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    Chemistry

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    Also known as: Tizanidine hcl, 64461-82-1, Zanaflex, Tizanidine (hydrochloride), 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride, Ds 103-282
    Molecular Formula
    C9H9Cl2N5S
    Molecular Weight
    290.17  g/mol
    InChI Key
    ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
    FDA UNII
    B53E3NMY5C
    Tizanidine HCl
    Tizanidine Hydrochloride is the hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine and increasing the inhibitory effect on alpha motor neurons and motor reflexes. Tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors and imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall, tizanidine hydrochloride causes muscle relaxation, reduces spasticity and antinociceptive effects.
    1 2D Structure

    Tizanidine HCl

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
    2.1.3 InChI Key
    ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    B53E3NMY5C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole

    2. Ds 103-282

    3. Sirdalud

    4. Tizanidine

    5. Tizanidine Monohydrochloride

    6. Zanaflex

    2.3.2 Depositor-Supplied Synonyms

    1. Tizanidine Hcl

    2. 64461-82-1

    3. Zanaflex

    4. Tizanidine (hydrochloride)

    5. 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine Hydrochloride

    6. Ds 103-282

    7. An021

    8. 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-amine Hydrochloride

    9. B53e3nmy5c

    10. Tizanidine (as Hydrochloride)

    11. 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Monohydrochloride

    12. 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine;hydrochloride

    13. Ds-103-282

    14. 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Hydrochloride

    15. An-021

    16. 64461-82-1 (hcl)

    17. 2,1,3-benzothiadiazol-4-amine, 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-, Monohydrochloride

    18. 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3-benzothiadiazole-4-amine Hydrochloride

    19. Smr000499584

    20. Unii-b53e3nmy5c

    21. Sr-01000765392

    22. Tizanidine * Hcl

    23. Zanaflex (tn)

    24. Mfcd00798231

    25. Tizanidine Hydrochloride [usan:usp:jan]

    26. 5-iodoisoquinolin-8-ol

    27. Schembl41199

    28. Mls001076686

    29. Mls001306412

    30. Mls001333593

    31. Chebi:9609

    32. Tizanidine Hydrochloride- Bio-x

    33. Chembl1200329

    34. Dtxsid9046990

    35. Ds-103282 Ch

    36. Hy-b0194a

    37. An-021a

    38. Nvd-422

    39. Amy18121

    40. Bcp28540

    41. Tox21_501114

    42. S1437

    43. Tizanidine Hydrochloride [mi]

    44. Tizanidine Hydrochloride (jp17/usp)

    45. Tizanidine Hydrochloride [jan]

    46. Akos005267234

    47. Brn0618691

    48. Ccg-220602

    49. Ccg-222418

    50. Ks-1120

    51. Lp01114

    52. Nc00654

    53. Tizanidine Hydrochloride [usan]

    54. Tizanidine Hydrochloride [mart.]

    55. Tizanidine Hydrochloride [vandf]

    56. Ncgc00261799-01

    57. Tizanidine Hydrochloride [who-dd]

    58. Ac-22546

    59. Bt164478

    60. Db-011661

    61. Ds-103282

    62. Ds103-282

    63. Ft-0656022

    64. Sw199068-2

    65. T2527

    66. En300-49853

    67. Tizanidine Hydrochloride [orange Book]

    68. D00776

    69. D70434

    70. Tizanidine Hydrochloride [ep Monograph]

    71. Tizanidine Hydrochloride [usp Impurity]

    72. Tizanidine Hydrochloride [usp Monograph]

    73. Tizanidine Hydrochloride, >=98% (hplc), Powder

    74. Sr-01000765392-4

    75. Q27274381

    76. Tizanidine Hydrochloride 100 Microg/ml In Acetonitrile

    77. 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazolehydrochloride

    78. Tizanidine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    79. (5-chloro-2,1,3-benzothiadiazol-4-yl)-(4,5-dihydro-1h-imidazol-2-yl)azanium;chloride

    80. 5-(chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine Hydrochloride

    81. 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Monohydrochloride.

