Find Tiagabine Hydrochloride manufacturers, exporters & distributors on PharmaCompass

Tiagabine Hydrochloride

Chemwerth Tiagabine Hydrochloride

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

Contact Supplier

xyz-pharma-m-2024-10-07

Contact Supplier

With Fermion, start the journey of your innovative API.

Contact Supplier

Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

Contact Supplier

xyz-pharma-m-2024-10-07

Contact Supplier

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

7 API Suppliers, 6 USDMF, 2 EU WC, 2 NDC API, 3 Listed Suppliers

7 API Suppliers
6 USDMF
2 EU WC
2 NDC API
3 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

31 FDF Dossiers, 22 FDA Orange Book, 3 Europe, 6 Australia

31 FDF Dossiers
22 FDA Orange Book
3 Europe
6 Australia

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 12MG, TABLET;ORAL - 16MG, TABLET;ORAL - 2MG, TABLET;ORAL - 4MG

drugProductComposition
TABLET;ORAL - 12MG
TABLET;ORAL - 16MG
TABLET;ORAL - 2MG
TABLET;ORAL - 4MG

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 12 DKSH, 3 Faran Shimi Pharmaceutical, 4 Boai NKY Pharmaceuticals Ltd, 10 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 5 Actylis, 1 Aeon Procare, 1 Alcedo Pharmachem, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 18 BASF, 10 Corel Pharma Chem, 5 DFE Pharma, 1 Finar, 11 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 36 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 14 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 3 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 17 Roquette, 13 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 The Dow Chemical Company, 1 Ulanqab Kema New Material, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

71 Fillers, Diluents & Binders, 46 Coating Systems & Additives, 36 Direct Compression, 25 Controlled & Modified Release, 24 Thickeners and Stabilizers, 21 Disintegrants & Superdisintegrants, 20 Granulation, 19 Solubilizers, 17 Lubricants & Glidants, 16 Co-Processed Excipients, 12 Film Formers & Plasticizers, 11 Topical, 9 Chewable & Orodispersible Aids, 8 Parenteral, 7 Emulsifying Agents, 7 Taste Masking, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 4 Coloring Agents, 3 Rheology Modifiers, 2 Surfactant & Foaming Agents

DIGITAL CONTENT

2 NEWS #PharmaBuzz

media
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 3 Finished Drug Prices

globalSalesInformation
2 US Medicaid Prescriptions
3 Finished Drug Prices

MARKET PLACE

3 APIs

marketPlace
3 APIs

REF. STANDARDS & IMPURITIES

3 USP , 4 Others

otherSolutions
3 USP
4 Others

Chemwerth Tiagabine Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

7

API Suppliers

6

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

2

EU WC

0

KDMF

2

NDC API

0

VMF

3

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 0

MARKET PLACE

3

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

31

FDF Dossiers

22

FDA Orange Book

FDA (Orange Book)

3

Europe

0

Canada

6

Australia

0

South Africa

0

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

3

USP

0

JP

4

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

2

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

11,850,835

Annual Reports (USD Million)

NA

Finished Drug Prices

225 RELATED EXCIPIENT COMPANIES

372EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Click the button for full data set

Also known as: 145821-59-6, Tiagabine hcl, Gabitril, Abbott 70569.hcl, Abbott-70569.1, Nnc-05-0328

Molecular Formula

C₂₀H₂₆ClNO₂S₂

Molecular Weight

412.0 g/mol

InChI Key

YUKARLAABCGMCN-PKLMIRHRSA-N

FDA UNII

DQH6T6D8OY

Tiagabine Hydrochloride

A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of EPILEPSY, for refractory PARTIAL SEIZURES.

