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    Chemistry

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    Also known as: 157283-68-6, Travatan, Travatan z, Izba, Al-6221, Travaprost
    Molecular Formula
    C26H35F3O6
    Molecular Weight
    500.5  g/mol
    InChI Key
    MKPLKVHSHYCHOC-AHTXBMBWSA-N
    FDA UNII
    WJ68R08KX9
    Travoprost
    A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.
    Travoprost is a Prostaglandin Analog.
    1 2D Structure

    Travoprost

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
    2.1.2 InChI
    InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
    2.1.3 InChI Key
    MKPLKVHSHYCHOC-AHTXBMBWSA-N
    2.1.4 Canonical SMILES
    CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC(=C2)C(F)(F)F)O)O)O
    2.1.5 Isomeric SMILES
    CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    WJ68R08KX9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (((1r)-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    2. Al 6221

    3. Al-6221

    4. Al6221

    5. Travatan

    6. Travatan Z

    7. Z, Travatan

    2.3.2 Depositor-Supplied Synonyms

    1. 157283-68-6

    2. Travatan

    3. Travatan Z

    4. Izba

    5. Al-6221

    6. Travaprost

    7. Trovoprost

    8. Otx-tp

    9. Chebi:746859

    10. Propan-2-yl (z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate

    11. Al6221

    12. Wj68r08kx9

    13. Nsc-760366

    14. Travoprost [usan]

    15. Travatanz

    16. (z)-isopropyl 7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((r,e)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    17. Isopropyl (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-{(1e,3r)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

    18. Travatan (tn)

    19. 5-heptenoic Acid, 7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl Ester, (5z)-

    20. Propan-2-yl (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoate

    21. Propan-2-yl (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-{(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate

    22. Travoprostum

    23. Unii-wj68r08kx9

    24. (((1r)-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    25. (+)-fluprostenol Isopropyl Ester

    26. Travoprost [usan:usp:inn:ban]

    27. Travoprost In Bulk

    28. Travoprostintermediates

    29. Travoprost [mi]

    30. Travoprost [inn]

    31. Travoprost [jan]

    32. Travoprost [vandf]

    33. Travoprost [mart.]

    34. Travoprost [usp-rs]

    35. Travoprost [who-dd]

    36. Schembl93818

    37. Travoprost (jan/usp/inn)

    38. (1r-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    39. (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((1e,3r)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate

    40. 5-heptenoic Acid, 7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester, (1r-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-

    41. Travoprost [ema Epar]

    42. Gtpl7102

    43. Chembl1200799

    44. Travoprost [orange Book]

    45. Dtxsid80896948

    46. Travoprost [usp Monograph]

    47. Duotrav Component Travoprost

    48. Ex-a1772

    49. Hy-b0584

    50. Zinc4474682

    51. Bdbm50248302

    52. S3738

    53. Akos024458039

    54. Travoprost Component Of Duotrav

    55. Ac-6103

    56. Am84515

    57. Ccg-269692

    58. Db00287

    59. Nsc 760366

    60. Ncgc00346741-02

    61. 5-heptenoic Acid, 7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((1e,3r)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester, (5z)-

    62. Bs-15509

    63. Fluprostenol Isopropyl Ester;al6221;flu-ipr

    64. D01964

    65. 283t686

    66. Sr-01000942266

    67. Sr-01000946860

    68. J-502633

    69. Q2193376

    70. Sr-01000942266-1

    71. Sr-01000946860-1

    72. Fluprostenol Isopropyl Ester, >=98%, Ethanol Solution

    73. (1r-(1.alpha.(z),2.beta.(1e,3r*),3.alpha.,5.alpha.))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    74. (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid 1-methyethyl Ester

    75. (z)-isopropyl 7-((1r,2r)-3,5-dihydroxy-2-((s,e)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    76. (z)-isopropyl 7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((r,e)-3-hydroxy-4-(3-(trifluoromethyl) Phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    77. (z)-isopropyl7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((r,e)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    78. Isopropyl (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((1e,3r)-3-hydroxy-4-((.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate

