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Chemistry

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Also known as: 591230-99-8, Transcrocetinate sodium, Disodium trans-crocetinate, Transcrocetinate disodium, Trans-sodium crocetinate, Trans-crocetin sodium
Molecular Formula
C20H22Na2O4
Molecular Weight
372.4  g/mol
InChI Key
RMDMBHQVNHQDDD-VFWKRBOSSA-L
FDA UNII
YP57637WMX

Trans Sodium Crocetinate
Trans Sodium Crocetinate is the sodium salt of the trans-isomer of the carotenoid crocetin with potential antihypoxic and radiosensitizing activities. Trans sodium crocetinate (TSC) increases the diffusion rate of oxygen in aqueous solutions such as from plasma to body tissue. The agent has been shown to increase available oxygen during hypoxic and ischemic conditions that may occur in hemorrhage, vascular and neurological disorders, and in the tumor microenvionment.
1 2D Structure

Trans Sodium Crocetinate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate
2.1.2 InChI
InChI=1S/C20H24O4.2Na/c1-15(11-7-13-17(3)19(21)22)9-5-6-10-16(2)12-8-14-18(4)20(23)24;;/h5-14H,1-4H3,(H,21,22)(H,23,24);;/q;2*+1/p-2/b6-5+,11-7+,12-8+,15-9+,16-10+,17-13+,18-14+;;
2.1.3 InChI Key
RMDMBHQVNHQDDD-VFWKRBOSSA-L
2.1.4 Canonical SMILES
CC(=CC=CC=C(C)C=CC=C(C)C(=O)[O-])C=CC=C(C)C(=O)[O-].[Na+].[Na+]
2.1.5 Isomeric SMILES
C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)[O-])/C)/C)/C=C/C=C(/C(=O)[O-])\C.[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
YP57637WMX
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2e,4e,6e,8e,10e,12e,14e)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioic Acid

2. Crocetin

3. Crocetin Sodium Salt

4. Trans-sodium Crocetinate

5. Transcrocetinate Sodium

6. Tsc

7. Tsc Cpd

2.3.2 Depositor-Supplied Synonyms

1. 591230-99-8

2. Transcrocetinate Sodium

3. Disodium Trans-crocetinate

4. Transcrocetinate Disodium

5. Trans-sodium Crocetinate

6. Trans-crocetin Sodium

7. Transcrocetinate Sodium [usan]

8. Yp57637wmx

9. 591230-99-8 (sodium 1

10. Disodium (all-e)-2,6,11,15-tetramethylhexadecahepta-2,4,6,8,10,12,14-enedioate

11. 64603-92-5

12. 2,4,6,8,10,12,14-hexadecaheptaenedioic Acid, 2,6,11,15-tetramethyl-, Sodium Salt (1:2), (2e,4e,6e,8e,10e,12e,14e)-

13. Sodium (2e,4e,6e,8e,10e,12e,14e)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

14. Unii-yp57637wmx

15. Crocetin Sodium

16. Chembl3137335

17. Akos037515031

18. Transcrocetinate Sodium [who-dd]

19. E80767

20. Q27294636

21. Transcrocetinate Disodium (disodium Trans-crocetinate)

22. Disodium;(2e,4e,6e,8e,10e,12e,14e)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 372.4 g/mol
Molecular Formula C20H22Na2O4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass372.13134774 g/mol
Monoisotopic Mass372.13134774 g/mol
Topological Polar Surface Area80.3 Ų
Heavy Atom Count26
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count7
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticarcinogenic Agents

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)


Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)


ABOUT THIS PAGE

Trans Sodium Crocetinate Manufacturers

A Trans Sodium Crocetinate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trans Sodium Crocetinate, including repackagers and relabelers. The FDA regulates Trans Sodium Crocetinate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trans Sodium Crocetinate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Trans Sodium Crocetinate Suppliers

A Trans Sodium Crocetinate supplier is an individual or a company that provides Trans Sodium Crocetinate active pharmaceutical ingredient (API) or Trans Sodium Crocetinate finished formulations upon request. The Trans Sodium Crocetinate suppliers may include Trans Sodium Crocetinate API manufacturers, exporters, distributors and traders.

Trans Sodium Crocetinate GMP

Trans Sodium Crocetinate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trans Sodium Crocetinate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trans Sodium Crocetinate GMP manufacturer or Trans Sodium Crocetinate GMP API supplier for your needs.

Trans Sodium Crocetinate CoA

A Trans Sodium Crocetinate CoA (Certificate of Analysis) is a formal document that attests to Trans Sodium Crocetinate's compliance with Trans Sodium Crocetinate specifications and serves as a tool for batch-level quality control.

Trans Sodium Crocetinate CoA mostly includes findings from lab analyses of a specific batch. For each Trans Sodium Crocetinate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trans Sodium Crocetinate may be tested according to a variety of international standards, such as European Pharmacopoeia (Trans Sodium Crocetinate EP), Trans Sodium Crocetinate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trans Sodium Crocetinate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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