1 2D Structure

Tiagabine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride

2.1.2 InChI

InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1

2.1.3 InChI Key

YUKARLAABCGMCN-PKLMIRHRSA-N

2.1.4 Canonical SMILES

CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl

2.1.5 Isomeric SMILES

CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C.Cl

2.2 Other Identifiers

2.2.1 UNII

DQH6T6D8OY

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (r)-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic Acid, Hydrochloride

2. Gabitril

3. N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipecotic Acid

4. No 328

5. No 329

6. No-328

7. No-329

8. Tiagabine

9. Tiagabine, (s)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 145821-59-6

2. Tiagabine Hcl

3. Gabitril

4. Abbott 70569.hcl

5. Abbott-70569.1

6. Nnc-05-0328

7. No-05-0328

8. (r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic Acid Hydrochloride

9. Abt-569

10. Tiagabine (hydrochloride)

11. Tgb Hydrochloride

12. Abbott-70569.hcl

13. Gabitril Hydrochloride

14. No328 Hydrochloride

15. Dqh6t6d8oy

16. No050328 Hydrochloride

17. Abbott-705691

18. Chebi:85388

19. Abbott-70569 Hydrochloride

20. Nnc-050328

21. No-050328

22. Gabitril (tn)

23. 145821-59-6 (hcl)

24. (-)-(r)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic Acid Hydrochloride

25. 3-piperidinecarboxylic Acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)-, Hydrochloride, (r)-

26. Dsstox_cid_24218

27. Dsstox_rid_80125

28. Dsstox_gsid_44218

29. (3r)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic Acid;hydrochloride

30. (3r)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic Acid Hydrochloride

31. Cas-145821-59-6

32. Tiagabine Hydrochloride [usan]

33. Abt 569

34. Ncgc00164626-01

35. Unii-dqh6t6d8oy

36. Tiabex

37. (-)-(r)-1-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)nipecotic Acid Hydrochloride

38. Tiagabine Hydrochloride [usan:usp]

39. Mfcd07369025

40. (r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)piperidine-3-carboxylic Acid Hydrochloride

41. Tiagabine Monohydrochloride

42. (-)-(r)-1-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)nipecotic Acid, Hydrochloride

43. Chembl1695

44. Schembl41860

45. Mls001401367

46. Tiagabine Hydrochloride (usp)

47. Tiagabine Hydrochloride Solution

48. Dtxsid2044218

49. Hy-b0696a

50. Cep-6671

51. Tiagabine Hydrochloride [mi]

52. Tox21_112245

53. Nn-301

54. No-328

55. S4661

56. Akos024258856

57. Tox21_112245_1

58. Ccg-100885

59. H03t543

60. Ks-1217

61. Nc00135

62. Tiagabine Hydrochloride [mart.]

63. Tiagabine Hydrochloride [vandf]

64. Tiagabine Hydrochloride [usp-rs]

65. Tiagabine Hydrochloride [who-dd]

66. Ncgc00164626-02

67. 3-piperidinecarboxylic Acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-buten-yl)-, Hydrochloride, (r)-

68. 3-piperidinecarboxylic Acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, Hydrochloride (1:1), (3r)-

69. Smr000469176

70. Tiagabine Hydrochloride, >=98% (hplc)

71. T3165

72. Tiagabine Hydrochloride [orange Book]

73. Ethanone, 1-imidazo[1,2-b]pyridazin-3-yl-

74. C72768

75. D02097

76. Tiagabine Hydrochloride [usp Monograph]

77. A-70569

78. A884577

79. J-008159

80. Q27158534

81. Z2216208631

82. Tiagabine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

83. (3r)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic Acid Hydrochloride

84. (3r)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]-3-carboxypiperidinium Chloride

85. (3r)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic Acid Hydrochloride

86. (3r)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic Acid Monohydrochloride

