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Also known as: 27591-69-1, Tilorone hydrochloride, Tilorone 2hcl, Tilorone hcl, Tilorone (dihydrochloride), Deae-f
Molecular Formula
C25H36Cl2N2O3
Molecular Weight
483.5  g/mol
InChI Key
BSVYJQAWONIOOU-UHFFFAOYSA-N
FDA UNII
BJ507J4LKY

Tilorone Dihydrochloride
An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
1 2D Structure

Tilorone Dihydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride
2.1.2 InChI
InChI=1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H
2.1.3 InChI Key
BSVYJQAWONIOOU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
BJ507J4LKY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Amiksin

2. Amixin

3. Amyxin

4. Bis Deae Fluorenone

5. Bis-deae-fluorenone

6. Hydrochloride, Tilorone

7. Tilorone

8. Tilorone Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 27591-69-1

2. Tilorone Hydrochloride

3. Tilorone 2hcl

4. Tilorone Hcl

5. Tilorone (dihydrochloride)

6. Deae-f

7. Tilorone Hydrochloride [usan]

8. Nsc-143969

9. 2,7-bis[2-(diethylamino)ethoxy]-9-fluorenone Dihydrochloride

10. Bj507j4lky

11. Rmi 10008da

12. 2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one Dihydrochloride

13. 9h-fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, Dihydrochloride

14. 9h-fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, Dihydrochloride

15. Tilorone Hydrochloride (usan)

16. 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one Dihydrochloride

17. Bis-deae-fluorenone Hydrochloride

18. Unii-bj507j4lky

19. Lavomax

20. Amixin

21. 2,7-bis(2-(diethylamino)ethoxy)-9h-fluoren-9-one Dihydrochloride

22. 2,7-bis[2-(diethylamino)ethoxy]-9h-fluoren-9-one Dihydrochloride

23. Tilorone Dihcl

24. 2,7-bis(2-diethylaminoethoxy)fluoren-9-one Dihydrochloride

25. Tiloronedihydrochloride

26. Schembl146373

27. Tilorone Dihydrochloride, 95%

28. Chembl539581

29. Chebi:147356

30. Act08564

31. Amy10986

32. Bcp18046

33. Ex-a5740

34. Hy-b1080

35. Mfcd00134071

36. S5020

37. Tilorone Dihydrochloride [mi]

38. Akos005145903

39. Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, Dihydrochloride

40. Tilorone Hydrochloride [mart.]

41. Ccg-269573

42. Cs-4636

43. Ks-5182

44. Tilorone Hydrochloride [who-dd]

45. Ft-0656019

46. T2836

47. D06149

48. 591t691

49. J-016822

50. J-524971

51. Q27274704

52. 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 483.5 g/mol
Molecular Formula C25H36Cl2N2O3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass482.2102984 g/mol
Monoisotopic Mass482.2102984 g/mol
Topological Polar Surface Area42 Ų
Heavy Atom Count32
Formal Charge0
Complexity477
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)


Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)


Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Interferon Inducers

Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons. (See all compounds classified as Interferon Inducers.)


API Reference Price

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22-Feb-2021
20-Oct-2023
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Looking for 27591-69-1 / Tilorone Dihydrochloride API manufacturers, exporters & distributors?

Tilorone Dihydrochloride manufacturers, exporters & distributors 1

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Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tilorone Dihydrochloride manufacturer or Tilorone Dihydrochloride supplier.

PharmaCompass also assists you with knowing the Tilorone Dihydrochloride API Price utilized in the formulation of products. Tilorone Dihydrochloride API Price is not always fixed or binding as the Tilorone Dihydrochloride Price is obtained through a variety of data sources. The Tilorone Dihydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tilorone Dihydrochloride

Synonyms

27591-69-1, Tilorone hydrochloride, Tilorone 2hcl, Tilorone hcl, Tilorone (dihydrochloride), Deae-f

Cas Number

27591-69-1

Unique Ingredient Identifier (UNII)

BJ507J4LKY

About Tilorone Dihydrochloride

An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.

Tilorone Dihydrochloride Manufacturers

A Tilorone Dihydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tilorone Dihydrochloride, including repackagers and relabelers. The FDA regulates Tilorone Dihydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tilorone Dihydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tilorone Dihydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tilorone Dihydrochloride Suppliers

A Tilorone Dihydrochloride supplier is an individual or a company that provides Tilorone Dihydrochloride active pharmaceutical ingredient (API) or Tilorone Dihydrochloride finished formulations upon request. The Tilorone Dihydrochloride suppliers may include Tilorone Dihydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Tilorone Dihydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tilorone Dihydrochloride GMP

Tilorone Dihydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tilorone Dihydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tilorone Dihydrochloride GMP manufacturer or Tilorone Dihydrochloride GMP API supplier for your needs.

Tilorone Dihydrochloride CoA

A Tilorone Dihydrochloride CoA (Certificate of Analysis) is a formal document that attests to Tilorone Dihydrochloride's compliance with Tilorone Dihydrochloride specifications and serves as a tool for batch-level quality control.

Tilorone Dihydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Tilorone Dihydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tilorone Dihydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Tilorone Dihydrochloride EP), Tilorone Dihydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tilorone Dihydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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