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    Also known as: 26921-17-5, (s)-timolol maleate, Timolol maleate salt, Blocadren, Timoptic, Timolol hydrogen maleate
    Molecular Formula
    C17H28N4O7S
    Molecular Weight
    432.5  g/mol
    InChI Key
    WLRMANUAADYWEA-NWASOUNVSA-N
    FDA UNII
    P8Y54F701R
    Timolol Maleate
    A beta-adrenergic antagonist that is similar in action to PROPRANOLOL; the levo-isomer is more active. Timolol has been proposed as an anti-hypertensive, anti-arrhythmic, anti-angina, and anti-glaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
    1 2D Structure

    Timolol Maleate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
    2.1.2 InChI
    InChI=1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1
    2.1.3 InChI Key
    WLRMANUAADYWEA-NWASOUNVSA-N
    2.1.4 Canonical SMILES
    CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    P8Y54F701R
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (s)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol

    2. 2-propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (s)-

    3. Blocadren

    4. L 714,465

    5. L-714,465

    6. L714,465

    7. Mk 950

    8. Mk-950

    9. Mk950

    10. Optimol

    11. Timacar

    12. Timolol

    13. Timolol Hemihydrate

    14. Timolol Maleate, (1:1) Salt

    15. Timoptic

    16. Timoptol

    2.3.2 Depositor-Supplied Synonyms

    1. 26921-17-5

    2. (s)-timolol Maleate

    3. Timolol Maleate Salt

    4. Blocadren

    5. Timoptic

    6. Timolol Hydrogen Maleate

    7. Istalol

    8. (s)-timolol (maleate)

    9. (s)-timolol Hydrogen Maleate

    10. Timoptic-xe

    11. Ophtamolol

    12. Aquanil

    13. Mk 950

    14. Timolol (as Maleate)

    15. Timolol Hydrogen Maleate Salt

    16. Timolol Maleate, S-enantiomer

    17. Wp-934

    18. Mls000028539

    19. Chebi:9600

    20. 60469-65-0

    21. P8y54f701r

    22. (-)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol Maleate

    23. Nsc-757351

    24. (-)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol Maleate (1:1) (salt)

    25. (z)-but-2-enedioic Acid;(2s)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

    26. 2-propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (s)-, (z)-2-butenedioate (1:1) (salt)

    27. Smr000058305

    28. Timacor

    29. Betime

    30. L-timolol Maleate

    31. Timoptic In Ocudose

    32. Mfcd00058356

    33. 2-propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2s)-, (2z)-2-butenedioate (salt)

    34. Ccris 1057

    35. Einecs 248-111-5

    36. Cas-26921-17-5

    37. (s)-(-)-timolol Maleate

    38. Timololmaleate

    39. Timololi Maleas

    40. Unii-p8y54f701r

    41. S-timolol Maleate

    42. Blocadren (tn)

    43. Timolol Maleate [usan:usp:jan]

    44. Timoptic (tn)

    45. Einecs 262-251-4

    46. Istalol (tn)

    47. Bimatoprost / Timolol

    48. Timolol Hydrogenmaleate

    49. Opera_id_1256

    50. Dsstox_cid_27504

    51. Dsstox_rid_82384

    52. Dsstox_gsid_47504

    53. Schembl26233

    54. Mls001076135

    55. Timolol Maleate [jan]

    56. Timolol Maleate (jp17/usp)

    57. Timolol Maleate [usan]

    58. L-714,465 (maleate)

    59. Timolol Maleate [vandf]

    60. Chembl1200870

    61. Dtxsid3047504

    62. Timolol Maleate [mart.]

    63. Timolol Maleate [usp-rs]

    64. Timolol Maleate [who-dd]

    65. Timolol Maleate [who-ip]

    66. Hms1570n18

    67. Hms2097n18

    68. Hms2230n19

    69. Hms2234f03

    70. Hms3411m12

    71. Hms3675m12

    72. Hms3714n18

    73. Hms3885l05

    74. Tox21_302468

    75. S4123

    76. Timolol Maleate [orange Book]

    77. Akos024458595

    78. Timolol Maleate [ep Monograph]

    79. Timolol Maleate [usp Impurity]

    80. Ccg-220948

    81. Cosopt Component Timolol Maleate

    82. Cs-1028

    83. Nsc 757351

    84. Timolol Maleate [usp Monograph]

    85. Timololi Maleas [who-ip Latin]

    86. (s)-3-(3-(tert-butylamino)-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole Maleate

