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Ticlopidine

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ACTIVE PHARMA INGREDIENTS

22 API Suppliers, 7 USDMF, 8 CEP/COS, 6 JDMF, 2 EU WC, 1 KDMF, 4 NDC API, 6 Listed Suppliers, $ API Reference Price

22 API Suppliers
7 USDMF
8 CEP/COS
6 JDMF
2 EU WC
1 KDMF
4 NDC API
6 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

59 FDF Dossiers, 11 FDA Orange Book, 46 Europe, 1 Canada, 1 Listed Dossiers

59 FDF Dossiers
11 FDA Orange Book
46 Europe
1 Canada
1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 3 DKSH, 2 Jai Radhe Sales, 4 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 11 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 5 Actylis, 1 Aeon Procare, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 20 BASF, 1 Clariant, 10 Corel Pharma Chem, 3 DFE Pharma, 1 Finar, 10 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 15 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 11 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 4 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 18 Roquette, 13 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 The Dow Chemical Company, 1 Ulanqab Kema New Material, 3 Vasa Pharmachem

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GLOBAL SALES INFORMATION

44 Finished Drug Prices

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REF. STANDARDS & IMPURITIES

2 EDQM , 3 USP , 3 Others

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3 USP
3 Others

Synopsis

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Canada

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Chemistry

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Also known as: 53885-35-1, Ticlopidine hcl, Ticlid, Ticlodix, Ticlodone, Panaldine

Molecular Formula

C₁₄H₁₅Cl₂NS

Molecular Weight

300.2 g/mol

InChI Key

MTKNGOHFNXIVOS-UHFFFAOYSA-N

FDA UNII

A1L4914FMF

An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.

1 2D Structure

Ticlopidine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine;hydrochloride

2.1.2 InChI

InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H

2.1.3 InChI Key

MTKNGOHFNXIVOS-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

A1L4914FMF

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 53 32c

2. 53-32c

3. 5332c

4. Hydrochloride, Ticlopidine

5. Ticlid

6. Ticlodix

7. Ticlodone

8. Ticlopidine

2.3.2 Depositor-Supplied Synonyms

1. 53885-35-1

2. Ticlopidine Hcl

3. Ticlid

4. Ticlodix

5. Ticlodone

6. Panaldine

7. Tiklid

8. 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hydrochloride

9. Ipaton

10. Ticlopidine (hydrochloride)

11. 53-32c

12. 4-c-32

13. Nsc-759165

14. Mls000083578

15. A1l4914fmf

16. Tiklyd

17. Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, Hydrochloride

18. Smr000048468

19. 5-[(2-chlorophenyl)methyl]-4h,5h,6h,7h-thieno[3,2-c]pyridine Hydrochloride

20. Chebi:9589

21. 5-[(2-chlorophenyl)methyl]-6,7-dihydro-4h-thieno[3,2-c]pyridine;hydrochloride

22. Ticlopidinehydrochloride

23. Einecs 258-837-4

24. Unii-a1l4914fmf

25. Aplaket

26. Sr-01000003130

27. Ticlopidine, Hcl

28. Prestwick_502

29. Mfcd00079606

30. Ticlid (tn)

31. 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hydrochloride

32. Ticlopidine Hydrochloride [usan:usp:jan]

33. Opera_id_1799

34. 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno-(3,2-c)pyridine Hydrochloride

35. Chembl1717

36. Schembl33596

37. Mls000028579

38. Mls001401394

39. Ticlopidine Hydrochloride,(s)

40. Hy-b0153a

41. Dtxsid80202141

42. Hms1568i15

43. Pharmakon1600-01505677

44. Bcp23429

45. Nsc759165

46. S1984

47. Ticlopidine Hydrochloride [mi]

48. 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridinium Chloride

49. Akos015905580

50. Ticlopidine Hydrochloride (jp17/usp)

51. Ac-8973

52. Ccg-101023

53. Cs-1985

54. Nc00273

55. Nsc 759165

56. Ticlopidine Hydrochloride [jan]

57. Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-(o-chlorobenzyl)-, Hydrochloride

58. Ticlopidine Hydrochloride [usan]

59. Ticlopidine Hydrochloride [mart.]

60. Ticlopidine Hydrochloride [vandf]

61. As-10890

62. Bt164472

63. Ticlopidine Hydrochloride [usp-rs]

64. Ticlopidine Hydrochloride [who-dd]

65. Bcp0726000288

66. Ft-0630664

67. T3110

68. D01028

69. I11518

70. Ticlopidine Hydrochloride [ep Impurity]

71. Ticlopidine Hydrochloride [ep Monograph]

72. Ticlopidine Hydrochloride [orange Book]

73. Ticlopidine Hydrochloride [usp Monograph]

74. 885t351

75. Sr-01000003130-6

76. W-105699

77. Q27108439

78. 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hcl

79. Ticlopidine Hydrochloride, Analytical Standard, For Drug Analysis

80. 5-(2-chloro-benzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hydrochloride