    79. Isopropyl (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((3r,e)-3-hydroxy-4-(3-(trifluoromethyl)-phenoxy)-but-1-enyl)-cyclopentyl)-hept-5-enoate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 500.5 g/mol
    Molecular Formula C26H35F3O6
    XLogP34.1
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count13
    Exact Mass500.23857332 g/mol
    Monoisotopic Mass500.23857332 g/mol
    Topological Polar Surface Area96.2 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity693
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameTravatan z
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength0.004%
    Market StatusPrescription
    CompanyAlcon Pharms

    2 of 4  
    Drug NameTravoprost
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops; Solution
    RouteOphthalmic; ophthalmic
    Strength0.004%
    Market StatusTentative Approval; Prescription
    CompanyPar Pharm

    3 of 4  
    Drug NameTravatan z
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength0.004%
    Market StatusPrescription
    CompanyAlcon Pharms

    4 of 4  
    Drug NameTravoprost
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops; Solution
    RouteOphthalmic; ophthalmic
    Strength0.004%
    Market StatusTentative Approval; Prescription
    CompanyPar Pharm

    4.2 Drug Indication

    Travoprost ophthalmic solution is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Travoprost is also currently indicated for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma.

    FDA Label

    Decrease of elevated intraocular pressure in adult patients with ocular hypertension or open-angle glaucoma (see section 5. 1). Decrease of elevated intraocular pressure in paediatric patients aged 3 years to < 18 years with ocular hypertension or paediatric glaucoma.

    Decrease of elevated intraocular pressure in adult patients with ocular hypertension or open-angle glaucoma (see section 5. 1).

    Decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma (see section 5. 1).

    Treatment of glaucoma

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Travoprost, an isopropyl ester prodrug, is a synthetic prostaglandin F2 alpha analog that is rapidly hydrolyzed by esterases in the cornea to its biologically active free acid. The travoprost free acid is potent and highly selective for the FP prostanoid receptor.

    5.2 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    TRAVOPROST
    5.3.2 FDA UNII
    WJ68R08KX9
    5.3.3 Pharmacological Classes
    Prostaglandins [CS]; Prostaglandin Analog [EPC]
    5.4 ATC Code

    S01EE04

    S01EE04

    S - Sensory organs

    S01 - Ophthalmologicals

    S01E - Antiglaucoma preparations and miotics

    S01EE - Prostaglandin analogues

    S01EE04 - Travoprost

    5.5 Absorption, Distribution and Excretion

    Absorption

    Travoprost is systemically absorbed through the cornea. In humans, peak plasma concentrations of travoprost free acid were low (25 pg/mL or less) and occurred within 30 minutes following topical ocular administration of one drop of 0.004% travoprost ophthalmic solution.

    Route of Elimination

    Less than 2% of the topical ocular dose of travoprost was excreted in the urine within 4 hours as the travoprost free acid. Moreover, elimination from plasma is rapid, resulting in concentrations below the limit of quantitation (< 10 pg/mL) by one hour. Furthermore, in rats, 95% of a subcutaneous radiolabeled dose was eliminated within 24 hours. The major route of elimination was via the bile (61%) with the remainder excreted by the kidneys.

    Volume of Distribution

    Given the data currently available, it has been recorded that travoprost free acid is moderately distributed into body tissues with a volume of distribution of 2.6 L/kg in rats.

    Clearance

    Data regarding the clearance of travoprost is not readily available or accessible.

    5.6 Metabolism/Metabolites

    Travoprost, an isopropyl ester prodrug, is hydrolyzed by esterases in the cornea to its biologically active free acid. Systemically, travoprost free acid is rapidly and extensively metabolized in the kidney, liver, and lung to inactive metabolites via beta-oxidation of the α(carboxylic acid) chain to give the 1,2-dinor and 1,2,3,4-tetranor analogs, via oxidation of the 15-hydroxyl moiety, as well as via reduction of the 13,14 double bond.