    87. Duotrav Component Timolol Maleate

    88. Ganfort Component Timolol Maleate

    89. Xalacom Component Timolol Maleate

    90. Combigan Component Timolol Maleate

    91. Ncgc00256737-01

    92. 2-propanol, 1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-, (-)-, Maleate (1:1) (salt)

    93. 2-propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2s)-, (2z)-2-butenedioate (1:1) (salt)

    94. As-18090

    95. Bs164420

    96. Hy-17380

    97. Smr000653470

    98. Timolol Hydrogen Maleate Salt [mi]

    99. Timolol Maleate Component Of Cosopt

    100. Timolol Maleate Component Of Duotrav

    101. Timolol Maleate Component Of Ganfort

    102. T2905

    103. Timolol Maleate Component Of Combigan

    104. Timolol Maleate Salt, >=98% (tlc), Powder

    105. A13429

    106. D00603

    107. F20622

    108. Timolol Maleate, S-enantiomer [who-dd]

    109. 921t175

    110. Sr-01000003102

    111. Q-201836

    112. Sr-01000003102-3

    113. Q27108445

    114. Timolol Maleate 1.0 Mg/ml In Methanol (as Free Base)

    115. Timolol Maleate, British Pharmacopoeia (bp) Reference Standard

    116. Timolol Maleate, European Pharmacopoeia (ep) Reference Standard

    117. Timolol Maleate, United States Pharmacopeia (usp) Reference Standard

    118. (s)-1-tert-butylamino-3-(4-morpholin-4-yl-[1,2,5]thiadiazol-3-yloxy)-propan-2-ol Maleate

    119. 1-( Tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol Maleate

    120. Timolol For System Suitability, European Pharmacopoeia (ep) Reference Standard

    121. (2s)-1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol (2z)-but-2-enedioate

    122. (s)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol Maleate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 432.5 g/mol
    Molecular Formula C17H28N4O7S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count9
    Exact Mass432.16787042 g/mol
    Monoisotopic Mass432.16787042 g/mol
    Topological Polar Surface Area183 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity429
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameTimoptic-xe
    Drug LabelTIMOPTIC-XE (timolol maleate ophthalmic solution) is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-1-(tert-butylamino)-3- [(4-morpholino-1, 2, 5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol malea...
    Active IngredientTimolol maleate
    Dosage FormSolution, gel forming/drops
    RouteOphthalmic
    Strengtheq 0.25% base; eq 0.5% base
    Market StatusPrescription
    CompanyValeant Pharms

    2 of 8  
    Drug NameTimolol maleate
    Active IngredientTimolol maleate
    Dosage FormSolution/drops; Tablet; Solution, gel forming/drops
    RouteOphthalmic; Oral
    Strengtheq 0.25% base; 5mg; 10mg; eq 0.5% base; 20mg
    Market StatusPrescription
    CompanyWockhardt; Falcon Pharms; Pacific Pharma; Hi Tech Pharma; Bausch And Lomb; Fdc; Mylan; Akorn

    3 of 8  
    Drug NameTimoptic
    Drug LabelTimolol Maleate Ophthalmic Gel Forming Solution is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-1-(tert-butylamino)-3- [(4-morpholino-1, 2, 5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol maleate p...
    Active IngredientTimolol maleate
    Dosage FormSolution/drops
    RouteOphthalmic
    Strengtheq 0.25% base; eq 0.5% base
    Market StatusPrescription
    CompanyAton

