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Also known as: Coltramyl, Thiocolchicine glycoside, Coltrax, Miorel, N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide, Nsc624673
Molecular Formula
C27H33NO10S
Molecular Weight
563.6  g/mol
InChI Key
LEQAKWQJCITZNK-MSQQGMGVSA-N

Thiocolchicoside
1 2D Structure

Thiocolchicoside

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
2.1.2 InChI
InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16?,19-,22-,23+,24-,27-/m1/s1
2.1.3 InChI Key
LEQAKWQJCITZNK-MSQQGMGVSA-N
2.1.4 Canonical SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC4C(C(C(C(O4)CO)O)O)O
2.1.5 Isomeric SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 2,14-di-(demethoxy)-2-glucosidoxy-14- Methylthiocolchicine

2. Coltramyl

3. Miorel

4. Myoplge

5. Thiocolchicoside

2.2.2 Depositor-Supplied Synonyms

1. Coltramyl

2. Thiocolchicine Glycoside

3. Coltrax

4. Miorel

5. N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide

6. Nsc624673

7. 2-demethoxy-2-glucosidoxythiocolchicine

8. Nsc-147755

9. Thiocolchicoside-d3

10. Prestwick_875

11. Prestwick0_000539

12. Prestwick1_000539

13. Prestwick2_000539

14. Prestwick3_000539

15. Bspbio_000557

16. Mls002153865

17. 602-41-5 (unlabeled)

18. Schembl719194

19. Spbio_002478

20. Bpbio1_000613

21. Chembl1705373

22. Chebi:91529

23. Hms1569l19

24. Hms2096l19

25. Hms2234k08

26. Bdbm50248250

27. N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide

28. Smr001233221

29. Sr-01000841233

30. Q1165293

31. Sr-01000841233-2

32. Brd-a11605036-001-03-2

33. N-(3-(hexopyranosyloxy)-1,2-dimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

2.3 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 563.6 g/mol
Molecular Formula C27H33NO10S
XLogP3-0.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass563.18251742 g/mol
Monoisotopic Mass563.18251742 g/mol
Topological Polar Surface Area189 Ų
Heavy Atom Count39
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API Reference Price

