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Chemistry

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Also known as: L59d69szn5, Rac-(ru(dmb)2(ip-3t))cl2, Tld1433, Tld-1433, 1471479-22-7, Unii-l59d69szn5
Molecular Formula
C49H38Cl2N8RuS3
Molecular Weight
1007.1  g/mol
InChI Key
AVOZSOCUVHJHTQ-UHFFFAOYSA-L
FDA UNII
L59D69SZN5

TLD-1433
Photodynamic Compound TLD-1433 is a non-toxic ruthenium-based coordination-complex and photosensitizer, with potential antineoplastic activity upon photodynamic therapy (PDT). Upon intravesical administration, light-activated photodynamic compound (PDC) TLD-1433 targets and binds to transferrin (Tf) and is subsequently taken up by Tf receptors which are located on tumor cells. Upon exposure to green light (525nm), TLD-1433 becomes activated locally and induces the generation of reactive oxygen species (ROS) and singlet oxygen. The release of free radicals may induce apoptosis and destroy the tumor cells. Cancer cells have many more Tf receptors than normal cells,
1 2D Structure

TLD-1433

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-methyl-2-(4-methylpyridin-2-yl)pyridine;ruthenium(2+);2-[5-(5-thiophen-2-ylthiophen-2-yl)thiophen-2-yl]-1H-imidazo[4,5-f][1,10]phenanthroline;dichloride
2.1.2 InChI
InChI=1S/C25H14N4S3.2C12H12N2.2ClH.Ru/c1-4-14-21(26-11-1)22-15(5-2-12-27-22)24-23(14)28-25(29-24)20-10-9-19(32-20)18-8-7-17(31-18)16-6-3-13-30-16;2*1-9-3-5-13-11(7-9)12-8-10(2)4-6-14-12;;;/h1-13H,(H,28,29);2*3-8H,1-2H3;2*1H;/q;;;;;+2/p-2
2.1.3 InChI Key
AVOZSOCUVHJHTQ-UHFFFAOYSA-L
2.1.4 Canonical SMILES
CC1=CC(=NC=C1)C2=NC=CC(=C2)C.CC1=CC(=NC=C1)C2=NC=CC(=C2)C.C1=CC2=C3C(=C4C=CC=NC4=C2N=C1)N=C(N3)C5=CC=C(S5)C6=CC=C(S6)C7=CC=CS7.[Cl-].[Cl-].[Ru+2]
2.2 Other Identifiers
2.2.1 UNII
L59D69SZN5
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. L59d69szn5

2. Rac-(ru(dmb)2(ip-3t))cl2

3. Tld1433

4. Tld-1433

5. 1471479-22-7

6. Unii-l59d69szn5

7. Ruthenium(2+), Bis(4,4'-dimethyl-2,2'-bipyridine-.kappa.n1,.kappa.n1')(2-(2,2':5',2''-terthiophen)-5-yl-1h-imidazo(4,5-f)(1,10)phenanthroline-.kappa.n7,.kappa.n8)-, Chloride (1:2), (oc-6-21)-

8. Ruthenium(2+), Bis(4,4'-dimethyl-2,2'-bipyridine-kappan1,kappan1')(2-(2,2':5',2''-terthiophen)-5-yl-1h-imidazo(4,5-f)(1,10)phenanthroline-kappan7,kappan8)-, Chloride (1:2), (oc-6-21)-

2.4 Create Date
2020-01-23
3 Chemical and Physical Properties
Molecular Weight 1007.1 g/mol
Molecular Formula C49H38Cl2N8RuS3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count5
Exact Mass1006.080202 g/mol
Monoisotopic Mass1006.080202 g/mol
Topological Polar Surface Area191 Ų
Heavy Atom Count63
Formal Charge0
Complexity843
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count6

ABOUT THIS PAGE

TLD-1433 Manufacturers

A TLD-1433 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TLD-1433, including repackagers and relabelers. The FDA regulates TLD-1433 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TLD-1433 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TLD-1433 Suppliers

A TLD-1433 supplier is an individual or a company that provides TLD-1433 active pharmaceutical ingredient (API) or TLD-1433 finished formulations upon request. The TLD-1433 suppliers may include TLD-1433 API manufacturers, exporters, distributors and traders.

TLD-1433 GMP

TLD-1433 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TLD-1433 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TLD-1433 GMP manufacturer or TLD-1433 GMP API supplier for your needs.

TLD-1433 CoA

A TLD-1433 CoA (Certificate of Analysis) is a formal document that attests to TLD-1433's compliance with TLD-1433 specifications and serves as a tool for batch-level quality control.

TLD-1433 CoA mostly includes findings from lab analyses of a specific batch. For each TLD-1433 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TLD-1433 may be tested according to a variety of international standards, such as European Pharmacopoeia (TLD-1433 EP), TLD-1433 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TLD-1433 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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