    4 of 8  
    Drug NameTimoptic in ocudose
    PubMed HealthTimolol (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTIMOPTIC-XE (timolol maleate ophthalmic solution) is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-1-(tert-butylamino)-3- [(4-morpholino-1, 2, 5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol malea...
    Active IngredientTimolol maleate
    Dosage FormSolution/drops
    RouteOphthalmic
    Strengtheq 0.25% base; eq 0.5% base
    Market StatusPrescription
    CompanyAton

    5 of 8  
    Drug NameTimoptic-xe
    Drug LabelTIMOPTIC-XE (timolol maleate ophthalmic solution) is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-1-(tert-butylamino)-3- [(4-morpholino-1, 2, 5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol malea...
    Active IngredientTimolol maleate
    Dosage FormSolution, gel forming/drops
    RouteOphthalmic
    Strengtheq 0.25% base; eq 0.5% base
    Market StatusPrescription
    CompanyValeant Pharms

    6 of 8  
    Drug NameTimolol maleate
    Active IngredientTimolol maleate
    Dosage FormSolution/drops; Tablet; Solution, gel forming/drops
    RouteOphthalmic; Oral
    Strengtheq 0.25% base; 5mg; 10mg; eq 0.5% base; 20mg
    Market StatusPrescription
    CompanyWockhardt; Falcon Pharms; Pacific Pharma; Hi Tech Pharma; Bausch And Lomb; Fdc; Mylan; Akorn

    7 of 8  
    Drug NameTimoptic
    Drug LabelTimolol Maleate Ophthalmic Gel Forming Solution is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-1-(tert-butylamino)-3- [(4-morpholino-1, 2, 5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol maleate p...
    Active IngredientTimolol maleate
    Dosage FormSolution/drops
    RouteOphthalmic
    Strengtheq 0.25% base; eq 0.5% base
    Market StatusPrescription
    CompanyAton

    8 of 8  
    Drug NameTimoptic in ocudose
    PubMed HealthTimolol (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTIMOPTIC-XE (timolol maleate ophthalmic solution) is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-1-(tert-butylamino)-3- [(4-morpholino-1, 2, 5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol malea...
    Active IngredientTimolol maleate
    Dosage FormSolution/drops
    RouteOphthalmic
    Strengtheq 0.25% base; eq 0.5% base
    Market StatusPrescription
    CompanyAton

