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1. 679 Br, Ba
2. 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane Bromide
3. Ba 679 Br
4. Ba-679 Br
5. Ba679 Br
6. Br, Ba 679
7. Bromide, Tiotropium
8. Spiriva
9. Tiotropium
1. 136310-93-5
2. Spiriva
3. Ba 679 Br
4. Tiotropium (bromide)
5. Spiriva Handihaler
6. Ba 679br
7. Ba-679 Br
8. Spiriva Respimat
9. (1r,2r,4s,5s,7s)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Bromide
10. Xx112xzp0j
11. Chembl4638964
12. 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane Bromide
13. Ba-679-br
14. (1r,2r,4s,5s,7r)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium Bromide
15. (1r,2r,4s,5s,7s)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0
16. Tiopropium
17. Tiotropium Bromide Anhydrous
18. Ba-679br
19. (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide
20. Ncgc00167971-01
21. Tiotropium Bromide [inn]
22. Unii-xx112xzp0j
23. Tiotropium Bromide [usan:inn:ban]
24. Tiotropium Bromide- Bio-x
25. Schembl8625
26. Dsstox_cid_24214
27. Dsstox_rid_80122
28. Dsstox_gsid_44214
29. Schembl440873
30. Schembl7607795
31. Tiotropium Bromide [mi]
32. Chembl3189058
33. Chembl4440620
34. Dtxsid2044214
35. Chebi:90959
36. Tiotropium Bromide [usan]
37. Hms2090h20
38. Act04740
39. Act04741
40. Amy23428
41. Bcp02925
42. Tiotropium Bromide [who-dd]
43. Tox21_112598
44. Bdbm50538220
45. Mfcd00867027
46. Akos015920264
47. Akos025400979
48. Ac-1300
49. Cs-0903
50. Ks-1402
51. Tiotropium Bromide [orange Book]
52. Tiotropium Bromide(spiriva, Ba 679br)
53. As-75172
54. Bt164474
55. Hy-17360
56. Bcp0726000293
57. Cas-136310-93-5
58. T3032
59. A846824
60. Q27162952
61. (1?,2?,4?,5?,7?)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide
62. (1alpha,2beta,4beta,5alpha,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane Bromide
63. (1r,2r,4s,5s)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0(2),?]nonan-9-ium Bromide
64. (1r,2r,4s,5s,7r)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0?,?]nonan-9-ium Bromide
65. (1r,2r,4s,5s,7s)-7-[2-hydroxy-2,2-di(2-thienyl)acetoxy]-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Bromide
66. [(1r,2r,4s,5s)-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide
67. [(1r,2r,4s,5s)-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl]2-hydroxy-2,2-dithiophen-2-yl-acetate Bromide
68. 1.alpha., 2.beta., 4.beta, 5.alpha, 7.beta-7-((hydroxydi-2-thienylacetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0 Sup(2,4))nonane Bromide
69. 3-oxa-9-azoniatricyclo(3,3.1.0(2,4))nonane, 7-((hydroxydi-2-thienylacetyl)oxy)-9,9-dimethyl-, Bromide, (1alpha,2beta,4beta,5alpha,7beta)-
70. 3-oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 7-((hydroxydi-2-thienacetyl)oxy)-9,9-dimethyl-, Bromide, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-
71. 3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, Bromide (1:1), (1alpha,2beta,4beta,5alpha,7beta)-
72. 6.beta.,7.beta.-epoxy-3.beta.-hydroxy-8-methyl-1.alpha.h,5.alpha.h-tropanium Bromide, Di-2-thienylglycolate
73. Rel-(1r,2r,4s,5s,7s)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Bromide
74. Rel-(1r,2r,4s,5s,7s)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide
1. Tiotropiumbromide
2. Gsp 304
3. Tiotropium Cation
4. Respimat
Molecular Weight | 472.4 g/mol |
---|---|
Molecular Formula | C19H22BrNO4S2 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 7 |
Rotatable Bond Count | 5 |
Exact Mass | 471.01736 g/mol |
Monoisotopic Mass | 471.01736 g/mol |
Topological Polar Surface Area | 116 Ų |
Heavy Atom Count | 27 |
Formal Charge | 0 |
Complexity | 564 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 4 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 2 |
1 of 4 | |
---|---|
Drug Name | Spiriva |
PubMed Health | tiotropium |
Drug Classes | Bronchodilator |
Drug Label | SPIRIVA HandiHaler consists of a capsule dosage form containing a dry powder formulation of tiotropium intended for oral inhalation only with the HandiHaler device.Each light green, hard gelatin SPIRIVA capsule contains 18 mcg tiotropium (equivalent... |
Active Ingredient | Tiotropium bromide |
Dosage Form | Powder |
Route | Inhalation |
Strength | eq 0.018mg base/inh |
Market Status | Prescription |
Company | Boehringer Ingelheim |
Patent | 8022082; 6908928; RE38912; 7694676; RE39820; 7309707; 7642268; 7070800; 6777423 |
2 of 4 | |
---|---|
Drug Name | Spiriva respimat |
PubMed Health | tiotropium |
Drug Label | The active component of SPIRIVA RESPIMAT is tiotropium. The drug substance, tiotropium bromide monohydrate, is an anticholinergic with specificity for muscarinic receptors. It is chemically described as (1, 2, 4, 5, 7)-7-[(Hydroxydi-2-thien... |
Active Ingredient | Tiotropium bromide |
Dosage Form | Spray, metered |
Route | Inhalation |
Strength | eq 0.0025mg base/inh |
