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1. Fc-11
2. Fluorotrichloromethane
3. Freon 11
4. Genetron 11
5. Trichlorofluoromethane Hydrate
6. Trichlorofluoromethane, (18)f-labeled
7. Trichloromonofluoromethane
1. Fluorotrichloromethane
2. 75-69-4
3. Trichloro(fluoro)methane
4. Trichloromonofluoromethane
5. Fluorochloroform
6. Cfc-11
7. Eskimon 11
8. Trichlorofluorocarbon
9. Refrigerant 11
10. Algofrene Type 1
11. Freon Mf
12. Freon 11
13. Arcton 9
14. Monofluorotrichloromethane
15. Arcton 11
16. Methane, Trichlorofluoro-
17. Electro-cf 11
18. Fluorocarbon 11
19. Propellant 11
20. Chladone 11
21. Genetron 11
22. Genetron 11sba
23. Daiflon 11
24. Isotron 11
25. Kaltron 11
26. Khladon 11
27. Daiflon S 1
28. Frigen 11
29. Frigen 11a
30. Dymel 11
31. Fluon 11
32. Freon 11a
33. Halon 11
34. Ledon 11
35. Ccl3f
36. Frigen S 11
37. Isceon 131
38. F 11 (halocarbon)
39. Trichloromethyl Fluoride
40. Methane, Fluorotrichloro-
41. Cfcl3
42. Fkw 11
43. F 11b
44. Fc 11
45. F 11
46. R 11
47. Trichloromonofluoromethane [nf]
48. Chebi:48236
49. 990tyb331r
50. Freon He
51. Halocarbon 11
52. Refrigerant R 11
53. Trichloromonofluoromethane (nf)
54. Ucon Flurocarbon 11
55. Ucon Refrigerant 11
56. Freon 11b
57. Freon-11
58. Caswell No. 878
59. Fluorocarbon No. 11
60. R 11 (refrigerant)
61. Fc 11 (halocarbon)
62. Ccris 604
63. Fluorotrojchlorometan
64. Fluorotrojchlorometan [polish]
65. Cfc 11
66. Hsdb 138
67. Nci-c04637
68. Einecs 200-892-3
69. Rcra Waste No. U121
70. Epa Pesticide Chemical Code 000013
71. Brn 1732469
72. F-11
73. Unii-990tyb331r
74. Distillex Ds6
75. Refrigerant R11
76. Triclorofluormethane
77. R 11, Halocarbon
78. Fc 11, Halocarbon
79. Trichlorfluomethane
80. Freon 11 (tn)
81. Dsstox_cid_1384
82. Fluorotrichloromethane 99%
83. Schembl1320
84. Dsstox_rid_76126
85. Chlorofluoromethane (ccl3f)
86. Dsstox_gsid_21384
87. Chlorofluorocarbon 11
88. 4-01-00-00054 (beilstein Handbook Reference)
89. Chembl348290
90. Dtxsid5021384
91. Trichlorofluoromethane [mi]
92. Trichlorofluoromethane, >=99.5%
93. Amy33469
94. Zinc8214698
95. Tox21_201190
96. Mfcd00000784
97. Trichlorofluoromethane [mart.]
98. Akos007930402
99. Trichloromonofluoromethane [ii]
100. Trichlorofluoromethane [who-dd]
101. Cas-75-69-4
102. Trichloromonofluoromethane [hsdb]
103. Ncgc00091043-01
104. Ncgc00091043-02
105. Ncgc00258742-01
106. Trichloromonofluoromethane [vandf]
107. Trichlorofluoromethane, Analytical Standard
108. Db-055980
109. Ft-0631315
110. D06220
111. Fluorotrichloromethane 100 Microg/ml In Methanol
112. Trichlorofluoromethane 100 Microg/ml In Methanol
113. Fluorotrichloromethane 5000 Microg/ml In Methanol
114. Q423000
115. Trichlorofluoromethane Solution, 200 Mug/ml In Methanol, Analytical Standard
116. Trichlorofluoromethane Solution, Certified Reference Material, 5000 Mug/ml In Methanol
117. Trichlorofluoromethane Solution, Nmr Reference Standard, 10% In Acetone-d6 (99.9 Atom % D), 1,2-dichloro-1,1-difluoroethane 1 %, Tms 6 %
118. Trichlorofluoromethane Solution, Nmr Reference Standard, 50% In Chloroform-d (99.8 Atom % D), Nmr Tube Size 5 Mm X 8 In.