    5.7 Biological Half-Life

    The terminal elimination half-life of travoprost free acid is determined to be approximately 45 minutes, although studies demonstrated half-life values that ranged from 17 to 86 minutes.

    5.8 Mechanism of Action

    Travoprost, a prostaglandin F2 analogue, is a highly selective full agonist which has a high affinity for the prostaglandin FP receptor, and facilitates reductions in intraocular pressure by increasing the outflow of aqueous humour via trabecular meshwork and uveoscleral pathways. Reduction of the intraocular pressure in man starts about 2 hours after administration and maximum effect is reached after 12 hours. Significant lowering of intraocular pressure can be maintained for periods exceeding 24 hours with a single dose.

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    Travoprost

    Registration Number : 227MF10153

    Registrant's Address : ul. Pra(´)ce 657,277 11 Neratovice, Czech Republic

    Initial Date of Registration : 2015-06-01

    Latest Date of Registration : 2022-09-14

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    Registration Number : 227MF10136

    Registrant's Address : To(´) utca 1-5. , 1045 Budapest, Hungary

    Initial Date of Registration : 2015-05-12

    Latest Date of Registration : 2017-01-13

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    Registration Number : 227MF10195

    Registrant's Address : 207, Sujeong-ro, Jangan-myeon, Hwaseong-si, Gyeonggi-do, 18581, Republic of Korea

    Initial Date of Registration : 2015-08-03

    Latest Date of Registration : 2015-08-03

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    Travoprost (USP)

    Date of Issue : 2022-09-02

    Valid Till : 2025-05-05

    Written Confirmation Number : WC-0349

    Address of the Firm : MIs. MSN Laboratories Private Limited, Unit-II, sv. No, 50, Kardanur (Village), ...

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    Registrant Name : Novartis Korea Ltd.

    Registration Date : 2012-11-08

    Registration Number : 20121108-208-I-101-01

    Manufacturer Name : Dr. Reddy's Laboratories (EU...

    Manufacturer Address : Steanard Lane, Mirfield, West Yorkshire, WF14 8HZ

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    Registrant Name : YS Life Science Co., Ltd.

    Registration Date : 2017-06-23

    Registration Number : 20170623-208-I-528-02

    Manufacturer Name : YS Life Science Co., Ltd.

    Manufacturer Address : 207 Sujeong-ro, Jangan-myeon, Hwaseong-si, Gyeonggi-do

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    Travoprost

    About the Company : Cayman Pharma, a leading European provider of cGMP prostaglandin APIs, was formed in 2006 through the merger of Cayman Chemical and NeraPharm, both with vast expertise in prostagla...

    Cayman Pharma, a leading European provider of cGMP prostaglandin APIs, was formed in 2006 through the merger of Cayman Chemical and NeraPharm, both with vast expertise in prostaglandin chemistry. With almost 60 years of experience, Cayman Pharma owns and uses a patented route for the prostaglandin core structure and has received GMP approvals from European and US regulatory agencies. The company offers validated GMP routes and regulatory approvals for various therapeutic areas, including fertility, eye care, glaucoma and pulmonary hypertension, enabling the development and market launch of its products.
    Cayman

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    02

    Chirogate International

    Taiwan
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    German Wound Congress
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothChirogate is a professional Prostaglandin manufacturer.

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    About the Company : Chirogate, established in 1999, is a leading supplier of niche-market molecules, specializing in prostaglandins. With a focus on quality and compliance, Chirogate has built a reput...

    Chirogate, established in 1999, is a leading supplier of niche-market molecules, specializing in prostaglandins. With a focus on quality and compliance, Chirogate has built a reputation as a professional API supplier. Through innovative proprietary processes and advanced technology platforms, Chirogate offers competitively priced prostaglandin products to customers in both regulated and unregulated markets worldwide. Its activities adhere to stringent cGMP regulations and international drug manufacturing codes, guaranteeing the safety and quality of its products. Chirogate has been successfully inspected by regulatory agencies like the USFDA.
    Chirogate CB

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    03

    Century Pharmaceuticals

    India
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    iPHEX India
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothCentury has been an API manufacturer for over 40 years & is the partner of choice for multipurpose custom manufacturing projects.

