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Also known as: Thiethylperazine dimalate, 52239-63-1, Torecan, Thietylperazine malate, Hp46xk89xb, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine malate (1:2)
Molecular Formula
C30H41N3O10S2
Molecular Weight
667.8  g/mol
InChI Key
GTHHLZDYRHLACN-UHFFFAOYSA-N
FDA UNII
HP46XK89XB

Thiethylperazine
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
1 2D Structure

Thiethylperazine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;2-hydroxybutanedioic acid
2.1.2 InChI
InChI=1S/C22H29N3S2.2C4H6O5/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24;2*5-2(4(8)9)1-3(6)7/h4-5,7-10,17H,3,6,11-16H2,1-2H3;2*2,5H,1H2,(H,6,7)(H,8,9)
2.1.3 InChI Key
GTHHLZDYRHLACN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C.C(C(C(=O)O)O)C(=O)O.C(C(C(=O)O)O)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
HP46XK89XB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Norzine

2. Thiethylperazine

3. Thiethylperazine Maleate (2:1)

4. Torecan

2.3.2 Depositor-Supplied Synonyms

1. Thiethylperazine Dimalate

2. 52239-63-1

3. Torecan

4. Thietylperazine Malate

5. Hp46xk89xb

6. 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine Malate (1:2)

7. 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;2-hydroxybutanedioic Acid

8. Thiethylperazine Malate (jan)

9. Norzine Ampuls

10. Thiethylperazine Malate [jan]

11. 10h-phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, 2-hydroxy-1,4-butanedioate (1:2)

12. Malic Acid, Compound With 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10h-phenothiazine (2:1)

13. Ncgc00017115-01

14. Cas-52239-63-1

15. Unii-hp46xk89xb

16. Thiethylperazine Malate [usp]

17. Malic Acid, Compound With 2-(ethylthio)-10-(3-(4-methylpiperazin-1-yl)propyl)-10h-phenothiazine (2:1)

18. Einecs 257-780-2

19. Torecan (tn)

20. Dsstox_cid_25586

21. Dsstox_rid_80982

22. Dsstox_gsid_45586

23. Schembl466913

24. Chembl2359670

25. Dtxsid1045586

26. Hms1571e18

27. Hms2098e18

28. Hms3715e18

29. Tox21_110784

30. Thiethylperazine Dimalate [mi]

31. Ccg-221068

32. Thiethylperazine Malate [mart.]

33. Thiethylperazine Malate [orange Book]

34. D02610

35. Sr-01000841243

36. Sr-01000841243-2

37. Q27280042

38. 2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-10h-phenothiazine Hydroxybutanedioate (1:2)

39. Butanedioic Acid, Hydroxy-, Compd. With 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazine (2:1)

40. Hydroxybutanedioic Acid Compd. With 2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-10h-phenothiazine (2:1)

2.4 Create Date
2006-11-22
3 Chemical and Physical Properties
Molecular Weight 667.8 g/mol
Molecular Formula C30H41N3O10S2
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count15
Rotatable Bond Count12
Exact Mass667.22333686 g/mol
Monoisotopic Mass667.22333686 g/mol
Topological Polar Surface Area250 Ų
Heavy Atom Count45
Formal Charge0
Complexity584
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


ABOUT THIS PAGE

Thiethylperazine Manufacturers

A Thiethylperazine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thiethylperazine, including repackagers and relabelers. The FDA regulates Thiethylperazine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thiethylperazine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Thiethylperazine Suppliers

A Thiethylperazine supplier is an individual or a company that provides Thiethylperazine active pharmaceutical ingredient (API) or Thiethylperazine finished formulations upon request. The Thiethylperazine suppliers may include Thiethylperazine API manufacturers, exporters, distributors and traders.

click here to find a list of Thiethylperazine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Thiethylperazine USDMF

A Thiethylperazine DMF (Drug Master File) is a document detailing the whole manufacturing process of Thiethylperazine active pharmaceutical ingredient (API) in detail. Different forms of Thiethylperazine DMFs exist exist since differing nations have different regulations, such as Thiethylperazine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Thiethylperazine DMF submitted to regulatory agencies in the US is known as a USDMF. Thiethylperazine USDMF includes data on Thiethylperazine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Thiethylperazine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Thiethylperazine suppliers with USDMF on PharmaCompass.

Thiethylperazine GMP

Thiethylperazine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Thiethylperazine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thiethylperazine GMP manufacturer or Thiethylperazine GMP API supplier for your needs.

Thiethylperazine CoA

A Thiethylperazine CoA (Certificate of Analysis) is a formal document that attests to Thiethylperazine's compliance with Thiethylperazine specifications and serves as a tool for batch-level quality control.

Thiethylperazine CoA mostly includes findings from lab analyses of a specific batch. For each Thiethylperazine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Thiethylperazine may be tested according to a variety of international standards, such as European Pharmacopoeia (Thiethylperazine EP), Thiethylperazine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thiethylperazine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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