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    Chemistry

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    Also known as: Trans-thiothixene, Thiothixene, (e)-thiothixene, 3313-27-7, Orbinamon, 5591-45-7
    Molecular Formula
    C23H29N3O2S2
    Molecular Weight
    443.6  g/mol
    InChI Key
    GFBKORZTTCHDGY-UFWORHAWSA-N
    FDA UNII
    7UE42HF37R
    Thiothixene
    A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
    1 2D Structure

    Thiothixene

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (9E)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide
    2.1.2 InChI
    InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8+
    2.1.3 InChI Key
    GFBKORZTTCHDGY-UFWORHAWSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
    2.1.5 Isomeric SMILES
    CN1CCN(CC1)CC/C=C/2\C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
    2.2 Other Identifiers
    2.2.1 UNII
    7UE42HF37R
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Navane

    2. Thiothixene

    3. Tiotixene

    2.3.2 Depositor-Supplied Synonyms

    1. Trans-thiothixene

    2. Thiothixene

    3. (e)-thiothixene

    4. 3313-27-7

    5. Orbinamon

    6. 5591-45-7

    7. Thiothixene, (e)-

    8. P-4657a

    9. Navan

    10. 7ue42hf37r

    11. Cp-12,252-1 Base

    12. (9e)-n,n-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide

    13. 9h-thioxanthene-2-sulfonamide,n,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-

    14. P 4657b

    15. P-4657 B

    16. P-4657-b

    17. N,n-dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9h-thioxanthene-2-sulfonamide

    18. Smr000653538

    19. Unii-7ue42hf37r

    20. Trans-tiotixen

    21. Nsc108165

    22. 9h-thioxanthene-2-sulfonamide, N,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-

    23. N,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide

    24. Ncgc00015998-04

    25. Spectrum5_001150

    26. Lopac-t-0780

    27. Bspbio_002022

    28. Mls001146956

    29. Mls001360493

    30. Schembl718331

    31. Spectrum1500576

    32. 2-(dimethylsulfamoyl)-[9-(4-methyl-1-piperazinyl)propylidene]thioxanthene

    33. Chembl1336727

    34. Bdbm86187

    35. Chebi:93708

    36. Hms501a17

    37. (e)-n,n-dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9h-thioxanthene-2-sulfonamide

    38. N,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thiaxanthene-2-sulfonamide

    39. Dtxsid401316424

    40. Hms1921e13

    41. Hms2092m15

    42. Hms2230h09

    43. Pharmakon1600-01500576

    44. (e)-thiothixene [usp-rs]

    45. Nsc_5454

    46. Ccg-39271

    47. Nsc757350

    48. Pdsp1_000169

    49. Pdsp1_000550

    50. Pdsp2_000168

    51. Pdsp2_000548

    52. Thiothixene Trans-ismer [mi]

    53. Zinc29747244

    54. Akos024283092

    55. At12061

    56. Nsc-757350

    57. Idi1_000335

    58. Thioxanthene-2-sulfonamide, N,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, (e)-

    59. Trans-n,n-dimethyl-9-(3-(4-methyl-piperazinyl)propylidene)thioxanthene-2-sulfonamide

    60. Ncgc00015998-01

    61. Ncgc00015998-02

    62. Ncgc00015998-03

    63. Ncgc00015998-06

    64. Ncgc00094793-01

    65. Ncgc00094793-02

    66. Ncgc00094793-04

    67. Sbi-0051534.p003

    68. Cas_22189-31-7

    69. Ab00052109_11

    70. L001204

    71. Sr-05000002078

    72. Sr-05000002078-1

    73. Brd-k97309399-001-02-9

    74. Brd-k97309399-001-05-2

    75. Q27268863

    76. Wln: T C666 Bs Iyj Fswn1&1 Iu3- At6n Dntj D1

    77. (9e)-n,n-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9h-thioxanthene-2-sulfonamide

    78. 9h-thioxanthene-2-sulfonamide,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-

    79. 9h-thioxanthene-2-sulfonamide,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-, (z)-

    80. Thioxanthene-2-sulfonamide,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-

    81. 9h-thioxanthene-2-sulfonamide, N,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, (9e)-

