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Chemistry

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Also known as: 2398-96-1, Tinactin, Tonoftal, Tolnaphthate, Sporiline, Tinaderm
Molecular Formula
C19H17NOS
Molecular Weight
307.4  g/mol
InChI Key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
FDA UNII
06KB629TKV

Tolnaftate
A synthetic antifungal agent.
1 2D Structure

Tolnaftate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
2.1.2 InChI
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
2.1.3 InChI Key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2
2.2 Other Identifiers
2.2.1 UNII
06KB629TKV
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aftate

2. Breezee

3. Chinofungin

4. Chlorisept

5. Curatin

6. Genaspor

7. Micoisdin

8. Np 27

9. Np-27

10. Np27

11. Ony Clear

12. Ony-clear

13. Purder N, Tolnaftat

14. Sporiline

15. Tinactin

16. Tinaderm

17. Tinatox

18. Tineafax

19. Ting

20. Tolnaftat Purder N

21. Tonoftal

22. Zeasorb

2.3.2 Depositor-Supplied Synonyms

1. 2398-96-1

2. Tinactin

3. Tonoftal

4. Tolnaphthate

5. Sporiline

6. Tinaderm

7. Tolsanil

8. Aftate

9. Chinofungin

10. Dermoxin

11. Focusan

12. Tinavet

13. Pitrex

14. Naphthiomate T

15. Phytoderm

16. Timoped

17. Tritin

18. Hi-alazin

19. Fungistop

20. Tolnaftato

21. Tolnaftatum

22. Separin

23. Sorgoa

24. Sch 10144

25. O-2-naphthyl M,n-dimethylthiocarbanilate

26. Dungistop

27. Tniaderm

28. Naphthiomate-t

29. Hi-alarzin

30. 2-naphthyl N-methyl-n-(3-tolyl)thionocarbamate

31. M,n-dimethylthiocarbanilic Acid O-2-naphthyl Ester

32. O-naphthalen-2-yl N-methyl-n-(3-methylphenyl)carbamothioate

33. Prestwick_472

34. Dr. Scholl's Athlete's Foot Spray

35. Methyl (3-methylphenyl)carbamothioic Acid O-2-naphthalenyl Ester

36. Carbamothioic Acid, Methyl(3-methylphenyl)-, O-2-naphthalenyl Ester

37. Carbanilic Acid, M,n-dimethylthio-, O-2-naphthyl Ester

38. Carbanilic Acid, N,m-dimethylthio-, O-2-naphthyl Ester

39. Nsc 233648

40. Mls000028526

41. N-methyl-n-(3-methylphenyl)-1-naphthalen-2-yloxy-methanethioamide

42. O-naphthalen-2-yl N-methyl-n-(3-methylphenyl)thiocarbamate

43. Nsc-233648

44. Smr000058288

45. 06kb629tkv

46. Chebi:9620

47. Tolnaftato [dcit]

48. O-naphthalen-2-yl Methyl(m-tolyl)carbamothioate

49. O-2-naphthyl Methyl(3-methylphenyl)carbamothioate

50. Sch-10144

51. Tolnaftatum [inn-latin]

52. Ncgc00016610-01

53. Tolnaftato [inn-spanish]

54. Tinavet (veterinary)

55. Genaspore Cream

56. Tinactin Powder

57. Cas-2398-96-1

58. Tinactin Cream

59. Pitrex Cream

60. N-methyl-n-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide

61. Ting Products

62. Tinactin Solution

63. Carbamothioic Acid, N-methyl-n-(3-methylphenyl)-, O-2-naphthalenyl Ester

64. Dsstox_cid_22477

65. Dsstox_rid_80034

66. Zeasorb-af Powder

67. Dsstox_gsid_42477

68. Tinactin (tn)

69. Separin (tn)

70. Np-27 Solution

71. Tinactin Plus Powder

72. Ting Antifungal Cream

73. Np-27 Powder

74. Ting Antifungal Powder

75. Np-27 Cream

76. Tinactin Aerosol Liquid

77. Tinactin Aerosol Powder

78. Np-27 Spray Powder

79. Tinactin Jock Itch Cream

80. Aftate For Jock Itch Gel

81. Tinactin Plus Aerosol Powder

82. Ting Antifungal Spray Liquid

83. Ting Antifungal Spray Powder

84. Aftate For Athlete's Foot Gel

85. Tolnafrate

86. Tinactin Jock Itch Spray Powder

87. Tinactin Jock Itch Aerosol Powder

88. Sr-01000003084

89. Aftate For Jock Itch Sprinkle Powder

90. Einecs 219-266-6

91. Brn 2752620

92. Tolnoftate

93. Unii-06kb629tkv

94. Tolnaflate

95. O-2-naphthyl N,n-dimethylthiocarbanilate

96. Aftate For Jock Itch Aerosol Spray Powder

97. Tinactin Antifungal Deodorant Powder Aerosol

98. Methyl-(3-methylphenyl)carbamothioic Acid O-2-naphthyl Ester

99. Tolnaftate-10kg

100. Carbamothiolic Acid

101. O-2-naphthyl Methyl(3-methylphenyl)thiocarbamate

102. Mfcd00056611

103. O-naphthalen-2-yl Methyl(3-methylphenyl)carbamothioate

104. Tolnaftate [usan:usp:inn:ban:jan]

105. Spectrum_000963

106. N-dimethylthiocarbanilate

107. Tolnaftate [mi]

108. Tolnaftate [inn]

109. Tolnaftate [jan]

110. Opera_id_1698