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    Travoprost

    About the Company : Century Pharmaceuticals, established in 1982, has 40 years of experience in manufacturing APIs. It has been supplying APIs produced in-house to several major pharma companies in In...

    Century Pharmaceuticals, established in 1982, has 40 years of experience in manufacturing APIs. It has been supplying APIs produced in-house to several major pharma companies in India and abroad. Its APIs are manufactured in accordance with cGMP, 21CFR part 10 and ICH guidelines. It also produces intermediates and develops new APIs as per the needs of its clients. Century conducts biotechnological research that focuses on human therapeutic proteins. Currently, research is underway to find treatments for asthma, mastocytosis and basophilic leukemia. Century supplies research-grade biotech products and a wide range of animal health products.
    Century Company Banner

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    04

    EUROAPI

    France
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    TIDES USA
    Attending
    • fda
    • EDQM
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    Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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    Travoprost

    About the Company : EUROAPI is focused on reinventing active ingredient solutions to meet the needs of customers and patients worldwide sustainably. We are a leading player in APIs with approximately ...

    EUROAPI is focused on reinventing active ingredient solutions to meet the needs of customers and patients worldwide sustainably. We are a leading player in APIs with approximately 200 products in our portfolio, offering a large span of technologies while developing innovative molecules through our CDMO activities. Taking action for health by enabling access to essential therapies inspires our 3,650 people every day. With strong research and development capabilities and six manufacturing sites, all located in Europe, EUROAPI ensures API manufacturing of the highest quality to supply customers in more than 80 countries.
    EUROAPI Compnay Banner

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    05

    Transo-Pharm USA LLC

    U.S.A
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    German Wound Congress
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothTransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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    Travoprost

    About the Company : Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout...

    Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout the entire API life cycle, from product development through sales. Transo-Pharm serves as a sourcing and regulatory marketing agent for API manufacturers. It aids clients in establishing DMFs and provides GMP consulting. With a dedicated regulatory department, a warehouse, proprietary IPs for API processes, and partnerships with laboratories, Transo-Pharm offers a wide range of services. It operates from its offices in Shanghai, Hong Kong, Singapore, and the US.
    Transo Pharm USA Company Banner

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    06

    LGM Pharma

    U.S.A
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    CPhI North America
    Booth #1147
    • fda
    • EDQM
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    Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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    Travoprost

    About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

    LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
    LGM Pharma CB

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    07

    Dr. Reddy's Laboratories

    India
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    MAGHREB PHARMA
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Travoprost

    About the Company : Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfoli...

    Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfolio that provides high-quality, low-cost APIs to leading pharma companies in 80+ countries. It has 8 USFDA-inspected facilities – 6 in India & 1 each in Mexico & the UK & are inspected by international regulatory authorities on a regular basis. Its facilities are supplemented by formulation facilities that provide a wide range of dosage forms. Product(s) under patent(s) are offered only for R&D purposes U/S 107A of the Patent Act and not for commercial sale
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    08

    Gentec Pharmaceutical Group

    Spain
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    CPhI WW Frankfurt
    Booth #11.1C90
    • fda
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    Virtual BoothGentec Pharmaceutical Group is focused on manufacturing & developing APIs/HPAPIs, Advanced Intermediates & Fine Chemicals.

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    Travoprost

    About the Company : With more than 30 years of experience, Gentec Pharmaceutical Group has established itself as one of the leaders in raw materials and ingredients for the food, dietary and nutrition...

    With more than 30 years of experience, Gentec Pharmaceutical Group has established itself as one of the leaders in raw materials and ingredients for the food, dietary and nutrition sectors. It manufactures and commercializes more than 200 active pharmaceutical ingredients. It also offers a wide range of finished products. Gentec develops and manufactures services for APIs and intermediates as well as HPAPIs at its Duke Chem and Pharmanoid plants. It also offers a wide range of additional services that cover regulatory and legal matters, such as licenses for the elaboration of product ranges and market assessment.
    Gentec Company Banner

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    09

    Capital Farma

    Spain
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    CDMO Live
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothCapital Farma, a leading European pharmaceutical company focusing on the development & distribution of niche APIs & Pharma Services.