    82. Cis-thiothixene N,n-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide

    83. N,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-9h-thioxanthene-2-sulfonamide, (e)-

    2.4 Create Date
    2005-07-09
    3 Chemical and Physical Properties
    Molecular Weight 443.6 g/mol
    Molecular Formula C23H29N3O2S2
    XLogP33.8
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count5
    Exact Mass443.17011952 g/mol
    Monoisotopic Mass443.17011952 g/mol
    Topological Polar Surface Area77.5 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity711
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameThiothixene
    PubMed HealthThiothixene (By mouth)
    Drug ClassesAntipsychotic
    Drug LabelThiothixene is a thioxanthene derivative. Specifically, it is the cis isomer of N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide. It may be represented by the following structural formula:The thioxanthenes differ from...
    Active IngredientThiothixene
    Dosage FormCapsule
    RouteOral
    Strength1mg; 5mg; 2mg; 10mg
    Market StatusPrescription
    CompanySandoz; Mylan

    2 of 2  
    Drug NameThiothixene
    PubMed HealthThiothixene (By mouth)
    Drug ClassesAntipsychotic
    Drug LabelThiothixene is a thioxanthene derivative. Specifically, it is the cis isomer of N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide. It may be represented by the following structural formula:The thioxanthenes differ from...
    Active IngredientThiothixene
    Dosage FormCapsule
    RouteOral
    Strength1mg; 5mg; 2mg; 10mg
    Market StatusPrescription
    CompanySandoz; Mylan

    4.2 Therapeutic Uses

    Antipsychotic Agents; Dopamine Antagonists

    National Library of Medicine's Medical Subject Headings. Citalopram. Online file (MeSH, 2018). Available from, as of February 2, 2018: https://meshb.nlm.nih.gov/search

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Thiothixene is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of February 2, 2018: https://clinicaltrials.gov/

    Thiothixene capsules are effective in the management of schizophrenia. /Included in US product label/

    NIH; DailyMed. Current Medication Information for Thiothixene Capsule (Updated: March 24, 2017). Available from, as of February 7, 2018: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=265f456a-b7eb-41ba-8eb4-fa417a5191cb

    Experience with the drug in treating neurotic conditions is limited and does not indicate that thiothixene is likely to have advantages over anxiolytic agents, butyrophenones, phenothiazines, or chlorprothixene (no longer commercially available in the US). Thiothixene has not been evaluated in the management of behavioral complications in mentally retarded patients.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    4.3 Drug Warning

    /BOXED WARNING/ Increased Mortality in Elderly Patients with Dementia-Related Psychosis: Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Thiothixene is not approved for the treatment of patients with dementia-related psychosis.

    NIH; DailyMed. Current Medication Information for Thiothixene Capsule (Updated: March 24, 2017). Available from, as of February 7, 2018: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=265f456a-b7eb-41ba-8eb4-fa417a5191cb

    Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs, including thiothixene. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown.

    NIH; DailyMed. Current Medication Information for Thiothixene Capsule (Updated: March 24, 2017). Available from, as of February 7, 2018: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=265f456a-b7eb-41ba-8eb4-fa417a5191cb

    A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs, including thiothixene. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias).

    NIH; DailyMed. Current Medication Information for Thiothixene Capsule (Updated: March 24, 2017). Available from, as of February 7, 2018: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=265f456a-b7eb-41ba-8eb4-fa417a5191cb

    The most frequent adverse effects of thiothixene are drowsiness (which usually is mild and subsides with continuation of therapy) and extrapyramidal symptoms. Like propylpiperazine phenothiazines, thiothixene is more likely to produce akathisia and dystonia than parkinson-like syndromes. Generally, extrapyramidal effects can be controlled by reducing the dosage of thiothixene and/or administering an antiparkinsonian drug.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    For more Drug Warnings (Complete) data for Thiothixene (21 total), please visit the HSDB record page.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Typical Antipsychotic [EPC]
    5.3 Absorption, Distribution and Excretion

    Fifty-nine plasma thiothixene concentrations were measured in 42 patients as part of routine therapeutic drug monitoring. Data collection included concomitant medications, smoking history, and demographic variables. A retrospective analysis was performed to assess the effect of these parameters on oral thiothixene clearance. When groups of patients were categorized by concomitant medications (i.e., no interacting drugs, enzyme/clearance inducers, and enzyme/clearance inhibitors), thiothixene clearance was found to be significantly increased by enzyme inducing drugs (e.g., anticonvulsants) and decreased by clearance inhibiting agents (e.g., cimetidine). Tobacco smoking significantly increased the hepatic clearance of thiothixene within the no interactions and inhibitor groups, but not in the inducer group. Significantly more patients in the inducer group had nondetectable plasma concentrations of thiothixene than the other groups. When the entire patient population was dichotomized by age, patients less than 50 years old had a significantly greater mean clearance (48.2 +/- 37.8 liters/min) versus those greater than or equal to 50 (20.0 +/- 12.6 liters/min). Men in this cohort exhibited a significantly higher clearance (49.2 +/- 38.7 liters/min) than did the women (22.0 +/- 13.5 liters/min). By taking into account these potential sources of pharmacokinetic variability when monitoring plasma thiothixene concentrations, more appropriate dosing of thiothixene may be achieved. Controlled, prospective studies are needed to validate these findings.

