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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 3 USDMF, 1 EU WC, 2 NDC API, 10 Listed Suppliers, $ API Reference Price

13 API Suppliers
3 USDMF
1 EU WC
2 NDC API
10 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

22 FDF Dossiers, 10 FDA Orange Book, 1 Europe, 1 Canada, 2 Australia, 3 South Africa, 5 Listed Dossiers

22 FDF Dossiers
10 FDA Orange Book
1 Europe
1 Canada
2 Australia
3 South Africa
5 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INJECTION - EQ 3.75MG BASE/15ML (EQ 0.25MG BASE/ML), SOLUTION;INTRAVENOUS - EQ 12.5MG BASE/250ML (EQ 0.05MG BASE/ML), SOLUTION;INTRAVENOUS - EQ 5MG BASE/100ML (EQ 0.05MG BASE/ML)

drugProductComposition
SOLUTION;INJECTION - EQ 3.75MG BASE/15ML (EQ 0.25MG BASE/ML)
SOLUTION;INTRAVENOUS - EQ 12.5MG BASE/250ML (EQ 0.05MG BASE/ML)
SOLUTION;INTRAVENOUS - EQ 5MG BASE/100ML (EQ 0.05MG BASE/ML)

RELATED EXCIPIENT COMPANIES

4 Actylis

relatedExcipients
4 Actylis

EXCIPIENTS BY APPLICATIONS

2 Parenteral, 2 Controlled & Modified Release

excipientsByApplications
2 Parenteral
2 Controlled & Modified Release

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 13 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
13 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 Finished Drug Prices

globalSalesInformation
1 Finished Drug Prices

MARKET PLACE

3 FDF Dossiers

marketPlace
3 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 Health Canada Patents

patents
4 Health Canada Patents

REF. STANDARDS & IMPURITIES

15 Others

otherSolutions
15 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

4EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Tirofiban hydrochloride, 142373-60-2, Tirofiban hcl, Tirofiban (hydrochloride), Tirofiban hydrochloride anhydrous, Ike1p4x57j

Molecular Formula

C₂₂H₃₇ClN₂O₅S

Molecular Weight

477.1 g/mol

InChI Key

KPKFFYOMPGOQRP-BOXHHOBZSA-N

FDA UNII

IKE1P4X57J

Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.

1 2D Structure

Tirofiban

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid;hydrochloride

2.1.2 InChI

InChI=1S/C22H36N2O5S.ClH/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H/t21-;/m0./s1

2.1.3 InChI Key

KPKFFYOMPGOQRP-BOXHHOBZSA-N

2.1.4 Canonical SMILES

CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.Cl

2.1.5 Isomeric SMILES

CCCCS(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.Cl

2.2 Other Identifiers

2.2.1 UNII

IKE1P4X57J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Agrastat

2. L 700,462

3. L 700462

4. L-700,462

5. L-700462

6. L700,462

7. Mk 383

8. Mk-383

9. N-(butylsulfonyl)-o-(4-(4-piperidyl)butyl)-l-tyrosine

10. Tirofiban

11. Tirofiban Hydrochloride

12. Tirofiban Hydrochloride Monohydrate

2.3.2 Depositor-Supplied Synonyms

1. Tirofiban Hydrochloride

2. 142373-60-2

3. Tirofiban Hcl

4. Tirofiban (hydrochloride)

5. Tirofiban Hydrochloride Anhydrous

6. Ike1p4x57j

7. (s)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic Acid Hydrochloride

8. Mk 383

9. L 700462

10. 142373-60-2 (hcl)

11. L-tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, Monohydrochloride

12. Tirofibanhydrochloridemonohydrate

13. N-(butylsulfonyl)-o-[4-(4-piperidinyl)butyl]-l-tyrosine Hydrochloride

14. L-700462

15. Mk-383

16. Unii-ike1p4x57j

17. N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-l-tyrosine Monohydrochloride

18. Chembl1704

19. Schembl41327

20. Dtxsid70931418

21. 2-(butylsulfonylamino)-3-[4-[4-(4-piperidinyl)butoxy]phenyl]propanoic Acid Hydrochloride

22. Amy23379

23. Ex-a2875

24. Hy-17369a

25. Mfcd00868210

26. Akos025311245

27. Tirofiban Hydrochloride [who-dd]

28. Cs-0009551

29. T3640

30. Tirofiban Hydrochloride Anhydrous [mi]

31. 915t405

32. Q27280770

33. (s)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride

34. L-tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, Hydrochloride (1:1)

35. N-(butane-1-sulfonyl)-o-[4-(piperidin-4-yl)butyl]tyrosine--hydrogen Chloride (1/1)

36. (2s)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic Acid;hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₃₇ClN₂O₅S
Molecular Weight	477.1 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	14
Exact Mass	476.2111712 g/mol
Monoisotopic Mass	476.2111712 g/mol
Topological Polar Surface Area	113 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	579
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Fibrinolytic Agents

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)

Platelet Aggregation Inhibitors

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

API SUPPLIERS

01

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Wisdom Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

03

GLAND PHARMA LIMITED

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

04

Wisdom Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

05

Guangzhou Tosun Pharmaceutical

China

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

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USDMF

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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INTERMEDIATES SUPPLIERS

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FDF Dossiers

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FDA Orange Book

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Europe

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Canada

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Australia

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South Africa

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION;INJECTION - EQ 3.75MG BASE/...DOSAGE - SOLUTION;INJECTION - EQ 3.75MG BASE/15ML (EQ 0.25MG BASE/ML)

USFDA APPLICATION NUMBER - 20912

DOSAGE - SOLUTION;INTRAVENOUS - EQ 12.5MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 12.5MG BASE/250ML (EQ 0.05MG BASE/ML)

USFDA APPLICATION NUMBER - 20913

DOSAGE - SOLUTION;INTRAVENOUS - EQ 5MG BASE/1...DOSAGE - SOLUTION;INTRAVENOUS - EQ 5MG BASE/100ML (EQ 0.05MG BASE/ML)

USFDA APPLICATION NUMBER - 20913

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Parenteral

Controlled & Modified Release

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DATA COMPILATION #PharmaFlow

NEWS #PharmaBuzz

Global Sales Information

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Finished Drug Prices

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Market Place

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FDF DOSSIERS

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Patents & EXCLUSIVITIES

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Health Canada Patents

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REF. STANDARDS & IMPURITIES

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Others

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Market Place

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers

3 USDMF

1 EU WC

2 NDC API

10 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

22 FDF Dossiers

10 FDA Orange Book

1 Europe

1 Canada

2 Australia

3 South Africa

5 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INJECTION - EQ 3.75MG BASE/15ML (EQ 0.25MG BASE/ML)

SOLUTION;INTRAVENOUS - EQ 12.5MG BASE/250ML (EQ 0.05MG BASE/ML)

SOLUTION;INTRAVENOUS - EQ 5MG BASE/100ML (EQ 0.05MG BASE/ML)

RELATED EXCIPIENT COMPANIES

4 Actylis

EXCIPIENTS BY APPLICATIONS

2 Parenteral

2 Controlled & Modified Release

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

13 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 Finished Drug Prices

MARKET PLACE

3 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 Health Canada Patents

REF. STANDARDS & IMPURITIES

15 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 164,216

MARKET PLACE

FINISHED DOSAGE FORMULATIONS

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

4EXCIPIENTS BY APPLICATIONS

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Average Price (USD/KGS)

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Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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