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Chemistry

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Also known as: Sodium thiopental, Sodium pentothal, Thiopentone sodium, Farmotal, Hypnostan, Leopental
Molecular Formula
C11H17N2NaO2S
Molecular Weight
264.32  g/mol
InChI Key
AWLILQARPMWUHA-UHFFFAOYSA-M

Thiopental Sodium
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.
1 2D Structure

Thiopental Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;5-ethyl-4,6-dioxo-5-pentan-2-yl-1H-pyrimidine-2-thiolate
2.1.2 InChI
InChI=1S/C11H18N2O2S.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1
2.1.3 InChI Key
AWLILQARPMWUHA-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CCCC(C)C1(C(=O)NC(=NC1=O)[S-])CC.[Na+]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Bomathal

2. Nesdonal

3. Penthiobarbital

4. Pentothal

5. Pentothal Sodico

6. Sodipental

7. Thiomebumal

8. Thionembutal

9. Thiopental

10. Thiopental Nycomed

11. Thiopentobarbital

12. Thiopentone

13. Tiobarbital Braun

14. Trapanal

2.2.2 Depositor-Supplied Synonyms

1. Sodium Thiopental

2. Sodium Pentothal

3. Thiopentone Sodium

4. Farmotal

5. Hypnostan

6. Leopental

7. Nesdonal

8. Ravonal

9. Penthiobarbital Sodium

10. Sodium Thiopentone

11. Thiomebumal Sodium

12. Pentothal

13. Trapanal

14. 71-73-8

15. Thiopentalum Natricum

16. Tiopental Sodico

17. Sodium Pentothiobarbital

18. Sodium Thiopentobarbital

19. Thiopental Sodique

20. Monosodium 5-ethyl-5-(1-methylbutyl) Thiobarbiturate

21. Sodium 5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate

22. Pentothal Sodium-potassium Salt

23. Chebi:9561

24. Sodium (+-)-5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate

25. Intraval Sodium

26. Nesdonal Sodium

27. Thiothal Sodium

28. Trapanal Sodium

29. Pentothal Sodium

30. Tiopental Sodium

31. Dsstox_cid_1744

32. Thiomebumalnatrium

33. Thiopenton-natrium

34. Dsstox_rid_76302

35. Sodium 5-ethyl-4,6-dioxo-5-(pentan-2-yl)-1,4,5,6-tetrahydropyrimidine-2-thiolate

36. Soluble Thiopentone

37. Dsstox_gsid_21744

38. Thiopentalum-natrium

39. Thiopentobarbitone Sodium

40. Thiopentalum Solubile

41. Sodium Penthiobarbital

42. Thiopental Sodium Salt

43. Tiopentale Sodico

44. Tiopentale Sodico [dcit]

45. Cas-71-73-8

46. 49y44qzl70

47. Tiopental Sodico [inn-spanish]

48. Thiopental Sodique [inn-french]

49. Nsc-759557

50. Thiopental, Sodium Salt

51. Thiopentalum Natricum [inn-latin]

52. Ncgc00159524-01

53. Einecs 200-763-1

54. Unii-49y44qzl70

55. Pentothal (tn)

56. Thiopental Sodium [usp:inn:jan]

57. 4,6(1h,5h)-pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, Monosodium Salt

58. 5-ethyl-5-(1-methylbutyl)-2-thiobarbituric Acid Monosodium

59. Chembl738

60. Schembl34621

61. Spectrum1900005

62. Dtxsid1021744

63. Hms503g07

64. Hms2094g03

65. Barbituric Acid, 5-ethyl-5-(1-methylbutyl)-2-thio-, Sodium Salt

66. Tox21_111741

67. Ccg-39536

68. Thiopental Sodium (jp17/usp/inn)

69. Akos025392174

70. Akos037653994

71. Tox21_111741_1

72. Ks-1432

73. Nsc 759557

74. Sodium 5-ethyl-5-(1-methylbutyl)-4,6-dioxo-1,4,5,6-tetrahydropyrimidine-2-thiolate

75. Ncgc00095773-01

76. Ncgc00159524-02

77. 4,6(1h,5h)-pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, Monosodium Salt, (+-)-

78. D00714

79. Q410179

2.3 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 264.32 g/mol
Molecular Formula C11H17N2NaO2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass264.09084324 g/mol
Monoisotopic Mass264.09084324 g/mol
Topological Polar Surface Area59.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity346
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anesthetics, Intravenous

Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174) (See all compounds classified as Anesthetics, Intravenous.)


Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)


Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)


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18-Feb-2021
10-Sep-2024
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ABOUT THIS PAGE

Thiopental Sodium Manufacturers

A Thiopental Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thiopental Sodium, including repackagers and relabelers. The FDA regulates Thiopental Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thiopental Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Thiopental Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Thiopental Sodium Suppliers

A Thiopental Sodium supplier is an individual or a company that provides Thiopental Sodium active pharmaceutical ingredient (API) or Thiopental Sodium finished formulations upon request. The Thiopental Sodium suppliers may include Thiopental Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Thiopental Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Thiopental Sodium USDMF

A Thiopental Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Thiopental Sodium active pharmaceutical ingredient (API) in detail. Different forms of Thiopental Sodium DMFs exist exist since differing nations have different regulations, such as Thiopental Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Thiopental Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Thiopental Sodium USDMF includes data on Thiopental Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Thiopental Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Thiopental Sodium suppliers with USDMF on PharmaCompass.

Thiopental Sodium JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Thiopental Sodium Drug Master File in Japan (Thiopental Sodium JDMF) empowers Thiopental Sodium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Thiopental Sodium JDMF during the approval evaluation for pharmaceutical products. At the time of Thiopental Sodium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Thiopental Sodium suppliers with JDMF on PharmaCompass.

Thiopental Sodium CEP

A Thiopental Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Thiopental Sodium Certificate of Suitability (COS). The purpose of a Thiopental Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Thiopental Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Thiopental Sodium to their clients by showing that a Thiopental Sodium CEP has been issued for it. The manufacturer submits a Thiopental Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Thiopental Sodium CEP holder for the record. Additionally, the data presented in the Thiopental Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Thiopental Sodium DMF.

A Thiopental Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Thiopental Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Thiopental Sodium suppliers with CEP (COS) on PharmaCompass.

Thiopental Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Thiopental Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Thiopental Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Thiopental Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Thiopental Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Thiopental Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Thiopental Sodium suppliers with NDC on PharmaCompass.

Thiopental Sodium GMP

Thiopental Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Thiopental Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thiopental Sodium GMP manufacturer or Thiopental Sodium GMP API supplier for your needs.

Thiopental Sodium CoA

A Thiopental Sodium CoA (Certificate of Analysis) is a formal document that attests to Thiopental Sodium's compliance with Thiopental Sodium specifications and serves as a tool for batch-level quality control.

Thiopental Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Thiopental Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Thiopental Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Thiopental Sodium EP), Thiopental Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thiopental Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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