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Adrenergic beta-Antagonists

    Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

    API Reference Price

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MALPENSA","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"103.00","actualQuantity":"103","unit":"KGS","unitRateFc":"2250","totalValueFC":"255262.8","currency":"EUR","unitRateINR":"209137.5","date":"05-Nov-2024","totalValueINR":"21541162.5","totalValueInUsd":"255262.8","indian_port":"Madras Air","hs_no":"29349990","bill_no":"6504031","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"SEDE LEGALE STRADA RIVOLTANA KM6\/7 RODANO (MI) ITALY","customerAddress":"NO.27,RACE COURSE ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732732200,"product":"TIMOLOL RELATED COMPOUND B (QTY: 2 X 20MG, VALUE USD: 903\/EACH) (FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"USP","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00004","unit":"KGS","unitRateFc":"45150000","totalValueFC":"1912.8","currency":"USD","unitRateINR":"4035461500","date":"28-Nov-2024","totalValueINR":"161418.46","totalValueInUsd":"1912.8","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"6938972","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,M D 21704 USA Frederick, , United Sta tes United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733855400,"product":"TIMOLOL MALEATE USP ITEM 9126900 (TIMOLOL MALEATE USP) (TIMOLOL MALEATE USP)","address":"236, OKHLA INDUSTRIAL AREA,PHASE.","city":"NEW DELHI","supplier":"FLAVINE","supplierCountry":"GERMANY","foreign_port":"MEMPHIS, TN","customer":"MANKIND PHARMA","customerCountry":"INDIA","quantity":"4.16","actualQuantity":"4.16","unit":"KGS","unitRateFc":"2000","totalValueFC":"8386.7","currency":"USD","unitRateINR":"171300","date":"11-Dec-2024","totalValueINR":"712608","totalValueInUsd":"8386.7","indian_port":"Delhi Air","hs_no":"29349990","bill_no":"7175830","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"MEMPHIS, TN","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY 07652 SDNF UNITED STATES OF AMERICA","customerAddress":"236, OKHLA INDUSTRIAL AREA,PHASE."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733855400,"product":"TIMOLOL MALEATE USP ITEM 9126900 (TIMOLOL MALEATE USP) (TIMOLOL MALEATE USP)","address":"208, OKHLA INDUSTRIAL ESTATE,,PHAS","city":"NEW DELHI,DELHI","supplier":"FLAVINE","supplierCountry":"GERMANY","foreign_port":"MEMPHIS, TN","customer":"MANKIND PHARMA","customerCountry":"INDIA","quantity":"1.03","actualQuantity":"1.03","unit":"KGS","unitRateFc":"2000","totalValueFC":"2076.5","currency":"USD","unitRateINR":"171300","date":"11-Dec-2024","totalValueINR":"176439","totalValueInUsd":"2076.5","indian_port":"Delhi Air","hs_no":"29349990","bill_no":"7175830","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"MEMPHIS, TN","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY 07652 SDNF UNITED STATES OF AMERICA","customerAddress":"208, OKHLA INDUSTRIAL ESTATE,,PHAS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733855400,"product":"TIMOLOL MALEATE USP ITEM 9126900 (TIMOLOL MALEATE USP) (TIMOLOL MALEATE USP)","address":"208, OKHLA INDUSTRIAL ESTATE,,PHAS","city":"NEW DELHI,DELHI","supplier":"FLAVINE","supplierCountry":"GERMANY","foreign_port":"MEMPHIS, TN","customer":"MANKIND PHARMA","customerCountry":"INDIA","quantity":"18.99","actualQuantity":"18.99","unit":"KGS","unitRateFc":"2000","totalValueFC":"38284.4","currency":"USD","unitRateINR":"171300","date":"11-Dec-2024","totalValueINR":"3252987","totalValueInUsd":"38284.4","indian_port":"Delhi Air","hs_no":"29349990","bill_no":"7175830","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"MEMPHIS, TN","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY 07652 SDNF UNITED STATES OF AMERICA","customerAddress":"208, OKHLA INDUSTRIAL ESTATE,,PHAS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734028200,"product":"TIMOLOL MALEATE USP TIMOLOL MALEATE USP","address":"NARBAVI NO3 LAKSHMANAN STREET,,T.N","city":"CHENNAI,TAMIL NADU","supplier":"FLAVINE","supplierCountry":"GERMANY","foreign_port":"N|RNBERG (NUREMBERG)","customer":"CAPLIN STERILES LIMITED","customerCountry":"INDIA","quantity":"0.69","actualQuantity":"0.69","unit":"KGS","unitRateFc":"2200","totalValueFC":"1530.2","currency":"USD","unitRateINR":"188430","date":"13-Dec-2024","totalValueINR":"130016.7","totalValueInUsd":"1530.2","indian_port":"Madras