Market Status | Prescription |
Company | Boehringer Ingelheim |
Patent | 7284474; 7802568; 6977042; 5964416; 7988001; 6176242; 6453795; RE39820; 7246615; 6988496; 7896264; 7837235; 6726124; 6846413; 6149054; 7396341; 7104470 |
3 of 4 | |
---|---|
Drug Name | Spiriva |
PubMed Health | tiotropium |
Drug Classes | Bronchodilator |
Drug Label | SPIRIVA HandiHaler consists of a capsule dosage form containing a dry powder formulation of tiotropium intended for oral inhalation only with the HandiHaler device.Each light green, hard gelatin SPIRIVA capsule contains 18 mcg tiotropium (equivalent... |
Active Ingredient | Tiotropium bromide |
Dosage Form | Powder |
Route | Inhalation |
Strength | eq 0.018mg base/inh |
Market Status | Prescription |
Company | Boehringer Ingelheim |
Patent | 8022082; 6908928; RE38912; 7694676; RE39820; 7309707; 7642268; 7070800; 6777423 |
4 of 4 | |
---|---|
Drug Name | Spiriva respimat |
PubMed Health | tiotropium |
Drug Label | The active component of SPIRIVA RESPIMAT is tiotropium. The drug substance, tiotropium bromide monohydrate, is an anticholinergic with specificity for muscarinic receptors. It is chemically described as (1, 2, 4, 5, 7)-7-[(Hydroxydi-2-thien... |
Active Ingredient | Tiotropium bromide |
Dosage Form | Spray, metered |
Route | Inhalation |
Strength | eq 0.0025mg base/inh |
Market Status | Prescription |
Company | Boehringer Ingelheim |
Patent | 7284474; 7802568; 6977042; 5964416; 7988001; 6176242; 6453795; RE39820; 7246615; 6988496; 7896264; 7837235; 6726124; 6846413; 6149054; 7396341; 7104470 |
Cholinergic Antagonists
Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists. (See all compounds classified as Cholinergic Antagonists.)
Parasympatholytics
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)
Bronchodilator Agents
Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)
R03BB04
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
R - Respiratory system
R03 - Drugs for obstructive airway diseases
R03B - Other drugs for obstructive airway diseases, inhalants
R03BB - Anticholinergics
R03BB04 - Tiotropium bromide
GDUFA
DMF Review : Reviewed
Rev. Date : 2021-04-30
Pay. Date : 2020-01-13
DMF Number : 34410
Submission : 2020-03-17
Status : Active
Type : II
Certificate Number : R0-CEP 2019-337 - Rev 01
Issue Date : 2023-05-16
Type : Chemical
Substance Number : 2420
Status : Valid
NDC Package Code : 64567-0026
Start Marketing Date : 2021-01-20
End Marketing Date : 2024-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT
Available Reg Filing : CN |
Vamsi Labs is one of the major manufacturers of Anti-asthmatic, Anti-migraine & Anti-psychotic APIs.
GDUFA
DMF Review : Reviewed
Rev. Date : 2021-01-11
Pay. Date : 2020-11-04
DMF Number : 34808
Submission : 2020-04-15
Status : Active
Type : II
Certificate Number : CEP 2012-285 - Rev 02
Issue Date : 2024-01-16
Type : Chemical
Substance Number : 2420
Status : Valid
Date of Issue : 2022-06-13
Valid Till : 2025-07-02
Written Confirmation Number : WC-0155
Address of the Firm :
NDC Package Code : 66412-0761
Start Marketing Date : 2020-04-20
End Marketing Date : 2024-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.
Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.
GDUFA
DMF Review : Reviewed
Rev. Date : 2015-01-16
Pay. Date : 2013-12-31
DMF Number : 28161
Submission : 2013-12-26
Status : Active
Type : II
Certificate Number : CEP 2014-271 - Rev 02
Issue Date : 2024-10-23
Type : Chemical
Substance Number : 2420
Status : Valid
NDC Package Code : 58175-0565
Start Marketing Date : 2011-12-12
End Marketing Date : 2025-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT
GDUFA
DMF Review : Reviewed
Rev. Date : 2014-03-15
Pay. Date : 2013-09-17
DMF Number : 27524
Submission : 2013-10-23
Status : Active
Type : II
GDUFA
DMF Review : Reviewed
Rev. Date : 2016-04-20
Pay. Date : 2015-11-19
DMF Number : 29726
Submission : 2016-01-20
Status : Active
Type : II
Certificate Number : R0-CEP 2019-126 - Rev 00
Issue Date : 2021-04-13
Type : Chemical
Substance Number : 2420
Status : Valid
GDUFA
DMF Review : Reviewed
Rev. Date : 2023-12-07
Pay. Date : 2023-07-27
DMF Number : 27120
Submission : 2013-04-30
Status : Active
Type : II
Certificate Number : R1-CEP 2016-326 - Rev 01
Issue Date : 2022-12-08
Type : Chemical
Substance Number : 2420
Status : Valid
NDC Package Code : 63190-0380
Start Marketing Date : 2011-07-04
End Marketing Date : 2024-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 18135
Submission : 2005-03-03
Status : Inactive
Type : II
Certificate Number : R1-CEP 2010-359 - Rev 00
Issue Date : 2016-10-06
Type : Chemical
Substance Number : 2420
Status : Valid
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 21939
Submission : 2008-09-05
Status : Inactive
Type : II
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