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Chemistry

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Also known as: 127869-51-6, C-type natriuretic peptide (32-53) (human, porcine, rat), C-type natriuretic peptide (cnp) (1-22), human, Atriopeptin c (pig), Natriuretic peptide,c-type, Cnp (1-22), human
Molecular Formula
C93H157N27O28S3
Molecular Weight
2197.6  g/mol
InChI Key
UHSBKBYWHCBDCJ-DYGWFTAGSA-N

Natriuretic Peptide, C-Type
A PEPTIDE of 22 amino acids, derived mainly from cells of VASCULAR ENDOTHELIUM. It is also found in the BRAIN, major endocrine glands, and other tissues. It shares structural homology with ATRIAL NATRIURETIC FACTOR. It has vasorelaxant activity thus is important in the regulation of vascular tone and blood flow. Several high molecular weight forms containing the 22 amino acids have been identified.
1 2D Structure

Natriuretic Peptide, C-Type

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,10S,16S,19S,22S,28S,31S,34S,37S,40S,43S,49S,52R)-52-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]acetyl]amino]-40-(4-aminobutyl)-49-benzyl-28-[(2S)-butan-2-yl]-31-(3-carbamimidamidopropyl)-34-(carboxymethyl)-16,22-bis(hydroxymethyl)-10,37,43-tris(2-methylpropyl)-19-(2-methylsulfanylethyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carboxylic acid
2.1.2 InChI
InChI=1S/C93H157N27O28S3/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-/m0/s1
2.1.3 InChI Key
UHSBKBYWHCBDCJ-DYGWFTAGSA-N
2.1.4 Canonical SMILES
CCC(C)C1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)CC(=O)O)CC(C)C)CCCCN)CC(C)C)CC2=CC=CC=C2)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)CN)C(=O)O)CC(C)C)CO)CCSC)CO
2.1.5 Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)CC(=O)O)CC(C)C)CCCCN)CC(C)C)CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)O)CC(C)C)CO)CCSC)CO
2.2 Synonyms
2.2.1 MeSH Synonyms

1. C Type Natriuretic Peptide

2. C Type Natriuretic Peptide 22

3. C Type Natriuretic Peptide 53

4. C-type Natriuretic Peptide

5. C-type Natriuretic Peptide-22

6. C-type Natriuretic Peptide-53

7. Cnp-22

8. Cnp-53

9. Natriuretic Peptide, C Type

10. Natriuretic Peptide-22, C-type

11. Natriuretic Peptide-53, C-type

12. Peptide, C-type Natriuretic

13. Peptide-22, C-type Natriuretic

14. Peptide-53, C-type Natriuretic

2.2.2 Depositor-Supplied Synonyms

1. 127869-51-6

2. C-type Natriuretic Peptide (32-53) (human, Porcine, Rat)

3. C-type Natriuretic Peptide (cnp) (1-22), Human

4. Atriopeptin C (pig)

5. Natriuretic Peptide,c-type

6. Cnp (1-22), Human

7. Unii-3vcd78874l

8. Cnp-53

9. Dtxsid60155686

10. 3vcd78874l

11. Bdbm287915

12. Us10087144, Compound Cnp

13. Akos024457659

14. Natriuretic Peptide, C-type, >=95% (hplc)

15. C-type Natriuretic Peptide (1-22) (human, Rat, Swine)

16. C-type Natriuretic Peptide (32-53) (human, Porcine, Rat) Acetate Salt

17. Natriuretic Peptide, C-type, Human And Porcine - Cas 127869-51-6

18. C-type Natriuretic Peptide (cnp) (1-22), Humanc-type Natriuretic Peptide (cnp) (1-22), Human

19. H-gly-leu-ser-lys-gly-cys-phe-gly-leu-lys-leu-asp-arg-ile-gly-ser-met-ser-gly-leu-gly-cys-oh

2.3 Create Date
2007-07-04
3 Chemical and Physical Properties
Molecular Weight 2197.6 g/mol
Molecular Formula C93H157N27O28S3
XLogP3-8.7
Hydrogen Bond Donor Count32
Hydrogen Bond Acceptor Count35
Rotatable Bond Count44
Exact Mass2196.0853510 g/mol
Monoisotopic Mass2196.0853510 g/mol
Topological Polar Surface Area962 Ų
Heavy Atom Count151
Formal Charge0
Complexity4490
Isotope Atom Count0
Defined Atom Stereocenter Count17
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Natriuretic Agents

Endogenous or exogenous chemicals that regulate the WATER-ELECTROLYTE BALANCE in the body. They consist of peptides and non-peptide compounds. (See all compounds classified as Natriuretic Agents.)


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TransCon CNP Manufacturers

A TransCon CNP manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TransCon CNP, including repackagers and relabelers. The FDA regulates TransCon CNP manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TransCon CNP API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TransCon CNP Suppliers

A TransCon CNP supplier is an individual or a company that provides TransCon CNP active pharmaceutical ingredient (API) or TransCon CNP finished formulations upon request. The TransCon CNP suppliers may include TransCon CNP API manufacturers, exporters, distributors and traders.

TransCon CNP GMP

TransCon CNP Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TransCon CNP GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TransCon CNP GMP manufacturer or TransCon CNP GMP API supplier for your needs.

TransCon CNP CoA

A TransCon CNP CoA (Certificate of Analysis) is a formal document that attests to TransCon CNP's compliance with TransCon CNP specifications and serves as a tool for batch-level quality control.

TransCon CNP CoA mostly includes findings from lab analyses of a specific batch. For each TransCon CNP CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TransCon CNP may be tested according to a variety of international standards, such as European Pharmacopoeia (TransCon CNP EP), TransCon CNP JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TransCon CNP USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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