

119. Thiamphenicol [ep Monograph]

120. Tox21_110577

121. Tox21_200816

122. Ccg-40309

123. Nsc758396

124. S2583

125. Akos015951269

126. Dl-threo-2-dichloroacetamido-1-(4-methylsulfonyl-phenyl)-1,3-propanediol

127. Tox21_110577_1

128. Db08621

129. Nsc-758396

130. Idi1_000842

131. Smp2_000125

132. Ncgc00178319-01

133. Ncgc00178319-02

134. Ncgc00178319-03

135. Ncgc00178319-06

136. Ncgc00178319-07

137. Ncgc00258370-01

138. (+-)-threo-2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)acetamide

139. Acetamide, 2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)-, D-threo-(+)

140. Acetamide, 2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)-, Threo-(+-)-

141. As-12501

142. Sbi-0051779.p002

143. Sw197006-3

144. T2802

145. Thiamphenicol 100 Microg/ml In Acetonitrile

146. Thiamphenicol 1000 Microg/ml In Acetonitrile

147. D01407

148. Ab00052321_10

149. Ab00052321_11

150. 318t453

151. A809401

152. Q425015

153. Sr-05000001829-1

154. Sr-05000001829-3

155. Brd-k79711234-001-06-8

156. Brd-k79711234-001-11-8

157. Thiamphenicol, European Pharmacopoeia (ep) Reference Standard

158. Thiophenicol; Dextrosulphenidol; Descocin; Hyrazin; Masatirin; Urfamycine

159. 2,2-dichloro-n-[(1r,2r)-1,3-dihydroxy-1-[4-(methylsulfonyl)phenyl]-2-propyl]acetamide

160. 2,2-dichloro-n-[(1r,2r)-2-hydroxy-2-(4-mesylphenyl)-1-methylol-ethyl]acetamide

161. 2,2-bis(chloranyl)-n-[(1r,2r)-1-(4-methylsulfonylphenyl)-1,3-bis(oxidanyl)propan-2-yl]ethanamide

162. Acetamide, 2,2-dichloro-n-((1r,2r)-2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, Rel-

163. Acetamide, 2,2-dichloro-n-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)-, Threo-(+/-)-

164. Acetamide, 2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, (r*,r*)-(+-)-

165. Acetamide, 2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, (r*,r*)-(+/-)-

166. Acetamide,2,2-dichloro-n-[(1r,2r)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-

167. Th8

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 356.2 g/mol
Molecular Formula C12H15Cl2NO5S
XLogP3-0.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass355.0047991 g/mol
Monoisotopic Mass355.0047991 g/mol
Topological Polar Surface Area112 Ų
Heavy Atom Count21
Formal Charge0
Complexity443
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


4.2 ATC Code

J01BA02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01B - Amphenicols

J01BA - Amphenicols

J01BA02 - Thiamphenicol


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[{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1650652200,"product":"THIAMPHENICOL - (100% EOU F.NO. CUS(P)BSN\/EP-PLG\/EOU\/BLISS-GVS\/5\/2020\/PL-I\/043 DATED 22.04.2022)","address":"UNIT NO 102, HYDE PARK SAKIVIHAR RO ANDHERI EAST","city":"MUMBAI","supplier":"ZHEJIANG HISOAR PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"BLISS GVS PHARMA LTD","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"90","totalValueFC":"18405.8","currency":"USD","unitRateINR":"6943.5","date":"23-Apr-2022","totalValueINR":"1388700","totalValueInUsd":"18405.8","indian_port":"BOMBAY AIR","hs_no":"29419090","bill_no":"8394545","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"UNIT NO 102, HYDE PARK SAKIVIHAR RO ANDHERI EAST"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677004200,"product":"THIAMPHENICOL","address":"UNIT NO 102, HYDE PARK SAKIVIHAR RO ANDHERI EAST","city":"MUMBAI","supplier":"ZHEJIANG HISOAR PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"BLISS GVS PHARMA LTD","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"70","totalValueFC":"7089.8","currency":"USD","unitRateINR":"5855.5","date":"22-Feb-2023","totalValueINR":"585550","totalValueInUsd":"7089.8","indian_port":"JNPT","hs_no":"29419090","bill_no":"4755538","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"UNIT NO 102, HYDE PARK SAKIVIHAR RO ANDHERI EAST"}]
23-Apr-2022
22-Feb-2023
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ABOUT THIS PAGE

Thiamphenicol Manufacturers

A Thiamphenicol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thiamphenicol, including repackagers and relabelers. The FDA regulates Thiamphenicol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thiamphenicol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Thiamphenicol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Thiamphenicol Suppliers

A Thiamphenicol supplier is an individual or a company that provides Thiamphenicol active pharmaceutical ingredient (API) or Thiamphenicol finished formulations upon request. The Thiamphenicol suppliers may include Thiamphenicol API manufacturers, exporters, distributors and traders.

click here to find a list of Thiamphenicol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Thiamphenicol USDMF

A Thiamphenicol DMF (Drug Master File) is a document detailing the whole manufacturing process of Thiamphenicol active pharmaceutical ingredient (API) in detail. Different forms of Thiamphenicol DMFs exist exist since differing nations have different regulations, such as Thiamphenicol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Thiamphenicol DMF submitted to regulatory agencies in the US is known as a USDMF. Thiamphenicol USDMF includes data on Thiamphenicol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Thiamphenicol USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Thiamphenicol suppliers with USDMF on PharmaCompass.

Thiamphenicol GMP

Thiamphenicol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Thiamphenicol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thiamphenicol GMP manufacturer or Thiamphenicol GMP API supplier for your needs.

Thiamphenicol CoA

A Thiamphenicol CoA (Certificate of Analysis) is a formal document that attests to Thiamphenicol's compliance with Thiamphenicol specifications and serves as a tool for batch-level quality control.

Thiamphenicol CoA mostly includes findings from lab analyses of a specific batch. For each Thiamphenicol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Thiamphenicol may be tested according to a variety of international standards, such as European Pharmacopoeia (Thiamphenicol EP), Thiamphenicol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thiamphenicol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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