81. 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridinehydrochloride

82. Ticlopidine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

83. 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine Hydrochloride

84. 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine Hydrochloride

85. Ticlopidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₅Cl₂NS
Molecular Weight	300.2 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	299.0302260 g/mol
Monoisotopic Mass	299.0302260 g/mol
Topological Polar Surface Area	31.5 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	261
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Ticlopidine hydrochloride
Drug Label	Ticlopidine hydrochloride is a platelet aggregation inhibitor. Chemically it is 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c] pyridine hydrochloride. The structural formula is:C14H14ClNS HCl M.W. 300.25Ticlopidine hydrochloride is a...
Active Ingredient	Ticlopidine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	250mg
Market Status	Prescription
Company	Teva; Apotex; Sun Pharm Inds

2 of 2
Drug Name	Ticlopidine hydrochloride
Drug Label	Ticlopidine hydrochloride is a platelet aggregation inhibitor. Chemically it is 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c] pyridine hydrochloride. The structural formula is:C14H14ClNS HCl M.W. 300.25Ticlopidine hydrochloride is a...
Active Ingredient	Ticlopidine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	250mg
Market Status	Prescription
Company	Teva; Apotex; Sun Pharm Inds

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Platelet Aggregation Inhibitors

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

Fibrinolytic Agents

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)

Cytochrome P-450 CYP2C19 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19. (See all compounds classified as Cytochrome P-450 CYP2C19 Inhibitors.)

Purinergic P2Y Receptor Antagonists

Compounds that bind to and block the stimulation of PURINERGIC P2Y RECEPTORS. Included under this heading are antagonists for specific P2Y receptor subtypes. (See all compounds classified as Purinergic P2Y Receptor Antagonists.)

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API Reference Price

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FUHLSBUETT","customer":"HAMBURG EXPRESS","customerCountry":"GERMANY","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"75","totalValueFC":"5431.7","currency":"USD","unitRateINR":5520,"date":"09-Mar-2022","totalValueINR":"414000","totalValueInUsd":"5431.7","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"8811105","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"Mahendra Industrial Estate, Ground, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1646764200,"product":"DRUG & DRUG INTERMEDIATES - TICLOPIDINE","address":"Mahendra Industrial Estate, Ground","city":"MUMBAI","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"HAMBURG - FUHLSBUETT","customer":"INFA GMBH HAMBURG","customerCountry":"GERMANY","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"75","totalValueFC":"3581.8","currency":"USD","unitRateINR":5460,"date":"09-Mar-2022","totalValueINR":"273000","totalValueInUsd":"3581.8","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"8818629","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"Mahendra Industrial Estate, Ground, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1672857000,"product":"DRUG & DRUG INTERMEDIATES : TICLOPIDINE","address":"Mahendra Industrial Estate, Ground","city":"MUMBAI","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"LISBON","customer":"PORTUGAL PHARMA","customerCountry":"PORTUGAL","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"75","totalValueFC":"18652.3","currency":"USD","unitRateINR":6100,"date":"05-Jan-2023","totalValueINR":"1525000","totalValueInUsd":"18652.3","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"6732488","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"PORTUGAL","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"Mahendra Industrial Estate, Ground, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1675708200,"product":"TICLOPIDINE HYDROCHLORIDE E.P , TAX INV","address":"Mahendra Industrial Estate, Ground","city":"MUMBAI","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"KAOHSIUNG","customer":"TAIWAN PHARMA","customerCountry":"TAIWAN","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"74.7","totalValueFC":"36445.1","currency":"USD","unitRateINR":6020,"date":"07-Feb-2023","totalValueINR":"3010000","totalValueInUsd":"36445.1","indian_port":"JNPT","hs_no":"29420090","bill_no":"7615690","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"Mahendra Industrial Estate, Ground, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1675881000,"product":"DRUG & DRUG INTERMEDIATES - 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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

22 API Suppliers

7 USDMF

8 CEP/COS

6 JDMF

2 EU WC

1 KDMF

4 NDC API

6 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

59 FDF Dossiers

11 FDA Orange Book

46 Europe

1 Canada

1 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

49 Fillers, Diluents & Binders

47 Coating Systems & Additives

28 Direct Compression

28 Controlled & Modified Release

22 Solubilizers

22 Thickeners and Stabilizers

21 Disintegrants & Superdisintegrants

17 Granulation

16 Lubricants & Glidants

13 Film Formers & Plasticizers

13 Co-Processed Excipients

12 Topical

10 Parenteral

7 Taste Masking

7 Emulsifying Agents

6 Chewable & Orodispersible Aids

5 Empty Capsules