Tiazofurin

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

1 API Suppliers, 1 USDMF

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

EU WC

Listed Suppliers

API REF. PRICE (USD / KG)

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Tiazofurine, 60084-10-8, Riboxamide, 2-b-d-ribofuranosyl-4-thiazolecarboxamide, Tiazofurinum, Tiazofurina

Molecular Formula

C₉H₁₂N₂O₅S

Molecular Weight

260.27 g/mol

InChI Key

FVRDYQYEVDDKCR-DBRKOABJSA-N

FDA UNII

ULJ82834RE

Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5-monophosphate (IMP) dehydrogenase.

1 2D Structure

Tiazofurin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide

2.1.2 InChI

InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1

2.1.3 InChI Key

FVRDYQYEVDDKCR-DBRKOABJSA-N

2.1.4 Canonical SMILES

C1=C(N=C(S1)C2C(C(C(O2)CO)O)O)C(=O)N

2.1.5 Isomeric SMILES

C1=C(N=C(S1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N

2.2 Other Identifiers

2.2.1 UNII

ULJ82834RE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-beta-d-ribofuranosylthiazole-4-carboxamide

2. 2-ribofuranosylthiazole-4-carboxamide

3. Nsc 286193

4. Riboxamide

5. Tiazofurin, (alpha-d)-isomer

6. Tiazole

2.3.2 Depositor-Supplied Synonyms

1. Tiazofurine

2. 60084-10-8

3. Riboxamide

4. 2-b-d-ribofuranosyl-4-thiazolecarboxamide

5. Tiazofurinum

6. Tiazofurina

7. Tiazofurin [usan]

8. Tcar

9. Nsc-286193

10. Ci-909

11. Tiazofurine (inn)

12. Tiazofurine [inn]

13. Tiazofurin (usan)

14. 2-beta-d-ribofuranosyl-4-thiazolecarboxamide

15. Ulj82834re

16. Chebi:90239

17. 2-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)thiazole-4-carboxamide

18. Tiazofurinum [latin]

19. Tiazofurina [spanish]

20. 2-(beta-d-ribofuranosyl)-4-thiazolecarboxamide

21. (1r)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-d-ribitol

22. (1r)-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-d-ribitol

23. 2-.beta.-d-ribofuranosyl-4-thiazolecarboxamide

24. Brn 1084555

25. Unii-ulj82834re

26. Cpd-5825

27. 2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]thiazole-4-carboxamide

28. Tiazofurin [mi]

29. 2-beta-d-ribofuranosylthiazole-4-carboxamide

30. 4-thiazolecarboxamide, 2-beta-d-ribofuranosyl-

31. Schembl4287

32. 2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide

33. Tiazofurine [who-dd]

34. Dibutylaminehydrochloride

35. Chembl108358

36. Dtxsid00208827

37. Zinc4217560

38. Bdbm50368057

39. Mfcd00866494

40. Db13243

41. Bs-17271

42. Hy-114570

43. Cs-0063433

44. C22196

45. D06130

46. W18798

47. Q7800305

2.4 Create Date

2005-08-01

3 Chemical and Physical Properties

Molecular Formula	C₉H₁₂N₂O₅S
Molecular Weight	260.27 g/mol
XLogP3	-1.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	260.04669266 g/mol
Monoisotopic Mass	260.04669266 g/mol
Topological Polar Surface Area	154 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	305
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1