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    Travoprost

    About the Company : Capital Farma offers a comprehensive range of pharmaceutical solutions. Our API offering includes active ingredients sourced exclusively from top European manufacturers, ensuring t...

    Capital Farma offers a comprehensive range of pharmaceutical solutions. Our API offering includes active ingredients sourced exclusively from top European manufacturers, ensuring the highest quality and innovation. Additionally, we co-develop proprietary APIs with leading European Contract Manufacturing Organizations (CMOs), offering complete product packages by combining them with Finished Dosage Form (FDF) dossiers. Through our licensing services, we also offer FDF licenses to help clients expand their market reach and boost sales in regions with limited access. Partner with us for reliable, high-quality pharmaceutical products.
    Capital Farma

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    10

    CHEMO

    Spain
    German Wound Congress
    Not Confirmed
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    CHEMO

    Spain
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    German Wound Congress
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Travoprost

    About the Company : More than 35 years of dedication to quality, service and pursuit of excellence, CHEMO was founded by Hugo Sigman, M.D., and Silvia Gold, Biochemist, in Spain (Barcelona), in 1977, ...

    More than 35 years of dedication to quality, service and pursuit of excellence, CHEMO was founded by Hugo Sigman, M.D., and Silvia Gold, Biochemist, in Spain (Barcelona), in 1977, and starts business activities trading with pharmaceutical raw materials. In the 80's, the company expanded its operations into the Industrial Business, developing and manufacturing active pharmaceutical ingredients (APIs) in Italy (Industriale Chimica) and in Spain (Quimica Sintetica). In the 90's, CHEMO starts developing and manufacturing high quality and technology finished dosage forms (FDFs).
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    API Reference Price

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    06-Jan-2021
    28-Feb-2025
    GMS
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    01

    Brand Name : Travatan Z

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    Company :

    Travoprost

    Drug Cost (USD) : 14,924,685

    Year : 2022

    Prescribers : 10722

    Prescriptions : 37509

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    Travoprost

    Drug Cost (USD) : 129,313,971

    Year : 2022

    Prescribers : 137795

    Prescriptions : 560717

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    Travoprost

    Drug Cost (USD) : 25,577,164

    Year : 2021

    Prescribers : 31978

    Prescriptions : 77704

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    04

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    Travoprost

    Drug Cost (USD) : 144,152,907

    Year : 2021

    Prescribers : 157869

    Prescriptions : 615678

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    05

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    Travoprost

    Drug Cost (USD) : 122,232,660

    Year : 2020

    Prescribers : 112407

    Prescriptions : 387800

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    Brand Name : Travoprost

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    Company :

    Travoprost

    Drug Cost (USD) : 154,098,040

    Year : 2020

    Prescribers : 184367

    Prescriptions : 660013

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    07

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    Company :

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    Drug Cost (USD) : 391,469,827

    Year : 2019

    Prescribers : 291128

    Prescriptions : 1275031

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    Brand Name : Travoprost

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    Brand Name : Travoprost

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    • EDQM
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    Company :

    Travoprost

    Drug Cost (USD) : 864,560

    Year : 2019

    Prescribers : 3433

    Prescriptions : 3434

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    Brand Name : Travatan Z

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    Company :

    Travoprost

    Drug Cost (USD) : 393,794,154

    Year : 2018

    Prescribers : 317008

    Prescriptions : 1426934

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    Brand Name : Travoprost

    Country
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    German Wound Congress
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    Brand Name : Travoprost

    Country
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    German Wound Congress
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Company :

    Travoprost

    Drug Cost (USD) : 0

    Year : 2018

    Prescribers :