    82. 5-chloro-4-[(4,5-dihydro-1h-imidazol-2-yl)amino]-2,1,3-benzothiadiazole Hydrochloride

    83. 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3benzothiadiazole-4-amine Hydrochloride

    84. 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-aminehydrochloride

    85. Tizanidine Hydrochloride, 500 Mug/ml In Methanol, Certified Reference Material

    86. Tizanidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 290.17 g/mol
    Molecular Formula C9H9Cl2N5S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass288.9955719 g/mol
    Monoisotopic Mass288.9955719 g/mol
    Topological Polar Surface Area90.4 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity300
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameTizanidine hydrochloride
    PubMed HealthTizanidine (By mouth)
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Drug LabelZanaflex (tizanidine hydrochloride) is a centrally acting 2-adrenergic agonist. Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in...
    Active IngredientTizanidine hydrochloride
    Dosage FormTablet; Capsule
    RouteOral
    Strengtheq 4mg base; eq 2mg base; eq 6mg base
    Market StatusPrescription
    CompanyCorepharma; Mylan Pharms; Teva; Apotex; Sun Pharm Inds; Prosam Labs; Sandoz; Dr Reddys Labs; Mylan; Unichem Labs

    2 of 4  
    Drug NameZanaflex
    Drug LabelZanaflex (tizanidine hydrochloride) is a centrally acting 2-adrenergic agonist. Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in...
    Active IngredientTizanidine hydrochloride
    Dosage FormTablet; Capsule
    RouteOral
    Strengtheq 4mg base; eq 2mg base; eq 6mg base
    Market StatusPrescription
    CompanyAcorda

    3 of 4  
    Drug NameTizanidine hydrochloride
    PubMed HealthTizanidine (By mouth)
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Drug LabelZanaflex (tizanidine hydrochloride) is a centrally acting 2-adrenergic agonist. Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in...
    Active IngredientTizanidine hydrochloride
    Dosage FormTablet; Capsule
    RouteOral
    Strengtheq 4mg base; eq 2mg base; eq 6mg base
    Market StatusPrescription
    CompanyCorepharma; Mylan Pharms; Teva; Apotex; Sun Pharm Inds; Prosam Labs; Sandoz; Dr Reddys Labs; Mylan; Unichem Labs

    4 of 4  
    Drug NameZanaflex
    Drug LabelZanaflex (tizanidine hydrochloride) is a centrally acting 2-adrenergic agonist. Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in...
    Active IngredientTizanidine hydrochloride
    Dosage FormTablet; Capsule
    RouteOral
    Strengtheq 4mg base; eq 2mg base; eq 6mg base
    Market StatusPrescription
    CompanyAcorda

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Muscle Relaxants, Central

    A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

    Analgesics

    Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)

    Anticonvulsants

    Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

    Adrenergic alpha-2 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Central alpha-2 Adrenergic Agonist [EPC]; Adrenergic alpha2-Agonists [MoA]