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TRIBHUVA","customer":"NABIL BANK LIMITED","customerCountry":"NEPAL","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"385000","totalValueFC":"13440.8","currency":"INR","unitRateINR":380685,"date":"11-Dec-2024","totalValueINR":"1142055","totalValueInUsd":"13440.8","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"6348451","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NEPAL","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"TRILOKPUR ROAD,, N\/A","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734373800,"product":"THIOCOLCHICOSIDE FP BATCH NO 0000799871MFG DT. 25.11.2024 EXP DT 24.11.2029","address":"H-36, GREEN PARK EXTENSION","city":"NEW DELHI","supplier":"DR WILLMAR SCHWABE ","supplierCountry":"INDIA","foreign_port":"ISLAMABAD - ISLAMABA","customer":"HABIB METROPOLITAN BANK ","customerCountry":"PAKISTAN","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"3962","totalValueFC":"3912.2","currency":"USD","unitRateINR":332415,"date":"17-Dec-2024","totalValueINR":"332415","totalValueInUsd":"3912.2","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"6514414","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"H-36, GREEN PARK EXTENSION, NEW DELHI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734373800,"product":"THIOCOLCHICOSIDE FP BATCH NO 0000784592MFG DT. 20.09.2024 EXP DT 19.09.2029","address":"H-36, GREEN PARK EXTENSION","city":"NEW DELHI","supplier":"DR WILLMAR SCHWABE ","supplierCountry":"INDIA","foreign_port":"LAHORE","customer":"JS BANK LIMITED","customerCountry":"PAKISTAN","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"3888.1","totalValueFC":"7678.4","currency":"USD","unitRateINR":326211.5,"date":"17-Dec-2024","totalValueINR":"652423","totalValueInUsd":"7678.4","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"6517115","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"H-36, GREEN PARK EXTENSION, NEW DELHI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734546600,"product":"THIOCOLCHICOSIDE EP,B.NO.M092400179,MFG:01.09.2024,DOE:31.08.2027","address":"PLOT NO.2-B, SECTOR 126","city":"GAUTAM BUDH NAGAR,U.P.","supplier":"INDIA GLYCOLS","supplierCountry":"INDIA","foreign_port":"SAN JOSE","customer":"TO THE ORDER OF","customerCountry":"COSTA RICA","quantity":"4.50","actualQuantity":"4.5","unit":"KGS","unitRateFc":"4688.4","totalValueFC":"20832.4","currency":"USD","unitRateINR":393356.76000000001,"date":"19-Dec-2024","totalValueINR":"1770105.42","totalValueInUsd":"20832.4","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"6601407","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"COSTA RICA","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"PLOT NO.2-B, SECTOR 126, GAUTAM BUDH NAGAR,U.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734892200,"product":"DRUG MFD UNDER DRUG MFG LIC NO. 462-OSP(H) : THIOCOLCHICOSIDE FP (BATCH NO. 077203503001)","address":"301, AVALON APARTMENTS,MEHRAULI","city":"NEW DELHI","supplier":"ALCHEM INTERNATIONAL PRIVATE LTD","supplierCountry":"INDIA","foreign_port":"LAHORE","customer":"BANK AL HABIB ","customerCountry":"PAKISTAN","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"3900","totalValueFC":"3529.3","currency":"USD","unitRateINR":299883,"date":"23-Dec-2024","totalValueINR":"299883","totalValueInUsd":"3529.3","indian_port":"Delhi Air","hs_no":"29397900","bill_no":"6693505","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"301, AVALON APARTMENTS,MEHRAULI, NEW DELHI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735237800,"product":"THIOCOLCHICOSIDE","address":"VENKATESH,MAHANT ROAD EXTN,","city":"VILE PARLE[E],MUMBAI, MAHARASHTRA.","supplier":"VITAL HEALTH CARE PVT. LTD","supplierCountry":"INDIA","foreign_port":"BARCELONA","customer":"TO THE ORDER OF","customerCountry":"VENEZUELA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"4900.5","totalValueFC":"29154.2","currency":"USD","unitRateINR":412867.125,"date":"27-Dec-2024","totalValueINR":"2477202.75","totalValueInUsd":"29154.2","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"6805212","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VENEZUELA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"VENKATESH,MAHANT ROAD EXTN,, VILE PARLE[E],MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"THIOCOLCHICOSIDE","year":"2021","qtr":"Q1","strtotime":1616697000,"product":"THIOCOLCHICOSIDE {RE-IMPORT (RETURN\/REJECTED MATERIAL) ( COUNTRY OF ORIGIN INDIA) BATCH NO- M052000145","address":"C-124, OKHLA INDL AREA PHASE-I","city":"NEW DELHI","supplier":"GENSENTA PHARMACEUTICALS","supplierCountry":"TURKEY","foreign_port":"","customer":"INDIA GLYCOLS","customerCountry":"INDIA","quantity":"24.87","actualQuantity":"24.871","unit":"KGS","unitRateFc":"5900","totalValueFC":"150879.4","currency":"USD","unitRateINR":"441648","date":"26-Mar-2021","totalValueINR":"10984228.25","totalValueInUsd":"150879.4","indian_port":"DELHI AIR","hs_no":"29389090","bill_no":"3303004","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"C-124, OKHLA INDL AREA PHASE-I"}]
07-Jan-2021
27-Dec-2024
KGS
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Average Price (USD/KGS)

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Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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Europe

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01

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  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info :

Registration Country : Italy

Thiocolchicoside

Brand Name : Muscoril

Dosage Form :

Dosage Strength : 20 Cps 4 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

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VMX
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info :

Registration Country : Italy

Thiocolchicoside

Brand Name : Muscoril

Dosage Form :

Dosage Strength : 6 Ampoules Im 2 Ml 4 Mg/2 Ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

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VMX
Not Confirmed

Thiocolchicoside

Brand Name : Thiocolchicoside

Dosage Form :

Dosage Strength : 6 Ampoules Im 2 Ml 4 Mg/2 Ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

Sanofi

04

VMX
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Naproxen; Thiocolchicoside

Brand Name : Tiyoksen

Dosage Form : Film Coated Tablet

Dosage Strength : 550MG; 4MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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05

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Thiocolchicoside

Brand Name : Tiyozid

Dosage Form : Tablet

Dosage Strength : 4MG

Packaging :

