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Chemistry

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Also known as: Edo-s101, 1236199-60-2, Minomustine, Edo-s 101, Edo-s-101, Tinostamustine [usan]
Molecular Formula
C19H28Cl2N4O2
Molecular Weight
415.4  g/mol
InChI Key
GISXTRIGVCKQBX-UHFFFAOYSA-N
FDA UNII
29DKI2H2NY

Tinostamustine
Tinostamustine is an alkylating histone-deacetylase inhibitor (HDACi) fusion molecule composed of the alkylating agent bendamustine fused to the pan-HDACi vorinostat, with potential bi-functional antineoplastic activity. Upon administration of tinostamustine the vorinostat moiety targets and binds to HDACs. This leads to an accumulation of highly acetylated histones, which results in an induction of chromatin remodeling, a modulation of gene expression, an inhibition of tumor cell division and the induction of tumor cell apoptosis. The bendamustine moiety binds to, alkylates and crosslinks macromolecules, inhibiting DNA, RNA and protein synthesis, which also results in tumor cell apoptosis. Thus, tinostamustine shows superior efficacy compared to the activity of either agent alone. In addition, the inhibition of HDAC6 activity by tinostamustine induces the activation of inositol-requiring enzyme 1 (IRE-1), the key regulatory protein for the unfolded protein response (UPR). Induction of the UPR increases the sensitivity of certain cancer cell types to certain chemotherapeutic agents, such as proteasome inhibitors. Therefore, tinostamustine may work synergistically with proteasome inhibitors. HDACs, enzymes that deacetylate chromatin histone proteins, are overexpressed in various cancers and play a key role in proliferation and resistance of tumor cells.
1 2D Structure

Tinostamustine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]-N-hydroxyheptanamide
2.1.2 InChI
InChI=1S/C19H28Cl2N4O2/c1-24-17-9-8-15(25(12-10-20)13-11-21)14-16(17)22-18(24)6-4-2-3-5-7-19(26)23-27/h8-9,14,27H,2-7,10-13H2,1H3,(H,23,26)
2.1.3 InChI Key
GISXTRIGVCKQBX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCCCCC(=O)NO
2.2 Other Identifiers
2.2.1 UNII
29DKI2H2NY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Edo-s101

2.3.2 Depositor-Supplied Synonyms

1. Edo-s101

2. 1236199-60-2

3. Minomustine

4. Edo-s 101

5. Edo-s-101

6. Tinostamustine [usan]

7. Tinostamustine(edo-s101)

8. 29dki2h2ny

9. 7-(5-(bis(2-chloroethyl)amino)-1-methyl-1h-benzo[d]imidazol-2-yl)-n-hydroxyheptanamide

10. 7-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]-n-hydroxyheptanamide

11. 1h-benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-n-hydroxy-1-methyl-

12. 1h-benzimidazole-2-heptanamide, 5-(bis(2-chloroethyl)amino)-n-hydroxy-1-methyl-

13. Starbld0018955

14. Unii-29dki2h2ny

15. Tinostamustine (usan/inn)

16. Tinostamustine [inn]

17. Schembl7915449

18. Tinostamustine [who-dd]

19. Chembl3989941

20. Bcp20331

21. Ex-a1322

22. Bdbm50569838

23. Zinc68244536

24. Cs-6484

25. Db15147

26. Sb19172

27. Be170657

28. Hy-101780

29. S8769

30. D11182

31. E76854

32. 7-(5-(bis(2-chloroethyl)amino)-1-methyl-1h-benzimidazol-2-yl)-n-hydroxyheptanamide

2.4 Create Date
2010-08-09
3 Chemical and Physical Properties
Molecular Weight 415.4 g/mol
Molecular Formula C19H28Cl2N4O2
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count12
Exact Mass414.1589315 g/mol
Monoisotopic Mass414.1589315 g/mol
Topological Polar Surface Area70.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1236199-60-2 / Tinostamustine API manufacturers, exporters & distributors?

Tinostamustine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tinostamustine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tinostamustine manufacturer or Tinostamustine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tinostamustine manufacturer or Tinostamustine supplier.

PharmaCompass also assists you with knowing the Tinostamustine API Price utilized in the formulation of products. Tinostamustine API Price is not always fixed or binding as the Tinostamustine Price is obtained through a variety of data sources. The Tinostamustine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tinostamustine

Synonyms

Edo-s101, 1236199-60-2, Minomustine, Edo-s 101, Edo-s-101, Tinostamustine [usan]

Cas Number

1236199-60-2

Unique Ingredient Identifier (UNII)

29DKI2H2NY

About Tinostamustine

Tinostamustine is an alkylating histone-deacetylase inhibitor (HDACi) fusion molecule composed of the alkylating agent bendamustine fused to the pan-HDACi vorinostat, with potential bi-functional antineoplastic activity. Upon administration of tinostamustine the vorinostat moiety targets and binds to HDACs. This leads to an accumulation of highly acetylated histones, which results in an induction of chromatin remodeling, a modulation of gene expression, an inhibition of tumor cell division and the induction of tumor cell apoptosis. The bendamustine moiety binds to, alkylates and crosslinks macromolecules, inhibiting DNA, RNA and protein synthesis, which also results in tumor cell apoptosis. Thus, tinostamustine shows superior efficacy compared to the activity of either agent alone. In addition, the inhibition of HDAC6 activity by tinostamustine induces the activation of inositol-requiring enzyme 1 (IRE-1), the key regulatory protein for the unfolded protein response (UPR). Induction of the UPR increases the sensitivity of certain cancer cell types to certain chemotherapeutic agents, such as proteasome inhibitors. Therefore, tinostamustine may work synergistically with proteasome inhibitors. HDACs, enzymes that deacetylate chromatin histone proteins, are overexpressed in various cancers and play a key role in proliferation and resistance of tumor cells.

Tinostamustine Manufacturers

A Tinostamustine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tinostamustine, including repackagers and relabelers. The FDA regulates Tinostamustine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tinostamustine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tinostamustine Suppliers

A Tinostamustine supplier is an individual or a company that provides Tinostamustine active pharmaceutical ingredient (API) or Tinostamustine finished formulations upon request. The Tinostamustine suppliers may include Tinostamustine API manufacturers, exporters, distributors and traders.

Tinostamustine GMP

Tinostamustine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tinostamustine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tinostamustine GMP manufacturer or Tinostamustine GMP API supplier for your needs.

Tinostamustine CoA

A Tinostamustine CoA (Certificate of Analysis) is a formal document that attests to Tinostamustine's compliance with Tinostamustine specifications and serves as a tool for batch-level quality control.

Tinostamustine CoA mostly includes findings from lab analyses of a specific batch. For each Tinostamustine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tinostamustine may be tested according to a variety of international standards, such as European Pharmacopoeia (Tinostamustine EP), Tinostamustine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tinostamustine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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