Air","hs_no":"29335990","bill_no":"7214956","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"N|RNBERG (NUREMBERG)","supplierAddress":"61 SOUTH PARAMUS ROAD SUITE 565 PARAMUS NEW JERSEY SDNF US","customerAddress":"NARBAVI NO3 LAKSHMANAN STREET,,T.N"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734028200,"product":"TIMOLOL MALEATE USP TIMOLOL MALEATE USP","address":"NARBAVI NO3 LAKSHMANAN STREET,,T.N","city":"CHENNAI,TAMIL NADU","supplier":"FLAVINE","supplierCountry":"GERMANY","foreign_port":"N|RNBERG (NUREMBERG)","customer":"CAPLIN STERILES LIMITED","customerCountry":"INDIA","quantity":"3.39","actualQuantity":"3.39","unit":"KGS","unitRateFc":"2200","totalValueFC":"7517.8","currency":"USD","unitRateINR":"188430","date":"13-Dec-2024","totalValueINR":"638777.7","totalValueInUsd":"7517.8","indian_port":"Madras Air","hs_no":"29335990","bill_no":"7214956","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"N|RNBERG (NUREMBERG)","supplierAddress":"61 SOUTH PARAMUS ROAD SUITE 565 PARAMUS NEW JERSEY SDNF US","customerAddress":"NARBAVI NO3 LAKSHMANAN STREET,,T.N"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734028200,"product":"TIMOLOL MALEATE USP TIMOLOL MALEATE USP","address":"NARBAVI NO3 LAKSHMANAN STREET,,T.N","city":"CHENNAI,TAMIL NADU","supplier":"FLAVINE","supplierCountry":"GERMANY","foreign_port":"N|RNBERG (NUREMBERG)","customer":"CAPLIN STERILES LIMITED","customerCountry":"INDIA","quantity":"3.58","actualQuantity":"3.58","unit":"KGS","unitRateFc":"2200","totalValueFC":"7939.1","currency":"USD","unitRateINR":"188430","date":"13-Dec-2024","totalValueINR":"674579.4","totalValueInUsd":"7939.1","indian_port":"Madras Air","hs_no":"29335990","bill_no":"7214956","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"N|RNBERG (NUREMBERG)","supplierAddress":"61 SOUTH PARAMUS ROAD SUITE 565 PARAMUS NEW JERSEY SDNF US","customerAddress":"NARBAVI NO3 LAKSHMANAN STREET,,T.N"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734028200,"product":"TIMOLOL MALEATE USP TIMOLOL MALEATE USP","address":"NARBAVI NO3 LAKSHMANAN STREET,,T.N","city":"CHENNAI,TAMIL NADU","supplier":"FLAVINE","supplierCountry":"GERMANY","foreign_port":"N|RNBERG (NUREMBERG)","customer":"CAPLIN STERILES LIMITED","customerCountry":"INDIA","quantity":"6.73","actualQuantity":"6.73","unit":"KGS","unitRateFc":"2200","totalValueFC":"14924.7","currency":"USD","unitRateINR":"188430","date":"13-Dec-2024","totalValueINR":"1268133.9","totalValueInUsd":"14924.7","indian_port":"Madras Air","hs_no":"29335990","bill_no":"7214956","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"N|RNBERG (NUREMBERG)","supplierAddress":"61 SOUTH PARAMUS ROAD SUITE 565 PARAMUS NEW JERSEY SDNF US","customerAddress":"NARBAVI NO3 LAKSHMANAN STREET,,T.N"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734633000,"product":"TIMOLOL MALEATE USP (DMF) TIMOLOL MALEATE USP (DMF)","address":"NO.27,RACE COURSE ROAD,","city":"KARNATAKA","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"2356","totalValueFC":"238322.3","currency":"USD","unitRateINR":"202500","date":"20-Dec-2024","totalValueINR":"20250000","totalValueInUsd":"238322.3","indian_port":"Madras Air","hs_no":"29349990","bill_no":"7356002","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"SEDE LEGALE STRADA RIVOLTANA KM6\/7 RODANO (MI) ITALY","customerAddress":"NO.27,RACE COURSE ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734719400,"product":"TIMOLOLMALEATE TIMOLOLMALEATE","address":"28\/A, IDA,","city":"HYDERABAD, AP","supplier":"HOLOPACK-VERPACKUNGSTECHNIK-GMBH","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"ARAGEN LIFE SCIENCES LIMITED","customerCountry":"INDIA","quantity":"0.06","actualQuantity":"0.062","unit":"KGS","unitRateFc":"322.6","totalValueFC":"21.2","currency":"EUR","unitRateINR":"29032.3","date":"21-Dec-2024","totalValueINR":"1800","totalValueInUsd":"21.2","indian_port":"Hyderabad Air","hs_no":"29420021","bill_no":"7373979","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"BAHNHOFSTRASSE 18 D-74429 SULZBACH-LAUFEN SDNF DE","customerAddress":"28\/A, IDA,"}]
    02-Jan-2021
    31-Dec-2024
    KGS
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    Average Price (USD/KGS)

