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Chemistry

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Also known as: Ticrynafen, 40180-04-9, Thienylic acid, Selacryn, Diflurex, Ticrex
Molecular Formula
C13H8Cl2O4S
Molecular Weight
331.2  g/mol
InChI Key
AGHANLSBXUWXTB-UHFFFAOYSA-N
FDA UNII
HC95205SY4

Ticrynafen
A novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.
1 2D Structure

Ticrynafen

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid
2.1.2 InChI
InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)
2.1.3 InChI Key
AGHANLSBXUWXTB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
HC95205SY4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Acid, Thienylic

2. Acid, Tienilic

3. Anp 3624

4. Anp-3624

5. Anp3624

6. Selacryn

7. Skf 62698

8. Skf-62698

9. Skf62698

10. Thienylic Acid

11. Ticrynafen

2.3.2 Depositor-Supplied Synonyms

1. Ticrynafen

2. 40180-04-9

3. Thienylic Acid

4. Selacryn

5. Diflurex

6. Ticrex

7. Ticrynafen [usan]

8. Acido Tienilico

9. Acide Tienilique

10. Acidum Tienilicum

11. 2-(2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic Acid

12. (2,3-dichloro-4-(2-thenoyl)phenoxy)acetic Acid

13. 4-(2-thienylketo)-2,3-dichlorophenoxyacetic Acid

14. 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic Acid

15. (2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic Acid

16. Tienilic Acid [inn]

17. [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid

18. Sk&f 62698

19. (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)acetic Acid

20. Chebi:9590

21. Chembl267744

22. 4-(2-theonyl)-2,3-dichlorphenoxyessigsaeure

23. Anp 362

24. Acetic Acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-

25. Hc95205sy4

26. Ticrynafen (usan)

27. Tienilic Acid (inn)

28. Ncgc00159454-02

29. Ncgc00159454-03

30. Acetic Acid, [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-

31. Dsstox_cid_3670

32. Dsstox_rid_77137

33. Dsstox_gsid_23670

34. Tienilico Acido [spanish]

35. Acide Tienilique [inn-french]

36. Acido Tienilico [inn-spanish]

37. Acidum Tienilicum [inn-latin]

38. Tienilico Acido

39. 2-{2,3-dichloro-4-[(thiophen-2-yl)carbonyl]phenoxy}acetic Acid

40. Anp 3624

41. Skf 62698

42. Cas-40180-04-9

43. Ccris 5489

44. Einecs 254-826-3

45. Ce 3624

46. Fr 3068

47. Brn 1260086

48. Ticrynafan

49. {[2,3-dichloro-4-(2-thienylcarbonyl)phenyl]oxy}acetic Acid

50. 4-(2-theonyl)-2,3-dichlorphenoxyessigsaeure [german]

51. Tienilic-acid

52. Unii-hc95205sy4

53. Selacryn (tn)

54. Ticrynafen [mi]

55. Ticrynafen, Tienilic Acid

56. 5-18-02-00008 (beilstein Handbook Reference)

57. Schembl123608

58. Tienilic Acid [mart.]

59. Zinc2166

60. Tienilic Acid [who-dd]

61. Dtxsid4023670

62. Hms3650c20

63. Tienilic Acid, >=98% (hplc)

64. Tox21_111681

65. Tox21_111682

66. Bdbm50090674

67. Mfcd00867339

68. Akos000280732

69. Db04831

70. Sk&f-62698

71. Ncgc00159454-04

72. Ncgc00159454-09

73. Da-20731

74. Hy-21065

75. Cs-0012688

76. Ft-0675229

77. D02386

78. 7z-0042

79. Sr-00000000556

80. Q7801054

81. Sr-00000000556-2

82. Brd-k34098590-001-01-3

83. 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetic Acid

84. [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic Acid

85. [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxyl]-acetic Acid

86. 2-(2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy)aceticacid

87. [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic Acid(ticrynafen)

88. [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic Acid(tienilic Acid)

89. [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic Acid (tienilic Acid)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 331.2 g/mol
Molecular Formula C13H8Cl2O4S
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass329.9520353 g/mol
Monoisotopic Mass329.9520353 g/mol
Topological Polar Surface Area91.8 Ų
Heavy Atom Count20
Formal Charge0
Complexity379
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of hypertension.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Uricosuric Agents

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)


Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)


5.2 ATC Code

C - Cardiovascular system

C03 - Diuretics

C03C - High-ceiling diuretics

C03CC - Aryloxyacetic acid derivatives

C03CC02 - Tienilic acid


5.3 Metabolism/Metabolites

Ticrynafen has known human metabolites that include Thiophene-4,5-epoxide and Tienilic acid-s-oxide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


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Ticrynafen manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ticrynafen API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ticrynafen manufacturer or Ticrynafen supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ticrynafen manufacturer or Ticrynafen supplier.

PharmaCompass also assists you with knowing the Ticrynafen API Price utilized in the formulation of products. Ticrynafen API Price is not always fixed or binding as the Ticrynafen Price is obtained through a variety of data sources. The Ticrynafen Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ticrynafen

Synonyms

40180-04-9, Thienylic acid, Selacryn, Diflurex, Ticrex, Ticrynafen [usan]

Cas Number

40180-04-9

Unique Ingredient Identifier (UNII)

HC95205SY4

About Ticrynafen

A novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.

Ticrynafen Manufacturers

A Ticrynafen manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ticrynafen, including repackagers and relabelers. The FDA regulates Ticrynafen manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ticrynafen API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ticrynafen Suppliers

A Ticrynafen supplier is an individual or a company that provides Ticrynafen active pharmaceutical ingredient (API) or Ticrynafen finished formulations upon request. The Ticrynafen suppliers may include Ticrynafen API manufacturers, exporters, distributors and traders.

click here to find a list of Ticrynafen suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ticrynafen USDMF

A Ticrynafen DMF (Drug Master File) is a document detailing the whole manufacturing process of Ticrynafen active pharmaceutical ingredient (API) in detail. Different forms of Ticrynafen DMFs exist exist since differing nations have different regulations, such as Ticrynafen USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Ticrynafen DMF submitted to regulatory agencies in the US is known as a USDMF. Ticrynafen USDMF includes data on Ticrynafen's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ticrynafen USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Ticrynafen suppliers with USDMF on PharmaCompass.

Ticrynafen GMP

Ticrynafen Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ticrynafen GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ticrynafen GMP manufacturer or Ticrynafen GMP API supplier for your needs.

Ticrynafen CoA

A Ticrynafen CoA (Certificate of Analysis) is a formal document that attests to Ticrynafen's compliance with Ticrynafen specifications and serves as a tool for batch-level quality control.

Ticrynafen CoA mostly includes findings from lab analyses of a specific batch. For each Ticrynafen CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ticrynafen may be tested according to a variety of international standards, such as European Pharmacopoeia (Ticrynafen EP), Ticrynafen JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ticrynafen USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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