| Molecular Weight | 137.36 g/mol |
|---|---|
| Molecular Formula | CCl3F |
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 135.904961 g/mol |
| Monoisotopic Mass | 135.904961 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 5 |
| Formal Charge | 0 |
| Complexity | 28.4 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Pulmonary uptake of inhaled CFC-11 by rabbits and dogs is prompt. Peak circulating concentrations after exposure at 4500 to 5000 ppm were achieved in 15 seconds with steady-state reached at 20 minutes. Elimination is relatively rapid. Dogs exhaled within 1 hr essentially all the CFC-11 inhaled during a 6 to 20 min exposure at 5,000 ppm. Inhaled CFC-11 was promptly detected in blood, cerebrospinal fluid, bile, and urine of anesthetized rabbits and dogs ... . Unanesthetized dogs exposed to 1,000-10,000 ppm for 10 minutes showed a rapid rise in blood conc of CFC-11 during the first 5 min, which was followed by a rapid and then more gradual decline after exposure.
American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Trichlorofluoromethane p. 2 CD-ROM Cincinnati, OH 45240-4148 2012.
In male and female adult humans, 79% to 100% of inhaled (14)C-CFC-11 was exhaled within the first hour after a 7- or 17- minute inhalation at 1000 ppm. Only 0.12% of the inhaled compound was recovered as the carbon dioxide metabolite and only 0.08% appeared in the urine. At 30 minutes, retention of the labeled dose (approximately 7 mg Cl-CFC-11) inhaled in a single breath was 23% versus 10%, 20%, and 12% for comparable doses of CFC-12 1,1,2-trichloro-1,1,2-trifluoroethane (CFC-113), and dichlorotetrafluoroethane (CFC-114), respectively.
American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Trichlorofluoromethane p. 2 CD-ROM Cincinnati, OH 45240-4148 2012.
Radiocarbon-labeled trichlorofluoromethane (FC-11; (14)CC13F) and dichlorodifluormethane (FC-12; (14)CC12F2) were separately inhaled by a female subject and a male subject. A predetermined volume of fluorocarbon (1000 ppm; 100 muCi) in air was delivered through a non-rebreathing system and a tight-fitting face mask for 7-17 minutes. Total expired gases were collected during fluorocarbon exposure and afterward until no radioactivity was detectable. Expired (14)CO2 and (14)C-fluorocarbon were assayed. Urine was collected for 72 hours and assayed for nonvolatile radioactivity. Total recoveries of FC-11 were 99.5 and 79.4 per cent in the woman and the man, respectively. Total recoveries of FC-12 were 95.4 and 103.2 per cent. Traces of radioactivity were found in urine (FC-11, 0.07 and 0.09 per cent; FC-12, 0.02 and 0.03 per cent) and in exhaled carbon dioxide (FC-11, 0.13 and 0.10 per cent; FC-12, 0.08 per cent in both subjects). Total metabolites were equal to or less than 0.2 per cent of the administered dose. The amount of radioactivity in urine was insufficient to permit identification of possible fluorocarbon metabolites. The trace of metabolites could be products of radiolabeled impurities.