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    Total Quantity (KGS)

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    API Imports and Exports

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.25%...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.25% BASE

    USFDA APPLICATION NUMBER - 18086

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.5% ...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.5% BASE

    USFDA APPLICATION NUMBER - 18086

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.25%...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.25% BASE

    USFDA APPLICATION NUMBER - 19463

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.5% ...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.5% BASE

    USFDA APPLICATION NUMBER - 19463

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    DOSAGE - SOLUTION, GEL FORMING/DROPS;OPHTHALM...DOSAGE - SOLUTION, GEL FORMING/DROPS;OPHTHALMIC - EQ 0.25% BASE

    USFDA APPLICATION NUMBER - 20330

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    DOSAGE - SOLUTION, GEL FORMING/DROPS;OPHTHALM...DOSAGE - SOLUTION, GEL FORMING/DROPS;OPHTHALMIC - EQ 0.5% BASE

    USFDA APPLICATION NUMBER - 20330

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 2% BA...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE;EQ 0.5% BASE

    USFDA APPLICATION NUMBER - 20869

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.5% ...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.5% BASE

    USFDA APPLICATION NUMBER - 21516

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    USP

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    ABOUT THIS PAGE

    Timolol Manufacturers

    A Timolol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Timolol, including repackagers and relabelers. The FDA regulates Timolol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Timolol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Timolol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Timolol Suppliers

    A Timolol supplier is an individual or a company that provides Timolol active pharmaceutical ingredient (API) or Timolol finished formulations upon request. The Timolol suppliers may include Timolol API manufacturers, exporters, distributors and traders.

    click here to find a list of Timolol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Timolol USDMF

    A Timolol DMF (Drug Master File) is a document detailing the whole manufacturing process of Timolol active pharmaceutical ingredient (API) in detail. Different forms of Timolol DMFs exist exist since differing nations have different regulations, such as Timolol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Timolol DMF submitted to regulatory agencies in the US is known as a USDMF. Timolol USDMF includes data on Timolol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Timolol USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Timolol suppliers with USDMF on PharmaCompass.

    Timolol JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Timolol Drug Master File in Japan (Timolol JDMF) empowers Timolol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Timolol JDMF during the approval evaluation for pharmaceutical products. At the time of Timolol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Timolol suppliers with JDMF on PharmaCompass.

    Timolol KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Timolol Drug Master File in Korea (Timolol KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Timolol. The MFDS reviews the Timolol KDMF as part of the drug registration process and uses the information provided in the Timolol KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Timolol KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Timolol API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Timolol suppliers with KDMF on PharmaCompass.

    Timolol CEP

    A Timolol CEP of the European Pharmacopoeia monograph is often referred to as a Timolol Certificate of Suitability (COS). The purpose of a Timolol CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Timolol EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Timolol to their clients by showing that a Timolol CEP has been issued for it. The manufacturer submits a Timolol CEP (COS) as part of the market authorization procedure, and it takes on the role of a Timolol CEP holder for the record. Additionally, the data presented in the Timolol CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Timolol DMF.

    A Timolol CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Timolol CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Timolol suppliers with CEP (COS) on PharmaCompass.

    Timolol WC

    A Timolol written confirmation (Timolol WC) is an official document issued by a regulatory agency to a Timolol manufacturer, verifying that the manufacturing facility of a Timolol active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Timolol APIs or Timolol finished pharmaceutical products to another nation, regulatory agencies frequently require a Timolol WC (written confirmation) as part of the regulatory process.

    click here to find a list of Timolol suppliers with Written Confirmation (WC) on PharmaCompass.

    Timolol NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Timolol as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Timolol API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Timolol as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Timolol and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Timolol NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Timolol suppliers with NDC on PharmaCompass.

    Timolol GMP

    Timolol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Timolol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Timolol GMP manufacturer or Timolol GMP API supplier for your needs.

    Timolol CoA

    A Timolol CoA (Certificate of Analysis) is a formal document that attests to Timolol's compliance with Timolol specifications and serves as a tool for batch-level quality control.

    Timolol CoA mostly includes findings from lab analyses of a specific batch. For each Timolol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Timolol may be tested according to a variety of international standards, such as European Pharmacopoeia (Timolol EP), Timolol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Timolol USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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