111. Prestwick0_000070

112. Prestwick1_000070

113. Prestwick2_000070

114. Prestwick3_000070

115. Spectrum2_000950

116. Spectrum4_000360

117. Spectrum5_001000

118. Tolnaftate [inci]

119. Tolnaftate [usan]

120. Tolnaftate [vandf]

121. Cid_5510

122. Schembl3520

123. Tolnaftate [mart.]

124. Tolnaftate [usp-rs]

125. Tolnaftate [who-dd]

126. Bspbio_000259

127. Kbiogr_000799

128. Kbioss_001443

129. Mls001146910

130. O-(2-naphthyl) N-methyl-n-(m-tolyl)carbamothioate

131. Chembl83668

132. Divk1c_000334

133. Spectrum1500583

134. Spbio_000920

135. Spbio_002180

136. Bpbio1_000285

137. Tolnaftate (jp17/usp/inn)

138. Tolnaftate [green Book]

139. Dtxsid3042477

140. Bdbm39349

141. Hms501a16

142. Kbio1_000334

143. Kbio2_001443

144. Kbio2_004011

145. Kbio2_006579

146. Tolnaftate For System Suitability

147. Zinc57522

148. Tolnaftate [ep Monograph]

149. Ninds_000334

150. Hms1568m21

151. Hms1921e21

152. Hms2092o05

153. Hms2095m21

154. Hms2231o21

155. Hms3373p10

156. Hms3655d15

157. Hms3712m21

158. Pharmakon1600-01500583

159. Tolnaftate [usp Monograph]

160. Amy23403

161. Bcp12071

162. Hy-b0370

163. Tox21_110521

164. Tox21_301363

165. N-methyl-(3-methylphenyl)-carbamothioic Acid, O-2-naphthalenyl Ester

166. Nsc233648

167. Nsc757355

168. S2058

169. Stl069548

170. Akos005111014

171. Tox21_110521_1

172. Ac-5548

173. Ccg-212827

174. Db00525

175. Ks-5115

176. Nsc-757355

177. Idi1_000334

178. Ncgc00016610-02

179. Ncgc00016610-03

180. Ncgc00016610-04

181. Ncgc00016610-05

182. Ncgc00016610-07

183. Ncgc00016610-08

184. Ncgc00023506-03

185. Ncgc00255761-01

186. Carbamothioic Acid, O-2-naphthalenyl Ester

187. Sbi-0051538.p002

188. Db-046313

189. Ab00052111

190. Ft-0603605

191. Sw196682-3

192. T3059

193. D00381

194. H10435

195. O-naphthalen-2-ylmethyl(m-tolyl)carbamothioate

196. Ab00052111_17

197. Ab00052111_18

198. 398t961

199. A817026

200. O-(naphthalen-2-yl) Methyl(m-tolyl)carbamothioate

201. Q415238

202. Carbanilic Acid,m-dimethylthio-, O-2-naphthyl Ester

203. Carbanilic Acid,n-dimethylthio-, O-2-naphthyl Ester

204. Sr-01000003084-2

205. Sr-01000003084-4

206. W-107363

207. Brd-k44273375-001-04-5

208. Brd-k44273375-001-14-4

209. Brd-k44273375-001-23-5

210. O-(2-naphthyl) Methyl(3-methylphenyl)thiocarbamate #

211. Methyl(3-methylphenyl)carbamothioic Acid O-2-naphthyl Ester

212. N-methyl-n-(m-tolyl)thiocarbamic Acid O-(2-naphthyl) Ester

213. Tolnaftate, European Pharmacopoeia (ep) Reference Standard

214. Tolnaftate, United States Pharmacopeia (usp) Reference Standard

215. Methyl-[3-methyl-2-(2-naphthyl)phenyl]carbamothioic S-acid;tolnaftate

216. N-methyl-n-(3-methylphenyl)carbamothioic Acid O-(2-naphthalenyl) Ester

217. Tolnaftate, Pharmaceutical Secondary Standard; Certified Reference Material

218. Tinactin Pound>>tinaderm Pound>>aftate Pound>>np-27 Pound>>np 27 Pound>> Np27

219. Tolnaftate For System Suitability, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 307.4 g/mol
Molecular Formula C19H17NOS
XLogP35.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass307.10308534 g/mol
Monoisotopic Mass307.10308534 g/mol
Topological Polar Surface Area44.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Tolnaftate is a synthetic over-the-counter anti-fungal agent.


5.2 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Pharmacological Classes
Azoles [CS]; Azole Antifungal [EPC]
5.4 ATC Code

D - Dermatologicals

D01 - Antifungals for dermatological use

D01A - Antifungals for topical use

D01AE - Other antifungals for topical use

D01AE18 - Tolnaftate


5.5 Mechanism of Action

Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.


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08-Jan-2021
29-Nov-2024
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ABOUT THIS PAGE

Tolnaftate Manufacturers

A Tolnaftate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tolnaftate, including repackagers and relabelers. The FDA regulates Tolnaftate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tolnaftate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tolnaftate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tolnaftate Suppliers

