Find Tirasemtiv manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 1005491-05-3, Ck-2017357, Tirasemtiv(ck-2017357), 6-ethynyl-1-(pentan-3-yl)-1h-imidazo[4,5-b]pyrazin-2-ol, 5-ethynyl-3-pentan-3-yl-1h-imidazo[4,5-b]pyrazin-2-one, Ck2017357
Molecular Formula
C12H14N4O
Molecular Weight
230.27  g/mol
InChI Key
RSQGZEAXODVTOL-UHFFFAOYSA-N
FDA UNII
G8WSM7R635

Tirasemtiv
Tirasemtiv has been used in trials studying the treatment of Myasthenia Gravis, Intermittent Claudication, and Amyotrophic Lateral Sclerosis.
1 2D Structure

Tirasemtiv

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one
2.1.2 InChI
InChI=1S/C12H14N4O/c1-4-8-7-13-10-11(14-8)16(12(17)15-10)9(5-2)6-3/h1,7,9H,5-6H2,2-3H3,(H,13,15,17)
2.1.3 InChI Key
RSQGZEAXODVTOL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC(CC)N1C2=NC(=CN=C2NC1=O)C#C
2.2 Other Identifiers
2.2.1 UNII
G8WSM7R635
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ck-2017357

2.3.2 Depositor-Supplied Synonyms

1. 1005491-05-3

2. Ck-2017357

3. Tirasemtiv(ck-2017357)

4. 6-ethynyl-1-(pentan-3-yl)-1h-imidazo[4,5-b]pyrazin-2-ol

5. 5-ethynyl-3-pentan-3-yl-1h-imidazo[4,5-b]pyrazin-2-one

6. Ck2017357

7. G8wsm7r635

8. 6-ethynyl-1-(pentan-3-yl)-2h-imidazo(4,5-b)pyrazin-2-one

9. 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-2h-imidazo(4,5-b)pyrazin-2-one

10. 2h-imidazo(4,5-b)pyrazin-2-one, 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-

11. 2h-imidazo[4,5-b]pyrazin-2-one, 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-;2h-imidazo[4,5-b]pyrazin-2-one, 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-

12. Tirasemtiv [inn]

13. Tirasemtiv (usan/inn)

14. Tirasemtiv [usan:inn]

15. Unii-g8wsm7r635

16. Ck 2017357

17. 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-2h-imidazo[4,5-b]pyrazin-2-one

18. Tirasemtiv (ck-2017357)

19. Tirasemtiv [usan]

20. Tirasemtiv [who-dd]

21. Schembl976988

22. Gtpl8280

23. Chembl3039529

24. Dtxsid90143379

25. Ex-a367

26. Bcp27991

27. Bdbm50316148

28. Mfcd28023588

29. Zinc95627912

30. Akos027250724

31. Db12209

32. Sb16955

33. Ncgc00378555-02

34. Ac-35962

35. Bs-22417

36. Da-48425

37. Hy-15964

38. Ft-0746303

39. S0196

40. D10327

41. A898831

42. Q27088998

43. Ck2017357; Ck-2017357; Ck 2017357

44. 6-ethynyl-1-(pentan-3-yl)-1h-imidazo[4,5-b]pyrazin-2(3h)-one

45. 6-ethynyl-1-(pentan-3-yl)-1,3-dihydro-2h-imidazo[4,5-b]pyrazin-2-one

46. W97

2.4 Create Date
2008-02-19
3 Chemical and Physical Properties
Molecular Weight 230.27 g/mol
Molecular Formula C12H14N4O
XLogP31.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass230.11676108 g/mol
Monoisotopic Mass230.11676108 g/mol
Topological Polar Surface Area58.1 Ų
Heavy Atom Count17
Formal Charge0
Complexity344
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of amyotrophic lateral sclerosis


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ABOUT THIS PAGE

Looking for 1005491-05-3 / Tirasemtiv API manufacturers, exporters & distributors?

Tirasemtiv manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tirasemtiv API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tirasemtiv manufacturer or Tirasemtiv supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tirasemtiv manufacturer or Tirasemtiv supplier.

PharmaCompass also assists you with knowing the Tirasemtiv API Price utilized in the formulation of products. Tirasemtiv API Price is not always fixed or binding as the Tirasemtiv Price is obtained through a variety of data sources. The Tirasemtiv Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tirasemtiv

Synonyms

1005491-05-3, Ck-2017357, Tirasemtiv(ck-2017357), 6-ethynyl-1-(pentan-3-yl)-1h-imidazo[4,5-b]pyrazin-2-ol, 5-ethynyl-3-pentan-3-yl-1h-imidazo[4,5-b]pyrazin-2-one, Ck2017357

Cas Number

1005491-05-3

Unique Ingredient Identifier (UNII)

G8WSM7R635

About Tirasemtiv

Tirasemtiv has been used in trials studying the treatment of Myasthenia Gravis, Intermittent Claudication, and Amyotrophic Lateral Sclerosis.

Tirasemtiv Manufacturers

A Tirasemtiv manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tirasemtiv, including repackagers and relabelers. The FDA regulates Tirasemtiv manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tirasemtiv API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tirasemtiv Suppliers

A Tirasemtiv supplier is an individual or a company that provides Tirasemtiv active pharmaceutical ingredient (API) or Tirasemtiv finished formulations upon request. The Tirasemtiv suppliers may include Tirasemtiv API manufacturers, exporters, distributors and traders.

Tirasemtiv GMP

Tirasemtiv Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tirasemtiv GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tirasemtiv GMP manufacturer or Tirasemtiv GMP API supplier for your needs.

Tirasemtiv CoA

A Tirasemtiv CoA (Certificate of Analysis) is a formal document that attests to Tirasemtiv's compliance with Tirasemtiv specifications and serves as a tool for batch-level quality control.

Tirasemtiv CoA mostly includes findings from lab analyses of a specific batch. For each Tirasemtiv CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tirasemtiv may be tested according to a variety of international standards, such as European Pharmacopoeia (Tirasemtiv EP), Tirasemtiv JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tirasemtiv USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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