    API Reference Price

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EMIRATES","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"1814","totalValueFC":"23919.3","currency":"AED","unitRateINR":40089.400000000001,"date":"23-Sep-2024","totalValueINR":"2004470","totalValueInUsd":"23919.3","indian_port":"Bombay Air","hs_no":"29342000","bill_no":"4268600","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"H N.8-2-269\/W\/4,1ST FLOOR,PLOT NO., BANJARA HILLS HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"(PHARMACEUTICAL ALLOPATHIC RAW MATERIALSFOR PHARMACEUTICAL USE) TIZANIDINE HCLUSP","address":"224 A BLOCK SEVENTH HEAVEN","city":"AHMEDABAD","supplier":"NASSIL MEDICARE","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"TO THE ORDER OF","customerCountry":"PAKISTAN","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"600","totalValueFC":"1143.6","currency":"USD","unitRateINR":47916.199999999997,"date":"26-Sep-2024","totalValueINR":"95832.4","totalValueInUsd":"1143.6","indian_port":"Ahmedabad Air","hs_no":"29342000","bill_no":"4353486","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"224 A BLOCK SEVENTH HEAVEN, AHMEDABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"TIZANIDINE HYDROCHLORIDE (TAX INVOICE NO:24-25\/EXP-566 DT:26.09.2024)","address":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE","city":"HYDERABAD-AP","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"SINGAPORE","customer":"CLEO SINGAPORE PTE ","customerCountry":"SINGAPORE","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"680","totalValueFC":"2651.9","currency":"USD","unitRateINR":55707.5,"date":"01-Oct-2024","totalValueINR":"222830","totalValueInUsd":"2651.9","indian_port":"Hyderabad Air","hs_no":"29332990","bill_no":"4518875","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE, HYDERABAD-AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728066600,"product":"PHARMACEUTICAL RAW MATERIAL TIZANIDINE HCL USP BATCH NO.: - VTZD24003 MFG DT. AUGUST- 2024 EXPIRY DATE : JULY-2029","address":"PLOT NO 126, UDYOG NAGAR, NEAR AUTO BAJAJ SERVICES CENTER","city":"Navi Mumbai","supplier":"ZEON PHARMA INDUSTRIES INDIA PVT LTD","supplierCountry":"INDIA","foreign_port":"ISLAMABAD - ISLAMABA","customer":"SONERI BANK LIMITED","customerCountry":"PAKISTAN","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"520","totalValueFC":"956.3","currency":"USD","unitRateINR":40178.849999999999,"date":"05-Oct-2024","totalValueINR":"80357.7","totalValueInUsd":"956.3","indian_port":"Bombay Air","hs_no":"29342000","bill_no":"4614701","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO 126, UDYOG NAGAR, NEAR AUTO BAJAJ SERVICES CENTER, Navi Mumbai","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728412200,"product":"PHARMACEUTICAL RAW MATERIAL TIZANIDINE HCL USP BATCH NO.: - VTZD24003 MFG DT. AUGUST- 2024 EXPIRY DATE : JULY-2029","address":"PLOT NO 126, UDYOG NAGAR, NEAR AUTO BAJAJ SERVICES CENTER","city":"Navi Mumbai","supplier":"ZEON PHARMA INDUSTRIES INDIA PVT LTD","supplierCountry":"INDIA","foreign_port":"ISLAMABAD - ISLAMABA","customer":"SONERI BANK LIMITED","customerCountry":"PAKISTAN","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"520","totalValueFC":"956.3","currency":"USD","unitRateINR":40178.849999999999,"date":"09-Oct-2024","totalValueINR":"80357.7","totalValueInUsd":"956.3","indian_port":"Bombay Air","hs_no":"29342000","bill_no":"4697746","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO 126, UDYOG NAGAR, NEAR AUTO BAJAJ SERVICES CENTER, Navi Mumbai","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728930600,"product":"RAW MATERIAL FOR USE IN PHARMACEUTICAL INDUSTRY : TIZANIDINE HCL USP","address":"A 401 NEELKANTH AVENUE,OPP SEEMA H","city":"AHMEDABAD,GUJARAT","supplier":"GONANE PHARMA","supplierCountry":"INDIA","foreign_port":"SAN JOSE","customer":"HSBC BANK","customerCountry":"COSTA RICA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"500","totalValueFC":"12263.3","currency":"USD","unitRateINR":41217.599999999999,"date":"15-Oct-2024","totalValueINR":"1030440","totalValueInUsd":"12263.3","indian_port":"Ahmedabad Air","hs_no":"29342000","bill_no":"4814913","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"COSTA RICA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"A 401 NEELKANTH AVENUE,OPP SEEMA H, AHMEDABAD,GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729276200,"product":"TIZANIDINE HYDROCHLORIDE (TAX INVOICE NO: 24-25\/EXP-574 DT: 28\/09\/2024)","address":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE","city":"HYDERABAD-AP","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"HANOI - NOIBAI","customer":"WEALPHAR PHARMACEUTICAL JOINT STOCK","customerCountry":"VIETNAM","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"580","totalValueFC":"2839.8","currency":"USD","unitRateINR":47723.800000000003,"date":"19-Oct-2024","totalValueINR":"238619","totalValueInUsd":"2839.8","indian_port":"Hyderabad Air","hs_no":"29332990","bill_no":"4963080","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VIETNAM","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE, HYDERABAD-AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730053800,"product":"TIZANIDINE HYDROCHLORIDE (TAX INVOICE NO:24-25\/EXP-650 DT:19.10.2024)","address":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE","city":"HYDERABAD-AP","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"AL BARAKA BANK ","customerCountry":"PAKISTAN","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"365","totalValueFC":"35977","currency":"USD","unitRateINR":30230.259999999998,"date":"28-Oct-2024","totalValueINR":"3023026","totalValueInUsd":"35977","indian_port":"Hyderabad