87. (r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylicacidhydrochloride

88. Tiagabine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₆ClNO₂S₂
Molecular Weight	412.0 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	411.1093491 g/mol
Monoisotopic Mass	411.1093491 g/mol
Topological Polar Surface Area	97 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	474
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Gabitril
PubMed Health	Tiagabine (By mouth)
Drug Classes	Anticonvulsant
Drug Label	GABITRIL (tiagabine HCl) is an antiepilepsy drug available as 2 mg, 4 mg, 12 mg, and 16 mg tablets for oral administration. Its chemical name is (-)-(R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, its molecular formula is...
Active Ingredient	Tiagabine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	4mg; 12mg; 2mg; 16mg
Market Status	Prescription
Company	Cephalon

2 of 4
Drug Name	Tiagabine hydrochloride
Drug Label	GABITRIL (tiagabine HCl) is an antiepilepsy drug available as 2 mg, 4 mg, 12 mg, and 16 mg tablets for oral administration. Its chemical name is (-)-(R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, its molecular formula is...
Active Ingredient	Tiagabine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	4mg; 2mg
Market Status	Prescription
Company	Sun Pharm Inds

3 of 4
Drug Name	Gabitril
PubMed Health	Tiagabine (By mouth)
Drug Classes	Anticonvulsant
Drug Label	GABITRIL (tiagabine HCl) is an antiepilepsy drug available as 2 mg, 4 mg, 12 mg, and 16 mg tablets for oral administration. Its chemical name is (-)-(R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, its molecular formula is...
Active Ingredient	Tiagabine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	4mg; 12mg; 2mg; 16mg
Market Status	Prescription
Company	Cephalon

4 of 4
Drug Name	Tiagabine hydrochloride
Drug Label	GABITRIL (tiagabine HCl) is an antiepilepsy drug available as 2 mg, 4 mg, 12 mg, and 16 mg tablets for oral administration. Its chemical name is (-)-(R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, its molecular formula is...
Active Ingredient	Tiagabine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	4mg; 2mg
Market Status	Prescription
Company	Sun Pharm Inds

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

GABA Uptake Inhibitors

Compounds that suppress or block the plasma membrane transport of GAMMA-AMINOBUTYRIC ACID by GABA PLASMA MEMBRANE TRANSPORT PROTEINS. (See all compounds classified as GABA Uptake Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Decreased Central Nervous System Disorganized Electrical Activity [PE]; Anti-epileptic Agent [EPC]

API SUPPLIERS

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

EU WC

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

NDC API

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDF Dossiers

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDA Orange Book

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Europe

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Australia

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

DRUG PRODUCT COMPOSITIONS

Do you need Business Intel? Ask us

DOSAGE - TABLET;ORAL - 12MG

USFDA APPLICATION NUMBER - 20646

DOSAGE - TABLET;ORAL - 16MG

USFDA APPLICATION NUMBER - 20646

DOSAGE - TABLET;ORAL - 2MG

USFDA APPLICATION NUMBER - 20646

DOSAGE - TABLET;ORAL - 4MG

USFDA APPLICATION NUMBER - 20646

Related Excipient Companies

Upload your portfolio for free, ask us

Excipients by Applications

Click here to find the perfect excipient manufacturers by their capabilities

Fillers, Diluents & Binders

Coating Systems & Additives

Direct Compression

Controlled & Modified Release

Thickeners and Stabilizers

Disintegrants & Superdisintegrants

Granulation

Solubilizers

Lubricants & Glidants

Co-Processed Excipients

Film Formers & Plasticizers

Topical

Chewable & Orodispersible Aids

Parenteral

Emulsifying Agents

Taste Masking

Empty Capsules

API Stability Enhancers

Vegetarian Capsules

Coloring Agents

Rheology Modifiers

Surfactant & Foaming Agents

Digital Content

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

Global Sales Information

Do you need Business Intel? Ask us

US Medicaid Prescriptions

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Finished Drug Prices

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Market Place

Do you need sourcing support? Ask us

APIs

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

REF. STANDARDS & IMPURITIES

Upload your portfolio for free, ask us

USP

Others

Full Screen View

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

ABOUT THIS PAGE

Market Place

Home

Menu

Post Enquiry

Market Place

Search