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Chemistry

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Also known as: Eft508, 1849590-01-7, Eft-508, Tomivosertib [inn], Tomivosertib [usan], Eft 508
Molecular Formula
C17H20N6O2
Molecular Weight
340.4  g/mol
InChI Key
HKTBYUWLRDZAJK-UHFFFAOYSA-N
FDA UNII
U2H19X4WBV

Tomivosertib
Tomivosertib is an orally bioavailable inhibitor of mitogen-activated protein kinase (MAPK)-interacting serine/threonine-protein kinase 1 (MNK1) and 2 (MNK2), with potential antineoplastic activity. Upon oral administration, tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling. This inhibits tumor cell proliferation in MNK1/2-overexpressing tumor cells. MNK1/2 are overexpressed in a variety of tumor cell types and promote phosphorylation of eIF4E; eIF4E is overexpressed in many tumor cell types and contributes to tumor development, maintenance and resistance.
1 2D Structure

Tomivosertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
2.1.2 InChI
InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21)
2.1.3 InChI Key
HKTBYUWLRDZAJK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C2C(=O)NC3(N2C(=O)C(=C1)NC4=NC=NC(=C4)N)CCCCC3
2.2 Other Identifiers
2.2.1 UNII
U2H19X4WBV
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6'-((6-amino-4-pyrimidinyl)amino)-8'-methyl-2'h-spiro(cyclohexane-1,3'-imidazo(1,5-a)pyridine)-1',5'-dione

2. Eft508

3. Spiro(cyclohexane-1,3'(2'h)-imidazo(1,5-a)pyridine)-1',5'-dione, 6'-((6-amino-4-pyrimidinyl)amino)-8'-methyl-

2.3.2 Depositor-Supplied Synonyms

1. Eft508

2. 1849590-01-7

3. Eft-508

4. Tomivosertib [inn]

5. Tomivosertib [usan]

6. Eft 508

7. U2h19x4wbv

8. Chembl4073443

9. 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'h-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'h)-dione

10. 6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2h-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione

11. Eft508 Hcl

12. 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2'h-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione

13. Spiro(cyclohexane-1,3'(2'h)-imidazo(1,5-a)pyridine)-1',5'-dione, 6'-((6-amino-4-pyrimidinyl)amino)-8'-methyl-

14. Eft508; Tomivosertib

15. Tomivosertib (usan/inn)

16. Tomivosertib [usan:inn]

17. Eft-508 Hcl

18. Unii-u2h19x4wbv

19. Tomivosertib [who-dd]

20. Schembl17362622

21. Gtpl10167

22. Eft-508 (eft508)

23. Dtxsid601022534

24. Bcp18993

25. Ex-a2494

26. Bdbm50263263

27. Nsc791783

28. Nsc791784

29. Nsc804952

30. Zinc575623807

31. Ccg-267922

32. Cs-5841

33. Db15219

34. Nsc-791783

35. Nsc-791784

36. Nsc-804952

37. Compound 23 [pmid: 29526098]

38. Ncgc00492296-03

39. Ac-35882

40. Be168437

41. Bs-16162

42. Hy-100022

43. S8275

44. D11452

45. D71143

46. A902706

47. 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-2'hspiro(cyclohexane-1,3'-imidazo(1,5-a)pyridine)-1',5'-dione

48. N45

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 340.4 g/mol
Molecular Formula C17H20N6O2
XLogP31.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass340.16477390 g/mol
Monoisotopic Mass340.16477390 g/mol
Topological Polar Surface Area113 Ų
Heavy Atom Count25
Formal Charge0
Complexity664
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1849590-01-7 / Tomivosertib API manufacturers, exporters & distributors?

Tomivosertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tomivosertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tomivosertib manufacturer or Tomivosertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tomivosertib manufacturer or Tomivosertib supplier.

PharmaCompass also assists you with knowing the Tomivosertib API Price utilized in the formulation of products. Tomivosertib API Price is not always fixed or binding as the Tomivosertib Price is obtained through a variety of data sources. The Tomivosertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tomivosertib

Synonyms

Eft508, 1849590-01-7, Eft-508, Tomivosertib [inn], Tomivosertib [usan], Eft 508

Cas Number

1849590-01-7

Unique Ingredient Identifier (UNII)

U2H19X4WBV

About Tomivosertib

Tomivosertib is an orally bioavailable inhibitor of mitogen-activated protein kinase (MAPK)-interacting serine/threonine-protein kinase 1 (MNK1) and 2 (MNK2), with potential antineoplastic activity. Upon oral administration, tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling. This inhibits tumor cell proliferation in MNK1/2-overexpressing tumor cells. MNK1/2 are overexpressed in a variety of tumor cell types and promote phosphorylation of eIF4E; eIF4E is overexpressed in many tumor cell types and contributes to tumor development, maintenance and resistance.

Tomivosertib Manufacturers

A Tomivosertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tomivosertib, including repackagers and relabelers. The FDA regulates Tomivosertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tomivosertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tomivosertib Suppliers

A Tomivosertib supplier is an individual or a company that provides Tomivosertib active pharmaceutical ingredient (API) or Tomivosertib finished formulations upon request. The Tomivosertib suppliers may include Tomivosertib API manufacturers, exporters, distributors and traders.

Tomivosertib GMP

Tomivosertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tomivosertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tomivosertib GMP manufacturer or Tomivosertib GMP API supplier for your needs.

Tomivosertib CoA

A Tomivosertib CoA (Certificate of Analysis) is a formal document that attests to Tomivosertib's compliance with Tomivosertib specifications and serves as a tool for batch-level quality control.

Tomivosertib CoA mostly includes findings from lab analyses of a specific batch. For each Tomivosertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tomivosertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Tomivosertib EP), Tomivosertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tomivosertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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