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Chemistry

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Also known as: 69558-55-0, Ncgc00166412-01, Specplus_000687, Spectrum4_001271, Arg-lys-asp-val-tyr-oh, Thymopentin acetate(tp-5)
Molecular Formula
C30H49N9O9
Molecular Weight
679.8  g/mol
InChI Key
PSWFFKRAVBDQEG-UHFFFAOYSA-N

Thymopentin
Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.
1 2D Structure

Thymopentin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[[6-amino-2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[1-[[1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
2.1.2 InChI
InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)
2.1.3 InChI Key
PSWFFKRAVBDQEG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Pentapeptide, Thymopoietin

2. Thymopentin

3. Timunox

4. Tp-5

2.2.2 Depositor-Supplied Synonyms

1. 69558-55-0

2. Ncgc00166412-01

3. Specplus_000687

4. Spectrum4_001271

5. Arg-lys-asp-val-tyr-oh

6. Thymopentin Acetate(tp-5)

7. Thymopoietin Ii-32-36)

8. Kbiogr_001882

9. Divk1c_006783

10. Schembl989519

11. Chembl1868258

12. Kbio1_001727

13. Dtxsid10860899

14. Hms3369g09

15. (3s)-3-[[(2s)-6-amino-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2s)-1-[[(1s)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic Acid

16. Nsc645363

17. Akos015961651

18. Akos026750555

19. Ac-8959

20. Nsc-645363

21. As-13028

22. Dl-arginyl-dl-lysyl-dl-aspartyl-dl-valyl-dl-tyrosine

23. J-011348

24. N~5~-(diaminomethylidene)ornithyllysyl-alpha-aspartylvalyltyrosine

25. L-tyrosine, N-[n-[n-(n2-l-arginyl-l-lysly)-l-.alpha.-aspartyl]-l-valyl]-

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 679.8 g/mol
Molecular Formula C30H49N9O9
XLogP3-6.4
Hydrogen Bond Donor Count11
Hydrogen Bond Acceptor Count12
Rotatable Bond Count22
Exact Mass679.36532417 g/mol
Monoisotopic Mass679.36532417 g/mol
Topological Polar Surface Area328 Ų
Heavy Atom Count48
Formal Charge0
Complexity1110
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count5
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adjuvants, Immunologic

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)


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ABOUT THIS PAGE

Thymopentin Manufacturers

A Thymopentin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Thymopentin, including repackagers and relabelers. The FDA regulates Thymopentin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Thymopentin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Thymopentin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Thymopentin Suppliers

A Thymopentin supplier is an individual or a company that provides Thymopentin active pharmaceutical ingredient (API) or Thymopentin finished formulations upon request. The Thymopentin suppliers may include Thymopentin API manufacturers, exporters, distributors and traders.

click here to find a list of Thymopentin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Thymopentin GMP

Thymopentin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Thymopentin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Thymopentin GMP manufacturer or Thymopentin GMP API supplier for your needs.

Thymopentin CoA

A Thymopentin CoA (Certificate of Analysis) is a formal document that attests to Thymopentin's compliance with Thymopentin specifications and serves as a tool for batch-level quality control.

Thymopentin CoA mostly includes findings from lab analyses of a specific batch. For each Thymopentin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Thymopentin may be tested according to a variety of international standards, such as European Pharmacopoeia (Thymopentin EP), Thymopentin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Thymopentin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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