Air","hs_no":"29332990","bill_no":"5190358","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE, HYDERABAD-AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730399400,"product":"TIZANIDINE HCL USP","address":"7-2-A2, HETERO CORPORATE,","city":"HYDERABAD-A.P.","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"HAMBURG - FUHLSBUETT","customer":"ICARGO INTERNATIONALE LOGISTIK","customerCountry":"GERMANY","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"600","totalValueFC":"14623.6","currency":"USD","unitRateINR":49362.387199999997,"date":"01-Nov-2024","totalValueINR":"1234059.68","totalValueInUsd":"14623.6","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"5319359","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"7-2-A2, HETERO CORPORATE,, HYDERABAD-A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732213800,"product":"TIZANIDINE HYDROCHLORIDE USP (BATCH NO.TZL\/006\/24)","address":"T-11, MIDC INDUSTRIAL AREA,","city":"DIST- THANE.","supplier":"SHRI VINAYAK CHEMEX (INDIA) PVT.LTD.","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"TO THE ORDER","customerCountry":"INDONESIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"550","totalValueFC":"1619.7","currency":"USD","unitRateINR":45562,"date":"22-Nov-2024","totalValueINR":"136686","totalValueInUsd":"1619.7","indian_port":"Bombay Air","hs_no":"29342000","bill_no":"5835609","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"T-11, MIDC INDUSTRIAL AREA,, DIST- THANE.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q1","strtotime":1611945000,"product":"TIZANIDINE HYDROCHLORIDE USP","address":"ALEMBIC PHARMACEUTICALS LTD\\r\\nALEMBIC ROAD","city":"VADODARA","supplier":"FARMAK, A.S","supplierCountry":"CZECH REPUBLIC","foreign_port":"","customer":"ALEMBIC PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"19.00","actualQuantity":"19","unit":"KGS","unitRateFc":"2100","totalValueFC":"40289.1","currency":"USD","unitRateINR":"155085","date":"30-Jan-2021","totalValueINR":"2946615","totalValueInUsd":"40289.1","indian_port":"BOMBAY AIR","hs_no":"29349990","bill_no":"2573113","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"ALEMBIC PHARMACEUTICALS LTD\\r\\nALEMBIC ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1671474600,"product":"RE-IMPORT OF TIZANIDINE HCL USP43 (NO COMMERCIAL VALUE)","address":"OFF NO 8 ARIHANT ENCLAVE ASHOK,CHA KRAVARTI RD KANDIVALI EAST","city":"MUMBAI,MAHARASHTRA","supplier":"BUSICOM CO. LTD","supplierCountry":"INDIA","foreign_port":"NA","customer":"SHRI VINAYAK CHEMEX (INDIA) PVT.LTD.","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"485","totalValueFC":"10350.9","currency":"USD","unitRateINR":"42648.9","date":"20-Dec-2022","totalValueINR":"852977.51","totalValueInUsd":"10350.9","indian_port":"JNPT","hs_no":"29342000","bill_no":"3817317","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"OFF NO 8 ARIHANT ENCLAVE ASHOK,CHA KRAVARTI RD KANDIVALI EAST"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1671474600,"product":"TIZANIDINE HYDROCHLORIDE","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"FARMAK, A.S","supplierCountry":"CZECH REPUBLIC","foreign_port":"N\/A","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"2500","totalValueFC":"25347","currency":"USD","unitRateINR":"208875","date":"20-Dec-2022","totalValueINR":"2088750","totalValueInUsd":"25347","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29349990","bill_no":"1005309","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703529000,"product":"TIZANIDINE HCL - AUSPO0065845","address":"817 DEVPATH BESIDE LAL BUNGLOW","city":"AHMEDABAD ,GUJ","supplier":"RICONPHARMA LLC","supplierCountry":"CZECH REPUBLIC","foreign_port":"NEW YORK","customer":"STALLION LABORATORIES","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"2850","totalValueFC":"11476.3","currency":"USD","unitRateINR":"238830","date":"26-Dec-2023","totalValueINR":"955320","totalValueInUsd":"11476.3","indian_port":"Ahmedabad Air","hs_no":"29349990","bill_no":"9412088","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"100 FORD ROAD, SUITE 9DENVILLE, NJ 07834, USASDNF US","customerAddress":"817 DEVPATH BESIDE LAL BUNGLOW"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703529000,"product":"TIZANIDINE HCL - AUSPO0065845","address":"817 DEVPATH BESIDE LAL BUNGLOW","city":"AHMEDABAD ,GUJ","supplier":"RICONPHARMA LLC","supplierCountry":"CZECH REPUBLIC","foreign_port":"NEW YORK","customer":"STALLION LABORATORIES","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"2850","totalValueFC":"28690.6","currency":"USD","unitRateINR":"238830","date":"26-Dec-2023","totalValueINR":"2388300","totalValueInUsd":"28690.6","indian_port":"Ahmedabad Air","hs_no":"29349990","bill_no":"9412088","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"100 FORD ROAD, SUITE 9DENVILLE, NJ 07834, USASDNF US","customerAddress":"817 DEVPATH BESIDE LAL BUNGLOW"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705429800,"product":"TIZANIDINE HYDROCHLORIDE","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"FARMAK, A.S","supplierCountry":"CZECH REPUBLIC","foreign_port":"N\/A","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"2500","totalValueFC":"25342.4","currency":"USD","unitRateINR":"210625","date":"17-Jan-2024","totalValueINR":"2106250","totalValueInUsd":"25342.4","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29349990","bill_no":"1000198","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"}]
    04-Jan-2021
    22-Nov-2024
    KGS
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - EQ 2MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 2MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20397

