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Chemistry

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Also known as: 55837-29-1, Tiropramide [inn], Cr-605, R7s0904cn2, Tiropramide (inn), Benzenepropanamide, alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-n,n-dipropyl-, (+-)-
Molecular Formula
C28H41N3O3
Molecular Weight
467.6  g/mol
InChI Key
FDBWMYOFXWMGEY-UHFFFAOYSA-N
FDA UNII
R7S0904CN2

Tiropramide
Tiropramide is under investigation in clinical trial NCT01629212 (Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome).
1 2D Structure

Tiropramide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[3-[4-[2-(diethylamino)ethoxy]phenyl]-1-(dipropylamino)-1-oxopropan-2-yl]benzamide
2.1.2 InChI
InChI=1S/C28H41N3O3/c1-5-18-31(19-6-2)28(33)26(29-27(32)24-12-10-9-11-13-24)22-23-14-16-25(17-15-23)34-21-20-30(7-3)8-4/h9-17,26H,5-8,18-22H2,1-4H3,(H,29,32)
2.1.3 InChI Key
FDBWMYOFXWMGEY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCN(CCC)C(=O)C(CC1=CC=C(C=C1)OCCN(CC)CC)NC(=O)C2=CC=CC=C2
2.2 Other Identifiers
2.2.1 UNII
R7S0904CN2
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cr 605

2.3.2 Depositor-Supplied Synonyms

1. 55837-29-1

2. Tiropramide [inn]

3. Cr-605

4. R7s0904cn2

5. Tiropramide (inn)

6. Benzenepropanamide, Alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-n,n-dipropyl-, (+-)-

7. Tiropramida [spanish]

8. Tiropramida

9. Tiropramidum

10. Tiropramidum [inn-latin]

11. Tiropramida [inn-spanish]

12. N-(3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(dipropylamino)-1-oxopropan-2-yl)benzamide

13. N-[3-[4-[2-(diethylamino)ethoxy]phenyl]-1-(dipropylamino)-1-oxopropan-2-yl]benzamide

14. (+/-)-tiropramide

15. Brn 4162600

16. Maioral

17. Tirospan

18. Unii-r7s0904cn2

19. O-(diethylaminoethyl)-n-benzoyl-dl-tyrosyl-di-n-propylamide

20. Tiropramide [mi]

21. Dl-alpha-benzamido-para-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide

22. (+-)-alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-n,n-dipropylbenzenepropanamide

23. Schembl25693

24. Tiropramide [who-dd]

25. Chembl2104688

26. Dtxsid70866514

27. Chebi:135758

28. Akos015909639

29. Dl-alpha-benzamido-p-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide

30. Db13091

31. D07087

32. Q7809264

33. (+/-)-.alpha.-benzamido-p-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide

34. Dl-.alpha.-benzamido-p-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide

35. N-(2-{4-[2-(diethylamino)ethoxy]phenyl}-1-(dipropylcarbamoyl)ethyl)benzenecarboximidic Acid

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 467.6 g/mol
Molecular Formula C28H41N3O3
XLogP35.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count15
Exact Mass467.31479218 g/mol
Monoisotopic Mass467.31479218 g/mol
Topological Polar Surface Area61.9 Ų
Heavy Atom Count34
Formal Charge0
Complexity561
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


4.2 ATC Code

A - Alimentary tract and metabolism

A03 - Drugs for functional gastrointestinal disorders

A03A - Drugs for functional gastrointestinal disorders

A03AC - Synthetic antispasmodics, amides with tertiary amines

A03AC05 - Tiropramide


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ABOUT THIS PAGE

Tiropramide Manufacturers

A Tiropramide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tiropramide, including repackagers and relabelers. The FDA regulates Tiropramide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tiropramide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tiropramide Suppliers

A Tiropramide supplier is an individual or a company that provides Tiropramide active pharmaceutical ingredient (API) or Tiropramide finished formulations upon request. The Tiropramide suppliers may include Tiropramide API manufacturers, exporters, distributors and traders.

Tiropramide GMP

Tiropramide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tiropramide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tiropramide GMP manufacturer or Tiropramide GMP API supplier for your needs.

Tiropramide CoA

A Tiropramide CoA (Certificate of Analysis) is a formal document that attests to Tiropramide's compliance with Tiropramide specifications and serves as a tool for batch-level quality control.

Tiropramide CoA mostly includes findings from lab analyses of a specific batch. For each Tiropramide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tiropramide may be tested according to a variety of international standards, such as European Pharmacopoeia (Tiropramide EP), Tiropramide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tiropramide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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