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Chemistry

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Also known as: Tiazofurine, 60084-10-8, Riboxamide, 2-b-d-ribofuranosyl-4-thiazolecarboxamide, Tiazofurinum, Tiazofurina
Molecular Formula
C9H12N2O5S
Molecular Weight
260.27  g/mol
InChI Key
FVRDYQYEVDDKCR-DBRKOABJSA-N
FDA UNII
ULJ82834RE

Tiazofurin
Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5-monophosphate (IMP) dehydrogenase.
1 2D Structure

Tiazofurin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
2.1.2 InChI
InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1
2.1.3 InChI Key
FVRDYQYEVDDKCR-DBRKOABJSA-N
2.1.4 Canonical SMILES
C1=C(N=C(S1)C2C(C(C(O2)CO)O)O)C(=O)N
2.1.5 Isomeric SMILES
C1=C(N=C(S1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
2.2 Other Identifiers
2.2.1 UNII
ULJ82834RE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-beta-d-ribofuranosylthiazole-4-carboxamide

2. 2-ribofuranosylthiazole-4-carboxamide

3. Nsc 286193

4. Riboxamide

5. Tiazofurin, (alpha-d)-isomer

6. Tiazole

2.3.2 Depositor-Supplied Synonyms

1. Tiazofurine

2. 60084-10-8

3. Riboxamide

4. 2-b-d-ribofuranosyl-4-thiazolecarboxamide

5. Tiazofurinum

6. Tiazofurina

7. Tiazofurin [usan]

8. Tcar

9. Nsc-286193

10. Ci-909

11. Tiazofurine (inn)

12. Tiazofurine [inn]

13. Tiazofurin (usan)

14. 2-beta-d-ribofuranosyl-4-thiazolecarboxamide

15. Ulj82834re

16. Chebi:90239

17. 2-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)thiazole-4-carboxamide

18. Tiazofurinum [latin]

19. Tiazofurina [spanish]

20. 2-(beta-d-ribofuranosyl)-4-thiazolecarboxamide

21. (1r)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-d-ribitol

22. (1r)-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-d-ribitol

23. 2-.beta.-d-ribofuranosyl-4-thiazolecarboxamide

24. Brn 1084555

25. Unii-ulj82834re

26. Cpd-5825

27. 2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]thiazole-4-carboxamide

28. Tiazofurin [mi]

29. 2-beta-d-ribofuranosylthiazole-4-carboxamide

30. 4-thiazolecarboxamide, 2-beta-d-ribofuranosyl-

31. Schembl4287

32. 2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide

33. Tiazofurine [who-dd]

34. Dibutylaminehydrochloride

35. Chembl108358

36. Dtxsid00208827

37. Zinc4217560

38. Bdbm50368057

39. Mfcd00866494

40. Db13243

41. Bs-17271

42. Hy-114570

43. Cs-0063433

44. C22196

45. D06130

46. W18798

47. Q7800305

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 260.27 g/mol
Molecular Formula C9H12N2O5S
XLogP3-1.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass260.04669266 g/mol
Monoisotopic Mass260.04669266 g/mol
Topological Polar Surface Area154 Ų
Heavy Atom Count17
Formal Charge0
Complexity305
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antimetabolites, Antineoplastic

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)


Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


4.2 ATC Code

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01X - Other antineoplastic agents

L01XX - Other antineoplastic agents

L01XX18 - Tiazofurine


ABOUT THIS PAGE

Tiazofurin Manufacturers

A Tiazofurin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tiazofurin, including repackagers and relabelers. The FDA regulates Tiazofurin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tiazofurin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tiazofurin Suppliers

A Tiazofurin supplier is an individual or a company that provides Tiazofurin active pharmaceutical ingredient (API) or Tiazofurin finished formulations upon request. The Tiazofurin suppliers may include Tiazofurin API manufacturers, exporters, distributors and traders.

click here to find a list of Tiazofurin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tiazofurin USDMF

A Tiazofurin DMF (Drug Master File) is a document detailing the whole manufacturing process of Tiazofurin active pharmaceutical ingredient (API) in detail. Different forms of Tiazofurin DMFs exist exist since differing nations have different regulations, such as Tiazofurin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tiazofurin DMF submitted to regulatory agencies in the US is known as a USDMF. Tiazofurin USDMF includes data on Tiazofurin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tiazofurin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tiazofurin suppliers with USDMF on PharmaCompass.

Tiazofurin GMP

Tiazofurin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tiazofurin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tiazofurin GMP manufacturer or Tiazofurin GMP API supplier for your needs.

Tiazofurin CoA

A Tiazofurin CoA (Certificate of Analysis) is a formal document that attests to Tiazofurin's compliance with Tiazofurin specifications and serves as a tool for batch-level quality control.

Tiazofurin CoA mostly includes findings from lab analyses of a specific batch. For each Tiazofurin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tiazofurin may be tested according to a variety of international standards, such as European Pharmacopoeia (Tiazofurin EP), Tiazofurin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tiazofurin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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