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    DOSAGE - TABLET;ORAL - EQ 4MG BASE

    USFDA APPLICATION NUMBER - 20397

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    DOSAGE - CAPSULE;ORAL - EQ 2MG BASE

    USFDA APPLICATION NUMBER - 21447

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    DOSAGE - CAPSULE;ORAL - EQ 4MG BASE

    USFDA APPLICATION NUMBER - 21447

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    DOSAGE - CAPSULE;ORAL - EQ 6MG BASE

    USFDA APPLICATION NUMBER - 21447

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    USP

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    ABOUT THIS PAGE

    Tizanidine HCl Manufacturers

    A Tizanidine HCl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tizanidine HCl, including repackagers and relabelers. The FDA regulates Tizanidine HCl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tizanidine HCl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Tizanidine HCl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Tizanidine HCl Suppliers

    A Tizanidine HCl supplier is an individual or a company that provides Tizanidine HCl active pharmaceutical ingredient (API) or Tizanidine HCl finished formulations upon request. The Tizanidine HCl suppliers may include Tizanidine HCl API manufacturers, exporters, distributors and traders.

    click here to find a list of Tizanidine HCl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Tizanidine HCl USDMF

    A Tizanidine HCl DMF (Drug Master File) is a document detailing the whole manufacturing process of Tizanidine HCl active pharmaceutical ingredient (API) in detail. Different forms of Tizanidine HCl DMFs exist exist since differing nations have different regulations, such as Tizanidine HCl USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Tizanidine HCl DMF submitted to regulatory agencies in the US is known as a USDMF. Tizanidine HCl USDMF includes data on Tizanidine HCl's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tizanidine HCl USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Tizanidine HCl suppliers with USDMF on PharmaCompass.

    Tizanidine HCl JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Tizanidine HCl Drug Master File in Japan (Tizanidine HCl JDMF) empowers Tizanidine HCl API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Tizanidine HCl JDMF during the approval evaluation for pharmaceutical products. At the time of Tizanidine HCl JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Tizanidine HCl suppliers with JDMF on PharmaCompass.

    Tizanidine HCl KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Tizanidine HCl Drug Master File in Korea (Tizanidine HCl KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Tizanidine HCl. The MFDS reviews the Tizanidine HCl KDMF as part of the drug registration process and uses the information provided in the Tizanidine HCl KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Tizanidine HCl KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Tizanidine HCl API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Tizanidine HCl suppliers with KDMF on PharmaCompass.

    Tizanidine HCl CEP

    A Tizanidine HCl CEP of the European Pharmacopoeia monograph is often referred to as a Tizanidine HCl Certificate of Suitability (COS). The purpose of a Tizanidine HCl CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Tizanidine HCl EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Tizanidine HCl to their clients by showing that a Tizanidine HCl CEP has been issued for it. The manufacturer submits a Tizanidine HCl CEP (COS) as part of the market authorization procedure, and it takes on the role of a Tizanidine HCl CEP holder for the record. Additionally, the data presented in the Tizanidine HCl CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Tizanidine HCl DMF.

    A Tizanidine HCl CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Tizanidine HCl CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Tizanidine HCl suppliers with CEP (COS) on PharmaCompass.

    Tizanidine HCl WC

    A Tizanidine HCl written confirmation (Tizanidine HCl WC) is an official document issued by a regulatory agency to a Tizanidine HCl manufacturer, verifying that the manufacturing facility of a Tizanidine HCl active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Tizanidine HCl APIs or Tizanidine HCl finished pharmaceutical products to another nation, regulatory agencies frequently require a Tizanidine HCl WC (written confirmation) as part of the regulatory process.

    click here to find a list of Tizanidine HCl suppliers with Written Confirmation (WC) on PharmaCompass.

    Tizanidine HCl NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Tizanidine HCl as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Tizanidine HCl API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Tizanidine HCl as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Tizanidine HCl and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Tizanidine HCl NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Tizanidine HCl suppliers with NDC on PharmaCompass.

    Tizanidine HCl GMP

    Tizanidine HCl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Tizanidine HCl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tizanidine HCl GMP manufacturer or Tizanidine HCl GMP API supplier for your needs.

    Tizanidine HCl CoA

    A Tizanidine HCl CoA (Certificate of Analysis) is a formal document that attests to Tizanidine HCl's compliance with Tizanidine HCl specifications and serves as a tool for batch-level quality control.

    Tizanidine HCl CoA mostly includes findings from lab analyses of a specific batch. For each Tizanidine HCl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Tizanidine HCl may be tested according to a variety of international standards, such as European Pharmacopoeia (Tizanidine HCl EP), Tizanidine HCl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tizanidine HCl USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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