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Chemistry

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Also known as: 2062661-53-2, Imr-687, Tovinontrine [usan], Ck1598, Af68722, W248y1akor
Molecular Formula
C21H26N6O2
Molecular Weight
394.5  g/mol
InChI Key
GWGNPYYVGANHRJ-GDBMZVCRSA-N
FDA UNII
W248Y1AKOR

Tovinontrine
IMR-687 is under investigation in clinical trial NCT04474314 (A Study of IMR-687 in Subjects With Sickle Cell Disease).
1 2D Structure

Tovinontrine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-(oxan-4-yl)-7H-imidazo[1,5-a]pyrazin-8-one
2.1.2 InChI
InChI=1S/C21H26N6O2/c1-14-10-26(13-19-22-5-2-6-23-19)11-16(14)17-12-27-18(21(28)25-17)9-24-20(27)15-3-7-29-8-4-15/h2,5-6,9,12,14-16H,3-4,7-8,10-11,13H2,1H3,(H,25,28)/t14-,16-/m1/s1
2.1.3 InChI Key
GWGNPYYVGANHRJ-GDBMZVCRSA-N
2.1.4 Canonical SMILES
CC1CN(CC1C2=CN3C(=CN=C3C4CCOCC4)C(=O)N2)CC5=NC=CC=N5
2.1.5 Isomeric SMILES
C[C@@H]1CN(C[C@H]1C2=CN3C(=CN=C3C4CCOCC4)C(=O)N2)CC5=NC=CC=N5
2.2 Other Identifiers
2.2.1 UNII
W248Y1AKOR
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 2062661-53-2

2. Imr-687

3. Tovinontrine [usan]

4. Ck1598

5. Af68722

6. W248y1akor

7. Imr687

8. Ck-1598

9. Af-68722

10. 6-((3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-tetrahydropyran-4-yl-7himidazo(1,5-a)pyrazin-8-one

11. Imidazo(1,5-a)pyrazin-8(7h)-one, 6-((3s,4s)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl)-3-(tetrahydro-2h-pyran-4-yl)-

12. Tovinontrine [inn]

13. Unii-w248y1akor

14. Tovinontrine [who-dd]

15. Chembl4297290

16. Schembl20358493

17. Bdbm426313

18. Ex-a5357

19. Us10513524, Compound (p3

20. Who 11327

21. Hy-109193

22. Cs-0119133

23. 6-((3s,4s)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl)-3-(tetrahydro-2h-pyran-4-yl)imidazo(1,5-a)pyrazin-8(7h)-one

24. 6-[(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-(oxan-4-yl)-7h-imidazo[1,5-a]pyrazin-8-one

2.4 Create Date
2017-03-16
3 Chemical and Physical Properties
Molecular Weight 394.5 g/mol
Molecular Formula C21H26N6O2
XLogP30.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass394.21172409 g/mol
Monoisotopic Mass394.21172409 g/mol
Topological Polar Surface Area85.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity631
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Tovinontrine Manufacturers

A Tovinontrine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tovinontrine, including repackagers and relabelers. The FDA regulates Tovinontrine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tovinontrine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tovinontrine Suppliers

A Tovinontrine supplier is an individual or a company that provides Tovinontrine active pharmaceutical ingredient (API) or Tovinontrine finished formulations upon request. The Tovinontrine suppliers may include Tovinontrine API manufacturers, exporters, distributors and traders.

Tovinontrine GMP

Tovinontrine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tovinontrine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tovinontrine GMP manufacturer or Tovinontrine GMP API supplier for your needs.

Tovinontrine CoA

A Tovinontrine CoA (Certificate of Analysis) is a formal document that attests to Tovinontrine's compliance with Tovinontrine specifications and serves as a tool for batch-level quality control.

Tovinontrine CoA mostly includes findings from lab analyses of a specific batch. For each Tovinontrine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tovinontrine may be tested according to a variety of international standards, such as European Pharmacopoeia (Tovinontrine EP), Tovinontrine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tovinontrine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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