Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 Listed Suppliers

1 API Suppliers
1 Listed Suppliers

DEVELOPMENTS

25 Drugs in Development

25 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 2 FDA Orange Book

2 FDF Dossiers
2 FDA Orange Book

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 1 STOCK RECAP #PipelineProspector, 16 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
1 STOCK RECAP #PipelineProspector
16 NEWS #PharmaBuzz

PATENTS & EXCLUSIVITIES

4 US Patents, 4 US Exclusivities

patents
4 US Patents
4 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 1096708-71-2, Mln2480, Biib-024, Tak-580, Mln 2480, Mln-2480

Molecular Formula

C₁₇H₁₂Cl₂F₃N₇O₂S

Molecular Weight

506.3 g/mol

InChI Key

VWMJHAFYPMOMGF-ZCFIWIBFSA-N

FDA UNII

ZN90E4027M

Tovorafenib is an orally available inhibitor of wild-type and certain mutant forms of A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, tovorafenib inhibits Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor cell growth. Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated in human cancers and plays a key role in tumor cell proliferation and survival.

1 2D Structure

Tovorafenib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide

2.1.2 InChI

InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1

2.1.3 InChI Key

VWMJHAFYPMOMGF-ZCFIWIBFSA-N

2.1.4 Canonical SMILES

CC(C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=C(C(=NC=N3)N)Cl

2.1.5 Isomeric SMILES

C[C@H](C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=C(C(=NC=N3)N)Cl

2.2 Other Identifiers

2.2.1 UNII

ZN90E4027M

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-((1r)-1-((6-amino-5-chloropyrimidine-4-carbonyl)amino)ethyl)-n-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-1,3-thiazole-5-carboxamide

2. Mln 2480

3. Mln2480

4. Tak-580

2.3.2 Depositor-Supplied Synonyms

1. 1096708-71-2

2. Mln2480

3. Biib-024

4. Tak-580

5. Mln 2480

6. Mln-2480

7. Biib024

8. Tovorafenib

9. Biib 024

10. Day101

11. Tovorafenib [usan]

12. Tak-580 (mln2480)

13. Tak 580

14. Amg 2112819

15. Tak580

16. Zn90e4027m

17. 2-[(1r)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-n-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide

18. 6-amino-5-chloro-n-((1r)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-4-pyrimidinecarboxamide

19. 6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide

20. 4-pyrimidinecarboxamide, 6-amino-5-chloro-n-[(1r)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-

21. Unii-zn90e4027m

22. 4-pyrimidinecarboxamide, 6-amino-5-chloro-n-((1r)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl]-

23. 6-amino-5-chloro-n-[(1r)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide

24. Qop

25. Tovorafenib [inn]

26. Gtpl9977

27. Schembl4206123

28. Chembl3348923

29. Tak 580 [who-dd]

30. Day-101

31. Dtxsid70149011

32. Ex-a940

33. Chebi:167672

34. 4-pyrimidinecarboxamide, 6-amino-5-chloro-n-((1r)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-

35. Bcp13797

36. Mfcd22571730

37. Nsc766906

38. Nsc800798

39. S7121

40. Who 11985

41. Zinc43202464

42. Mln 2480(biib-024)

43. Akos027323782

44. Amg2112819

45. Ccg-269746

46. Cs-0751

47. Db15266

48. Nsc-766906

49. Nsc-800798

50. Amg-2112819

51. Ncgc00346458-01

52. Ncgc00346458-02

53. Example 10da [us20090036419]

54. Hy-15246

55. P13369

56. J-690031

57. Q27295775

58. (2z,3z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile - Ethanol (1:1)

2.4 Create Date

2009-02-23

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₁₂Cl₂F₃N₇O₂S
Molecular Weight	506.3 g/mol
XLogP3	3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	5
Exact Mass	505.0102337 g/mol
Monoisotopic Mass	505.0102337 g/mol
Topological Polar Surface Area	164 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	695
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1