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Chemistry

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Also known as: 35941-71-0, 5-chloro-3-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]thiazol-2(3h)-one hydrochloride, Tiaramide hcl, Solantal, Nta-194, Tiaramide hydrochloride-r
Molecular Formula
C15H19Cl2N3O3S
Molecular Weight
392.3  g/mol
InChI Key
UKNGDQSYPNBJAO-UHFFFAOYSA-N
FDA UNII
ITY1616X9T

Tiaramide Hydrochloride
1 2D Structure

Tiaramide Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-chloro-3-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethyl]-1,3-benzothiazol-2-one;hydrochloride
2.1.2 InChI
InChI=1S/C15H18ClN3O3S.ClH/c16-11-1-2-13-12(9-11)19(15(22)23-13)10-14(21)18-5-3-17(4-6-18)7-8-20;/h1-2,9,20H,3-8,10H2;1H
2.1.3 InChI Key
UKNGDQSYPNBJAO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CCO)C(=O)CN2C3=C(C=CC(=C3)Cl)SC2=O.Cl
2.2 Other Identifiers
2.2.1 UNII
ITY1616X9T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Fk 1160

2. Nta-194

3. Solantal

4. Tiaramide

5. Tiaramide Monohydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 35941-71-0

2. 5-chloro-3-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]thiazol-2(3h)-one Hydrochloride

3. Tiaramide Hcl

4. Solantal

5. Nta-194

6. Tiaramide Hydrochloride-r

7. Usv 2592 Hcl

8. Fk 1160

9. Nsc-289337

10. Fk-1160

11. 4-[(5-chloro-2-oxo-2h-benzothiazol-3-yl)acetyl]piperazine-1-ethanol Monohydrochloride

12. Ity1616x9t

13. Rhc-2592

14. 35941-71-0 (hcl)

15. 4-((5-chloro-2-oxo-3-benzothiazolinyl)acetyl)-1-piperazineethanol Monohydrochloride

16. Thiaramide

17. Fk 1160; Nsc 289337; Nta 194; Rhc 2592

18. Ventaval Tabletten

19. 1-piperazineethanol, 4-((5-chloro-2-oxo-3(2h)-benzothiazolyl)acetyl)-, Monohydrochloride

20. Thiaramide [german]

21. Nsc289337

22. Unii-ity1616x9t

23. 4-((5-chloro-2-oxo-2h-benzothiazol-3-yl)acetyl)piperazine-1-ethanol Monohydrochloride

24. Nta 194

25. Solantal (tn)

26. Einecs 252-802-7

27. Tiaramide Hydrochloride [usan:jan]

28. Nta-194tiaramide

29. Nsc 289337

30. Dsstox_cid_28683

31. Dsstox_rid_82953

32. Nta-194 Hcl

33. Dsstox_gsid_48757

34. Schembl181916

35. Chembl538059

36. Dtxsid6048757

37. Chebi:32222

38. Tiaramide Hydrochloride [mi]

39. Tox21_113221

40. Bdbm50222213

41. Fk1160

42. Mfcd01702832

43. Tiaramide Hydrochloride [jan]

44. 1-piperazineethanol, Monohydrochloride

45. Tiaramide Hydrochloride [usan]

46. Akos024464353

47. Tiaramide Hydrochloride (jp17/usan)

48. Tiaramide Hydrochloride [mart.]

49. 2-benzothiazolinone, 5-chloro-3-(4-(2-hydroxyethyl)-1-piperazinyl)carbonylmethyl-, Hcl

50. 4-((5-chloro-2-oxo-3(2h)-benzothiazolyl)acetyl)-1-piperazineethanol Hydrochloride

51. 5-chloro-3-(4-(2-hydroxyethyl)-1-piperazinyl)carbonylmethyl-2-benzothiazolinone Hydrochloride

52. Tiaramide Hydrochloride [who-dd]

53. 5-chloro-3-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethyl]-1,3-benzothiazol-2-one;hydrochloride

54. As-74709

55. Cas-35941-71-0

56. T3176

57. D01341

58. D92667

59. A874495

60. Q27280902

61. 1-piperazineethanol, 4-((5-chloro-2-oxo-3(2h)-benzothiazolyl)acetyl)-, Hydrochloride

62. 4-[(5-chloro-2-oxo-2h-benzothiazol-3-yl)acetyl]piperazine-1-ethanolmonohydrochloride

63. 4-[(5-chloro-2-oxo-3-benzothiazolinyl)acetyl]-1-piperazineethanol Hydrochloride

64. 2(3h)-benzothiazolone, 5-chloro-3-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-oxoethyl)-, Hydrochloride (1:1)

65. 5-chloro-3-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]thiazol-2(3h)-onehydrochloride

66. 5-chloro-3-[[4-(2-hydroxyethyl)piperazin-1-yl]carbonylmethyl]-2-benzothiazolinone Hydrochloride

67. 5-chloro-3-{2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethyl}-2,3-dihydro-1,3-benzothiazol-2-one Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 392.3 g/mol
Molecular Formula C15H19Cl2N3O3S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass391.0524180 g/mol
Monoisotopic Mass391.0524180 g/mol
Topological Polar Surface Area89.4 Ų
Heavy Atom Count24
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


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ABOUT THIS PAGE

Tiaramide Hydrochloride Manufacturers

A Tiaramide Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tiaramide Hydrochloride, including repackagers and relabelers. The FDA regulates Tiaramide Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tiaramide Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tiaramide Hydrochloride Suppliers

A Tiaramide Hydrochloride supplier is an individual or a company that provides Tiaramide Hydrochloride active pharmaceutical ingredient (API) or Tiaramide Hydrochloride finished formulations upon request. The Tiaramide Hydrochloride suppliers may include Tiaramide Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Tiaramide Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tiaramide Hydrochloride USDMF

A Tiaramide Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Tiaramide Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Tiaramide Hydrochloride DMFs exist exist since differing nations have different regulations, such as Tiaramide Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tiaramide Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Tiaramide Hydrochloride USDMF includes data on Tiaramide Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tiaramide Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tiaramide Hydrochloride suppliers with USDMF on PharmaCompass.

Tiaramide Hydrochloride GMP

Tiaramide Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tiaramide Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tiaramide Hydrochloride GMP manufacturer or Tiaramide Hydrochloride GMP API supplier for your needs.

Tiaramide Hydrochloride CoA

A Tiaramide Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Tiaramide Hydrochloride's compliance with Tiaramide Hydrochloride specifications and serves as a tool for batch-level quality control.

Tiaramide Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Tiaramide Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tiaramide Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Tiaramide Hydrochloride EP), Tiaramide Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tiaramide Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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