Find TP-3654 manufacturers, exporters & distributors on PharmaCompass

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Synopsis

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Chemistry

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Also known as: Tp-3654, 1361951-15-6, Tp3654, Sgi-9481, Eob0n7boy4, 2-(4-((3-(3-(trifluoromethyl)phenyl)imidazo(1,2-b)pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
Molecular Formula
C22H25F3N4O
Molecular Weight
418.5  g/mol
InChI Key
XRNVABDYQLHODA-UHFFFAOYSA-N
FDA UNII
EOB0N7BOY4

TP-3654
PIM Kinase Inhibitor TP-3654 is an orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, PIM kinase inhibitor TP-3654 selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival.
1 2D Structure

TP-3654

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexyl]propan-2-ol
2.1.2 InChI
InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)
2.1.3 InChI Key
XRNVABDYQLHODA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O
2.2 Other Identifiers
2.2.1 UNII
EOB0N7BOY4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Tp 3654

2. Tp3654

3. Vasoactive Intestinal Peptide-aba-gly-gly-ala-gly

4. Vip-aba-gly-gly-(d)-ala-gly

5. Vip-aminobutyric Acid-glycyl-glycyl-(d)-alanyl-glycine

2.3.2 Depositor-Supplied Synonyms

1. Tp-3654

2. 1361951-15-6

3. Tp3654

4. Sgi-9481

5. Eob0n7boy4

6. 2-(4-((3-(3-(trifluoromethyl)phenyl)imidazo(1,2-b)pyridazin-6-yl)amino)cyclohexyl)propan-2-ol

7. 4-((3-(3-(trifluoromethyl)phenyl)imidazo(1,2-b)pyridazin-6-yl)amino) -trans-cyclohexyl)propan-2-ol

8. 2-[4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexyl]propan-2-ol

9. Unii-eob0n7boy4

10. Schembl102560

11. Chembl3975308

12. Schembl19986953

13. Schembl20794171

14. Schembl22421478

15. Bdbm242374

16. Bcp30070

17. Ex-a1828

18. Nsc805149

19. Akos032960444

20. Cs-6293

21. Nsc-805149

22. Sb17245

23. Tp 3654

24. Ncgc00511354-02

25. Tp3654; Tp 3654

26. Ac-36196

27. Bs-15262

28. Hy-101126

29. S6774

30. C72454

31. A857573

32. Us9416132, 8-31

2.4 Create Date
2012-11-30
3 Chemical and Physical Properties
Molecular Weight 418.5 g/mol
Molecular Formula C22H25F3N4O
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass418.19804592 g/mol
Monoisotopic Mass418.19804592 g/mol
Topological Polar Surface Area62.4 Ų
Heavy Atom Count30
Formal Charge0
Complexity579
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

TP 3654 Manufacturers

A TP 3654 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TP 3654, including repackagers and relabelers. The FDA regulates TP 3654 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TP 3654 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TP 3654 Suppliers

A TP 3654 supplier is an individual or a company that provides TP 3654 active pharmaceutical ingredient (API) or TP 3654 finished formulations upon request. The TP 3654 suppliers may include TP 3654 API manufacturers, exporters, distributors and traders.

TP 3654 GMP

TP 3654 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TP 3654 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TP 3654 GMP manufacturer or TP 3654 GMP API supplier for your needs.

TP 3654 CoA

A TP 3654 CoA (Certificate of Analysis) is a formal document that attests to TP 3654's compliance with TP 3654 specifications and serves as a tool for batch-level quality control.

TP 3654 CoA mostly includes findings from lab analyses of a specific batch. For each TP 3654 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TP 3654 may be tested according to a variety of international standards, such as European Pharmacopoeia (TP 3654 EP), TP 3654 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TP 3654 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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