    PMID:1765572 Ereshefsky et al; J Clin Psychopharmacol 11 (5): 296-301 (1991)

    Thiothixene is widely distributed into body tissues and may remain in the body for several weeks following administration.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    Thiothixene is well absorbed from the GI tract. Therapeutic response may occur within a few days to several weeks following oral administration of the drug. Plasma concentrations required for therapeutic effects are not known.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    Two experiments are reported in which acute single test dose levels of thiothixene (Navane) were correlated with age. In the first study 20 mg oral doses were given to 28 male subjects and serum levels were drawn 2 hr later. Mean age was 30 and correlation of serum level with age was 0.43, P less than 0.02. In a second older group with a mean age of 41, 10 mg oral doses were given to 25 subjects. A correlation with age of 0.41, P less than 0.05 was obtained with age. In prior work such acute levels have been found to correlate with steady-state serum levels and with clinical response to the medication. ...

    PMID:6791222 Yesavage JA et al; Psychopharmacology (Berl) 74 (2): 170-2 (1981)

    5.4 Metabolism/Metabolites

    Thiothixene is metabolized in the liver and is excreted mainly in feces via biliary elimination as unchanged drug and as the demethyl, sulfoxide, demethylated sulfoxide, and hydroxylated thiothixene derivatives.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    API Reference Price

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CHENNAI\/TAMILNADU","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"ACTIVE PHARMACEUTICAL INGREDIENT(API) PACKED IN 30 LTR HDPE DRUM NAME OF API:THIOTHIXENE USP","address":"25","city":"CHENNAI, TAMILNADU","supplier":"NURAY CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"NEWARK, NJ","customer":"THE PURCHASE MANAGER","customerCountry":"UNITED STATES","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"5000","totalValueFC":"73772.5","currency":"USD","unitRateINR":413256.5,"date":"01-Oct-2024","totalValueINR":"6198847.5","totalValueInUsd":"73772.5","indian_port":"Madras Air","hs_no":"29335300","bill_no":"4489684","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"25, CHENNAI, TAMILNADU","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727893800,"product":"ACTIVE PHARMACEUTICAL INGREDIENT(API) PACKED IN 30 LTR HDPE DRUM NAME OF API:THIOTHIXENE USP","address":"25","city":"CHENNAI, TAMILNADU","supplier":"NURAY CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"NEWARK, NJ","customer":"THE PURCHASE MANAGER","customerCountry":"UNITED STATES","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"5000","totalValueFC":"73772.5","currency":"USD","unitRateINR":413256.5,"date":"03-Oct-2024","totalValueINR":"6198847.5","totalValueInUsd":"73772.5","indian_port":"Madras Air","hs_no":"29335300","bill_no":"4528628","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"25, CHENNAI, TAMILNADU","customerAddress":""},{"dataSource":"API Import","activeIngredients":"THIOTHIXENE","year":"2021","qtr":"Q2","strtotime":1617906600,"product":"THIOTHIXENE USP","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"ASPEN API","supplierCountry":"SOUTH AFRICA","foreign_port":"N\/A","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"17500","totalValueFC":"69718.8","currency":"USD","unitRateINR":"1297625","date":"09-Apr-2021","totalValueINR":"5190500","totalValueInUsd":"69718.8","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29359090","bill_no":"1001323","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"THIOTHIXENE","year":"2021","qtr":"Q2","strtotime":1618511400,"product":"THIOTHIXENE USP (THIOTHIXENE)","address":"1-1-151\/1, SAIRAM TOWERS, 4TH FLOORALEXANDER ROAD","city":"SECUNDERABAD, ANDHRA PRADESH","supplier":"VIATRIS","supplierCountry":"SOUTH AFRICA","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"VIATRIS","customerCountry":"INDIA","quantity":"51.00","actualQuantity":"51","unit":"KGS","unitRateFc":"18000","totalValueFC":"938973.4","currency":"USD","unitRateINR":"1370700","date":"16-Apr-2021","totalValueINR":"69905700","totalValueInUsd":"938973.4","indian_port":"BOMBAY AIR","hs_no":"29335300","bill_no":"3585891","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHICAGO O\\'HARE INT\\'L","supplierAddress":"","customerAddress":"1-1-151\/1, SAIRAM TOWERS, 4TH FLOORALEXANDER ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1652207400,"product":"THIOTHIXENE USP","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"ASPEN API","supplierCountry":"SOUTH AFRICA","foreign_port":"CAPE TOWN","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"20000","totalValueFC":"79756","currency":"USD","unitRateINR":"1541000","date":"11-May-2022","totalValueINR":"6164000","totalValueInUsd":"79756","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29359090","bill_no":"1001899","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"CAPE TOWN","supplierAddress":"N\/A","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1662489000,"product":"THIOTHIXENE USP","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"FINE CHEMICALS CORPORATION PTY LTD","supplierCountry":"SOUTH AFRICA","foreign_port":"CAPE TOWN","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"20000","totalValueFC":"40154.2","currency":"USD","unitRateINR":"1609000","date":"07-Sep-2022","totalValueINR":"3218000","totalValueInUsd":"40154.2","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29359090","bill_no":"1003682","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"CAPE TOWN","supplierAddress":"N\/A","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676053800,"product":"THIOTHIXENE USP","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"ASPEN API","supplierCountry":"SOUTH AFRICA","foreign_port":"CAPE TOWN","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"20000","totalValueFC":"40077.5","currency":"USD","unitRateINR":"1655000","date":"11-Feb-2023","totalValueINR":"3310000","totalValueInUsd":"40077.5","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29359090","bill_no":"1000596","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"CAPE TOWN","supplierAddress":"N\/A","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703529000,"product":"THIOTHIXENE USP","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"ASPEN API","supplierCountry":"SOUTH AFRICA","foreign_port":"CAPE TOWN","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"20550","totalValueFC":"165499.7","currency":"USD","unitRateINR":"1722090","date":"26-Dec-2023","totalValueINR":"13776720","totalValueInUsd":"165499.7","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29359090","bill_no":"1005224","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"CAPE TOWN","supplierAddress":"N\/A","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"}]
    11-Feb-2021
    03-Oct-2024
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    ABOUT THIS PAGE