    Prescriptions : 0

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    CzechRepublic.png
    Travoprost API needed in Czech Republic [ENA21470]
    A company that focuses on research, development and manufacturing of OSDs, ophthalmics, parenterals & solution is looking for suppliers of Travoprost (53 g/ annum) API for commercial purposes. The suppliers must support this enquiry with USDMF & CoA.
    19 Dec 2024

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    19 Dec 2024

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    19 Dec 2024

    CzechRepublic.png
    Travoprost (53 g/ annum) API needed in Czech Republic [ENA17378]
    A company that focuses on research, development and manufacturing of OSDs, ophthalmics, parenterals & solution is looking for suppliers of Travoprost (53 g/ annum) API for commercial purposes. The suppliers must support this enquiry with USFDA, USDMF & CoA.
    22 Jun 2023

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    22 Jun 2023

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    22 Jun 2023

    Bangladesh.png
    Travoprost (50 g) API needed in Bangladesh [ENA16298]
    A company that deals in the distribution of various pharmaceutical products is looking for suppliers of Travoprost (50 g) API for commercial purposes. The suppliers must support this enquiry with CoA.
    04 Feb 2023

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    04 Feb 2023

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    04 Feb 2023

    Brazil.png
    Travoprost API needed in Brazil [ENA14023]
    A company that provides consultancy services to pharmaceutical industry is looking for suppliers of Travoprost API for commercial purpose. The suppliers must support this enquiry with CoA.
    20 Jun 2022

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    20 Jun 2022

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    Reply Comment (7)

    20 Jun 2022

    Bangladesh.png
    Various Ophthalmic Grade APIs needed in Bangladesh [ENA12364]
    A company based in Bangladesh that provides world-class solutions to the local pharmaceutical industry & deals in active pharmaceutical ingredients and excipients is looking for suppliers of Various Ophthalmic Grade APIs for development purpose. The suppliers must support this enquiry with CoA. 1. Moxifloxacin HCl API 2. Levofloxacin Hemihydrate API 3. Travoprost API 4. Brinzolamide API 5. Brimonidine Tartrate API 6. Nepafenac API 7. Olopatadine HCl API 8. Dorzolamide HCl API 9. Tobramycin API 10. Ganciclovir API
    10 Jan 2022

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    10 Jan 2022

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    10 Jan 2022

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    Various APIs needed in India [ENA11833]
    A company that deals in the development & manufacturing of tablets, hard gelatin capsules, oral liquids, oral dry powders, dry powder injections & external preparations is looking for suppliers of Various APIs for development purpose. The suppliers must support this enquiry with CoA. 1. Travoprost (5 g) API 2. Acetylcysteine (400 g) API 3. Phytomenadione (5 g) API 4. Phytonadione (5 g) API 5. Homatropine Hydrochloride (50 g) API 6. Tropicamide (20 g) API
    10 Nov 2021

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    10 Nov 2021

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    10 Nov 2021

    india-flag.png
    Various APIs needed in India [ENA10641]
    A company specializing in analytical testing of a range of drug delivery systems is looking for Various APIs for development purposes. The required quantity is 50 g for each. The suppliers must support this enquiry with USDMF. The final market is the US. 1. USP Grade Brimonidine Tartrate API 2. Travoprost API 3. Timolol Maleate API 4. Budesonide (Sterile) API 5. Varenicline Tartrate API 6. Formoterol Fumarate API 7. Arformoterol Tartrate API 8. USP Grade Brinzolamide (Micronized) API 9. Loteprednol Etabonate API 10. Lifitegrast API 11. Naloxone Hydrochloride API
    15 Jun 2021

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    15 Jun 2021

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    15 Jun 2021

    Russia-big.png
    Travoprost (500 g) API needed in Russia [ENA08706]
    Bright Way, an import-export oriented company that deals in various pharmaceutical products is looking for suppliers of Travoprost (500 g) API. Interested suppliers can contact them via their email: o.chuiko@brightway.ru.
    01 Oct 2020

