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Chemistry

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Also known as: Sodium thiamylal, Thiamylal sodium salt, 337-47-3, Surital sodium salt, Ncgc00095772-01, 5-allyl-5-(1-methylbutyl)-2-thiobarbituric acid, sodium salt
Molecular Formula
C12H17N2NaO2S
Molecular Weight
276.33  g/mol
InChI Key
LYZGJWXNOGIVQA-UHFFFAOYSA-M

Thiamylal
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
1 2D Structure

Thiamylal

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;4,6-dioxo-5-pentan-2-yl-5-prop-2-enyl-1H-pyrimidine-2-thiolate
2.1.2 InChI
InChI=1S/C12H18N2O2S.Na/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16;/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17);/q;+1/p-1
2.1.3 InChI Key
LYZGJWXNOGIVQA-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CCCC(C)C1(C(=O)NC(=NC1=O)[S-])CC=C.[Na+]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Sodium, Thiamylal

2. Surital

3. Thiamylal

4. Thioquinalbarbitone

2.2.2 Depositor-Supplied Synonyms

1. Sodium Thiamylal

2. Thiamylal Sodium Salt

3. 337-47-3

4. Surital Sodium Salt

5. Ncgc00095772-01

6. 5-allyl-5-(1-methylbutyl)-2-thiobarbituric Acid, Sodium Salt

7. Surital Sodium

8. Thiomylal Sodium

9. Sodium 5-allyl-5-(1-methylbutyl)-2-thiobarbiturate

10. Thioseconal Sodium

11. T4l2p3kh7k

12. 5-allyl-5-(1-methylbutyl)-2-thiobarbituric Acid, Sodium Derivative

13. Surital Sodium Deriv.

14. Nsc-759558

15. 4,6-(1h,5h)-pyrimidinedione, Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-, Monosodium Salt

16. Einecs 206-415-5

17. Unii-t4l2p3kh7k

18. Thiamylal Sodium [usp:jan]

19. Surital (tn)

20. 5-allyl-5-(1-methylbutyl)-2-thiobarbiturate Sodium

21. 5-allyl-5-(1-methylbutyl)-2-thio-barbituric Acid Sodium Salt

22. Thiamylal Sodium (jp17)

23. Dsstox_cid_25988

24. Dsstox_rid_81275

25. Dsstox_gsid_45988

26. Schembl34746

27. Spectrum1900002

28. Chebi:9537

29. Chembl1201065

30. Dtxsid3045988

31. Hms503e21

32. Hms2094g05

33. Tox21_111517

34. Barbituric Acid, 5-allyl-5-(1-methylbutyl)-2-thio-, Sodium Salt

35. Ccg-213640

36. Nsc 759558

37. Ncgc00095772-02

38. 4,6(1h,5h)-pyrimidinedione, Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-, Monosodium Salt

39. Cas-337-47-3

40. D00713

41. Q27289664

2.3 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 276.33 g/mol
Molecular Formula C12H17N2NaO2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass276.09084324 g/mol
Monoisotopic Mass276.09084324 g/mol
Topological Polar Surface Area59.5 Ų
Heavy Atom Count18
Formal Charge0
Complexity384
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anesthetics, Intravenous

Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174) (See all compounds classified as Anesthetics, Intravenous.)


GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)


Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)


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ABOUT THIS PAGE

Thiamylal Manufacturers

A Thiamylal manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thiamylal, including repackagers and relabelers. The FDA regulates Thiamylal manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thiamylal API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Thiamylal Suppliers

A Thiamylal supplier is an individual or a company that provides Thiamylal active pharmaceutical ingredient (API) or Thiamylal finished formulations upon request. The Thiamylal suppliers may include Thiamylal API manufacturers, exporters, distributors and traders.

click here to find a list of Thiamylal suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Thiamylal USDMF

A Thiamylal DMF (Drug Master File) is a document detailing the whole manufacturing process of Thiamylal active pharmaceutical ingredient (API) in detail. Different forms of Thiamylal DMFs exist exist since differing nations have different regulations, such as Thiamylal USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Thiamylal DMF submitted to regulatory agencies in the US is known as a USDMF. Thiamylal USDMF includes data on Thiamylal's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Thiamylal USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Thiamylal suppliers with USDMF on PharmaCompass.

Thiamylal GMP

Thiamylal Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Thiamylal GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thiamylal GMP manufacturer or Thiamylal GMP API supplier for your needs.

Thiamylal CoA

A Thiamylal CoA (Certificate of Analysis) is a formal document that attests to Thiamylal's compliance with Thiamylal specifications and serves as a tool for batch-level quality control.

Thiamylal CoA mostly includes findings from lab analyses of a specific batch. For each Thiamylal CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Thiamylal may be tested according to a variety of international standards, such as European Pharmacopoeia (Thiamylal EP), Thiamylal JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thiamylal USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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