Find Tiomolibdate Choline manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Atn-224, 649749-10-0, Atn 224, Bis-choline tetrathiomolybdate, Tiomolibdate choline, Tiomolibdate choline [usan]
Molecular Formula
C10H30MoN2O2S4
Molecular Weight
434.6  g/mol
InChI Key
FSWNJZRQQVVVJT-UHFFFAOYSA-L
FDA UNII
FD57A79R4P

Tiomolibdate Choline
Tiomolibdate Choline is an orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. Tiomolibdate choline selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis.
1 2D Structure

Tiomolibdate Choline

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
bis(sulfanylidene)molybdenum;2-hydroxyethyl(trimethyl)azanium;sulfanide
2.1.2 InChI
InChI=1S/2C5H14NO.Mo.2H2S.2S/c2*1-6(2,3)4-5-7;;;;;/h2*7H,4-5H2,1-3H3;;2*1H2;;/q2*+1;;;;;/p-2
2.1.3 InChI Key
FSWNJZRQQVVVJT-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C[N+](C)(C)CCO.C[N+](C)(C)CCO.[SH-].[SH-].S=[Mo]=S
2.2 Other Identifiers
2.2.1 UNII
FD57A79R4P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ammonium Tetrathiomolybdate

2. Atn-224

3. Tetrathiomolybdate

4. Tetrathiomolybdate Bis-choline Salt

5. Tetrathiomolybdate, Dipotassium Salt

6. Tetrathiomolybdate, Disodium Salt

7. Thiomolybdate

8. Ttm Cpd

2.3.2 Depositor-Supplied Synonyms

1. Atn-224

2. 649749-10-0

3. Atn 224

4. Bis-choline Tetrathiomolybdate

5. Tiomolibdate Choline

6. Tiomolibdate Choline [usan]

7. Alxn1840

8. Fd57a79r4p

9. Wtx-101

10. 2-hydroxy-n,n,n-trimethylethan-1-aminium Tetrathiomolybdate

11. Unii-fd57a79r4p

12. Choline Tetrathiomolybdate

13. Schembl3785098

14. Wtx101

15. Alxn-1840

16. Tiomolibdate Choline [jan]

17. Hy-16074

18. Bis(choline) Tetrathiomolybdate [who-dd]

19. Q17005864

20. 2-hydroxy-n,n,n-trimethylethanaminium Tetrathiomolybdate

21. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, (t-4)-tetrathioxomolybdate(2-) (2:1)

22. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, (t-4)-tetrathioxomolybdate(2-)(2:1)

2.4 Create Date
2007-12-04
3 Chemical and Physical Properties
Molecular Weight 434.6 g/mol
Molecular Formula C10H30MoN2O2S4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass436.024417 g/mol
Monoisotopic Mass436.024417 g/mol
Topological Polar Surface Area107 Ų
Heavy Atom Count19
Formal Charge0
Complexity65.7
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count5
4 Drug and Medication Information
4.1 Drug Indication

Treatment of Wilson Disease


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Angiogenesis Inhibitors

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (See all compounds classified as Angiogenesis Inhibitors.)


Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


ABOUT THIS PAGE

Looking for 649749-10-0 / Tiomolibdate Choline API manufacturers, exporters & distributors?

Tiomolibdate Choline manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tiomolibdate Choline API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tiomolibdate Choline manufacturer or Tiomolibdate Choline supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tiomolibdate Choline manufacturer or Tiomolibdate Choline supplier.

PharmaCompass also assists you with knowing the Tiomolibdate Choline API Price utilized in the formulation of products. Tiomolibdate Choline API Price is not always fixed or binding as the Tiomolibdate Choline Price is obtained through a variety of data sources. The Tiomolibdate Choline Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tiomolibdate Choline

Synonyms

Atn-224, 649749-10-0, Atn 224, Bis-choline tetrathiomolybdate, Tiomolibdate choline, Tiomolibdate choline [usan]

Cas Number

649749-10-0

Unique Ingredient Identifier (UNII)

FD57A79R4P

About Tiomolibdate Choline

Tiomolibdate Choline is an orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. Tiomolibdate choline selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis.

Tiomolibdate Choline Manufacturers

A Tiomolibdate Choline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tiomolibdate Choline , including repackagers and relabelers. The FDA regulates Tiomolibdate Choline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tiomolibdate Choline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tiomolibdate Choline Suppliers

A Tiomolibdate Choline supplier is an individual or a company that provides Tiomolibdate Choline active pharmaceutical ingredient (API) or Tiomolibdate Choline finished formulations upon request. The Tiomolibdate Choline suppliers may include Tiomolibdate Choline API manufacturers, exporters, distributors and traders.

Tiomolibdate Choline GMP

Tiomolibdate Choline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tiomolibdate Choline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tiomolibdate Choline GMP manufacturer or Tiomolibdate Choline GMP API supplier for your needs.

Tiomolibdate Choline CoA

A Tiomolibdate Choline CoA (Certificate of Analysis) is a formal document that attests to Tiomolibdate Choline 's compliance with Tiomolibdate Choline specifications and serves as a tool for batch-level quality control.

Tiomolibdate Choline CoA mostly includes findings from lab analyses of a specific batch. For each Tiomolibdate Choline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tiomolibdate Choline may be tested according to a variety of international standards, such as European Pharmacopoeia (Tiomolibdate Choline EP), Tiomolibdate Choline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tiomolibdate Choline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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