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    01 Oct 2020

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    01 Oct 2020

    Egypt.png
    Travoprost API needed in Egypt [ENA07281]
    A company that develops a wide range of branded generic medicines, nutraceuticals, food supplements & veterinary products is looking for suppliers of Travoprost API.
    14 May 2020

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    14 May 2020

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    14 May 2020

    Thailand.png
    Travoprost API needed in Thailand [ENA06149]
    A quality-centered pharmaceutical company with its main focus on generic formulation development and contract manufacturing services with the highest manufacturing standard is looking for suppliers of Travoprost API. Suppliers must support with CoA, GMP and MSDS.
    26 Dec 2019

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    26 Dec 2019

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    26 Dec 2019

    Only 10 entries up to this point, click to access all click full view read-more
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    ABOUT THIS PAGE

    Looking for 157283-68-6 / Travoprost API manufacturers, exporters & distributors?

    Travoprost manufacturers, exporters & distributors 1

    63

    PharmaCompass offers a list of Travoprost API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Travoprost manufacturer or Travoprost supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Travoprost manufacturer or Travoprost supplier.

    PharmaCompass also assists you with knowing the Travoprost API Price utilized in the formulation of products. Travoprost API Price is not always fixed or binding as the Travoprost Price is obtained through a variety of data sources. The Travoprost Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Travoprost

    Synonyms

    157283-68-6, Travatan, Travatan z, Izba, Al-6221, Travaprost

    Cas Number

    157283-68-6

    Unique Ingredient Identifier (UNII)

    WJ68R08KX9

    About Travoprost

    A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.

    Travoprost Manufacturers

    A Travoprost manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Travoprost, including repackagers and relabelers. The FDA regulates Travoprost manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Travoprost API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Travoprost manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Travoprost Suppliers

    A Travoprost supplier is an individual or a company that provides Travoprost active pharmaceutical ingredient (API) or Travoprost finished formulations upon request. The Travoprost suppliers may include Travoprost API manufacturers, exporters, distributors and traders.

    click here to find a list of Travoprost suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Travoprost USDMF

    A Travoprost DMF (Drug Master File) is a document detailing the whole manufacturing process of Travoprost active pharmaceutical ingredient (API) in detail. Different forms of Travoprost DMFs exist exist since differing nations have different regulations, such as Travoprost USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Travoprost DMF submitted to regulatory agencies in the US is known as a USDMF. Travoprost USDMF includes data on Travoprost's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Travoprost USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Travoprost suppliers with USDMF on PharmaCompass.

    Travoprost JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Travoprost Drug Master File in Japan (Travoprost JDMF) empowers Travoprost API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Travoprost JDMF during the approval evaluation for pharmaceutical products. At the time of Travoprost JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Travoprost suppliers with JDMF on PharmaCompass.

    Travoprost KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Travoprost Drug Master File in Korea (Travoprost KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Travoprost. The MFDS reviews the Travoprost KDMF as part of the drug registration process and uses the information provided in the Travoprost KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Travoprost KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Travoprost API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Travoprost suppliers with KDMF on PharmaCompass.

    Travoprost WC

    A Travoprost written confirmation (Travoprost WC) is an official document issued by a regulatory agency to a Travoprost manufacturer, verifying that the manufacturing facility of a Travoprost active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Travoprost APIs or Travoprost finished pharmaceutical products to another nation, regulatory agencies frequently require a Travoprost WC (written confirmation) as part of the regulatory process.

    click here to find a list of Travoprost suppliers with Written Confirmation (WC) on PharmaCompass.

    Travoprost GMP

    Travoprost Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Travoprost GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Travoprost GMP manufacturer or Travoprost GMP API supplier for your needs.

    Travoprost CoA

    A Travoprost CoA (Certificate of Analysis) is a formal document that attests to Travoprost's compliance with Travoprost specifications and serves as a tool for batch-level quality control.

    Travoprost CoA mostly includes findings from lab analyses of a specific batch. For each Travoprost CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Travoprost may be tested according to a variety of international standards, such as European Pharmacopoeia (Travoprost EP), Travoprost JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Travoprost USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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