Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

18 Drugs in Development

18 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

18DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 591230-99-8, Transcrocetinate sodium, Disodium trans-crocetinate, Transcrocetinate disodium, Trans-sodium crocetinate, Trans-crocetin sodium

Molecular Formula

C₂₀H₂₂Na₂O₄

Molecular Weight

372.4 g/mol

InChI Key

RMDMBHQVNHQDDD-VFWKRBOSSA-L

FDA UNII

YP57637WMX

Trans Sodium Crocetinate is the sodium salt of the trans-isomer of the carotenoid crocetin with potential antihypoxic and radiosensitizing activities. Trans sodium crocetinate (TSC) increases the diffusion rate of oxygen in aqueous solutions such as from plasma to body tissue. The agent has been shown to increase available oxygen during hypoxic and ischemic conditions that may occur in hemorrhage, vascular and neurological disorders, and in the tumor microenvionment.

1 2D Structure

Trans Sodium Crocetinate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

2.1.2 InChI

InChI=1S/C20H24O4.2Na/c1-15(11-7-13-17(3)19(21)22)9-5-6-10-16(2)12-8-14-18(4)20(23)24;;/h5-14H,1-4H3,(H,21,22)(H,23,24);;/q;2*+1/p-2/b6-5+,11-7+,12-8+,15-9+,16-10+,17-13+,18-14+;;

2.1.3 InChI Key

RMDMBHQVNHQDDD-VFWKRBOSSA-L

2.1.4 Canonical SMILES

CC(=CC=CC=C(C)C=CC=C(C)C(=O)[O-])C=CC=C(C)C(=O)[O-].[Na+].[Na+]

2.1.5 Isomeric SMILES

C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)[O-])/C)/C)/C=C/C=C(/C(=O)[O-])\C.[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

YP57637WMX

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (2e,4e,6e,8e,10e,12e,14e)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioic Acid

2. Crocetin

3. Crocetin Sodium Salt

4. Trans-sodium Crocetinate

5. Transcrocetinate Sodium

6. Tsc

7. Tsc Cpd

2.3.2 Depositor-Supplied Synonyms

1. 591230-99-8

2. Transcrocetinate Sodium

3. Disodium Trans-crocetinate

4. Transcrocetinate Disodium

5. Trans-sodium Crocetinate

6. Trans-crocetin Sodium

7. Transcrocetinate Sodium [usan]

8. Yp57637wmx

9. 591230-99-8 (sodium 1

10. Disodium (all-e)-2,6,11,15-tetramethylhexadecahepta-2,4,6,8,10,12,14-enedioate

11. 64603-92-5

12. 2,4,6,8,10,12,14-hexadecaheptaenedioic Acid, 2,6,11,15-tetramethyl-, Sodium Salt (1:2), (2e,4e,6e,8e,10e,12e,14e)-

13. Sodium (2e,4e,6e,8e,10e,12e,14e)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

14. Unii-yp57637wmx

15. Crocetin Sodium

16. Chembl3137335

17. Akos037515031

18. Transcrocetinate Sodium [who-dd]

19. E80767

20. Q27294636

21. Transcrocetinate Disodium (disodium Trans-crocetinate)

22. Disodium;(2e,4e,6e,8e,10e,12e,14e)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₂Na₂O₄
Molecular Weight	372.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	372.13134774 g/mol
Monoisotopic Mass	372.13134774 g/mol
Topological Polar Surface Area	80.3 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	597
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	7
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anticarcinogenic Agents

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)

Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

Drugs in Development