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Thioacetazone

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

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Europe

Canada

Australia

South Africa

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0 DRUGS IN DEVELOPMENT

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PATENTS & EXCLUSIVITIES

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Finished Drug Prices

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Chemistry

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Also known as: Thiacetazone, Amithiozone, Ambathizon, Benzothiozane, Thiocarbazil, Conteben

Molecular Formula

C₁₀H₁₂N₄OS

Molecular Weight

236.30 g/mol

InChI Key

SRVJKTDHMYAMHA-WUXMJOGZSA-N

FDA UNII

MMG78X7SSR

A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217)

1 2D Structure

Thioacetazone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[4-[(E)-(carbamothioylhydrazinylidene)methyl]phenyl]acetamide

2.1.2 InChI

InChI=1S/C10H12N4OS/c1-7(15)13-9-4-2-8(3-5-9)6-12-14-10(11)16/h2-6H,1H3,(H,13,15)(H3,11,14,16)/b12-6+

2.1.3 InChI Key

SRVJKTDHMYAMHA-WUXMJOGZSA-N

2.1.4 Canonical SMILES

CC(=O)NC1=CC=C(C=C1)C=NNC(=S)N

2.1.5 Isomeric SMILES

CC(=O)NC1=CC=C(C=C1)/C=N/NC(=S)N

2.2 Other Identifiers

2.2.1 UNII

MMG78X7SSR

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ambathizon

2. Amithiozone

3. Conteben

4. Parazone

5. Tb I 698

6. Tb I-698

7. Tb I698

8. Tbi 698

9. Tbi-698

10. Tbi698

11. Thiacetazone

12. Thioacetazon

2.3.2 Depositor-Supplied Synonyms

1. Thiacetazone

2. Amithiozone

3. Ambathizon

4. Benzothiozane

5. Thiocarbazil

6. Conteben

7. Benzothiozon

8. Thioparamizone

9. Benthiozone

10. Thibone

11. Parazone

12. Thioacetazon

13. Tibon

14. Tubin

15. 104-06-3

16. Siocarbazone

17. Tebethione

18. Thiacetone

19. Thiacetozone

20. Thioazetazone

21. Thioparamizon

22. Thiotebesin

23. Thiotebezin

24. Thiotebicina

25. Tiacetazon

26. Tioacetazon

27. Tioatsetazon

28. Tubercazon

29. Aktivan

30. Amitiozon

31. Berkazon

32. Domakol

33. Livazone

34. Mivizon

35. Myvizone

36. Neotibil

37. Neustab

38. Novakol

39. Panrone

40. Seroden

41. Tebalon

42. Tebecure

43. Tebemar

44. Tebethion

45. Tebezon

46. Thiomicid

47. Thionicid

48. Thizone

49. Tibicur

50. Tibizan

51. Tiobicina

52. Tiocarone

53. Tiosecolo

54. Tubigal

55. Antib

56. Diasan

57. Ilbion

58. Thibon

59. Tibone

60. Berculon A

61. Tebesone I

62. 4-acetylaminobenzaldehyde Thiosemicarbazone

63. Nuclon Argentinian

64. Thiosemicarbazone

65. Thiosemicarbarzone

66. Tb I (bayer)

67. 4'-formylacetanilide Thiosemicarbazone

68. Tb I

69. Domagk's T.b.1 Conteben

70. Thioacetazonum

71. Tibione

72. Sdt 1041

73. Magk's T.b.1 Conteben

74. Tb I/698

75. P-acetamidobenzaldehyde Thiosemicarbazone

76. P-acetaminobenzylidenethiosemicarbazone

77. Citazone

78. Tibion

79. Cbc 903150

80. P-formylacetanilide-3-thiosemicarbazone

81. Sq 2321

82. Tb I-698

83. P-acetoaminobenzaldehyde Thiosemicarbazone

84. A 4081

85. 4207 Rp

86. Rp 4207

87. Acetamide, N-[4-[[(aminothioxomethyl)hydrazono]methyl]phenyl]-

88. P-acetylaminobenzadehyde Thiosemicarbazone

89. Nsc-3550

90. Mmg78x7ssr

91. Acetamide, N-(4-(((aminothioxomethyl)hydrazono)methyl)phenyl)-

92. Nsc3550

93. Acetanilide, 4'-formyl-, 4'-(thiosemicarbazone)

94. Thioacetazone (inn)

95. P-acetamidobenzaldehyde Thiosemicarbazon

96. Sq-2321

97. 4-acetamidobenzaldehyde Thiosemicarbazone

98. Ncgc00159389-02

99. Ncgc00159389-03

100. Ncgc00159389-04

101. P-acetylaminobenzaldehyde Thiosemicarbazone

102. N-[4-[(e)-(carbamothioylhydrazinylidene)methyl]phenyl]acetamide

103. Dsstox_cid_2593

104. Thioacetazone [inn]

105. Dsstox_rid_76650

106. Dsstox_gsid_22593

107. N-(4-((2-carbamothioylhydrazono)methyl)phenyl)acetamide

108. Mirizone Neustab

109. Tioacetazona

110. Thioacetazone [inn:ban]

111. Thioacetazonum [inn-latin]

112. Tioacetazona [inn-spanish]

113. Cas-104-06-3

114. Thiosemicarbazone (pharmaceutical)

115. Nsc 3550

116. Einecs 203-170-6

117. Unii-mmg78x7ssr

118. Brn 2810335

119. N-[4-[(e)-(carbamothioylhydrazono)methyl]phenyl]acetamide

120. N-{4-[(e)-(carbamothioylhydrazono)methyl]phenyl}acetamide

121. Acetamide, N-(4-(((aminothiomethyl)hydrazono)methylene)phenyl)-

122. Acetamide, N-[4-[[(aminothiomethyl)hydrazono]methylene]phenyl]-

123. Ai3-18591

124. 4207rp