    Thiothixene Manufacturers

    A Thiothixene manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thiothixene, including repackagers and relabelers. The FDA regulates Thiothixene manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thiothixene API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Thiothixene manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Thiothixene Suppliers

    A Thiothixene supplier is an individual or a company that provides Thiothixene active pharmaceutical ingredient (API) or Thiothixene finished formulations upon request. The Thiothixene suppliers may include Thiothixene API manufacturers, exporters, distributors and traders.

    click here to find a list of Thiothixene suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Thiothixene USDMF

    A Thiothixene DMF (Drug Master File) is a document detailing the whole manufacturing process of Thiothixene active pharmaceutical ingredient (API) in detail. Different forms of Thiothixene DMFs exist exist since differing nations have different regulations, such as Thiothixene USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Thiothixene DMF submitted to regulatory agencies in the US is known as a USDMF. Thiothixene USDMF includes data on Thiothixene's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Thiothixene USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Thiothixene suppliers with USDMF on PharmaCompass.

    Thiothixene WC

    A Thiothixene written confirmation (Thiothixene WC) is an official document issued by a regulatory agency to a Thiothixene manufacturer, verifying that the manufacturing facility of a Thiothixene active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Thiothixene APIs or Thiothixene finished pharmaceutical products to another nation, regulatory agencies frequently require a Thiothixene WC (written confirmation) as part of the regulatory process.

    click here to find a list of Thiothixene suppliers with Written Confirmation (WC) on PharmaCompass.

    Thiothixene NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Thiothixene as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Thiothixene API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Thiothixene as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Thiothixene and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Thiothixene NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Thiothixene suppliers with NDC on PharmaCompass.

    Thiothixene GMP

    Thiothixene Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Thiothixene GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thiothixene GMP manufacturer or Thiothixene GMP API supplier for your needs.

    Thiothixene CoA

    A Thiothixene CoA (Certificate of Analysis) is a formal document that attests to Thiothixene's compliance with Thiothixene specifications and serves as a tool for batch-level quality control.

    Thiothixene CoA mostly includes findings from lab analyses of a specific batch. For each Thiothixene CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Thiothixene may be tested according to a variety of international standards, such as European Pharmacopoeia (Thiothixene EP), Thiothixene JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thiothixene USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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