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Application Number :

Regulatory Info :

Registration Country : Turkey

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06

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Thiocolchicoside

Brand Name : Tiyozid

Dosage Form : Tablet

Dosage Strength : 8MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Turkey

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07

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Thiocolchicoside

Brand Name :

Dosage Form : CREAM

Dosage Strength : 8MG

Packaging : 10 Or 20 Capsules

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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FARMAC.CABER SpA

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VMX
Not Confirmed
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FARMAC.CABER SpA

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Thiocolchicoside

Brand Name : Tioside

Dosage Form :

Dosage Strength : 20 Cps 4 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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MDM SpA

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Not Confirmed
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MDM SpA

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Thiocolchicoside

Brand Name : Strialisin

Dosage Form :

Dosage Strength : 6 Ampoules Im 2 Ml 4 Mg/2 Ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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C.T. LAB.FARMACEUTICO Srl

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C.T. LAB.FARMACEUTICO Srl

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Thiocolchicoside

Brand Name : Sciomir

Dosage Form :

Dosage Strength : 6 Ampoules Im 2 Ml 4 Mg/2 Ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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ABOUT THIS PAGE

Thiocolchicoside Manufacturers

A Thiocolchicoside manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thiocolchicoside, including repackagers and relabelers. The FDA regulates Thiocolchicoside manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thiocolchicoside API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Thiocolchicoside manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Thiocolchicoside Suppliers

A Thiocolchicoside supplier is an individual or a company that provides Thiocolchicoside active pharmaceutical ingredient (API) or Thiocolchicoside finished formulations upon request. The Thiocolchicoside suppliers may include Thiocolchicoside API manufacturers, exporters, distributors and traders.

click here to find a list of Thiocolchicoside suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Thiocolchicoside USDMF

A Thiocolchicoside DMF (Drug Master File) is a document detailing the whole manufacturing process of Thiocolchicoside active pharmaceutical ingredient (API) in detail. Different forms of Thiocolchicoside DMFs exist exist since differing nations have different regulations, such as Thiocolchicoside USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Thiocolchicoside DMF submitted to regulatory agencies in the US is known as a USDMF. Thiocolchicoside USDMF includes data on Thiocolchicoside's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Thiocolchicoside USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Thiocolchicoside suppliers with USDMF on PharmaCompass.

Thiocolchicoside CEP

A Thiocolchicoside CEP of the European Pharmacopoeia monograph is often referred to as a Thiocolchicoside Certificate of Suitability (COS). The purpose of a Thiocolchicoside CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Thiocolchicoside EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Thiocolchicoside to their clients by showing that a Thiocolchicoside CEP has been issued for it. The manufacturer submits a Thiocolchicoside CEP (COS) as part of the market authorization procedure, and it takes on the role of a Thiocolchicoside CEP holder for the record. Additionally, the data presented in the Thiocolchicoside CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Thiocolchicoside DMF.

A Thiocolchicoside CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Thiocolchicoside CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Thiocolchicoside suppliers with CEP (COS) on PharmaCompass.

Thiocolchicoside WC

A Thiocolchicoside written confirmation (Thiocolchicoside WC) is an official document issued by a regulatory agency to a Thiocolchicoside manufacturer, verifying that the manufacturing facility of a Thiocolchicoside active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Thiocolchicoside APIs or Thiocolchicoside finished pharmaceutical products to another nation, regulatory agencies frequently require a Thiocolchicoside WC (written confirmation) as part of the regulatory process.

click here to find a list of Thiocolchicoside suppliers with Written Confirmation (WC) on PharmaCompass.

Thiocolchicoside GMP

Thiocolchicoside Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Thiocolchicoside GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thiocolchicoside GMP manufacturer or Thiocolchicoside GMP API supplier for your needs.

Thiocolchicoside CoA

A Thiocolchicoside CoA (Certificate of Analysis) is a formal document that attests to Thiocolchicoside's compliance with Thiocolchicoside specifications and serves as a tool for batch-level quality control.

Thiocolchicoside CoA mostly includes findings from lab analyses of a specific batch. For each Thiocolchicoside CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Thiocolchicoside may be tested according to a variety of international standards, such as European Pharmacopoeia (Thiocolchicoside EP), Thiocolchicoside JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thiocolchicoside USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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