PMID:1115387 Mergner GW et al; Anesthesiology 42 (3): 345-51 (1975)
A free compartment open model was proposed for disposition of iv trichlorofluoromethane in dogs with average half-lives of 3.2, 16 and 93 min for 3 disposition phases. Tissue compartment distribution following a single dose showed that about 2 hr were required to achieve pseudo distribution equilibrium, following which more than 90% of the drug remaining in the body was retained in tissue compartments.The volume of distribution was approximately 6 times the body weight in terms of blood concn and about 30% of the propellant was cleared from blood passing through the lungs in each cycle. Disposition of propellant followed dose independent kinetics after multiple dosing, and accumulation in tissues continued for a much longer period, resulting in high tissue compartment levels.
Niazi S, Chiou WL; J Pharm Sci 64 763-9 May (1975)
For more Absorption, Distribution and Excretion (Complete) data for TRICHLOROFLUOROMETHANE (15 total), please visit the HSDB record page.
Dogs /were/ exposed for 6-20 minutes to levels of
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5: 513
When trichlorofluoromethane was inhaled by humans, recovery of intact cmpd in exhaled air was 79-99% & in urine, 0.07-0.09%, & metabolites amt to 0.2% or less ... .
National Research Council. Drinking Water & Health Volume 1. Washington, DC: National Academy Press, 1977., p. 781
Rat-liver microsomes dechlorinate trichlorofluoromethane to dichlorofluoromethane. This reaction ... is mediated via the hepatic microsomal P450 enzyme system. Trichlorofluoromethane & dichlorofluoromethane admin as high acute inhalation dosages were expired unchanged by both dogs & rabbits.
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 4: A Review of the Literature Published during 1974 and 1975. London: The Chemical Society, 1977., p. 241
Theoretical metabolites of trichlorofluoromethane are dichlorofluoromethane & tetrachlorodifluoroethane. No evidence of free-radical formation in rats or mice has been shown; nor is there evidence of significant metabolism of trichlorofluoromethane ...
National Research Council. Drinking Water and Health. Volume 3. Washington, DC: National Academy Press, 1980., p. 166
For more Metabolism/Metabolites (Complete) data for TRICHLOROFLUOROMETHANE (6 total), please visit the HSDB record page.
The distribution half-life of the common fluorocarbons (Freon 11, Freon 12) averages 13 to 14 seconds; the elimination half-life is longer (1.5 hours) because of slower release from fat stores.
Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 884
... Fluorotrichloromethane (R-11) concentrations in urine--in contrast to blood or alveolar air--depend on the dose taken up. After termination of exposure, R-11 concentrations in alveolar air and in blood are excreted with biological half-lives of seven and eleven minutes respectively during the first phase of elimination and with 1.8 and 1.0 hr respectively during the second phase of elimination. ...
PMID:4030118 Angerer Jet al; Int Arch Occup Environ Health 56 (1): 67-72 (1985)
Volunteers exposed to CFC-11 at 3751 mg/cu m (657 ppm) for 150-210 min showed half-lives for the initial and second phases of elimination from venous blood of 11 min and 1 hr respectively. Half-lives for the initial and second phases of CFC-11 elimination in alveolar air were 7 min and 1.8 hr, respectively.
WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons p.60 (1990)
...Analysis of the human data also utilized a two-compartment pharmacokinetic model and found initial elimination half-times from blood and alveolar air of 7 and 11 minutes, respectively and half-times for the slow elimination phase from blood and alveolar air of 1.8 to 1.0 hour.
American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Trichlorofluoromethane p. 3 CD-ROM Cincinnati, OH 45240-4148 2012.
Analyses of a two-compartment pharmacokinetic model in dogs found an initial elimination half-time of 0.6 +/- 0.25 minute.
American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Trichlorofluoromethane p. 3 CD-ROM Cincinnati, OH 45240-4148 2012.
... The mechanism of FC-11 cardiotoxicity ... /originates/ from irritation of the respiratory tract which in turn reflexly influences the heart rate even prior to absorption of the fluorocarbon, followed by direct depression of the heart after absorption. FC-11 causes only depression of respiratory minute volume that is not preceded by stimulation of breathing. There is ultimate cessation of respiration, which is a manifestation of generalized depression of the CNS by FC-11.
Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 1183
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