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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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CEP/COS

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KDMF

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NDC API

NDC API

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VMF

NDC API

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API REF. PRICE (USD/KG)

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Chemistry

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Also known as: 1096708-71-2, Mln2480, Biib-024, Tak-580, Mln 2480, Mln-2480
Molecular Formula
C17H12Cl2F3N7O2S
Molecular Weight
506.3  g/mol
InChI Key
VWMJHAFYPMOMGF-ZCFIWIBFSA-N
FDA UNII
ZN90E4027M

Tovorafenib
Tovorafenib is an orally available inhibitor of wild-type and certain mutant forms of A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, tovorafenib inhibits Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor cell growth. Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated in human cancers and plays a key role in tumor cell proliferation and survival.
1 2D Structure

Tovorafenib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide
2.1.2 InChI
InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1
2.1.3 InChI Key
VWMJHAFYPMOMGF-ZCFIWIBFSA-N
2.1.4 Canonical SMILES
CC(C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=C(C(=NC=N3)N)Cl
2.1.5 Isomeric SMILES
C[C@H](C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=C(C(=NC=N3)N)Cl
2.2 Other Identifiers
2.2.1 UNII
ZN90E4027M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-((1r)-1-((6-amino-5-chloropyrimidine-4-carbonyl)amino)ethyl)-n-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-1,3-thiazole-5-carboxamide

2. Mln 2480

3. Mln2480

4. Tak-580

2.3.2 Depositor-Supplied Synonyms

1. 1096708-71-2

2. Mln2480

3. Biib-024

4. Tak-580

5. Mln 2480

6. Mln-2480

7. Biib024

8. Tovorafenib

9. Biib 024

10. Day101

11. Tovorafenib [usan]

12. Tak-580 (mln2480)

13. Tak 580

14. Amg 2112819

15. Tak580

16. Zn90e4027m

17. 2-[(1r)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-n-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide

18. 6-amino-5-chloro-n-((1r)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-4-pyrimidinecarboxamide

19. 6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide

20. 4-pyrimidinecarboxamide, 6-amino-5-chloro-n-[(1r)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-

21. Unii-zn90e4027m

22. 4-pyrimidinecarboxamide, 6-amino-5-chloro-n-((1r)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl]-

23. 6-amino-5-chloro-n-[(1r)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide

24. Qop

25. Tovorafenib [inn]

26. Gtpl9977

27. Schembl4206123

28. Chembl3348923

29. Tak 580 [who-dd]

30. Day-101

31. Dtxsid70149011

32. Ex-a940

33. Chebi:167672

34. 4-pyrimidinecarboxamide, 6-amino-5-chloro-n-((1r)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-

35. Bcp13797

36. Mfcd22571730

37. Nsc766906

38. Nsc800798

39. S7121

40. Who 11985

41. Zinc43202464

42. Mln 2480(biib-024)

43. Akos027323782

44. Amg2112819

45. Ccg-269746

46. Cs-0751

47. Db15266

48. Nsc-766906

49. Nsc-800798

50. Amg-2112819

51. Ncgc00346458-01

52. Ncgc00346458-02

53. Example 10da [us20090036419]

54. Hy-15246

55. P13369

56. J-690031

57. Q27295775

58. (2z,3z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile - Ethanol (1:1)

2.4 Create Date
2009-02-23
3 Chemical and Physical Properties
Molecular Weight 506.3 g/mol
Molecular Formula C17H12Cl2F3N7O2S
XLogP33
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count5
Exact Mass505.0102337 g/mol
Monoisotopic Mass505.0102337 g/mol
Topological Polar Surface Area164 Ų
Heavy Atom Count32
Formal Charge0
Complexity695
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

INTERMEDIATE SUPPLIERS

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01

SCI Pharmtech

Taiwan
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSCI Pharmtech offers high-quality, cost-effective APIs, advanced intermediates, & custom products with global expertise and precision.

CAS Number : 91-00-9

End Use API : Tovorafenib

About The Company : SCI Pharmtech Inc. offers APIs, advanced intermediates, and custom products, focusing on quick development and cost-effective production. Our research labs, pil...

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02

LinkChem

China
The Generic Rx Session
Not Confirmed
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LinkChem

China
The Generic Rx Session
Not Confirmed
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CAS Number : 4066-41-5

End Use API : Tovorafenib

About The Company : LinkChem is a leading China headquartered CMO | CRO provider within the pharmaceutical industry. Our core focus includes: custom synthesis, process development,...

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ABOUT THIS PAGE

Looking for 1096708-71-2 / Tovorafenib API manufacturers, exporters & distributors?

Tovorafenib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tovorafenib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tovorafenib manufacturer or Tovorafenib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tovorafenib manufacturer or Tovorafenib supplier.

PharmaCompass also assists you with knowing the Tovorafenib API Price utilized in the formulation of products. Tovorafenib API Price is not always fixed or binding as the Tovorafenib Price is obtained through a variety of data sources. The Tovorafenib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tovorafenib

Synonyms

1096708-71-2, Mln2480, Biib-024, Tak-580, Mln 2480, Mln-2480

Cas Number

1096708-71-2

Unique Ingredient Identifier (UNII)

ZN90E4027M

About Tovorafenib

Tovorafenib is an orally available inhibitor of wild-type and certain mutant forms of A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, tovorafenib inhibits Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor cell growth. Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated in human cancers and plays a key role in tumor cell proliferation and survival.

Tovorafenib Manufacturers

A Tovorafenib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tovorafenib, including repackagers and relabelers. The FDA regulates Tovorafenib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tovorafenib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tovorafenib Suppliers

A Tovorafenib supplier is an individual or a company that provides Tovorafenib active pharmaceutical ingredient (API) or Tovorafenib finished formulations upon request. The Tovorafenib suppliers may include Tovorafenib API manufacturers, exporters, distributors and traders.

Tovorafenib GMP

Tovorafenib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tovorafenib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tovorafenib GMP manufacturer or Tovorafenib GMP API supplier for your needs.

Tovorafenib CoA

A Tovorafenib CoA (Certificate of Analysis) is a formal document that attests to Tovorafenib's compliance with Tovorafenib specifications and serves as a tool for batch-level quality control.

Tovorafenib CoA mostly includes findings from lab analyses of a specific batch. For each Tovorafenib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tovorafenib may be tested according to a variety of international standards, such as European Pharmacopoeia (Tovorafenib EP), Tovorafenib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tovorafenib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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