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1. 2-(2-(hydroxy(hydroxycarbamoyl)methyl)-4-methylpentanoylamino)-2-phenylethanoic Acid Cyclopentyl Ester
2. Chr 2797
3. Chr-2797
4. Chr2797
1. 238750-77-1
2. Chr 2797
3. Chr-2797
4. Tosedostat (chr2797)
5. Kzk563j2uw
6. Unii-kzk563j2uw
7. (s)-cyclopentyl 2-((r)-2-((s)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate
8. Cyclopentyl (s)-2-((r)-2-((s)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate
9. Tosedostat [inn]
10. Tosedostat [usan:inn]
11. Bb-76163
12. Tosedostat (usan/inn)
13. Tosedostat [usan]
14. Chr-2797(tosedostat)
15. Chr-2797; Tosedostat
16. Chr2797 - Tosedostat
17. Tosedostat [who-dd]
18. Mls006011104
19. Chembl2103847
20. Schembl19236550
21. Chebi:95044
22. Dtxsid60178577
23. Bcpp000283
24. Hms3414a15
25. Hms3678a15
26. Cyclopentyl (2s)-2-[[(2r)-2-[(1s)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate
27. Ex-a2628
28. Bdbm50277143
29. Nsc806020
30. Zinc13914293
31. Akos024457707
32. At25061
33. Bcp9000524
34. Db11781
35. Nsc-806020
36. Ncgc00263175-01
37. Ac-35830
38. As-55983
39. Hy-14807
40. Smr004676647
41. Cs-0003570
42. D10026
43. 750t771
44. A857789
45. Brd-k92241597-001-01-1
46. Q27166812
47. Alpha-[[(2r)-2-[(1s)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]benzeneacetic Acid Cyclopentyl Ester
48. Benzeneacetic Acid, .alpha.-(((2r)-2-((1s)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4- Methyl-1-oxopenty)lamino)-, Cyclopentyl Ester, (.alpha.s)-
49. Benzeneacetic Acid, Alpha-(((2r)-2-((1s)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)amino)-, Cyclopentyl Ester, (alphas)-
50. Cyclopentyl (2s)-2-((2r)-2-((1s)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4- Methylpentanamido)-2-phenylacetate
| Molecular Weight | 406.5 g/mol |
|---|---|
| Molecular Formula | C21H30N2O6 |
| XLogP3 | 2.3 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 10 |
| Exact Mass | 406.21038668 g/mol |
| Monoisotopic Mass | 406.21038668 g/mol |
| Topological Polar Surface Area | 125 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 555 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Tosedostat has pleiotropic effects against a range of human tumor cell lines originating from diverse tumor types in vitro and in vivo.
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Tosedostat is anti-proliferative agent which induces apoptosis in leukemic cell lines in vitro. The mechanism underlying these anti-cancer actions is unclear, particularly since normal cells are much less sensitive to the agents than transformed cells. It exerts potent anti-proliferative, pro-apoptotic and anti-angiogenic effects in vitro and shows selectivity for transformed over non-transformed cells. It inhibits a number of M1 aminopeptidase enzyme family members in vitro (eg puromycin-sensitive aminopeptidase (PSA), leukotriene A4 hydrolase (LTA4H)).
ABOUT THIS PAGE
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PharmaCompass offers a list of Tosedostat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tosedostat manufacturer or Tosedostat supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tosedostat manufacturer or Tosedostat supplier.
PharmaCompass also assists you with knowing the Tosedostat API Price utilized in the formulation of products. Tosedostat API Price is not always fixed or binding as the Tosedostat Price is obtained through a variety of data sources. The Tosedostat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Tosedostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tosedostat, including repackagers and relabelers. The FDA regulates Tosedostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tosedostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Tosedostat supplier is an individual or a company that provides Tosedostat active pharmaceutical ingredient (API) or Tosedostat finished formulations upon request. The Tosedostat suppliers may include Tosedostat API manufacturers, exporters, distributors and traders.
Tosedostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Tosedostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tosedostat GMP manufacturer or Tosedostat GMP API supplier for your needs.
A Tosedostat CoA (Certificate of Analysis) is a formal document that attests to Tosedostat's compliance with Tosedostat specifications and serves as a tool for batch-level quality control.
Tosedostat CoA mostly includes findings from lab analyses of a specific batch. For each Tosedostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Tosedostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Tosedostat EP), Tosedostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tosedostat USP).