125. Citazone (tn)

126. Acetanilide, 4'-formyl-, Thiosemicarbazone

127. Thiacetazone [mi]

128. Schembl42515

129. Acetanilide, Thiosemicarbazone

130. Wln: Suyzmnu1r Dmv1

131. 4-14-00-00075 (beilstein Handbook Reference)

132. N-(4-([2-(aminocarbothioyl)hydrazono]methyl)phenyl)acetamide

133. Thioacetazone [mart.]

134. Acetamide, N1-(4-([2-(aminocarbothioyl)hydrazono]methyl)phenyl)

135. Thioacetazone [who-dd]

136. Thioacetazone [who-ip]

137. Chembl375492

138. Tb-1

139. Acetamide, N-[4-[[2-(aminothioxomethyl)hydrazinylidene]methyl]phenyl]-

140. Dtxsid80859179

141. Ex-a101

142. Chebi:134958

143. Hy-b1526

144. Tox21_111625

145. Tox21_111626

146. Acetanilide, 4'-(thiosemicarbazone)

147. Bdbm50247903

148. Mfcd00022157

149. Rp4207

150. Sq2321

151. Stl503688

152. Zinc32709513

153. Thioacetazonum [who-ip Latin]

154. Akos000304458

155. Tox21_111625_1

156. Db12829

157. Ac-36791

158. As-71466

159. Cs-0013329

160. D08584

161. A800888

162. Sr-01000872620

163. Sr-01000872620-2

164. N-{4-[(e)-[(carbamothioylamino)imino]methyl]phenyl}acetamide

165. N-(4-{(e)-[(aminocarbonothioyl)hydrazono]methyl}phenyl)acetamide

166. N-{4-[(e)-(2-carbamothioylhydrazinylidene)methyl]phenyl}acetamide

167. N-(4-(((amino-thioxomethyl)hydrazono)methyl)phenyl)acetamide [who-ip]

168. 910379-02-1

169. N-[4-[(2-carbamothioylhydrazono)methyl]phenyl]acetamide;n-[4-[(e)-(carbamothioylhydrazono)methyl]phenyl]acetamide

2.4 Create Date

2006-10-23

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₂N₄OS
Molecular Weight	236.30 g/mol
XLogP3	1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	236.07318219 g/mol
Monoisotopic Mass	236.07318219 g/mol
Topological Polar Surface Area	112 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	285
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antitubercular Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)

4.2 ATC Code

J - Antiinfectives for systemic use

J04 - Antimycobacterials

J04A - Drugs for treatment of tuberculosis

J04AK - Other drugs for treatment of tuberculosis

J04AK07 - Thioacetazone

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ABOUT THIS PAGE

Thioacetazone Manufacturers

A Thioacetazone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thioacetazone, including repackagers and relabelers. The FDA regulates Thioacetazone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thioacetazone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Thioacetazone Suppliers

A Thioacetazone supplier is an individual or a company that provides Thioacetazone active pharmaceutical ingredient (API) or Thioacetazone finished formulations upon request. The Thioacetazone suppliers may include Thioacetazone API manufacturers, exporters, distributors and traders.

click here to find a list of Thioacetazone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Thioacetazone USDMF

A Thioacetazone DMF (Drug Master File) is a document detailing the whole manufacturing process of Thioacetazone active pharmaceutical ingredient (API) in detail. Different forms of Thioacetazone DMFs exist exist since differing nations have different regulations, such as Thioacetazone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Thioacetazone DMF submitted to regulatory agencies in the US is known as a USDMF. Thioacetazone USDMF includes data on Thioacetazone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Thioacetazone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Thioacetazone suppliers with USDMF on PharmaCompass.

Thioacetazone GMP

Thioacetazone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Thioacetazone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thioacetazone GMP manufacturer or Thioacetazone GMP API supplier for your needs.

Thioacetazone CoA

A Thioacetazone CoA (Certificate of Analysis) is a formal document that attests to Thioacetazone's compliance with Thioacetazone specifications and serves as a tool for batch-level quality control.

Thioacetazone CoA mostly includes findings from lab analyses of a specific batch. For each Thioacetazone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Thioacetazone may be tested according to a variety of international standards, such as European Pharmacopoeia (Thioacetazone EP), Thioacetazone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thioacetazone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.