A Tolnaftate supplier is an individual or a company that provides Tolnaftate active pharmaceutical ingredient (API) or Tolnaftate finished formulations upon request. The Tolnaftate suppliers may include Tolnaftate API manufacturers, exporters, distributors and traders.

click here to find a list of Tolnaftate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tolnaftate USDMF

A Tolnaftate DMF (Drug Master File) is a document detailing the whole manufacturing process of Tolnaftate active pharmaceutical ingredient (API) in detail. Different forms of Tolnaftate DMFs exist exist since differing nations have different regulations, such as Tolnaftate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tolnaftate DMF submitted to regulatory agencies in the US is known as a USDMF. Tolnaftate USDMF includes data on Tolnaftate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tolnaftate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tolnaftate suppliers with USDMF on PharmaCompass.

Tolnaftate JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Tolnaftate Drug Master File in Japan (Tolnaftate JDMF) empowers Tolnaftate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Tolnaftate JDMF during the approval evaluation for pharmaceutical products. At the time of Tolnaftate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Tolnaftate suppliers with JDMF on PharmaCompass.

Tolnaftate CEP

A Tolnaftate CEP of the European Pharmacopoeia monograph is often referred to as a Tolnaftate Certificate of Suitability (COS). The purpose of a Tolnaftate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Tolnaftate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Tolnaftate to their clients by showing that a Tolnaftate CEP has been issued for it. The manufacturer submits a Tolnaftate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Tolnaftate CEP holder for the record. Additionally, the data presented in the Tolnaftate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Tolnaftate DMF.

A Tolnaftate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Tolnaftate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Tolnaftate suppliers with CEP (COS) on PharmaCompass.

Tolnaftate WC

A Tolnaftate written confirmation (Tolnaftate WC) is an official document issued by a regulatory agency to a Tolnaftate manufacturer, verifying that the manufacturing facility of a Tolnaftate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Tolnaftate APIs or Tolnaftate finished pharmaceutical products to another nation, regulatory agencies frequently require a Tolnaftate WC (written confirmation) as part of the regulatory process.

click here to find a list of Tolnaftate suppliers with Written Confirmation (WC) on PharmaCompass.

Tolnaftate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Tolnaftate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Tolnaftate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Tolnaftate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Tolnaftate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Tolnaftate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Tolnaftate suppliers with NDC on PharmaCompass.

Tolnaftate GMP

Tolnaftate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tolnaftate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tolnaftate GMP manufacturer or Tolnaftate GMP API supplier for your needs.

Tolnaftate CoA

A Tolnaftate CoA (Certificate of Analysis) is a formal document that attests to Tolnaftate's compliance with Tolnaftate specifications and serves as a tool for batch-level quality control.

Tolnaftate CoA mostly includes findings from lab analyses of a specific batch. For each Tolnaftate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tolnaftate may be tested according to a variety of international standards, such as European Pharmacopoeia (Tolnaftate EP), Tolnaftate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tolnaftate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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