Find Tofogliflozin manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 903565-83-3, Csg 452, Tofogliflozin [inn], Tofogliflozin anhydrous, Csg-452, (3s,3'r,4's,5's,6'r)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1h-2-benzofuran-3,2'-oxane]-3',4',5'-triol
Molecular Formula
C22H26O6
Molecular Weight
386.4  g/mol
InChI Key
VWVKUNOPTJGDOB-BDHVOXNPSA-N
FDA UNII
554245W62T

Tofogliflozin
Tofogliflozin has been used in trials studying the treatment and prevention of Diabetes Mellitus Type 2.
1 2D Structure

Tofogliflozin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
2.1.2 InChI
InChI=1S/C22H26O6/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22/h3-8,10,18-21,23-26H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22+/m1/s1
2.1.3 InChI Key
VWVKUNOPTJGDOB-BDHVOXNPSA-N
2.1.4 Canonical SMILES
CCC1=CC=C(C=C1)CC2=CC3=C(COC34C(C(C(C(O4)CO)O)O)O)C=C2
2.1.5 Isomeric SMILES
CCC1=CC=C(C=C1)CC2=CC3=C(CO[C@@]34[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C2
2.2 Other Identifiers
2.2.1 UNII
554245W62T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3h),2'-(2h)pyran)-3',4',5'-triol

2. Apleway

3. Csg452

4. Deberza

5. Tofogliflozin Anhydrous

6. Tofogliflozin Hydrate

2.3.2 Depositor-Supplied Synonyms

1. 903565-83-3

2. Csg 452

3. Tofogliflozin [inn]

4. Tofogliflozin Anhydrous

5. Csg-452

6. (3s,3'r,4's,5's,6'r)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1h-2-benzofuran-3,2'-oxane]-3',4',5'-triol

7. R-7201

8. 903565-83-3 (free)

9. 554245w62t

10. (1s,3'r,4's,5's,6'r)-6-(4-ethylbenzyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3h-spiro[isobenzofuran-1,2'-pyran]-3',4',5'-triol

11. Spiro(isobenzofuran-1(3h),2'-(2h)pyran)-3',4',5'-triol,6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-,(1s,3'r,4's,5's,6'r)-

12. Apleway

13. Deberza

14. Tofogliflozin Anyhydrous

15. Ro4998452

16. Ro-4998452

17. Unii-554245w62t

18. Tofogliflozin [mi]

19. Ec 619-989-0

20. Schembl903156

21. Tofogliflozin [who-dd]

22. Gtpl9395

23. Chembl2110731

24. Csg452;csg-452

25. Dtxsid90238097

26. Chebi:136041

27. Bdbm50396779

28. Zinc35826342

29. Db11824

30. Compound 16d [pmid: 22889351]

31. Ncgc00485920-01

32. Ac-31468

33. Q27261271

34. (1s,3'r,4's,5's,6'r)-6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-spiro(isobenzofuran-1(3h), 2'-(2h)pyran)-3',4',5'-triol

35. (1s,3'r,4's,5's,6'r)-6-((4-ethylphenyl)methyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3h-spiro(2-benzofuran-1,2'-pyran)-3',4',5'-triol

2.4 Create Date
2010-10-11
3 Chemical and Physical Properties
Molecular Weight 386.4 g/mol
Molecular Formula C22H26O6
XLogP31.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass386.17293854 g/mol
Monoisotopic Mass386.17293854 g/mol
Topological Polar Surface Area99.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity521
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Sodium-Glucose Transporter 2 Inhibitors

Compounds that inhibit SODIUM-GLUCOSE TRANSPORTER 2. They lower blood sugar by preventing the reabsorption of glucose by the kidney and are used in the treatment of TYPE 2 DIABETES MELLITUS. (See all compounds classified as Sodium-Glucose Transporter 2 Inhibitors.)


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Looking for 903565-83-3 / Tofogliflozin API manufacturers, exporters & distributors?

Tofogliflozin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tofogliflozin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tofogliflozin manufacturer or Tofogliflozin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tofogliflozin manufacturer or Tofogliflozin supplier.

PharmaCompass also assists you with knowing the Tofogliflozin API Price utilized in the formulation of products. Tofogliflozin API Price is not always fixed or binding as the Tofogliflozin Price is obtained through a variety of data sources. The Tofogliflozin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tofogliflozin

Synonyms

903565-83-3, Csg 452, Tofogliflozin [inn], Tofogliflozin anhydrous, Csg-452, (3s,3'r,4's,5's,6'r)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1h-2-benzofuran-3,2'-oxane]-3',4',5'-triol

Cas Number

903565-83-3

Unique Ingredient Identifier (UNII)

554245W62T

About Tofogliflozin

Tofogliflozin has been used in trials studying the treatment and prevention of Diabetes Mellitus Type 2.

Tofogliflozin Manufacturers

A Tofogliflozin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tofogliflozin, including repackagers and relabelers. The FDA regulates Tofogliflozin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tofogliflozin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tofogliflozin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tofogliflozin Suppliers

A Tofogliflozin supplier is an individual or a company that provides Tofogliflozin active pharmaceutical ingredient (API) or Tofogliflozin finished formulations upon request. The Tofogliflozin suppliers may include Tofogliflozin API manufacturers, exporters, distributors and traders.

click here to find a list of Tofogliflozin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tofogliflozin GMP

Tofogliflozin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tofogliflozin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tofogliflozin GMP manufacturer or Tofogliflozin GMP API supplier for your needs.

Tofogliflozin CoA

A Tofogliflozin CoA (Certificate of Analysis) is a formal document that attests to Tofogliflozin's compliance with Tofogliflozin specifications and serves as a tool for batch-level quality control.

Tofogliflozin CoA mostly includes findings from lab analyses of a specific batch. For each Tofogliflozin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tofogliflozin may be tested according to a variety of international standards, such as European Pharmacopoeia (Tofogliflozin EP), Tofogliflozin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tofogliflozin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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